Abstract:Objective:To observe the clinical efficacy of Xiaoxuming soup combined with modified six meridian dialectics with modifications in the treatment of ischemic stroke.Methods:To observe the clinical effect of Xiaoxuming Tang combined with the six meridian dialectical method with modifications in the treatment of ischemic stroke patients.Method:80 patients with ischemic stroke admitted to Jiujiang First People's Hospital from January 2022 to October 2023 were randomly divided into two groups,with 40 patients in each group,using a random number table method.The control group received conventional Western medicine treatment,and on this basis,the observation group was treated with Xiaoxuming Tang combined with the Six meridian dialectics with modifications.Both groups of patients were intervened continuously for one month.Compare the clinical efficacy,neurological function,limb motor function,and daily living ability between two groups of patients.Results:Compared with the control group,the observation group had a higher overall effective rate of treatment,and the difference was statistically significant(P＜0.05).After treatment,compared with the control group,the observation group had lower National Institutes of Health Stroke Scale(NIHSS)scores,higher Activities of Daily Living(ADL)scores,and Fugl Meyer Assessment(FMA)upper and lower limb scores,with statistically significant differences(P＜0.001).Conclusion:The combination of Xiaoxuming soup and six meridian dialectics with modifications has a better therapeutic effect on ischemic stroke,which can promote the recovery of damaged nerve function in patients,improve limb movement ability,and enhance daily living ability.

Abstract:Objective:To explore the application effect of Problem-Discussion-Guidance(PDG)teaching method under ideological and political perspective in the process of first-aid skills training of nursing students in emergency department.Methods:A total of 74 intern nursing students who interned in the emergency Department of Deyang People's Hospital from January to December 2023 were selected.Those who interned from January to June 2023 were included in the control group(37 students),while people who interned from July to December 2023 were included in the observation group(37 students).The control group implemented the conventional teaching mode,and the observation group implemented the problem-discussions-guidance(PDG)teaching method based on the control group.The professional identity,humanistic care ability,graduation assessment and teaching satisfaction between these two groups were compared.Results:After intervention,the scores of all dimensions and total scores of professional identity in the observation group were higher than the control group,the humanistic care ability Evaluation Scale(CAI)scores and total scores of the observation group were higher than those of the control group,the theoretical and operational test scores of the observation group were higher than those of the control group,the theoretical assessment result,practical assessment result and teaching satisfaction of the observation group were higher than the control group,and the difference were statistically significant(P＜0.05).Conclusion:The application of PDG teaching method from ideological and political perspective in the process of first-aid skills training of nurse interns in emergency department could effectively improve their professional identity and humanistic literacy ability,and their exam performance and teaching satisfaction are also high.

Abstract:Objective:To analyze the relevant factors and intervention measures associated with vascular cognitive impairment(VCI)in patients with acute ischemic stroke(AIS).Methods:A retrospective analysis of clinical data from 90 patients with acute ischemic stroke(AIS)admitted to Ruzhou First People's Hospital between January 2021 and December 2022 was conducted to assess the incidence of vascular-cognitive impairment(VCI)and identify risk factors contributing to its occurrence in this patient population.Results:Among 90 patients with AIS,23 developed VCI,with an incidence rate of 25.56％.The logistic regression analysis revealed that age＞60 years,history of hypertension,history of diabetes,hyperlipidemia,temporal lobe stroke location,elevated homocysteine levels,elevated serum uric acid levels,and elevated C-reactive protein levels were independent risk factors for VCI occurrence in AIS patients(P＜0.05).Conclusion:Patients with AIS have a higher risk of developing VCI,clinicians must prioritize high-risk individuals,implementing proactive,individualized interventions to safeguard patients' physical and mental health and improve their prognosis.

Abstract:Objective:To explore the specific effects of swallowing-breathing coordination training combined with tongue pressure resistance feedback training on patients with swallowing disorders after cerebralvascular accident(CVA).Methods:A total of 80 patients with swallowing disorders after CVA admitted to Zhoukou Central Hospital from January 2020 to April 2024 were divided into control group(n=40),received routine rehabilitation training,and observation group(n=40),received swallowing-breathing coordination training combined with tongue pressure resistance feedback training.The hyoid motor function,swallowing function,feeding ability and life quality were compared.Results:After the training,the hyoid motor function,swallowing function,feeding ability score and quality of life score of the patients in the observation group were all better than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion:In patients with swallowing disorders after CVA,the use of swallowing-breathing coordination training combined with tongue pressure resistance feedback training can effectively improve the hyoid motor function and feeding ability,promote the recovery of swallowing function,and improve the life quality of patients.

Abstract:Objective:To investigate the effect of digitoxin on the expression of sodium-iodine symporter(NIS)protein in thyroid papillary carcinoma(PTC)cells.Methods:Different concentrations of digoxigenin solution were prepared,and the concentration of digitoxin solution was 0.25umol/L,the concentration of rapamycin was 50 ug/mL,and the concentration of 3-methyladenine(3-MA)was 0.2mmol/L for subsequent experiments.The thyroid papillary carcinoma cell line BC-PAP was divided into a blank control group without any intervention,digitoxin as the experimental group,rapamycin as the positive control group,and digitoxin+3-MA was negative control group.The expression of NIS,autophagy-related protein microtubule-associated protein 1 light chain 3(MAP1LC3)and BECLIN 1 autophagy related protein(Beclin-1)in each group were detected by western blotting.The formation of autophagosomes was observed under transmission electron microscope.Results:Western blot showed that the relative expression of NIS,Beclin-1 and MAP1LC3 protein in digitoxin group was higher than that in control group,with statistically significant differences(P＜0.01).The relative expression of NIS and Beclin-1 protein in rapamycin group was higher than that in control group,with statistically significant differences(P＜0.01),the relative expression level of MAP1LC3 protein was higher than that of the control group,with statistically significant differences(P＜0.01).The relative expression of NIS,Beclin-1 and MAP1LC3 was higher in the digitoxin group than in the rapamycin group,with statistically significant differences(P＜0.01).The NIS,Beclin-1 and MAP1LC3 proteins in the digitoxin+3MA group were relative.The expression level was lower than that of the digitoxin group,with statistically significant differences(P＜0.01).Conclusion:Digitoxin can increase the expression of NIS protein in thyroid papillary carcinoma cells,and its mechanism may be related to the induction of autophagy.

Abstract:Objective:To explore the specific impact of holistic nursing supported by evidence-based theory on patients with transcatheter arterial chemoembolization(TACE)for liver cancer.Methods:From February 2022 to February 2024,90 liver cancer patients with TACE admitted to Luoyang Central Hospital were taken as the subjects,and all selected cases were randomly assigned to control group(n=45)and observation group(n=45).The patients of control group were provided with routine care intervention,and on this basis,the patients of observation group additionally took holistic nursing intervention supported by evidence-based theory.The comparisons were made on coping style,pain degree,psychological state and quality of life in both groups.Results:After the intervention,the scores of coping style,pain degree,psychological state and quality of life in the observation group were all better than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion:Holistic nursing supported by evidence-based theory can improve the coping style of liver cancer patients with TACE,relieve their pain,alleviate their negative emotions and improve their quality of life.

Abstract:Objective:To explore the impact of Bupleurum extract on the expression of adenosine in animal brain tissue and growth in body length.Methods:Thirty mice were randomly divided into a blank control group(deionized water),a Bupleurum extract group(Bupleurum extract aqueous solution at 0.470 mg/g),and a positive control group(Jujube seed saponin A aqueous solution at 0.013 mg/g),with 10 mice in each group,gavage once a day for 25 days.After the intervention,the body lengths of the mice in each group were measured,and the levels of growth hormone(GH)in the serum and adenosine(AP)in the brain tissue were determined by enzyme-linked immunosorbent assay(ELISA).Twenty-four rats were randomly divided into a blank control group(deionized water),a Bupleurum extract group(Bupleurum extract aqueous solution 0.330 mg/g),and a positive control group(Jujube seed saponin A aqueous solution 0.009 mg/g),with 8 rats in each group,gavage once daily for 3 days.Sleep status of the rats in each group was measured using Xiaomi bracelets,and the levels of GH in the serum and the AD and adenosine triphosphate(ATP)in the preoptic area of the hypothalamus were determined by ELISA.Sixty mice were randomly divided into a blank control group(deionized water),a Bupleurum extract group(Bupleurum extract aqueous solution 0.470 mg/g),an adenosine group(intraperitoneal injection of adenosine aqueous solution 0.280 mg/g),A1R group,A2AR group,and A3R group(Bupleurum extract aqueous solution 0.470 mg/g,simultaneously intraperitoneally injected with DPCPX 2 mg/kg,SCH58261 1 mg/kg,MRS-1523 1 mg/kg respectively),with 10 mice in each group,intervened once a day for 10 days.The levels of GH in the serum and the AD and ATP in the brain tissue were determined by ELISA.Results:Bupleurum extract could significantly increase the body length of mice,elevate the levels of serum GH and brain tissue AD,extend the duration of slow-wave sleep and total sleep time in rats,and increase the levels of serum GH and brain tissue AD and ATP in rats,and the difference was statistically significant(P＜0.05).A1 receptor antagonists could counteract the increase in AD and ATP content in mouse brain tissue caused by Bupleurum extract,A2A receptor antagonists could counteract the increase in GH,AD,and ATP levels simultaneously,and the difference was statistically significant(P＜0.05);A3 receptor antagonists have no significant effect on the indicators,and the difference were not statistically significant(P＞0.05).Conclusion:Bupleurum extract could promote the growth in body length of animals,and its mechanism of action might be related to the increased release of AD and ATP in brain tissue,activation of A1 and A2A receptors,extension of slow-wave sleep duration in animals,and promotion of GH secretion.

Abstract:Objective:To analyze the effects of acupuncture and moxibustion in the treatment of intrahepatic cholangiocarcinoma(ICC).Methods:A total of 120 patients with ICC admitted to Zhengzhou Traditional Chinese Medicine Hospital from January 2023 to October 2024 were selected as study objects and divided into two groups according to the number table method(n=60).The control group was treated with interventional therapy,and the observation group was treated with acupuncture and moxibustion to evaluate the curative effect.Results:Compared with the control group,the effective rate of the observation group was higher,the complication incidence was lower,and the difference was statistically significant(x2=3.927,4.386;P＜0.05);after treatment,the TCM syndrome score in the observation group was lower,with statistically significant difference(t=1 1.222,10.096,9.181,16.309,12.989;P＜0.001);the levels of(cluster of differentiation 3 positive CD3+)and(cluster of differentiation 4 positive CD4+)in the observation group were higher,while the levels of(cluster of differentiation 8 positive CD8+)in the observation group were lower,with statistically significant difference(t=3.696,6.887,33.246;P＜0.001).Conclusion:While taking the surgery on patients with intrahepatic cholangiocarcinoma,the application of acupuncture and moxibustion greatly improved the curative effect,including improving symptoms and immune function,and reducing related complications.

Abstract:Myocardial ischemia-reperfusion is a commonly used method in clinical practice to improve myocardial ischemia,but it can cause further damage to the heart.Mitochondria are the main site for energy production,and improving mitochondrial energy metabolism in the myocardium can effectively treat myocardial ischemia.The role of mitochondria in improving myocardial cell reperfusion injury cannot be ignored.In recent years,research has found that the ability of mitochondria to improve myocardial ischemic injury is closely related to mitochondrial biogenesis,reactive oxygen species(ROS)generation,adenosine triphosphate(ATP)synthesis,mitochondrial calcium overload,mitochondrial autophagy mediated maintenance of mitochondrial quantity and function,providing energy and signal transduction to cells.It elaborates on the regulation of mitochondrial energy metabolism to improve myocardial ischemia-reperfusion injury,providing new ideas for the future treatment of myocardial ischemia.

Abstract:Objective:To investigate the efficacy of evolocumab in patients with coronary heart disease complicated by hyperlipidemia and its effects on proprotein convertase subtilisin/kexin type 9(PCSK9)and lipoprotein(a)[Lp(a)]].Methods:A total of 80 patients with coronary heart disease complicated by hyperlipidemia admitted to Xiangcheng Traditional Chinese Medicine Hospital from June 2021 to June 2023 were selected as study subjects.They were randomly divided into a control group(treated with atorvastatin,40 cases)and an observation group(receiving evolocumab therapy in addition to the control group regimen,40 cases).The lipid levels,PCSK9 and Lp(a)levels,vascular endothelial function,and occurrence of major adverse cardiovascular events(MACE)were observed in the two patient groups.Results:After treatment,the lipid levels and vascular endothelial function in the observation group were superior to those in the control group,and PCSK9 and Lp(a)levels as well as the incidence of MACE were lower than in the control group,with all differences statistically significant(P＜0.05).Conclusion:Evolocumab effectively promotes recovery in patients with coronary heart disease complicated by hyperlipidemia.

Abstract:Objective:To explore the application effect of homogenization management model in maintenance hemodialysis(MHD)patients with central venous catheterization(CVC).Methods:From March 2021 to June 2023,a prospective investigation was carried out on 80 cases of MHD patients treated in Zhengzhou Seventh People's Hospital,they were assigned to control group(n-40)and observation group(n=40)with random numerical table.The patients of control group were provided with regular nursing,whereas the patients of observation group received homogenization management.The two groups were compared in terms of their cognition of the disease,psychological resilience,compliance behavior,the rate of catheter-related complications,quality of life,and patients' satisfaction.Results:The observation group had higher total score of the Revised Chinese Illness Perception Questionnaire(CIPQ-R),scores of Connor-Davidson Resilience Scale(CD-RISC),score of compliance behavior,Generic Quality of Life Inventory(GQOLI)-74 score and satisfaction score compared with the control group after nursing with statistically significant differences(P＜0.05).The observation group obtained lower incidence of catheter-related complications than the control group with statistically significant differences(P＜0.05).Conclusion:The homogenization management model can improve MHD patients'cognition of the disease,further improve their psychological resilience,promote the improvement of their compliance behavior,reduce the occurrence of catheter-related complications,facilitate the improvement and enhancement of their quality of life,and patients are highly satisfied with the nursing services.

Abstract:Objective:To explore the curative effect of sacubitril valsartan combined with dapagliflozin and its influences on myocardial injury and hemodynamics in patients with heart failure(HF).Methods:A total of 92 patients with HF admitted to Cardiovascular Department of Kaifeng People's Hospital were enrolled from January 2022 to January 2024.According to random number table method,they were divided into control group and study group,with 46 cases in each group.The clinical curative effect,serum N-terminal pro-brain nitric peptide(NT-proBNP),creatine kinase isoenzymes(CK-MB),cardiac troponin I(cTnI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),6-minute walking test(6MWT),cardiac output(CO),cardiac index(CI)and heather index(HI)before and after treatment,incidence of adverse reactions and major adverse cardiac events(MACE)were compared between the two groups.Results:Compared with control group,total response rate of treatment was higher in study group,with statistical difference(P＜0.05).After treatment,serum NT-ProBNP,cTnI,CK-MB and LVEDD in study group were lower than those in control group,while LVEF,6MWT,serum CO,CI and HI were higher than those in control group,with statistical difference(P＜0.001).There was no significant difference in the incidence of adverse reactions or MACE between the two groups,with statistical difference(P＞0.05).Conclusion:Sacubitril valsartan combined with dapagliflozin can improve clinical curative effect,reduce myocardial injury and stabilize hemodynamics in HF patients,with good safety.

Abstract:Objective:To explore the training demand and experiences of new palliative care nurses and to provide references for nursing student education and nurse induction training.Methods:The Specialist nurses in palliative care of nursing training base in a tertiary grade A hospital from October 2023 to February 2024 were selected by the method of target sampling.Semi-structured interviews were carried out content analysis was conducted to analyze the interview data.Results:Among 11 introduced cases of study objectives,five themes were extracted,including inadequate preparation of new palliative care nurses;after receiving palliative care training,the cognition and ability of palliative care nurses to implement quality care were improved,and the nurse-patient relationship was more harmonious;palliative care nurses are willing to be trained in symptom assessment,communication skills and death education;palliative care nurses need to receive training on life attitude and concept of palliative care;palliative care nurses want to be trained through clinical practice,simulation training or case teaching.Conclusion:The preparation of new admission palliative care nurses is insufficient.After receiving the training,the nurses'clinical practice ability were improved with more positive experience and optimized personal view on life.It is necessary to increase the training of knowledge and concept,and the training could be carried out through experiential teaching.

Abstract:Objective:To observe the effects of task-oriented role-playing game teaching model on improving nursing staffs'scientific research ability.Methods:A total of 64 nurses were selected from 32 clinical departments in the First Affiliated Hospital of Henan University(2 nurses selected from each department)in December 2021 as the research object and randomly divided into 16 groups,with 4 people in each group.Integrating with currently popular online games,4 team members were assigned as the roles of archer,mage,warrior and knight with different tasks.The scientific research skills training were conducted,including 5 topics,40 contents,28 class hours,lasting 5 months.One week after the training,with the provincial medical science and technology research project as the basis for simulated scientific research training,8 scientific capacities were summarized to conduct the project application writing and concluding defense.The audit team gives points and ranks according to the report and defense performance,and finally discusses the common problems existing in the audit process.Before and after the training,the changes of the level of research ability and the quantity of research output were assessed and compared.Results:After the training,the three dimension scores of research practice ability,professional and problem finding ability,and communication and coordination ability and total scores were significantly improved compared with those before the training,and the differences were statistically significant(P＜0.001).After training,research object paper and research application research output were significantly higher than that before training,and the differences were statistically significant(P＜0.05).Conclusion:Applying task-oriented role-playing games to scientific research teaching can improve nursing staff's scientific research capacity and increase the number of scientific research outputs.

Abstract:Objective:Through the analysis of outpatient diagnosis data,to understand the non-standard status of outpatient diagnosis,and explore the solution for outpatient diagnosis name standardization.Methods:All the disease diagnoses in the outpatient system of a tertiary first-class hospital in Chengdu in the first half of 2021 were exported to more than 770 000,and the diagnoses were processed by improving longest common subsequence(LCS)and other methods.Results:The names of more than 450 000 undiagnosed diseases were mainly multiple diagnoses in one column,abbreviated or too detailed,English abbreviations,descriptive language,pending diagnosis,etc.Based on international classification of diseases(ICD)-10 rules and medical terms,the code expansion mapping was carried out with National Clinical Edition 2.0 as the master to carry out clinical training and establish the outpatient diagnosis and maintenance mechanism.Conclusion:It is needed to establish the clinical version of outpatient disease diagnosis code base of a tertiary first-class hospital in Chengdu,realize outpatient diagnosis statistics,standardize outpatient diagnosis quality,provide basic data support for outpatient disease general,prescription comment,infectious disease management,follow-up,rare diseases,ambulatory patient groups(APG)payment reform and other work,give full play to the value of outpatient medical records,better use of outpatient data to carry out related management work,so as to provide experience for the standardization construction of regional outpatient diagnosis.

Abstract:Objective:To investigate the efficacy and value of semaglutide in treating patients with type 2 diabetes mellitus(T2DM)complicated by coronary heart disease.Methods:A total of 78 patients with type 2 diabetes mellitus(T2DM)complicated by coronary heart disease admitted to Nanyang Central Hospital from May 2023 to April 2024 were enrolled as study subjects.Based on differences in treatment strategies,they were divided into a control group and an observation group.The control group(n=39)received conventional therapy,while the observation group(n=39)received conventional therapy plus semaglutide treatment.The glycemic and lipid metabolism parameters,vascular endothelial function,total myocardial ischemia burden,and serum inflammato-ry factors were compared between the two patient groups.Results:After 12 weeks of treatment,the fasting blood glucose(FBG),2-hour postprandial glucose(2hPG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglycerides(TG),low-density lipopro-tein cholesterol(LDL-C),and plasma endothelin-1(ET-1)in the observation group were lower than those in the control group,while high-density lipoprotein cholesterol(HDL-C),vascular endothelial growth factor(VEGF),and nitric oxide(NO)were higher than those in the control group,with all differences being statistically significant(P＜0.05).After 12 weeks of treatment,patients in the observation group exhibited significantly lower levels of total myocardial ischemia burden,high-sensitivity C-reactive protein(hs-CRP),and interleukin-6(IL-6)compared to the control group,with all differences being statistically significant(P＜0.05).Conclusion:Semaglutide can improve glucose and lipid metabolism parameters in patients with T2DM complicated by coronary heart disease,enhance vascular endothelial function,reduce total myocardial ischemia burden,and lower serum inflammatory fac-tors.

Abstract:Objective:To explore the effect of meridian needling combined with neuromuscular electrical stimulation(NMES)on lower limb muscle spasticity and muscle tone in stroke patients with hemiplegia.Methods:A total of 90 patients with stroke hemiplegia admitted to Nanyang Central Hospital were divided into 2 groups according to random number table method.The case selection time was from June 2021 to December 2023,with 45 patients in each group.The control group was treated with NMES intervention,and the observation group was treated with Jingjin acupuncture.Compare the treatment effects,lower limb function,lower limb muscle spasm status,muscle tone,and self-care ability between two groups.Results:The treatment effect of the observation group was better than that of the control group,the difference was statistically significant(χ2=5.075,P＜0.05).After treatment,the scores of lower limb muscle spasm in the observation group were lower than those in the control group,and the scores of lower limb motor function,balance function,muscle tension and self-care ability were higher than those in the control group,with statistical significance(t=3.635,6.685,16.026,9.991,8.095;P＜0.05).Conclusion:The combination of Jingjin needling and NMES treatment is effective for stroke patients with hemiplegia,which is beneficial for improving the spasticity and tension of the lower limb muscles,promoting the recovery of lower limb movement and balance function,and enhancing the patients'self-care ability.It is worthy of widespread clinical application.

Abstract:Objective:To observe the effects of total intravenous anesthesia on both mothers and newborns in the selection of anesthesia protocols for cesarean deliveries among primiparous women.Methods:Fifty primiparous women undergoing elective cesarean sections between December 2022 and January 2024 were randomly divided into two groups using a random number table.The control group received combined inhalation anesthesia with intravenous administration,while the observation group received total intravenous anesthesia,with 25 patients in each group.The hemodynamic fluctuations,neonatal Apgar scores,and cognitive function differences were compared between the two groups.Results:There was no statistically significant difference in blood oxygen saturation between the two groups of primiparous women at any time point(P＞0.05).There was no statistically significant difference in mean arterial pressure between the two groups of primiparous women at T0 and T3(P＞0.05).The mean arterial pressure at T1 and T2 was higher in the observation group of primiparas than in the control group,with statistically significant difference(P＜0.05).There was no statistically significant difference in heart rate between the two groups of primiparas at T0 and T3(P＞0.05).The heart rate at T1 and T2 was lower in the observation group of primiparas than in the control group,with statistically significant difference(P＜0.05).There was no statistically significant difference in Apgar scores between the two groups at 1 min and 5 min postpartum(P＞0.05).The cognitive function scores of primiparous women in the observation group were higher than those in the control group,with statistically significant difference(P＜0.05).Conclusion:The choice of total intravenous anesthesia for cesarean delivery relies entirely on intravenous anesthesia,which maintains stable hemodynamics,minimally impacts cognitive function in primiparous women,carries minimal risk of neonatal asphyxia,and ensures maternal and infant safety.

Abstract:Objective:To investigate the consistency of gastric biopsy hematoxylin-eosin(HE)staining and carbon 13 breath test in the detection of Helicobacter pylori(HP)infection.Methods:A total of 100 patients who underwent gastroscopy,HE staining of gastric mucosa biopsy and carbon 13 breath test in our hospital from May 2024 to September 2024 were selected as the research objects.The detection of HP infection by HE staining and carbon-13 breath test of gastric mucosa biopsy were analyzed,and the consistency of the two methods in detecting HP infection was compared.Results:Among the 100 patients,19(19%)were positive for HP infection diagnosed by gastric mucosal biopsy with HE staining,and 24(24%)were positive for carbon 13 breath test.Taking the results of HE staining of gastric mucosa biopsy as the"gold standard",the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of carbon 13 breath test in the diagnosis of HP infection were 89.47%,91.36%,91.00%,70.83%and 97.37%,respectively.The Kappa value of HE and carbon 13 breath test of gastric mucosa biopsy was 0.734.Conclusion:C-13 breath test is moderately consistent with HE staining of gastric mucosa biopsy in the diagnosis of HP infection.It can be used as an effective method for the detection of HP infection in clinical practice.

Abstract:Objective:To explore the application value of health management program based on disease prevention in pre-dia-betes in physical examination center.Methods:From April 2021 to March 2022,68 people who underwent health examinations at the Physical Examination Center of a tertiary hospital in Jingdezhen City and met the criteria for prediabetes were selected as the research subjects.According to the random number table method,they were divided into the control group(conventional interven-tion,34 cases)and the intervention group(intervention based on the health management plan for disease prevention,34 cases).Comparing the proportion of people with prediabetes who developed diabetes,the level of blood glucose control,the awareness of di-abetes knowledge,the level of self-management,and the quality of life between the two groups.Results:The rate of transformation into type 2 diabetes in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).At 6 and 12 months after the intervention,the blood glucose levels of both groups decreased,while the awareness of diabetes knowl-edge,self-management and quality of life increased;the blood glucose level of the study group was lower than that of the control group,while the awareness of diabetes knowledge,self-management and quality of life were higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion:The health management plan based on disease prevention can reduce the rate of prediabetes to type 2 diabetes in the physical examination center,improve the blood sugar level,improve the awareness of diabetes knowledge,self-management and quality of life.