Abstract:Objective To investigate the practical effects of implementing high-quality nursing for patients with secretory otitis media.Methods A retrospective analysis was conducted on 90 patients with secretory otitis media treated in our hospital from January 2023 to December 2023.The patients were divided into a control group(n=46)receiving routine care and an observation group(n=44)receiving high-quality nursing care.The observation indicators included:duration of sensation of fullness and tinnitus,hearing recovery time,Self-Rating Anxiety/Depression Scale(SAS/SDS)scores,General Comfort Questionnaire(GCQ)scores,36-Item Short Form Health Survey(SF-36)scores,and family satisfaction.Results The duration of sensation of fullness and tinnitus,as well as the hearing recovery time in the observation group were shorter than those in the control group[(3.2±0.4)d,(4.1±0.6)d and(5.3±1.0)d vs.(4.4±0.7)d,(5.5±0.8)d and(7.1±1.1)d,respectively,P<0.05].Before treatment,there were no significant differences in SAS and SDS scores between the two groups(P>0.05).After treatment,the scores decreased in both groups and were lower in the observation group compared with the control group(P<0.05).There were no significant differences in GCQ and SF-36 scores between the two groups before treatment(P>0.05).After treatment,the scores increased in both groups and were higher in the observation group compared with the control group(P<0.05).The recurrence rate in the observation group was 4.55%,lower than the 19.57%in the control group(χ2=4.729,P=0.030).Conclusion For patients with secretory otitis media,the implementation of high-quality nursing care can rapidly improve symptoms,specifically alleviate negative emotions and discomfort,thereby enhance the quality of life during treatment.It also helps control the risk of disease recurrence and improves satisfaction,gaining patient acceptance.It is worthy of active promotion and application in clinical practice.

Abstract:Objective To analyze the clinical application effect of electronic staining endoscopy in vocal cord leukoplakia.Methods 65 patients with vocal cord leukoplakia who visited our hospital from January 2017 to October 2023 were selected for routine white light and narrow band imaging examinations,and the differences in examination results were analyzed.Results Compared with ordinary white light examination,the application of narrow band imaging mode had a higher overall detection rate for vocal cord leukoplakia(P<0.05).The sensitivity,specificity,and accuracy of narrow band imaging mode in diagnosing malignant lesions of vocal cord leukoplakia were higher than those of ordinary white light mode(97.5%vs 85.0%,96.0%vs 72.0%,96.9%vs 80.0%,χ2=3.914,5.357,9.119,P=0.048,0.021,0.003,respectively).Conclusion For vocal cord leukoplakia,electronic staining endoscopy is used for examination.Compared with ordinary white light mode,narrow band imaging mode has a higher overall detection rate of the lesion,and demonstrates significant diagnostic value for differential diagnosis of malignant vocal cord leukoplakia.

Abstract:Objective To explore the effectiveness and adverse reactions of the combined therapy of gamma-oryzanol with rabeprazole enteric coated capsules in patients with dysphagia.Methods Using the random number table method,half of 80 patients with dysphagia(treated from January 2022 to December 2023 in our hodpital)were included in the control group(treated with rabeprazole enteric coated capsules as a single therapy),while the remaining study subjects were assigned to the observation group(treated with a combination of gamma-oryzanol with rabeprazole enteric coated capsules).The grouping strategy was based on different treatment plans,and the observation indicators were treatment effectiveness,adverse reactions,and recurrence.Results The research results showed that the total effective rate of treatment in the observation group was higher than that in the control group(95.00%vs 80.00%,χ2=4.114,P=0.043),and the incidence of adverse reactions and the recurrence rate(5%vs 22%,χ2=5.165,P=0.023)after treatment were lower than those in the control group(P<0.05).Conclusion After scientific treatment with a comprehensive plan of gamma-oryzanol and rabeprazole enteric coated capsules,patients with dysphagia can significantly improve their condition.The risk of common adverse reactions and recurrence after treatment are low,and they have high safety and excellent clinical effects.

Abstract:Objective To explore the efficacy and accuracy of spiral CT multiplanar reconstruction technology in the diagnosis of laryngeal cancer.Methods A total of 80 patients with laryngeal cancer diagnosed by histopathological examination and admitted to our hospital from February 2018 to June 2023 were selected as the research subjects.Cross-sectional imaging and cross-sectional multi-planar reconstruction were selected to analyze the diagnostic sensitivity,specificity and accuracy of spiral CT examination for intra-and extra-tissue invasion of larynx.Results The diagnostic sensitivities of the cross-sectional multiplanar reconstruction for the laryngeal structures such as the epiglottis,aryloepiglottis folds,ventricular bands,vocal cords,and anterior joint were 100.00%,100.00%,100.00%,97.10%,and 96.55%,respectively.All were higher than those of the cross-sectional imaging(91.38%,93.55%,92.31%,88.71%,and 85.19%,respectively;P<0.05).The diagnostic accuracies of the cross-sectional multiplanar reconstruction for the laryngeal structures such as the epiglottis,aryloepiglottis fold,ventricular band,vocal cords,and anterior joint were 100.00%,97.50%,94.50%,95.00%,and 95.00%,respectively.They were significantly higher than those of the cross-sectional imaging(83.75%,83.75%,83.75%,78.75%,77.50%,respectively;P<0.05).The diagnostic sensitivities of the cross-sectional multiplanar reconstruction for the epiglottic space,paratygeal space and piriform fossa of the external laryngeal structures were 100.00%,100.00%and 97.87%respectively,which were significantly higher than those of the cross-sectional imaging at 87.93%,86.89%and 79.17%respectively(P<0.05).The diagnostic accuracies of the cross-sectional multiplanar reconstruction for the epiglottic space,paratygeal space and piriform pit of the external laryngeal structures were 100.00%,98.75%and 96.25%respectively,which were significantly higher than those of the cross-sectional imaging at 90.00%,87.50%and 85.00%respectively(P<0.05).Conclusion Compared with simple cross-sectional imaging,the spiral CT cross-sectional multiplanar reconstruction technology has a high accuracy rate in diagnosing laryngeal cancer,providing a favorable reference for the early intervention of the disease.

Abstract:Objective To investigate the therapeutic efficacy of pulse acupuncture and moxibustion in the clinical treatment of sudden deafness.Methods A total of 82 patients with sudden deafness of the liver depression and spleen deficiency type admitted to the Hekou Community Health Service Center in Dongying,Shandong Province,China,from January 2022 to January 2024 were enrolled.They were randomly divided into an observation group(pulse acupuncture and moxibustion treatment,n=41)and a control group(routine acupuncture,n=41)to compare the treatment effects.Results After treatment the average hearing threshold,the Tinnitus Handicap Inventory(THI)score and hearing loss score in the observation group[(30.18±6.30)dB,23.91±4.12 and 1.19±0.28,respectively]were lower than those in the control group[(39.75±7.29)dB,28.64±4.53 and 1.57±0.36,respectively](all P<0.05).For hemorheological indices,whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity in the observation group[(2.98±0.55,10.31±1.60 and 1.29±0.25)mPa·s,respectively]were lower than those in the control group[(4.36±0.73,14.59±2.74 and 1.90±0.32)mPa·s,respectively](all P<0.05).The time to tinnitus relief[(9.8±1.7)d]and the time to vertigo disappearance[(6.7±1.2)d]in the observation group were both shorter than those in the control group[(12.0±2.3)d and(8.6±1.3)d,respectively](all P<0.05).Conclusion Pulse acupuncture and moxibustion is an effective therapeutic approach for patients with sudden deafness of liver depression and spleen deficiency type.

Abstract:Objective To observe the effect of combining Traditional Chinese and Western medicine in the treatment of allergic rhinitis.Methods 62 patients(admitted from November 2022 to May 2024)were randomly and evenly divided.The control group received conventional Western medicine treatment,while the observation group received a combination of Traditional Chinese and Western medicine treatment.The total IgE levels,nasal eosinophil counts,and subjective efficacy evaluation results were compared between two groups before and after treatment.Results Before treatment,the total IgE levels in both groups were high,both exceeding 100 IU/mL,with no statistically significant difference(P>0.05).After treatment,the total IgE levels in both groups decreased,but in the observation group it decreased to below 100 IU/ml,while in the control group it remained above 100 IU/ml,with a statistically significant difference(P<0.05).Before treatment,the nasal eosinophil counts in both groups were high(both exceeding 5%),but the difference was not statistically significant(P>0.05).After treatment,the nasal eosinophil counts in both groups decreased,but in the observation group it decreased to below 2%,while in the control group it remained above 2%,with a statistically significant difference(P<0.05).The total effective rate by subjective efficacy evaluation in the observation group was as high as 96.77%,which was higher than the 70.97%in the control group,with P<0.05.Conclusion When treating allergic rhinitis,a combination of Traditional Chinese and Western medicine can achieve more significant therapeutic effects compared with Western medicine alone.

Abstract:Objective To analyze the clinical effect of Banxia Houpo decoction combined with Gegen Qinlian decoction in the treatment of chronic pharyngitis.Methods Forty patients with chronic pharyngitis who visited our hospital from January 2023 to June 2024 were selected as the research subjects.The 40 patients were randomly assigned to a control group and an experimental group using the hidden envelope method,with 20 patients in each group.The control group received conventional Western medicine treatment for chronic pharyngitis,while the experimental group was treated with Banxia Houpo decoction modified and combined with Gegen Qinlian decoction orally on the basis of the control group.The two groups of patients under different treatment regimens were compared in the clinical efficacy,inflammatory factor expression[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],adverse reactions,and recurrence rate.Results The effective rate of treatment in the experimental group(95%)was higher than that in the control group(85%)(χ2=2.259,P=0.003).After treatment,the scores of the main and secondary symptoms in the experimental group were lower than those in the control group(P<0.05).After treatment,the expression levels of IL-6,CRP and TNF-α in the experimental group[(4.26±1.15)、(19.38±2.78)、(85.09±10.74)]were lower than those in the control group[(5.35±1.21)、(22.09±2.81)、(98.17±9.86)](t=2.920、3.066、4.012,P=0.006、0.004、<0.001).The incidence and recurrence rate of adverse reactions in the experimental group(10%and 5%,respectively)were lower than those in the control group(20%and 15%,respectively)(χ2=1.090、1.121,P=0.011、0.005).Conclusion The application of Banxia Houpo decoction combined with Gegen Qinlian decoction in the treatment of chronic pharyngitis has significant clinical therapeutic effects,and can comprehensively improve patients'clinical symptoms,with high medication safety and low recurrence rate,thus has clinical promotion value.

Abstract:Objective To achieve the goal of comprehensive talent cultivation in higher education for traditional Chinese medicine(TCM)in the new era,this study actively explores the application of the innovative"5-5-5"curriculum model—Five Senses,Five Organs,and Five Educations—under the context of"integration of five types of education"in the training of talents in TCM otolaryngology.Methods Based on the characteristics of TCM otolaryngology courses,a preliminary exploration,investigation,and integration of the"5-5-5"innovative curriculum model was conducted within the professional course teaching under the context of"integration of five types of education."This approach combines classroom teaching with traditional culture,classroom education with professional literacy,and integrates internet platforms.It seeks to appropriately integrate students'professional knowledge and skill development into TCM otolaryngology teaching from the perspectives of morality,intelligence,physical education,aesthetic education,and labor education.Conclusion The"integration of five types of education"aligns with the current standards for talent cultivation in higher education.Guided by morality,it is suggested to establish a triad educational system encompassing ideological-political courses,classroom teaching,and clinical practice.Guided by intelligence,teaching innovation reform should be optimized through online and offline teaching modes and formative evaluation,achieving a comprehensive upgrade of the curriculum system.Guided by physical education,TCM theory should be combined with exercise to develop new training approaches for the senses and organs.Guided by aesthetics,aesthetic education within TCM otolaryngology teaching should be strengthened to form a diversified aesthetic education system.Guided by labor,the distinctive features of TCM otolaryngology should be utilized to build a labor education ecosystem,thereby realizing the integration of the five educations and cultivating qualified TCM talents who meet the requirements of the era.

Abstract:Objective To investigate the effect of comprehensive rehabilitation training on patients with dysphagia after stroke.Methods A total of 150 patients with dysphagia after stroke admitted to the Department of Rehabilitation of Linyi Central Hospital from January 2021 to December 2024 were selected and randomly divided into a control group(receiving conventional neurotrophic drugs and rehabilitation training)and an observation group(receiving comprehensive rehabilitation training including acupuncture,bioelectrical stimulation,ice stimulation,balloon dilation,etc.),with 75 cases in each group.The scores of choking,dysphagia,and tongue stiffness with speech impairment,the Modified Water Swallowing Test(MWST)grade,the Functional Oral Intake Scale(FOIS)score,and the quality of life(QOL)score were compared between the two groups.Results After treatment in the observation and control groups,the scores of choking[(1.10±0.28)vs(1.74±0.32)],dysphagia[(0.83±0.21)vs(1.29±0.38)],and tongue stiffness with speech impairment[(0.87±0.18)vs(1.40±0.32)]all decreased with the observation group scoring lower than the control group(all P<0.05).After treatment,the MWST grading of both groups of patients improved compared with before treatment,and the observation group was better than the control group(the proportions of grades 1,2,3 and 4 in the observation group were 14.60%,37.33%,34.67%and 13.33%,respectively,while those in the control group were 6.67%,22.60%,46.67%and 24.00%,respectively).The FOIS scores increased in both groups,and the observation group scored higher than the control group[(5.23±0.87)vs(4.75±1.12),P<0.05].After treatment,the language function grading results of the observation group were better than those of the control group:the proportions of grades 1,2 and 3 in the observation group were 22.67%,46.67%and 30.69%,respectively,while those in the control group were 5.33%,37.33%and 57.33%,respectively(Z=14.886,P<0.05).After treatment,the QOL scores of both groups increased,with the observation group scoring higher than the control group[(79.65±9.20)vs(58.92±7.14),t=15.416,P<0.05].Conclusion Comprehensive rehabilitation therapy can improve the swallowing and language functions of post-stroke patients with swallowing disorders,and enhance their quality of life.

Abstract:Objective To analyze the effect of comfortable nursing care in patients with foreign body removal from pharynx and larynx under fiberoptic laryngoscope.Methods From January 2023 to December 2023,72 patients with pharyngeal foreign body removal under fiberoptic laryngoscopy were selected in the study.According to different nursing modes,they were divided into control group(routine nursing)and observation group(comfortable nursing),36 cases each,to compare their effects.Results The nursing satisfaction of observation group(100.00%)was higher than that of control group(86.11%)(χ2=5.373,P=0.020).The removal time of foreign bodies in observation group was(2.25±0.28)min,which was shorter than(4.54±1.12)min in control group(t=11.902,P=0.000).The incidence of adverse reactions in observation group(0.00%)was lower than that in control group(11.11%)(χ2=4.235,P=0.040).Conclusion Compared with routine care,comfortable nursing care is superior in improving procedural efficiency and patient outcomes during fiberoptic laryngoscopic foreign body removal,suggesting its clinical adoption.

Abstract:Objective To investigate the effect of combination of comfortable care and intensive psychological nursing in the treatment of chronic sinusitis by nasal endoscopic surgery.Methods A retrospective study was conducted,enrolling 300 patients with chronic rhinosinusitis(CRS)who were presented to the Department of Otolaryngology from July 2023 to January 2024.They were allocated into two groups based on the intervention received:Group A(n=150)and Group B(n=150).Group A received comfort-oriented nursing care,while Group B received an additional structured intensive psychological nursing intervention on top of the standard comfortable care.A comparative analysis was performed to assess the differences in pain intensity,anxiety levels,comfort degree,and patient satisfaction between the two groups.Results No significant intergroup difference was observed in pain scores at 2 hours postoperatively(P>0.05).However,at postoperative day 1 and day 3,the pain scores in Group B[(3.40±0.72),(2.59±0.44)]were significantly lower than those in Group A[(4.59±0.60),(3.67±0.49)](P<0.05).Preoperative anxiety scale scores were comparable between the groups(P>0.05).Significantly lower anxiety scores were noted in Group B compared with Group A at 2 hours,1 day,and 3 days post-surgery[(40.45±3.27)vs.(52.23±4.01),(36.72±1.95)vs.(48.26±3.16),and(33.06±1.58)vs.(40.29±2.51),respectively](P<0.05).While pre-intervention comfort scores showed no significant difference(P>0.05),the post-intervention comfort score was significantly higher in Group B(113.04±4.25)than in Group A(105.73±4.09)(P<0.05).Furthermore,patient satisfaction was significantly higher in Group B(99.33%)compared with Group A(94.67%)(P<0.05).Conclusion The combined implementation of intensive psychological nursing and comfortable care in the nasal endoscopic surgery nursing of chronic sinusitis is conducive to reducing postoperative pain and anxiety,and improving the comfort and satisfaction of patients,thus has high application value.

Abstract:Objective To explore the mechanism of Ginkgo leaf extract in the treatment of benign paroxysmal positional vertigo(BPPV)through network pharmacology research methods.Methods First,the effective active components and target genes of Ginkgo leaf were obtained from the TCMSP database.The target genes of BPPV were retrieved from the GeneCards database.Then a"drug-effective component-target"network was constructed to analyze the key active components.Using the STRING database,a protein-protein interaction(PPI)network was built to investigate the interaction relationships among related proteins.Finally,the core targets were subjected to GO functional enrichment and KEGG pathway enrichment analysis via the Metascape database.Results The effective active ingredients of Ginkgo leaf were screened,yielding 27 compounds and 253 related targets which were converted to gene symbols and reduced to 112 after removing duplicates.There were 1,600 target genes associated with BPPV,with 47 overlapping genes related to Ginkgo leaf drug.GO functional analysis primarily involved responses to inorganic substances,hypoxia,hormones,positive regulation of cell migration,and reactions to lipopolysaccharides.KEGG pathway analysis mainly covered lipid and atherosclerosis,cancer pathways,the AGE-RAGE signaling pathway in diabetic complications,activation of chemical carcinogens,and proteoglycans in cancer.Conclusion The potential mechanism of Ginkgo leaf extract in treating BPPV is as follows:quercetin,kaempferol,luteolin,and isorhamnetin may be the primary effective bioactive components responsible for its efficacy.IL-6,MYC,VEGFA,HIF1 A,NFKBIA,and FOS could be potential targets of Ginkgo leaf in treating BPPV,exerting biological effects such as anti-inflammation,antivirus,antitumor,antioxidation,antiplatelet aggregation,and immune response activities.

Abstract:Objective This study was conducted to investigate the effect of artificial nasolacrimal duct implantation in the treatment of chronic dacryocystitis by comparing it with traditional treatment methods,and to evaluate the advantages of artificial nasolacrimal duct implantation in terms of operation duration,recovery time,treatment efficiency and postoperative complication rate,so as to provide better treatment plan for patients.Methods In this study,patients with chronic dacryocystitis who received artificial nasolacrimal duct implantation from January 2023 to January 2024 in our hospital were assigned to the experimental group,while those who received traditional treatment were assigned to the control group.The data of operation duration,recovery time,treatment effectiveness and postoperative complication rate of the two groups were collected,analyzed and compared by statistical methods.At the same time,the effect of artificial nasolacrimal duct implantation was further verified by evaluating the quality of life and functional score changes of patients before and after treatment.Results Artificial nasolacrimal duct implantation showed significant advantages in the treatment of chronic dacryocystitis.The operation duration and recovery time of the experimental group were significantly shortened,and the treatment effective rate was as high as 95%,far exceeding the 75%of the control group(χ2=6.274,P=0.001).More importantly,the postoperative complication rate of patients in the experimental group was extremely low,only 0%,which brought a safer treatment experience for patients.In addition,the quality of life of patients in the experimental group was significantly improved after treatment,and all functional scores increased compared with the control group[vitality status:(72.80±2.45)vs(60.40±7.36);physiological funtion(75.40±2.50)vs(61.40±8.36);emotional function(72.63±2.41)vs(62.48±6.26);social function(73.40±2.20)vs(63.52±7.36);t=11.024,11.184,10.264,9.234,P=0.004,0.004,0.004,0.004,respectively].Conclusion In summary,artificial nasolacrimal duct implantation shows significant advantages in the treatment of chronic dacryocystitis with its characteristics of high efficiency,safety and rapid recovery.This treatment can not only improve the effective rate of treatment,and reduce the incidence of complications,but also significantly improve the quality of life of patients.Therefore,artificial nasolacrimal duct implantation provides a new treatment option for patients with chronic dacryocystitis,which is worthy of widespread promotion and application in clinical practice.

Abstract:Objective To investigate the efficacy of different middle turbinate treatments in endoscopic sinus surgery for chronic sinusitis with nasal polyps(CRSwNP).Methods 118 patients with CRSwNP admitted to Jiaozhou Hospital,East Hospital Affiliated to Tongji University from June 2020 to September 2022 were divided into control group and observation group according to the treatment method of middle turbinate,with 59 cases in each group.Both groups underwent endoscopic sinus surgery,in which the control group retained the middle turbinate,while the observation group partially removed the middle turbinate.The two groups were compared in terms of treatment efficacy,nasal function[nasal volume(NCV),minimum nasal cross-sectional area(NMCA),distance from minimum nasal cross-sectional area to anterior nostril(DCAN)and nasal airway resistance(NAR)],Lund-Kennedy nasal endoscopy score,SNOT-20 score,and incidence of intraoperative cavity adhesion.Results The total effective rate of the observation group was higher than that of the control group(98.31%vs 86.44%,χ2=4.330,P=0.037).Three months after surgery,the DCAN,NAR,Lund-Kennedy nasal endoscopy scores,and SNOT-20 scores in the observation group were lower than those in the control group[(1.58±0.13)vs(1.69±0.17),(0.25±0.04)vs(0.36±0.09),(2.17±0.41)vs(3.42±0.66),(10.15±1.13)vs(13.84±1.71),respectively,P<0.05],while NCV and NMCV were higher than those in the control group[(19.48±2.26)vs(15.46±1.93),(0.59±0.10)vs(0.52±0.08),respectively,P<0.05].After 1 year of postoperative follow-up,the incidence of intraoperative cavity adhesion in the observation group was lower than that in the control group(5.08%vs 20.34%,χ2=6.186,P=0.013).Conclusion Compared with preserving the middle turbinate,partial removal of the middle turbinate during endoscopic sinus surgery for CRSwNP can improve clinical efficacy,promote nasal mucosal repair,reduce postoperative cavity adhesion,and improve the nasal function and quality of life in patients.

Abstract:Objective To study the effect of recurrent laryngeal nerve monitor on recurrent laryngeal nerve damage and vocal function in thyroid tumor surgery.Methods From March 2023 to February 2024,134 patients undergoing thyroid tumor surgery in Juye County People's Hospital were randomly selected and divided into a control group and an observation group using a random number table method,with 67 cases per group.The control group received routine surgical treatment for thyroid tumors,while the observation group received additional intraoperative recurrent laryngeal nerve monitoring intervention.The surgical treatment effects of the two groups were compared.Results The intraoperative bleeding volume and nerve search time in the observation group were lower than those in the control group[(13.90±2.15)ml,(11.43±1.08)min vs(16.52±1.83)ml,(12.80±1.12)min,respectively](P<0.05).There was no significant difference in the incidence of temporary or permanent damage to the recurrent laryngeal nerve between the two groups(P>0.05).The observation group had significantly lower Voice Handicap Index(VHI)score(26.71±5.38 vs 34.87±6.31)and longer maximum phonation time(MTP)[(20.32±3.46)s vs(16.70±2.54)s]compared with the control group(P<0.05).Conclusion The use of recurrent laryngeal nerve monitoring devices in thyroid tumor surgery can help doctors quickly locate the recurrent laryngeal nerve,thereby shorten the operation time,reduce intraoperative bleeding and minimize vocal function impairment.

Abstract:Objective To explore the clinical efficacy of fluconazole injection in the treatment of fungal infections in the ear,nose and throat.Methods With a random number table generated by the SPSS software,82 patients with fungal infections in the ear,nose or throat at Yangxin Chinese Medicine Hospital from January 2022 to June 2023 were divided into conventional group(41 cases,with conventional treatment)and treatment group(41 cases,with conventional treatment+fluconazole injection in topical treatment).The two groups were compared through the clinical curative effect,inflammation index and adverse reactions.Results The overall response rate of the treatment group was 95.12%,80.49%higher than that in the conventional group.The recurrence rate of follow-up at 6 months in the treatment group(0.00%)was lower than that in the conventional group(14.63%,χ2=4.100,4.496,P<0.05).Levels of procalcitonin,C-reactive protein and interleukin 6 of the treatment group were Lower than those of the conventional group[(0.67±0.25)ng/L vs(0.85±0.21)ng/L,(7.67±2.86)mg/L vs(9.65±2.47)mg/L,and(1.18±0.16)ng/L vs(1.34±0.44)ng/L,respectively,t=2.188-3.530,P<0.05).The incidence of adverse reactions in the treatment group was 4.88%,slightly lower than the 9.76%in the conventional group(χ2=0.180,P>0.05).Conclusion Fluconazole injection has certain local safety,and its rational use in the treatment of fungal infections in the ear,nose and throat is conducive to reducing inflammation,eliminating symptoms,improving efficacy and reducing recurrence rate.

Abstract:Objective To investigate the contributing factors and nursing strategies for malnutrition in nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy.Methods A total of 80 nasopharyngeal carcinoma patients receiving concurrent chemoradiotherapy were enrolled from January 2023 to January 2024.Their nutritional status was assessed using the Mini Nutritional Assessment Scale-Short Form(MNA-SF)to determine malnutrition prevalence.Demographic data including age and gender were collected to identify risk factors.Results Malnutrition was observed in 19(23.75%)of the 80 patients.Conclusion Multiple high-risk factors contribute to malnutrition during concurrent chemoradiotherapy.Clinical practice should prioritize monitoring these high-risk groups and implement targeted nursing strategies to ensure patients'physical and mental well-being.

Abstract:Objective To explore the application effect of Xiao'er Chiqiao Qingre Granules combined with injection of amoxicillin and clavulanate potassium in the treatment of children with acute tonsillitis.Method A total of 116 cases of acute tonsillitis patients admitted to our hospital from July 2022 to June 2023 were selected for the study.After random grouping,the control group(n=58)was treated with injection of amoxicillin and clavulanate potassium for intervention.The observation group was treated with a combination of Xiao'er Chiqiao Qingre Granules on the basis of the control group,and the therapeutic effects were compared between the two groups.Results Compared with the control group,the total effective rate of clinical treatment in the observation group was higher(96.55%vs 86.21%,χ2=10.157,P=0.000).The improvements of clinical symptoms of fever,sore throat and swallow obstruction in the obervation group were earlier than those in the control group[(1.01±0.46)d vs(1.65±0.32)d,(1.82±0.51)d vs(2.13±0.44)d,and(3.17±0.37)d vs(4.59±0.24)d;t=2.175,4.166,6.703;P=0.032,0.015,0.000,respectively].Compared with before treatment,the TCM symptom scores of both groups of children decreased after treatment,and the primary symptom score(6.79±1.32)and secondary symptom score(2.43±0.32)in the observation group were both lower than those in the control group[(8.73±1.27)and(3.75±0.26);t=8.066,24.382;P<0.001,<0.001,respectively].Compared with before treatment,the expression levels of CRP,IL-6 and IFN-γ in both groups of children decreased after treatment,and those in the observation group were lower than those in the control group[(10.95±1.79)mg/L vs(13.59±2.01)mg/L,(8.67±1.80)ng/L vs(10.09±1.85)ng/L,(20.07±4.87)ng/L vs(26.24±4.55)ng/L;t=7.470,4.190,7.050;P<0.001,<0.001,<0.001,respectively].There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Xiao'er Chiqiao Qingre Granules and amoxicillin/clavulanate potassium is effective in treating acute tonsillitis in children,accelerating symptom recovery,reducing inflammation,and ensuring safety.

Abstract:Objective To observe the effect of nursing intervention in patients with chronic pharyngitis treated with atomization inhalation.Methods A total of 30 patients with chronic pharyngitis admitted from January 2018 to October 2023 were selected and divided by double-blind method into a control group(15 cases,routine nursing care)and an observation group(15 cases,comprehensive nursing care).The two groups were comparable in general data(P>0.05).Symptom scores,anxiety,quality of life,incidence of oral ulcers,and satisfaction were compared.Results The observation group showed lower symptom scores[throat itching:(0.52±0.14)vs(1.65±0.58),anxiety scores:(22.34±4.08)vs(35.80±6.27)],lower incidence of oral ulcers(6.67%vs 40.00%),higher quality of life score[(95.52±6.39)vs(75.48±5.21)],and higher satisfaction(100.00%vs 66.67%)compared with the control group(all P<0.01).Conclusion Comprehensive nursing care can effectively improve symptoms,alleviate anxiety,and enhance quality of life and satisfaction in chronic pharyngitis patients undergoing atomization treatment.

Abstract:Objective To analyze the efficacy stratification and corresponding influencing factors of the first 131 I treatment after surgery for intermediate-to high-risk differentiated thyroid cancer.Methods A total of 90 patients with intermediate-to high-risk differentiated thyroid cancer who underwent surgery in our hospital from June 2020 to June 2023 were selected as the study subjects.According to the initial dose of 131 I,they were divided into three groups:low dose group(1.11～3.70 GBq),medium dose group(3.70～5.55 GBq),and high dose group(5.55～7.40 GBq).The clinical efficacy and its related influencing factors of 131 I treatment were analyzed.Results After 131 I treatment,90 patients underwent follow-up examination at(4±1)months,and the results showed that 62 cases achieved successful thyroid remnant ablation,with a success rate of 68.89%.There were statistically significant differences(P<0.001)in the thyroid surgery method,time to surgery,and serum TSH level before treatment between patients with successful and unsuccessful thyroid remnant ablation.The thyroid surgery method(OR=7.584,P<0.001),the time to surgery(OR=0.721,P<0.001),and the serum TSH level before treatment(OR=8.428,P<0.001)were independent influencing factors for the efficacy of the first 131 I treatment after thyroid cancer surgery.Conclusion The type of thyroid surgery,surgical time,and serum TSH level before treatment are important factors affecting the efficacy of the first 131 I treatment for thyroid cancer after surgery.