Curative Effect of Sacubitril Valsartan Combined with Dapagliflozin and Its Influences on Myocardial Injury and Hemodynamics in Patients with Heart Failure
Sun Lu
Zhu Chengshuo
Zhao Hehong
Abstract：Objective:To explore the curative effect of sacubitril valsartan combined with dapagliflozin and its influences on myocardial injury and hemodynamics in patients with heart failure(HF).Methods:A total of 92 patients with HF admitted to Cardiovascular Department of Kaifeng People's Hospital were enrolled from January 2022 to January 2024.According to random number table method,they were divided into control group and study group,with 46 cases in each group.The clinical curative effect,serum N-terminal pro-brain nitric peptide(NT-proBNP),creatine kinase isoenzymes(CK-MB),cardiac troponin I(cTnI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),6-minute walking test(6MWT),cardiac output(CO),cardiac index(CI)and heather index(HI)before and after treatment,incidence of adverse reactions and major adverse cardiac events(MACE)were compared between the two groups.Results:Compared with control group,total response rate of treatment was higher in study group,with statistical difference(P＜0.05).After treatment,serum NT-ProBNP,cTnI,CK-MB and LVEDD in study group were lower than those in control group,while LVEF,6MWT,serum CO,CI and HI were higher than those in control group,with statistical difference(P＜0.001).There was no significant difference in the incidence of adverse reactions or MACE between the two groups,with statistical difference(P＞0.05).Conclusion:Sacubitril valsartan combined with dapagliflozin can improve clinical curative effect,reduce myocardial injury and stabilize hemodynamics in HF patients,with good safety.
Keywords：Heart failureSacubitril valsartanDapagliflozinClinical curative effectMyocardial injuryHemodynamics
Publication Date：2026-01-25
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：3( 197-199 )