Honokiol Reduces Airway Inflammation by Inhibiting Oxidative Stress in Asthma Mice
Tang Dachun
Liu Xiaogao
Dai Xi
Abstract：Objective:It investigated the protective actions of Honokiol on lung inflammation of asthma mice and analyzed its related mechanism.Methods:Twenty 6-week-old healthy female C57BL/6J mice were selected and randomly divided into control(CTRL)group,ovalbumin(OVA)group,dexamethasone(DXM)group,and magnolol(HNK)group.The classic asthma mice model was constructed with OVA+Al(OH)3.During stimulation process,mice of the DXM group were injected with dexamethasone solution intraperitoneally while mice of HNK group were injected with Honokiol solution intraperitoneally.Mice of CTRL group were given an equal amount of PBS.It detected airway hyperresponsiveness,inflammatory cell infiltration status,cytology classification of BALF,and the expression and oxidative stress level of serum inflammatory factors in different groups.Results:After the intervention,the airway inflammation,serum,inflammation factor level of mice,and the lung oxidative stress were decreased,the cytology classification was decreased,and the differences were statistically significant.Conclusion:Honokiol can release lung inflammation by inhibiting oxidative stress in asthma mice.
Keywords：AsthmaOxidative stressHonokiolInflammation
Publication Date：2026-01-25
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：4( 135-137,142 )