Effects of Semaglutide on Total Myocardial Ischemia Burden and Serum Inflammatory Factors in Patients with Type 2 Diabetes and Coronary Heart Disease
Su Zhipeng
Abstract：Objective:To investigate the efficacy and value of semaglutide in treating patients with type 2 diabetes mellitus(T2DM)complicated by coronary heart disease.Methods:A total of 78 patients with type 2 diabetes mellitus(T2DM)complicated by coronary heart disease admitted to Nanyang Central Hospital from May 2023 to April 2024 were enrolled as study subjects.Based on differences in treatment strategies,they were divided into a control group and an observation group.The control group(n=39)received conventional therapy,while the observation group(n=39)received conventional therapy plus semaglutide treatment.The glycemic and lipid metabolism parameters,vascular endothelial function,total myocardial ischemia burden,and serum inflammato-ry factors were compared between the two patient groups.Results:After 12 weeks of treatment,the fasting blood glucose(FBG),2-hour postprandial glucose(2hPG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglycerides(TG),low-density lipopro-tein cholesterol(LDL-C),and plasma endothelin-1(ET-1)in the observation group were lower than those in the control group,while high-density lipoprotein cholesterol(HDL-C),vascular endothelial growth factor(VEGF),and nitric oxide(NO)were higher than those in the control group,with all differences being statistically significant(P＜0.05).After 12 weeks of treatment,patients in the observation group exhibited significantly lower levels of total myocardial ischemia burden,high-sensitivity C-reactive protein(hs-CRP),and interleukin-6(IL-6)compared to the control group,with all differences being statistically significant(P＜0.05).Conclusion:Semaglutide can improve glucose and lipid metabolism parameters in patients with T2DM complicated by coronary heart disease,enhance vascular endothelial function,reduce total myocardial ischemia burden,and lower serum inflammatory fac-tors.
Keywords：Type 2 diabetesCoronary heart diseaseSimeglutideSugar metabolismLipid metabolismTotal burden of myo-cardial ischemiaInflammatory factors
Publication Date：2026-02-10
Online Publishing Date：2026-03-16(First online date of this platform, not the publication date of the document)
Pages：4( 333-336 )