Analysis on Correlation between Mammography Molybdenum Target,Serum Hps90a and CA153 Levels and Molecular Typing,Receptor and Ki-67 Expression in Invasive Breast Cancer
Liang Wanli
Xie Zhouming
Ye Peiji
Abstract：Objective:To explore the research value of mammography mammography target,serum heat shock protein 90a(Hps90a),and cancer antigen 153(Ca153)levels in the pathological molecular typing,progesterone receptor(PR),estrogen receptor(ER),human epidermal growth factor receptor 2(HER2),and Ki-67 expressions of invasive breast cancer(IBC).Methods:The clinical and pathological data of 61 patients with IBC hospitalized in sample hospital from January 2023 to March 2024 were selected as study objects.According to molecular typing,they were classified as:LuminalA type,LuminalB type,triple-negative type and HER-2 overexpression type.Comparative analysis of molybdenum target results(tumor morphology,tumor edge,tumor density,microcalcification),pathological features,and serum heat shock protein 90a(Hps9a);the relationship between the level of Ca153 and pathological molecular typing,as well as the expression of ER,PR,HER-2,and proliferation index Ki-67.Results:In 61 patients with invasive breast cancer,PR was positive in 39 cases,negative in 22 cases,ER positive in 44 cases,negative in 17 cases,HER2 positive in 18 cases,negative in 43 cases,Ki-67 high expression in 41 cases,low expression in 20 cases;there were 19 cases of Luminal A type,27 cases of Luminal B type,7 cases of triple negative type,and 9 cases of HER-2 overexpression type.Density in ER negative and positive groups;morphology and density in PR positive and negative groups;morphology,density,and tissue grading were observed in the Ki-67 high expression and low expression groups;the differences in morphology,density,and microcalcifications among Luminal A,Luminal B,triple negative,and HER-2 overexpression groups were statistically significant(P＜0.05).The difference in serum CA153 between HER-2 overexpression group and Luminal A group and Luminal B group was statistically significant(P＜0.05).Conclusion:The mammographic characteristics of breast are related to the expression of CA153 receptor and molecular typing,which provides scientific basis for clinical diagnosis and treatment of invasive breast cancer.
Keywords：Breast cancerMolybdenum targetHeat shock protein 90aCancer antigen-153Molecular typing
Publication Date：2026-01-25
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：5( 138-142 )