Abstract:Objective To observe the clinical healing effect of cryotherapy combined with compound betamethasone injection on keloids smaller than 90 mm2.Methods A total of 120 patients with keloids treated in the Department of Dermatology,the 7th Medical Center,Chinese PLA General Hospital from January 2023 to April 2024 were enrolled in this study.Patients with a treatment area ranging from 15 mm2 to 30 mm2 were included in the observation group,and those with 31-90 mm2 of treatment area were selected in the control group,with 60 cases per group.All patients were followed up after 3 times of treatment of cryotherapy combined with compound betamethasone injection and at 1 year of the final treatment.Results There were 59(98.33％)cure cases,1(1.67％)valid case,and none of invalid cases in the observation group.In the control group,there were 41(68.33％)cure cases,18(30.00％)valid cases,and 1(1.67％)invalid case.The cure rate in the observation group was significantly higher than that of the control group(P＜0.05).Scores of the post-treatment Vancouver Scar Scale(VSS,2.35±0.755 points vs 2.82±1.214 points)and visual analogue scale(VAS,0.02±0.129 points vs 0.28±0.81 points)were significantly lower in the observation group than those of the control group(P＜0.05).Conclusion Cryotherapy combined with compound betamethasone injection is superior in treating keloids with an area of 15-30 mm2.

Abstract:Acne is a common chronic inflammatory condition of the sebaceous glands of hair follicles,with acne scarring being a frequent sequela.Multiple factors influence acne scarring formation,including genetics,age,gender,microbial environment,and inflammatory responses in acne patients.The formation of acne scarring involves stages such as inflammation,granulation tissue formation,and matrix remodeling.Its pathogenesis is associated with various mechanisms,including transforming growth factors,matrix metalloproteinases,and vascular endothelial growth factors.Current treatment methods for acne scarring include photoelectric technologies,medications,biological therapies,fillers,chemical peels,and surgical interventions.As research on acne scarring remains limited,this article reviews the etiology,pathogenesis,and treatment of acne scarring,aiming to provide references for clinical diagnosis and management.

Abstract:Objective To observe the clinical efficacy and safety of autologous concentrated growth factors(CGFs)in the treatment of non-scarring diffuse alopecia.Methods Sixty patients with non-scarring diffuse alopecia who visited the Department of Dermatology,Suining Central Hospital from December 2023 to June 2024 were included.All patients were treated with CGFs once a month for three consecutive times.The improvement of hair density,hair diameter,and the proportion of single-hair follicular units in the frontal,temporal and vertex regions was comprehensively evaluated through pre-and post-treatment images and trichoscopy,thus assessing the efficacy.Adverse events during the treatment were observed.Satisfaction of doctors and patients at the end of treatment was recorded.Results The overall effective rate of CGF treatment was 95％.Compared with pre-treatment values,the average hair density in the frontal,temporal and vertex regions of patients with non-scarring diffuse alopecia significantly increased by 18.58±11.97,18.73±12.46 and 26.83±16.01 hair/cm2(all P＜0.001).The average hair shaft diameter significantly increased by 13.49±8.79 μm,and the proportion of single-hair follicular units significantly decreased by 11.46％±7.20％compared with those before treatment(both P＜0.001).The satisfaction rate of doctors was 91.67％,and that of patients was 93.3％.The most common adverse events were pain and discomfort in the scalp after injection(5 cases)and local erythema and ecchymosis(3 cases),all of which relieved spontaneously several hours later.Conclusion CGFs treatment of non-scarring diffuse alopecia is characterized by rapid efficacy,which can effectively improve hair density and hair shaft diameter and reduce the proportion of single-hair follicular units in patients with non-scarring diffuse alopecia,especially in the vertex region.It is highly safe and has high satisfaction rates for both doctors and patients,showing broad application prospects.

Abstract:Objective To investigate the clinical efficacy of apocrine exfoliation with single small incision in the treatment of severe bromhidrosis and its effect on traumatic stress.Methods A total of 106 patients with severe bromhidrosis treated in the Department of Medical Cosmetology,Xinyang Central Hospital from January 2021 to December 2022 were selected.According to the different treatment methods,they were divided into the control group(n=50,apocrine gland exfoliation via double incisions)and observation group(n=56,apocrine gland exfoliation with a single incision).The clinical efficacy,traumatic stress,surgical complications and treatment satisfaction of the two groups were compared.Results The overall efficacy rate was 98.21％in the observation group,and 98.00％in the control group,showing no significant difference(P＞0.05).The recurrent rate was 3.57(2/56)in the observation group,and 2.00％(1/50)in the control group,showing no significant difference(P＞0.05).Serum cortisol(Cor)and epinephrine(E)at 2 hours postoperatively were significantly lower in the observation group than those of the control group(P＜0.05).The incidence of complications was significantly lower in the observation group than that of the control group(1.79％vs 12.00％,P＜0.05).The satisfaction scores of intraoperative tolerance,incision healing,postoperative odor improvement,scar appearance and upper limb movement function were significantly higher in the observation group than those of the control group(P＜0.05).Conclusion Apocrine exfoliation with single small incision shows a comparable efficacy with that of double incisions in the surgical treatment of bromhidrosis,which effectively reduces traumatic stress,lowers the risk of complications,and elevates the overall treatment satisfaction.

Abstract:Candida albicans is an important opportunistic pathogenic fungus in the human body,usually colonizing the skin,oral mucosa,vagina and gastrointestinal tract of healthy humans asymptomatically.It is the most common clinical pathogen of fungal bloodstream infections.Immune dysfunction in the body triggers the invasion of Candida albicans against the physiological barrier,leading to skin,mucous membrane and deep infection.In recent years,with the widespread use of drugs like glucocorticoids and immunosuppressants,the incidence and mortality of Candida albicans infections have increased significantly,reaching 46％-75％of the death rate,and still rising year by year.Secretory aspartic proteases(Saps)are invasive enzymes with protein hydrolyzing activity.As a key pathogenic factor for mucosal colonization and systemic dissemination of Candida albicans,Saps play an important role in the occurrence,development and drug resistance mechanism of Candida albicans.This article aims to review the main mechanism of Saps in the process of Candida albicans infection,in order to provide theoretical basis and new ideas for the diagnosis and treatment of Candida albicans infectious and the development of new drugs.

Abstract:A case of diffuse cutaneous mastocytosis was reported.A 6-month-old male infant presented with a one-month history of erythematous blisters and bullae on the trunk.Dermatological examination revealed diffuse yellowish-red patches and plaques on the back,with blisters and bullae arising on erythematous bases across the chest and abdomen.The Nikolsky sign was negative,while the Darier sign-indicative of mast cell activation—was positive.Histopathological analysis of skin lesions demonstrated subepidermal blister formation and dense,diffuse infiltration of mast cells within the dermis.Giemsa staining was positive.The paitent was eventually diagnosed with diffuse cutaneous mastocytosis.

Abstract:A case of eosinophilic pustular folliculitis was reported.A 58-year-old man presented with facial papules and plaques for 12 days.Dermatological examination showed flaky dark red infiltrating plaques on both sides of the cheek,zygomatic region and posterior area of the right ear,with clear borders.Red papules were visible on the basis of the plaques,showing pint-sized pustules,yellow scales and crusts on the top of them.Red papules ranging in size from rice grains to mung beans were seen on the forehead and chin.A few pustules and scales could also be seen on the chin.Histopathological examination of the lesion showed mucin deposition in the dermal hair follicles,and infiltration of a large number of eosinophils,neutrophils,histiocytes and lymphocytes in blood vessels and around the hair follicles.The patient was finally diagnosed with eosinophilic pustular folliculitis.After treatment with prednisone and indomethacin tablets,the skin lesions completely subsided.Recurrence was not reported during the 18 months of follow-up.

Abstract:Objective To observe the efficacy and safety of micro-plasma radio-frequency combined with subcision in treating atrophic acne scars.Methods Sixty-eight eligible patients with atrophic acne scars who visited the Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University from January 2022 to June 2023 were divided into the observation group(n=34)and the control group(n=34)using the random number table.Patients in the observation group were first treated with subcision for atrophic acne scars,followed by micro-plasma radio-frequency treatment.Those in the control group received only micro-plasma radio-frequency treatment.Interventions in both groups were given once every 6 weeks,for a total of 5 sessions.Results There was no significant difference in the scores of ECCA(Echelle D'Evaluation Clinique des Cicatrices D'Acne)grading scale between the two groups before treatment(P＞0.05).After treatment,ECCA scores were significantly lower in the observation group compared to the control group,and the decline of the ECCA scores was significantly pronounced in the observation group than that of the control group(P＜0.05).The efficacy rate was significantly higher in the observation group than that of the control group(97.06％[33/34]vs 82.35％[28/34],P＜0.05).No significant difference was found in the Visual Analogue Scale(VAS)scores between the observation group and the control group(5.67±1.36 vs 5.62±1.44,P＞0.05).The incidence of adverse events was 20.59％in the observation group and 14.71％in the control group,showing no significant difference(P＞0.05).Adverse events mainly consisted of pigmentation,persistent erythema,and subcutaneous hemorrhage.Conclusion Micro-plasma radio-frequency technology combined with subcision has good clinical efficacy that effectively alleviates symptoms of atrophic acne scars.It has better efficacy than single micro-plasma radio-frequency,and with good safety and mild adverse events.It is an effective,available treatment method for atrophic acne scars.

Abstract:Generalized pustular psoriasis(GPP)is a rare subtype of psoriasis characterized by acute onset,rapid progression,high recurrence rate,and frequent association with other systemic diseases.Predisposing factors include infection,genetic factors,immune dysfunction,medication use,and psychological stress.Currently,there is no uniform clinical treatment protocol for GPP.Spesolimab injection,an anti-human interleukin-36(IL-36)receptor antibody,has demonstrated significant clinical efficacy in the treatment of adult GPP.This paper reports the nursing care of a patient with acute generalized pustular psoriasis treated with spesolimab injection,aiming to provide a reference for clinical nursing practice.

Abstract:Objective To screen psoriasis-related cuproptosis genes,and to explore possible regulatory mechanisms using bioinformatics methods.Methods A psoriasis dataset GSE 30999 was downloaded from the Gene Expression Omnibus(GEO)database to screen differentially expressed genes(DEGs)between lesional and non-lesional skin tissues.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)enrichment analysis were carried out to identify biological functions and enriched pathways of the DEGs,respectively.Immune infiltration analysis was used to obtain the distribution of immune cells in psoriasis tissues.DEGs were intersected with previously reported cuproptosis genes,thus screening out the cuproptosis-related differentially expressed genes(CR-DEGs).Molecular docking with acitretin was utilized to verify its binding activity with CR-DEGs.The single-cell dataset GSE 230842 was used for cell clustering analysis to clarify the distribution of CR-DEGs in key cell clusters.Results A total of 2,061 DEGs were obtained.GO analysis showed that DEGs were mainly enriched in iron ion binding and fatty acid metabolic process,while KEGG pathway enrichment analysis revealed that the DEGs were significantly enriched in cytokine-cytokine receptor interactions,and PPAR signalling pathways.The results of immune infiltration indicated that the immune cells,such as CD4+T cells and γδT cells were significantly elevated in psoriasis lesions(P＜0.05).There were 19 cuproptosis genes,and two CR-DEGs,namely DLAT and SLC31A1,were screened by taking an intersection.Single-cell analysis showed that they were abundantly expressed in keratinocytes.The results of molecular docking showed that acitretin well bound with these two genes,especially with SLC31A1.Conclusion DLAT and SLC31A1,as psoriasis-associated cuproptosis genes,may affect the occurrence and development of psoriasis by regulating the proliferation and differentiation of keratinocyte and promoting neovascularization.Acitretin binds strongly to SLC31A1,which may be used for the treatment of psoriasis through the cuproptosis pathway.

Abstract:Objective To examine the expression levels,clinical significance and potentials of armadillo repeat-containing protein 7(ARMC 7)in cutaneous melanomas based on bioinformatics methods.Methods The mRNA expressions,DNA methylation and clinical data of cutaneous melanomas were obtained from the cancer genome atlas(TCGA)and the gene expression omnibus(GEO).Additionally,protein expression datasets of ARMC 7 were sourced from the human protein atlas(HPA).Differential expressions of ARMC 7 between melanoma tissues and normal tissues were compared.The diagnostic performance of ARMC 7 expression levels in cutaneous melanomas was assessed using the receiver operating characteristic(ROC)curves.Survival differences between groups with different ARMC 7 expression levels were evaluated using the Kaplan-Meier curves,and the hazard ratio(HR)was calculated using Cox regression.Mutations of the ARMC 7 gene in cutaneous melanomas were analyzed using the cBioPortal database.The methylation levels of the ARMC 7 gene were analyzed using the XENA database.The expression of ARMC 7 and its correlation with immune cell infiltration were displayed in lollipop plots.Gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses were conducted to illustrate the underlying functional mechanisms.Results The mRNA expression levels of ARMC 7 in melanoma tissues were significantly higher than those in the normal skin tissues and nevus cells(P＜0.001),showing a high diagnostic efficacy(area under the curve[AUC]=0.712).Cutaneous melanoma patients with high expression levels of ARMC 7 had significantly shorter overall survival and worse prognosis than those with low levels(P=0.026).cBioPortal data analysis showed a mutation rate of the ARMC 7 gene of 2％.XENA database analysis found that the methylation levels of 6 CpG sites in the promoter region of ARMC 7 were significantly correlated with the prognosis of cutaneous melanomas.ARMC 7 expression levels were negatively correlated with most immune cells,and only positively correlated with natural killer(NK)cells.Functional enrichment analysis of GO and KEGG suggested the enrichment of chemokine signaling pathways and ubiquitin proteolysis.Conclusion ARMC 7 is highly expressed in cutaneous melanomas and is closely associated with poor prognosis,serving as a potential diagnostic and prognostic biomarker for melanomas.

Abstract:With the deepening advancement of digital transformation in education,massive open online courses(MOOCs)are a type of large-scale open online educational resource that have become a crucial vehicle for educational reform and gained widespread recognition and application.Taking Herpes Zoster-an award-winning MOOC-as an example,this article systematically introduced its course design and production process,summarized the key stages and implementation essentials of MOOC construction,and deeply explored its pedagogical implications and educational value.The aim is to provide practical references and construction insights into creating medical online"award-winning courses"characterized by high-order,innovative,and challenging nature.

Abstract:Vitiligo is characterized by a complex pathogenesis,frequent relapse,and resistance to cure.Emerging evidence identifies the Janus kinase-signal transducer and activator of transcription(JAK-STAT)pathway as a tractable therapeutic target.Accordingly,JAK inhibitors have demonstrated promising clinical efficacy in vitiligo and are receiving growing clinical and research attention.This review summarizes recent clinical studies and real-world applications of commonly used JAK inhibitors in the management of vitiligo.

Abstract:Objective To explore the efficacy of Lingshu Taohong Granules combined with Guilian Ointment in treating psoriasis of blood stasis type.Methods Sixty patients with psoriasis of blood stasis type treated in the Dermatology Department of Langfang TCM Hospital from February 2023 to October 2024 were selected.They were randomly randomly assigned in a 1∶1 ratio to either oral Lingshu Taohong Granules+Vaseline for topical use(control group)or oral Lingshu Taohong Granules+Guilian Ointment for topical use(study group)for 4 weeks.Psoriasis area and severity index(PASI)score,pruritus scores and traditional Chinese medicine(TCM)syndrome scores,therapeutic effect,and adverse events were compared.Results Post-treatment PASI scores,pruritus scores,and dimensions of skin lesion color,skin nail misalignment,skin lesion thickness in the TCM syndrome were significantly reduced in both groups compared to pre-treatment values(P＜0.05),which were significantly lower in the study group than the control group(P＜0.05).The overall efficacy rate was significantly higher in the study group than the control group(86.67％vs 63.33％,x2=4.356,P=0.037).The incidence of adverse events was comparable between groups(P＞0.05).Conclusion Oral Lingshu Taohong Granules combined with Guilian Ointment for topical use offers superior properties in alleviating skin lesions and itching in patients with psoriasis of blood stasis type over the monotherapy of Lingshu Taohong Granules.

Abstract:A 67-year-old female patient presented with a growingly enlarged pale yellow plaque for 2 years.A plaque of 2 cm× 1.5 cm in size could be seen on the patient's right buttock,showing an irregular morphology,light yellow in color,blurred margin,hard texture in touch,and drivable base.She occasionally experienced itching in the plaque,without pain and sting sensation.Histopathological examination revealed mild hyperkeratosis of the epidermis,proliferation of spindle shaped cells in the dermis,spindle-shaped muscle cells,long and blunt nucleus without nuclear atypia,and eosinophilic cytoplasm.Immunohistochemistry showed positivity for smooth muscle actin(SMA)and smooth muscle desmin(Des).The patient was diagnosed with skin leilmyoma and treated with surgical procedures.No recurrence was observed during the 18 months of follow-up.

Abstract:Objective To investigate the melanin-inhibiting and collagen-promoting effects of non-crosslinked sodium hyaluronate(SH)solution combined with nicotinamide and amino acids.Methods First,the concentration of nicotinamide in the SH complex solution was determined using a mouse melanoma cell(B16-F10 cell)melanin inhibition model.Then,the effects of the non-crosslinked SH solution combined with nicotinamide and amino acids on tyrosinase activity and melanin production were evaluated using a zebrafish model.The effects of the SH complex solution on the viability of Haman skin fibroblasts HSF and collagen content were detected,and the moisturizing effect of the SH complex solution was verified through clinical trials.Results The SH solution with nicotinamide significantly inhibited melanin production in B16-F10 cells.When the addition amount was above 1.25 mg/mL,the inhibition rate of melanin production in B16-F10 cells exceeded 20％,but the effect on cellular tyrosinase activity was not significant.The SH complex solution significantly inhibited both tyrosinase activity and melanin production in zebrafish,with the 8％SH complex solution group showing inhibition rates of 21.3％and 50.6％,respectively.Meanwhile,the SH complex solution significantly promoted HSF proliferation and collagen regeneration.Compared with the normal group,the 10％SH complex solution group increased cell growth by 35.7％and 28.0％after 24 h and 48 h of cell treatment,respectively,and the SH solution increased cellular collagen synthesis by 98.80％after 48 h of cell treatment.Clinical trial results showed that the SH complex solution had a significant moisturizing effect.One week after administration of the SH complex solution,the water content in the middle of the forehead,the middle of the right face,the middle of the left face,and the middle of the jaw of the subjects was significantly higher than before injection(P＜0.05),with increase rates of 32.48％,20.11％,28.01％,and 31.05％,respectively.Moreover,the skin dryness improvement effect score one week after injection signficantly lower than before injection(P＜0.05).Conclusion The non-crosslinked SH complex solution has obvious effects of inhibiting melanin production and promoting collagen regeneration,and has a good moisturizing effect.

Abstract:Objective To evaluate the efficacy of radiotherapy following keloid resection.Methods A total of 70 patients(75 lesions)who underwent keloid resection in the Department of Burn and Plastic Surgery(45 cases)and Department of Dermatology(25 cases)at Dongguan Tungwah Hospital between May 2020 and June 2022 were enrolled.For 34 keloids in low-recurrence areas,electron beam radiotherapy was administered at a total dose of 15 Gy(5 Gy per fraction,once daily for 3 consecutive days).For 41 keloids in high-recurrence areas,the total dose was 20 Gy(5 Gy per fraction,once daily for 4 consecutive days).Clinical efficacy was assessed at 3,6,and 12 months post-radiotherapy,with grading of radiation dermatitis evaluated at 3 months.During 12-24 months of follow-up,the effective symptom control duration,recurrence rate,and complication incidence were compared between low and high-recurrence areas.Results At 3,6,and 12 months post-radiotherapy,no significant differences were observed in total effective rates between low and high-recurrence areas(88.24%vs 87.80%,91.18%vs 90.24%,97.06%vs 92.68%)or in radiation dermatitis grading at 3 months(all P>0.05).During follow-up,no significant differences were found in effective symptom control duration,recurrence rate,or complication incidence between the two areas(all P>0.05).Conclusion Postoperative radiotherapy with large-fraction,low-frequency regimens(different doses for low/high-recurrence areas)demonstrates favorable efficacy for keloids,with low recurrence and complication risks,supporting its clinical application.

Abstract:A case of Klebsiella pneumoniae sepsis complicated with Kaposi varicelliform eruption was reported,accompanied by a literature review.A 56-year-old male patient was admitted to the hospital due to"abdominal pain,diarrhea,vomiting for 3 days,and chills,fever for 2 days".After admission,the patient developed a sudden rash on his face and trunk.Dermatological examination revealed multiple erythemas on the patient's lip margin,corners of the mouth,and right auricle,with umbilicated vesicles,papulovesicles,and some pustules on the erythematous base,clustering together to form patches.After the vesicles ruptured,erosions formed.Blood culture results indicated positive for Klebsiella pneumoniae.PCR test for herpes simplex virus(HSV)in the pustular fluid showed positive for HSV-1.Based on the patient's main clinical manifestations and laboratory results,the diagnosis was Klebsiella pneumonia sepsis complicated by Kaposi's varicelliform eruption.The patient was treated with sulperazone and levofloxacin for Klebsiella pneumonia sepsis,and with valaciclovir,compound glycyrrhizin,and loratadine for Kaposi's varicelliform eruption.More than one week after admission,the patient recovered well and was discharged from the hospital.

Abstract:Objective To investigate the effects of dupilumab combined with tripterygium glycosides on investigator global assessment(IGA)score,transepidermal water loss(TEWL),clinical efficacy,and safety in adult patients with atopic dermatitis(AD).Methods From October 2021 to October 2023,152 adult AD patients admitted to Zhangjiakou First Hospital were divided into an observation group(treated with tripterygium glycosides combined with dupilumab,n=76)and a control group(treated with tripterygium glycosides alone,n=76).After 12 weeks of continuous treatment,symptom scores,clinical efficacy,skin barrier function indices,inflammatory factors,immune function,and treatment safety were evaluated.Results After treatment,the observation group showed significantly lower IGA scores,Eczema Area and Severity Index(EASI)scores,AD Scoring System(SCORAD)scores,and Dermatology Life Quality Index(DLQI)scores compared to the control group(P<0.05).The effective rate in the observation group was 92.11%(70/76),significantly higher than 78.95%(60/76)in the control group(P<0.05).The observation group exhibited lower TEWL,higher stratum corneum ceramide(Cer)in non-lesional skin,and higher skin hydration levels than the control group(P<0.05).Levels of interleukin(IL)-4,intercellular adhesion molecule-1(ICAM-1),and leukotriene B4(LTB4)were significantly lower in the observation group(P<0.05).Immunological analyses revealed higher CD3+,CD4+,and CD4+/CD8+levels,and lower CD8+levels in the observation group compared to the control group(P<0.05).No significant difference in adverse event incidence was observed between groups(P>0.05).Conclusion Dupilumab combined with tripterygium glycosides demonstrates favorable efficacy in adult AD patients,reducing symptom scores,improving skin barrier function,lowering inflammatory factor levels,and enhancing immune function,with good safety profiles.

Abstract:Objective To explore the therapeutic effects of ultrasonic drug penetration therapy and occlusion therapy on hypertrophic lesions of extremities in moderate-to-severe plaque psoriasis.Methods A total of 90 patients with moderate-to-severe plaque psoriasis admitted to a tertiary hospital from January 2023 to December 2024 were selected and divided into the occlusion group,superconducting group,and control group,with 30 cases in each group.Hypertrophic plaque lesions on the extremities were selected as the test sites.The control group received conventional treatment and nursing measures,including oral antihistamines,intravenous infusion of anti-allergic drugs,and topical glucocorticoid ointments.The occlusive dressing group received occlusive dressing therapy in addition to topical medication as the control group.The ultrasound-mediated drug delivery group received ultrasound-mediated drug delivery therapy in addition to the same topical medication as the control group.Treatment efficacy was evaluated using the Psoriasis Area and Severity Index(PASI),plaque thickness scores,and plaque resolution time.Results PASI assessment showed that all three groups demonstrated significant reductions in PASI scores post-treatment compared to baseline(all P<0.001).No significant inter-group differences in PASI scores were observed either pre-treatment or post-treatment(all P>0.05).For limb plaque thickness scores post-treatment,the ultrasound-mediated drug delivery group(0.43±0.50 points)showed significantly greater improvement in plaque thickness compared to the occlusive dressing group(0.96±0.61 points)(P=0.001).Analysis of plaque resolution time revealed that the ultrasound-mediated drug delivery group(4.20±1.51 days)achieved significantly faster resolution than the occlusive dressing group(5.46±2.20 days)(P<0.001).Conclusion Ultrasound-mediated drug delivery therapy is significantly superior to occlusive dressing therapy in improving the degree and speed of hypertrophic plaque resolution in limbs,effectively shortening treatment duration.