Abstract:Objective:Examining the impact of psychological guidance and sensory integration training on the psychological and behavioral traits of children with autism spectrum disorder.Methods:A total of 66 children with autism spectrum disorder visiting our hospital from March 2019 to March 2024 were selected as research subjects.They were randomly divided into a control group and an observation group,each with 33 cases.The control group received sensory integration training,while the observation group underwent psychological guidance combined with sensory integration training.The differences in the assessment results of the Autism Treatment Evaluation Scale(ATEC),Autism Behavior Scale(ABC),Childhood Autism Rating Scale(CARS),Psychological Education Scale 3rd Edition(PEP-3),Children's Anxiety Disorder Self Rating Scale(SCARED),and Children's Depression Self Rating Scale(DSRSC)between the two groups before and after treatment were compared,and their clinical efficacy was recorded.Results:Following treatment,the ATEC,ABC score levels of both groups of children were lower than those before treatment,and those of the observation group were lower than those of the control group,with statistically significant differences(P＜0.05).After Treatment,the scores of CARS and PEP-3 in both groups of children improved,compared with the control group,the CARS score of children in the observation group was lower and the PEP-3 score was higher after treatment,with statistically significant differences(P＜0.05).After the treatment,the SCARED and DSRSC scores of the children in both groups decreased;compared with the control group,the above scores of the children in the observation group were lower after treatment,with statistically significant differences(P＜0.05).The total clinical effective rate of the observation group was higher than that of the control group,with statistically significant differences(P＜0.05).Conclusions:The combination of psychological guidance and sensory integration training shows a superior therapeutic effect on children with autism spectrum disorder,leading to significant improvements in condition severity and reductions in depression,anxiety,and other related emotions.

Abstract:Objective:To investigate the effect of trastuzumab in combination with pertuzumab on the survival outcomes of patients with human epidermal growth factor receptor 2(HER2)-positive breast cancer.Methods:A cohort of 100 HER2-positive breast cancer patients treated at our hospital between March 2020 and March 2023 was included in this study.The patients were randomly divided into the trastuzumab group(n=50)and the combined group(n=50)by envelope drawing method.The trastuzumab group was treated with trastuzumab,while the combined group received trastuzumab and pertuzumab.The clinical efficacy,tumor-related indicators,adverse reactions,and survival rates of the two groups were compared after treatment.Results:After treatment,the disease control rate and overall efficacy rate of the combined group were higher than those of the trastuzumab group(P＜0.05).The levels of carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153),and carcinoembryonic antigen(CEA)in the combined group were lower than those in the trastuzumab group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups,with statistically significant differences(P＞0.05).The progression-free survival(PFS)and overall survival(OS)of the combined group were higher than those of the trastuzumab group,with statistically significant differences(P＜0.05).Conclusion:The combination of trastuzumab and pertuzumab has a significant impact on the survival of HER2-positive breast cancer patients.

Abstract:Objective:To explore the current status of professional identity among male nurses in internships,examine various factors influencing their professional identity,study the effect of cognitive interventions in enhancing the professional identity of male nursing students,and propose strategies for improving the professional identity of male nursing students,so as to provide references and guidance for nursing and clinical education.Methods:A cluster sampling method was used to select 76 male nursing students from a vocational college who have completed a 5-month clinical internship in the nursing major of 2020,and their professional identity was investigated.A self-made male nursing student internship questionnaire and focus group interview method were used for investigation.These male nursing students were randomly divided into a control group and an intervention group,with 38 students in each group.The control group received routine internship education,while the intervention group received cognitive intervention.Results:After the experiment,the professional identity of male nursing students in the intervention group was elevated compared to the control group,and the differences were statistical significant(t=-8.268,P＜0.05).The post-experimental professional identity of male nursing students in the intervention group was greater than their pre-experimental level,and the difference was statistically significant(t=-7.501,P＜0.05).No significant statistical difference was observed in the control group between pre-and post-experiment,and the difference was not statistically significant(t=-0.689,P＞0.05).Factors affecting their professional identity include family members' lack of understanding,the filling of volunteer applications,lack of understanding from patients and their families,negative influence from teaching instructors,unreasonable arrangement of internship departments and content,and the qualifications of teaching instructors.Conclusion:The professional identity level of male nursing interns is below average;Cognitive intervention could effectively improve the professional identity level of male nursing interns.

Abstract:Objective:To investigate the efficacy of high-flow nasal cannula oxygen therapy(HFNC)and non-invasive positive pressure ventilation(NIPPV)in the treatment of severe pneumonia(SP)complicated with respiratory failure(RF).Methods:A total of 63 patients with SP combined with RF admitted in the First People's Hospital of Zhumadian from March 2023 to May 2024 were selected and divided into control group and observation group according to different treatment methods.Based on routine treatment,the control group(n=33)were treated with NIPPV and the observation group(n=33)were treated with HFNC.It compared the clinical efficacy,incidence of adverse reactions of the two groups,as well as pulmonary function,blood gas,sputum viscosity and serum inflammatory factors level before and after treatment.Results:The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the ratio levels of forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),FEV1/forced vital capacity(FVC)in observation group were higher than those in control group(P＜0.05).After treatment,partial pressure of carbon dioxide(PaCO2)level in observation group was lower than that in control group,arterial partial oxygen pressure(PaO2)and peripheral oxygen saturation(SpO2)levels were higher than that in control group(P＜0.05).After treatment,the proportion of grade Ⅱ and Ⅲ in observation group was higher than that in control group,and the proportion of grade Ⅳ was lower than that in control group(P＜0.05).After treatment,the levels of high mobility group box-1 protein(HMGB-1),interleukin(IL)-6,soluble myeloid cell trigger receptor(sTREM)-1,tumor necrosis factor(TNF)-α in the observation group were decreased more than those in the control group(P＜0.05).There was significant difference in the incidence of adverse reactions between the two groups(P＜0.05).Conclusion:HFNC combined with conventional methods is effective in the treatment of SP combined with RF,which can not only improve lung function,reduce sputum viscosity,but also inhibit inflammation in vivo,with fewer adverse reactions,and has high clinical value.

Abstract:Objective:To investigate the improvement effect and its mechanism of green tea polyphenols on allergic rhinitis in rats.Methods:Forty rats were randomly divided into normal group,model group,green tea polyphenol group and loratadine group,with 10 rats in each group.Except for normal group,allergic rhinitis rats in other groups were infected by obumin+aluminum hydroxide powder.After successful model creation,green tea polyphenol group rats were intragastatically injected with green tea polyphenol suspension 300 mg/kg,loratadine group rats were intragastatically injected with loratadine 0.9 mg/kg,normal group and model group were intragastatically injected with the same amount of normal saline.Behavioral symptom scores,serum immunoglobulin E(IgE),histamine(HIS),interleukin(IL)-10 and IL-17 were compared among all groups,and pathological injury of nasal mucosa was observed by HE staining.qRT-PCR and western blot were used to detect mRNA and protein expression levels of retinoic acid receptor-related orphan receptor gamma-t(RORγt),forkhead box P3(Foxp3)and p38 mitogen-activated protein kinase(MAPK).Results:In normal group,there was no obvious abnormality in nasal mucosa,and the epithelium structure was intact and arranged neatly.In the model group,the nasal mucosal epithelium was disorganized,some epithelial cells were shed,glands were hyperplastic and swollen,and inflammatory cells were infiltrated.In the green tea polyphenol group and loratadine group,the pathological damage of nasal mucosa was reduced,the epithelial structure was slightly normal,and the inflammatory cells were reduced.Compared with the normal group,behavioral symptomatology scores,IgE,IL-17 and HIS levels,ROR γt mRNA and protein expression,p38 MAPK mRNA expression and p-p38 MAPK protein expression of rats in the model group were increased;while IL-10 level,the mRNA and protein expressions of Foxp3 were decreased,with statistically significant differences(P＜0.05).Compared with the model group,the behavioral symptomatology scores,IgE,IL-17 and HIS levels,ROR γt mRNA and protein expression levels,p38 MAPK mRNA expression levels and p-p38 MAPK protein expression levels of green tea polyphenol group and loratadine group were decreased,while IL-10 levels,mRNA and protein expressions of Foxp3 were increased,with statistically significant differences(P＜0.05).Green tea polyphenols significantly reduced behavioral scores in rats and decreased serum levels of IgE,HIS,IL-17,and IL-10,with statistically significant differences(P＜0.05).Histopathological examination of nasal mucosal tissue revealed that green tea polyphenols mitigated disruption of the nasal epithelial structure and inflammatory cell infiltration.Furthermore,tea polyphenols significantly downregulated RORγt and p38 MAPK mRNA and protein expression while simultaneously upregulating Foxp3 mRNA and protein expression,with statistically significant differences(P＜0.05).Conclusion:Green tea polyphenols can improve the nasal allergic symptoms of rats with allergic rhinitis,which may play a role in regulating the immune balance of Treg/Th17 cells by inhibiting p38 MAPK pathway.

Abstract:Objective:To explore the application effect of precise low ligation based on preoperative enhanced computer tomography(CT)in No.253 lymph node dissection.Methods:The data of 80 patients undergoing laparoscopic lymph node dissection were retrospectively analyzed and divided into high ligation group(n=36)and low ligation group(n=44)according to different surgical plans.Compare the basic indicators of two groups of patients.No.253 lymph node dissection time and amount of No.253 lymph node dissection,as well as postoperative complications such as anastomotic hemorrhage,anastomotic leakage,urinary retention and quality of life.Results:The operation time of patients in the low ligation group was significantly longer,the time and number of lymph node dissections at No.253 were greater,the incidence of complications such as anastomotic bleeding,anastomotic leakage,and urinary retention was lower,and the quality of life was better 3 months after the operation.The differences were all statistically significant(P＜0.05).Conclusion:Accurate low ligation based on enhanced CT before surgery has significant advantages in the laparoscopic operation of No.253 lymph node dissection with left colic artery preserved.This can improve the thoroughness of lymph node dissection,reduce the incidence of postoperative complications,and improve the quality of life of patients after surgery.

Abstract:Objective:To compare the postoperative outcomes of displaced inferior patellar fractures treated with intermittent vertical wire suturing versus wire ring fixation.Methods:From January 2020 to January 2023,116 cases of displaced infrapatellar fractures treated in the Orthopedic Department of the Third Division General Hospital of the Xinjiang Production and Construction Corps were selected,with two distinct surgical fixation techniques applied.Group A underwent interrupted vertical wire suturing(n=66),while Group B received wire"O"-shaped circumferential fixation(n=50).The age,gender,body mass index(BMI),underlying medical conditions,American Society of Anesthesiologists(ASA)physical status classification,fracture type,and smoking status of the two patient groups were recorded and compared.Additionally,complications,range of motion of the affected knee,and knee function were followed up and compared between the two groups at 12 months postoperatively.Results:The knee joint range of motion was significantly greater in Group A patients than in Group B patients after surgery,with a statistically significant difference(P＜0.05).Postoperative knee joint Bostrom scores were significantly higher in Group A than in Group B,with a statistically significant difference(P＜0.05).There was no statistically significant difference between the two groups in terms of surgery-related indicators and complication rates(P＞0.05).Conclusion:Compared with steel wire"O"-ring fixation technique,patients treated with interrupted vertical steel wire suturing for infrapatellar fractures demonstrated superior knee range of motion and Bostrom knee function scores at 12-month follow-up.Both groups exhibited comparable surgical safety.Interrupted vertical steel wire suturing should be considered as an alternative treatment for infrapatellar fractures.

Abstract:Objective:To evaluate the prognostic value of the extravascular lung water index(ELWI)in patients with adult respiratory distress syndrome(ARDS)treated with extracorporeal membrane oxygenation(ECMO).Methods:A retrospective analysis of 68 patients with ARDS admitted to the sample hospital from January 2010 to December 2022 was conducted to collect the detailed clinical data,including ECMO parameters,respiratory settings,and pulse indicator continuous cardiac output measurements.Differences between the suivival group(n=36)and the death group(n=32)were compared.The predictive value of ELWI at different time points for suivival to discharge was assessed using receiver operating characteristic(ROC)curves.Results:ELWI was higher in the death group at 24h,48h,72h,and 1 week post-ECMO initiation,and at 72h and 1 week,the differences were statistically significant(P＜0.05).The ROC curve showed that 72h ELWI was the best predictor of survival,with an area under the curve of 0.823(95％CI 0.730-0.917),a cutoff value of 13.6 mL/kg,sensitivity of 81％,and specificity of 68％.Conclusion:ELWI at 72 hours post-ECMO holds high predictive value for ARDS patients.

Abstract:Objective:It investigated the protective actions of Honokiol on lung inflammation of asthma mice and analyzed its related mechanism.Methods:Twenty 6-week-old healthy female C57BL/6J mice were selected and randomly divided into control(CTRL)group,ovalbumin(OVA)group,dexamethasone(DXM)group,and magnolol(HNK)group.The classic asthma mice model was constructed with OVA+Al(OH)3.During stimulation process,mice of the DXM group were injected with dexamethasone solution intraperitoneally while mice of HNK group were injected with Honokiol solution intraperitoneally.Mice of CTRL group were given an equal amount of PBS.It detected airway hyperresponsiveness,inflammatory cell infiltration status,cytology classification of BALF,and the expression and oxidative stress level of serum inflammatory factors in different groups.Results:After the intervention,the airway inflammation,serum,inflammation factor level of mice,and the lung oxidative stress were decreased,the cytology classification was decreased,and the differences were statistically significant.Conclusion:Honokiol can release lung inflammation by inhibiting oxidative stress in asthma mice.

Abstract:Objective:To explore the training effect and feasibility of endoscopic specialist nurses in the hospital school collaborative teaching mode.Methods:A total of 74 specialized nurses who studied in Deyang People's Hospital from August 2020 to March 2024 were selected as the research subjects.A historical controlled study design was used to select 37 nurses who studied in our department from August 2020 to March 2022 as the control group;a total of 37 nurses who received specialized training in laparoscopic nursing in our hospital from August 2022 to March 2024 were selected as the experimental group.The control group received training on conventional teaching methods,while the experimental group received training on the college school collaborative teaching mode.The theoretical assessment scores,vocational operation assessment scores,job competence,and teaching satisfaction of the two groups of students were compared after the training.Results:After the training,the theoretical assessment scores of the experimental group were higher than those of the control group,the specialized operation skills assessment scores of the experimental group were higher than those of the control group,the job competency scores of the experimental group were higher than those of the control group,and the teaching satisfaction of the experimental group was higher than that of the control group.The differences were all statistically significant(P＜0.05).Conclusion:The application training of specialized nurses using the hospital school collaborative mode can improve their theoretical scores,specialized operation scores,job competencies,and teaching satisfaction.

Abstract:Objective:To explore the role of integrated medical care intervention in patients with endometrial cancer.Methods:A total of 88 patients with endometrial cancer admitted to Zhengzhou People's Hospital from March 2022 to March 2024 were selected as the research objects and divided into the control group(n=44)and the observation group(n=44)by the random number table method.The control group received conventional nursing intervention,while the observation group received integrated medical care intervention.Comparing the two groups with negative mood,postoperative rehabilitation process,recovery of bladder function,complication rate,quality of life level,and patient satisfaction with nursing services.Results:After the nursing care,the depression-anxiety-stress scale(DASS)score,short form 36 health survey(SF-36)score,postoperative rehabilitation indicators,recovery of bladder function and satisfaction score of the patients in the observation group were all better than those in the control group,with statistically significant differences(P＜0.05);the incidence of complications in the observation group was lower than that in the control group,with statistically significant difference(P＜0.05).Conclusion:The integrated medical care intervention of medical care can effectively regulate the adverse psychological state of endometrial cancer patients,accelerate the postoperative rehabilitation process,facilitate the improvement and recovery of bladder function,reduce the risk of postoperative complications,promote the improvement of patients' quality of life,so as to improve patient satisfaction.

Abstract:Objective:To observe the application effectiveness of phased rehabilitation training based on the Information-Knowledge-Attitude-Practice(IKAP)model for patients with subarachnoid hemorrhage(SAH).Methods:A total of 118 patients with SAH admitted to Xinyang No.154 Hospital from October 2021 to March 2023 were enrolled as study subjects.Using computerized randomization,they were divided into a conventional group(n-59)and an IKAP group(n=59).The conventional group underwent standard rehabilitation training,while the IKAP group received phased neurological rehabilitation training based on the IKAP protocol.The health cognition,psychological status[General Self Efficacy Scale(GESE),Self Efficacy Scale(GSES),Connor Davidson Resilience Scale(CD-RISC)],neurological and limb function recovery[Neurofunctional Impairment Scale(NIHSS),Modified Rakin Scale(mRs),Simplified Fugl Meyer Motor Function Assessment(FMA)],and incidence of complications were compared between the two groups of patients.Results:Under different rehabilitation training modes,the IKAP group scored higher than the conventional group in terms of pathological knowledge,rehabilitation points,precautions during rehabilitation,personal management points,and other dimensions,and the difference was statistically significant(P＜0.05).The GESE and CD-RISC scores of the IKAP group were higher than those of the conventional group,and the difference was statistically significant(P＜0.05).The NIHSS score and mRs score of the IKAP group were lower than those of the conventional group,and the FMA score was higher than that of the conventional group,and the difference was statistically significant(P＜0.05).The incidence of comorbidities in the IKAP group was lower than that of the conventional group,with a statistically significant difference(P＜0.05).Conclusion:The stage based rehabilitation training based on IKAP can enhance the health cognition and improve the psychological state of SAH patients,and has a positive significance in promoting the recovery of neurological and limb functions and reducing the risk of complications.

Abstract:Objective:To explore the efficacy of progesterone combined with hysteroscopic surgery in the treatment of endometrial polyps and its impact on postoperative recurrence.Methods:A retrospective analysis of clinical data from 75 patients with endometrial polyps admitted to Xinyang Central Hospital between January 2021 and January 2023 was conducted.Based on different treatment modalities,patients were divided into an observation group(38 cases)and a control group(37 cases).The control group underwent hysteroscopic surgery alone,while the observation group received hysteroscopic surgery combined with progestin therapy.The levels of menstrual flow(PBAC)score,endometrial thickness,progesterone receptor,estrogen receptor,reproductive endocrine hormones including luteinizing hormone(LH),follicle stimulating hormone(FSH),and estradiol(E2)before and 6 months after surgery between the two groups,as well as the recurrence rate within 6 months after surgery were compared.Results:At 6 months postoperatively,patients in the observation group exhibited significantly lower endometrial thickness,PBAC scores,estrogen receptor levels,FSH,E2,and LH compared to the control group,while showing significantly higher progesterone receptor levels and recurrence rates,with all differences statistically significant(P＜0.05).Conclusion:Hysteroscopic surgeiy combined with progestin therapy demonstrates significant efficacy in treating endometrial polyps.This approach reduces postoperative menstrual flow,regulates progesterone receptor,estrogen receptor,and reproductive endocrine hormone levels,improves endometrial thickness,and decreases postoperative recurrence.

Abstract:Objective:To investigate the specific effects of combined treatment with nimodipine and flunarizine on migraine patients.Methods:A total of 100 migraine patients admitted to the Department of Neurology at Xixia County People's Hospital in Henan Province from February 2021 to February 2024 were selected as study subjects.Using a random number table,they were divided into two groups,with 50 patients in each group.Patients in the control group received flunarizine therapy,while patients in the intervention group received combined nimodipine and flunarizine therapy.Both groups underwent continuous treatment for 12 weeks.Clinical efficacy,seizure frequency,seizure duration,pain scores,cerebral hemodynamics[middle cerebral artery(MCA),posterior cerebral artery(PCA),anterior cerebral artery(ACA)],vascular endothelial function[endothelin(ET),nitric oxide(NO),serotonin(5-HT)],and adverse reactions were compared between the two groups.Results:The total response rate in the observation group was higher than that in the control group,and the pain scores,frequency of episodes,and duration were all significantly better than those in the control group,with statistically significant differences(x2=7.162,t=5.902,6.686,31.583,P＜0.05).After treatment,MCA,ACA,PCA,ET,NO,and 5-HT levels in the observation group were all lower than those in the control group,with statistically significant differences(t=1 2.747,6.704,6.951,13.449,15.012,17.328,P＜0.05).Conclusion:Combination therapy with nimodipine and flunarizine effectively alleviates headache symptoms in migraine patients,shortens headache duration,reduces attack frequency,improves cerebral hemodynamics and vascular endothelial function,without increasing adverse reactions.

Abstract:Objective:To explore the research value of mammography mammography target,serum heat shock protein 90a(Hps90a),and cancer antigen 153(Ca153)levels in the pathological molecular typing,progesterone receptor(PR),estrogen receptor(ER),human epidermal growth factor receptor 2(HER2),and Ki-67 expressions of invasive breast cancer(IBC).Methods:The clinical and pathological data of 61 patients with IBC hospitalized in sample hospital from January 2023 to March 2024 were selected as study objects.According to molecular typing,they were classified as:LuminalA type,LuminalB type,triple-negative type and HER-2 overexpression type.Comparative analysis of molybdenum target results(tumor morphology,tumor edge,tumor density,microcalcification),pathological features,and serum heat shock protein 90a(Hps9a);the relationship between the level of Ca153 and pathological molecular typing,as well as the expression of ER,PR,HER-2,and proliferation index Ki-67.Results:In 61 patients with invasive breast cancer,PR was positive in 39 cases,negative in 22 cases,ER positive in 44 cases,negative in 17 cases,HER2 positive in 18 cases,negative in 43 cases,Ki-67 high expression in 41 cases,low expression in 20 cases;there were 19 cases of Luminal A type,27 cases of Luminal B type,7 cases of triple negative type,and 9 cases of HER-2 overexpression type.Density in ER negative and positive groups;morphology and density in PR positive and negative groups;morphology,density,and tissue grading were observed in the Ki-67 high expression and low expression groups;the differences in morphology,density,and microcalcifications among Luminal A,Luminal B,triple negative,and HER-2 overexpression groups were statistically significant(P＜0.05).The difference in serum CA153 between HER-2 overexpression group and Luminal A group and Luminal B group was statistically significant(P＜0.05).Conclusion:The mammographic characteristics of breast are related to the expression of CA153 receptor and molecular typing,which provides scientific basis for clinical diagnosis and treatment of invasive breast cancer.

Abstract:Objective:To explore the effects of nursing intervention on reducing the incidence of deep venous thrombosis of lower limbs,improving pain and quality of life based on Autar risk assessment.Methods:A total of 94 patients with femoral fractures admitted to Nanyang Central Hospital from February 2022 to February 2024 were selected as the research subjects and randomly assigned to control group(n=47)and observation group(n=47).The control group were provided with routine care,and the observation group took nursing based on the Autar risk assessment.The incidence of lower extremity deep vein thrombosis(DVT),pain condition,and comfort level were compared between the two groups.Results:The observation group obtained lower incidence of lower extremity deep vein thrombosis and complications than the control group after nursing,and the differences were statistically different(P＜0.05).Compared with the control group,the observation group had better scores of numerical rating scale(NRS)score and general comfort questionnaire(GCQ),and the differences were statistically different(P＜0.05).Conclusion:Nursing intervention based on Autar risk assessment can reduce the incidence of lower extremity deep vein thrombosis in patients with femoral fractures,which is conducive to reducing pain and increasing comfort.

Abstract:Objective:To analyze the clinical value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in evaluating the infiltration of endometrial cancer(EC)lesions.Methods:A total of 68 EC patients admitted to Shuyang Hospital Affiliated to Xuzhou Medical University from April 2021 to June 2024 were selected and subjected to standardized DCE-MRI examinations.The quantitative parameters of rate constant(Kep),capacity transfer constant(Ktrans),and volume ratio of extracellular spaces outside of blood vessels(Ve)were measured.Pathological methods were used to determine the depth of muscle infiltration in the lesion,and patients were divided into non infiltration group(13 cases),superficial muscle infiltration group(32 cases),and deep muscle infiltration group(23 cases).Pearson correlation analysis was applied to analyze the correlation between various quantitative parameters and the depth of endometrial cancer invasion.It implemented receiver operating characteristic(ROC)curve drawing,and evaluated the specific efficacy of MRI in diagnosing muscle infiltration in EC patients.Results:The extravascular volume fraction(Ve),rate constant(Kep),and volume transfer constant(Ktrans)of the superficial and deep muscle infiltration groups were higher than the non infiltration group,while the above indicators were higher in the deep muscle infiltration group than in the superficial muscle infiltration group,and the difference was statistically significant(P＜0.05).According to the Pearson analysis,the infiltration depth of EC muscle layer is positively correlated with Kep and Ktrans(r=0.673,0.024,P＜0.05),but not with Ve(r=0.326,P＞0.05).Among these three parameters,Ktrans has the highest sensitivity,and specificity.Conclusion:In the quantitative parameters of DCE-MRI,Ve,Kep,and Ktrans increased with the depth of EC infiltration,and Ktrans and Kep were positively correlated with them,which has important diagnostic value in this regard.

Abstract:Vascular dementia(VD)is a progressive cognitive disorder caused by reduced cerebral blood flow and cerebrovascular disease.It ranks second only to Alzheimer's disease in incidence and remains the only preventable form of dementia.Pharmacological treatments offer limited efficacy and are associated with side effects.Auricular therapy,as a non-pharmacological treatment,offers advantages such as safety,efficacy,preventive and therapeutic capabilities,and simplicity.It has garnered significant attention in recent years,with its fundamental principles involving meridians,internal organs,nerves,delta reflexes,and holographic theory.This article aims to summarize the clinical application and related mechanisms of auricular therapy in treating VD.Analysis of relevant studies reveals that auricular therapy can improve cognitive function and quality of life in VD patients,with mechanisms involving anti-inflammatory effects,antioxidant stress protection,and regulation of cerebral blood flow.

Abstract:Objective:To analyze the diagnostic significance of QRS complex duration in predicting clinical outcomes for patients with acute myocardial infarction(AMI).Methods:A total of 90 patients with AMI admitted to Henan Yanjin County People's Hospital from June 2019 to June 2020 were selected as study subjects.After admission,ultrasound electrocardiogram(ECG)was performed immediately to evaluate the application of QRS duration of ECG in AMI patients.Results:Patients with Grade Ⅳ QRS complex duration exhibited the highest plasma N-termiral pro-B-type natriuretic peptide(N-proBNP)levels and lowest Left Ventricular Ejection Fractions(LVEF),followed by Grades Ⅲ,Ⅱ,and Ⅰ.Grade Ⅰ patients demonstrated the lowest QRS complex duration and N-proBNP levels,along with the highest LVEF,and differences were statistically significant(P＜0.05).Pearson linear correlation analysis confirmed a positive correlation between QRS complex duration and N-proBNP concentration(r＞0,P＜0.05),while a negative correlation was observed with LVEF(r＜0,P＞0.05).Regarding the incidence of malignant arrhythmias,patients in Grade Ⅳ had the highest rate,followed by Grade Ⅲ,Grade Ⅱ,and the lowest rate in Grade Ⅰ,and differences were statistically significant(P＜0.05).However,no significant statistical differences were observed in cardiogenic shock,acute pulmonary edema,or mortality rates across different grading groups,with none statistical differences had none ly significance(P＞0.05).Conclusion:QRS group duration can early identify patients with AMI,and can provide basis for the formulation of early treatment plan,so as to control the disease and improve the poor prognosis.

Abstract:Cervical radiculopathy(CSR)is one of the common diseases of motor nerve and spinal system,with neck pain,limited movement and upper limb numbness as the main clinical manifestations.With the change of people's way of working,living and learning,the pressure on the cervical spine is increasing,resulting in an increasing prevalence of CSR,so it is of great significance to actively seek the best treatment for CSR.Traditional Chinese Medicine includes traditional Chinese medicine,acupuncture,massage,etc.,and has the advantages of fast effect,simple operation,low side effects,and low price compared with Western medicine.It reviews the relevant literature on the clinical research of traditional Chinese medicine in the treatment of CSR in the past five years,in order to provide a clinical theoretical basis for the treatment of CSR.