Abstract:Objective:To explore the effect of electric traction combined with acupoint injection in the treatment of patients with cervical spondylosis.Method:Eighty patients with cervical spondylosis admitted to the General Hospital of Ninghua County,Sanming City,Fujian Province from January 2020 to December 2022 were selected and randomly divided into the observation group and the control group by the random number table method,with 40 cases in each group.The control group received electric traction treatment,while the observation group received electric traction combined with acupoint injection treatment.The therapeutic effects,TCM syndrome scores,cervical spine functions and neck muscle tissue elasticity of the two groups were compared.Result:The total effective rate of the control group was lower than that of the observation group,and the difference was statistically significant(P＜0.05).After treatment,the TCM syndrome scores of both groups were lower than those of the control group,while the cervical symptom scores,quality of life scores,range of motion for forward flexion,backward extension,left flexion and right flexion,work done and displacement were all higher than those of the control group.The differences were statistically significant(all P＜0.05).Conclusion:The application of electric traction combined with acupoint injection in the treatment of patients with cervical spondylosis has improved clinical efficacy,can alleviate clinical symptoms and the elasticity of cervical muscle tissue,and the treatment process is safe and reliable.

Abstract:Objective:To explore the feasibility of using FIT(fecal occult blood test by immunoassay)and colonoscopy for screening precancerous lesions and early cancer in high-risk populations of colorectal tumors.Method:A total of 8,156 permanent residents aged 40 to 74 years in the county area from June 2024 to March 2025 were selected for screening.Through questionnaire surveys and immunochemical fecal occult blood tests,the high-risk groups of colorectal cancer were initially screened and evaluated.The high-risk patients underwent colonoscopy screening and histopathological diagnosis.The results were analyzed based on colonoscopy and pathological examinations.Taking the pathological examination results as the gold standard,Kappa consistency analysis was used to compare the application value of FIT and colonoscopy in the early screening of precancerous lesions.Result:Among the 8,156 study population,the proportion of male gender(60.36％)was relatively high,the proportion of those aged 51～60(38.19％)was relatively high,the proportion of those with a junior high school education or below(53.73％)was relatively high,46.95％of the population had a history of smoking,57.53％had a history of drinking alcohol,and 6.41％had a history of previous polyp detection.4.76％had a previous history of chronic colitis.A total of 8,156 people were screened in the entire county area,among which 449 cases(5.51％)were positive for FIT,and 374 cases underwent gastroscopy and colonoscopy.Among the 374 patients who underwent gastroscopy and colonoscopy,45 cases were confirmed positive by histopathology,including 31 cases of advanced colon cancer,12 cases of early colon cancer,1 case of advanced gastric cancer,and 1 case of early gastric cancer.The number of negative cases was 329.Taking histopathological examination as the gold standard,there were 239 positive patients diagnosed by gastroscopy and colonoscopy,among which 41 were true positive patients,198 were false positive patients and 4 were false negative patients.The sensitivity of gastroscopy and colonoscopy was 91.11％,the specificity was 39.82％,the accuracy was 45.99％,the positive predictive value was 17.15％,the negative predictive value was 97.04％,and the Kappa value was 0.108.Conclusion:The combined examination of FIT and endoscopy can better improve the sensitivity and specificity of early screening for high-risk populations of colorectal tumors,and enhance the clinical screening ability for precancerous lesions and early cancer.

Abstract:Objective:To evaluate the efficacy and safety of gefitinib combined with whole-brain radiotherapy(WBRT)in patients with epidermal growth factor receptor(EGFR)-mutant non-small cell lung cancer(NSCLC)with brain metastases.Method:Clinical data of 84 patients with EGFR-mutant NSCLC and brain metastases diagnosed at Shuyang Hospital of Traditional Chinese Medicine between January 2021 and December 2023 were retrospectively analyzed.According to treatment modality,patients were divided into a control group(gefitinib monotherapy)and a combination group(gefitinib plus WBRT),with 42 patients in each group.Intracranial objective response rate(iORR),intracranial disease control rate(iDCR),progression-free survival(PFS),overall survival(OS),and adverse events were compared between the two groups.Result:The iORR in the combination group was 71.4％,significantly higher than that in the control group(47.6％),and the iDCR was also higher in the combination group(P＜0.05).The median PFS was significantly longer in the combination group than in the control group(P＞0.05).The median OS was 20.2 months in the combination group and 16.4 months in the control group,with a statistically significant difference(P＜0.05).There was no significant difference in the incidence of grade ≥ 3 adverse events between the two groups.Conclusion:Gefitinib combined with WBRT can increase the intracranial response rate of patients with brain metastases of EGFR-mutated NSCLC,prolong PFS and OS,and its safety is controllable.It has a good clinical application prospect.

Abstract:Objective:To explore and analyze the evaluation value of soluble Triggering Receptor Expressed on Myeloid cells-1(sTREM-1)and nuclear transcription factor-κ B(NF-κ B)in the disease progression and prognosis of patients with acute lung injury(ALI)caused by sepsis.Method:A total of 120 patients with ALI due to sepsis who were diagnosed and admitted to Nanxishan Hospital in Guangxi Zhuang Autonomous Region between March 2022 and March 2024.According to disease severity,they were stratified into a mild group(n=58),a moderate group(n=37),and a severe group(n=25).Levels of sTREM-1 and NF-κB,Sequential Organ Failure Assessment(SOFA)scores,and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores were compared among the patients.The Pearson method was used to analyze the correlations between serum sTREM-1,NF-κB and SOFA and APACHE Ⅱ scores.A 28-day follow-up was conducted to record survival outcomes.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of serum sTREM-1 and NF-κB levels for sepsis-induced ALI.Result:In patients with sepsis-induced ALI,serum levels of sTREM-1 and NF-κB,as well as SOFA and APACHE Ⅱ scores,showed a graded increase across severity groups:severe group＞moderate group＞mild group,with statistically significant differences(P＜0.05).The levels of serum sTREM-1 and NF-κB in patients with sepsis ALI were significantly positively correlated with the SOFA and APACHEII scores,and the difference was statistically significant(P＜0.05).Furthermore,serum sTREM-1 and NF-κB levels were significantly higher in the non-survivor group compared to the survivor group(P＜0.05).The area under the disease prediction curve(AUC)values,specific values and sensitive values of serum sTREM-1 and NF-κB for patients with sepsis and ALI were 0.861,85.57％,78.26％and 0.797,74.23％,73.91％,respectively.Conclusion:sTREM-1 and NF-κB can serve as important biomarkers for disease progression and prognosis in patients with acute lung injury caused by sepsis.By detecting the levels of sTREM-1 and NF-κB,disease progression can be detected at an early stage,providing a basis for clinical treatment.

Abstract:Objective:To investigate the current situation of pain catastrophization among patients with lumbar intervertebral disc protrusion and analyze its correlation with family care and social support.Method:A total of 126 patients with lumbar intervertebral disc protrusion in Guizhou Hospital of Beijing Jishuitan Hospital from May 2024 to May 2025 were selected as the research subjects.Questionnaire surveys were conducted using the Pain Catastrophizing Scale(PCS),the Family APGAR Index Questionnaire(APGAR),and the Social Support Rating Scale(SSRS).Pearson correlation analysis was used to explore the correlation between pain catastrophization and family care degree as well as social support.Result:Among the 126 patients,the average total score of PCS was(30.48±3.16)points,among which 72 cases had a score of ≥ 30 points,and the incidence of pain catastrophization was 57.14％(72/126).The dimensions and total scores of APGAR and SSRS in the disaster group were all lower than those in the non-disaster group,and the difference was statistically significant(P＜0.05).The results of Pearson correlation analysis showed that each dimension and total score of PCS in patients with lumbar intervertebral disc protrusion were negatively correlated with the total score of APGAR(r＜0,P＜0.05),and negatively correlated with the total score of SSRS(r＜0,P＜0.05).Conclusion:The incidence of pain catastrophization in patients with lumbar intervertebral disc protrusion is relatively high,and it is significantly negatively correlated with family care and social support.This suggests that clinical practice should attach importance to the family and social psychological support of patients,and reduce the perception of pain catastrophization by strengthening family functions and social support networks,thereby improving the prognosis of patients.

Abstract:Objective:To investigate the preventive effect of the addition and subtraction of Taohong Siwu Tang combined with auricular pressure seeds on deep vein thrombosis(DVT)in elderly postoperative hip fracture patients.Method:Eighty elderly patients with postoperative hip fractures admitted to Zhenjiang Traditional Chinese Medicine Hospital between January 2018 and January 2023 were selected as the study objects and randomized via a random number table into a control group(conventional treatment)and an observation group(conventional treatment plus modified Taohong Siwu Tang combined with auricular acupressure),with 40 cases in each group.Hemodynamic parameters,coagulation function indicators,and D-dimer levels were compared between the two groups pre-intervention,7 days post-intervention,and 14 days post-intervention.The incidence of postoperative DVT was observed,and quality of life was assessed using the Quality of Life scale before and after the intervention.Result:At both 7 and 14 days post-intervention,the observation group demonstrated significantly lower levels in all hemodynamic parameters,D-dimer(D-D),and the incidence of postoperative DVT compared to the control group,while showing significantly higher coagulation function indicators and quality of life scores.These differences were statistically significant(P＜0.05).Conclusion:The addition and subtraction of Taohong Siwu Tang combined with auricular pressure seeds can effectively improve the haemodynamics and coagulation function of elderly postoperative hip fracture patients,reduce the risk of deep vein thrombosis,and improve the quality of life.

Abstract:Objective:To investigate the current status of chronic disease resource utilization in patients undergoing cardiac radiofrequency ablation and analyze its influencing factors.Method:Convenience sampling was used to select 150 patients who underwent cardiac radiofrequency ablation at the Department of Cardiology of Nanping First Hospital from January 2022 to January 2025 as the survey subjects.The survey includes a general information questionnaire and a chronic disease resource survey scale.Multiple linear regression analysis is used to investigate the current status and influencing factors of chronic disease resource utilization in patients undergoing cardiac radiofrequency ablation.A total of 150 patients undergoing cardiac radiofrequency ablation were included,with a CIRS total score of(49.12±11.79)points.The results of multiple linear regression analysis showed that employment status,presence of other chronic diseases,comorbidities,community neighborhood,media and policies,social organizations,and total score of chronic disease resource survey scale were the influencing factors of chronic disease resource utilization in patients undergoing cardiac radiofrequency ablation(P＜0.05).Conclusion:The utilization rate of chronic disease management resources in patients undergoing cardiac radiofrequency ablation needs to be improved.Nursing staff need to actively popularize knowledge about the use of chronic disease management resources to patients and their families,and assist the community where the patients are located in improving the resource support system,in order to effectively improve the utilization level of relevant resources by patients.

Abstract:Objective:To investigate the impact of nursing interventions based on Goal Attainment Theory on preventing venous thromboembolism(VTE)in patients with liver failure undergoing artificial liver support therapy.Method:A total of 122 liver failure patients treated with artificial liver support at the First Affiliated Hospital of Bengbu Medical University between March 2022 and March 2025 were selected as the study objects.According to random number table method,they were divided into a randomization table to either a control group and an observation group.The control group received conventional nursing care,while the observation group received nursing interventions based on Goal Attainment Theory.VTE incidence,coagulation function parameters,quality of life scores,and nursing satisfaction were compared between the two groups.Result:After the intervention,the observation group exhibited a VTE incidence of 1.64％,significantly lower than the 14.75％in the control group.Coagulation function indicators in the observation group were all lower than those in the control group,whereas quality of life scores and nursing satisfaction were significantly higher.The differences were statistically significant(P＜0.05).Conclusion:Nursing intervention based on the achievement theory has a significant effect in preventing VTE in patients with liver failure treated with artificial liver.At the same time,it can improve the coagulation function of patients,enhance their quality of life and nursing satisfaction.

Abstract:Objective:To explore the application value of rhubarb enema-assisted hierarchical intervention program in patients with acute pancreatitis.Method:A total of 102 patients with acute pancreatitis admitted to Nantong Rehabilitation Hospital from June 2023 to December 2024 were selected as the study objects and divided into the control group and the experimental group by random number table method,with 51 cases in each group.The control group received conventional intervention,while the experimental group received a rhubarb enema combined with a hierarchical intervention plan.The gastrointestinal function(recovery time of abdominal pain,abdominal distension,bowel sounds,defecation,etc.),inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)],disease severity[indicators for estimating the severity of acute pancreatitis(Ranson score)],Pancreatic CT Severity Index(CTSI)score and gastrointestinal quality of life[Gastrointestinal Quality of Life Index(GIQLI)score]were compared between the two groups.Result:After the intervention,the recovery time of abdominal pain,abdominal distension,bowel sounds and defecation in the experimental group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).The levels of TNF-α,CRP and IL-6 in the experimental group were lower than those in the control group,and the difference was statistically significant(P＜0.05).The Ranson score and CTSI score of the experimental group were lower than those of the control group,and the difference was statistically significant(P＜0.05).The GIQLI scores of the experimental group were higher than those of the control group(P＜0.05).Conclusion:Rhubarb enema assisted hierarchical intervention can effectively promote the recovery of gastrointestinal function in patients with acute pancreatitis,reduce the levels of inflammatory factors,alleviate the severity of the disease,and improve the quality of gastrointestinal life.

Abstract:Objective:To explore the application of the one-time electronic flexible ureteroscopy staged lithotripsy treatment plan in the treatment of patients with 2 to 4 cm upper urinary tract calculi.Method:The clinical data of 120 patients with 2 to 4 cm upper urinary tract calculi who underwent one-time electronic flexible ureteroscopic staged lithotripsy and were admitted to Shiyan People's Hospital of Bao'an District,Shenzhen City from June 2024 to June 2025 were selected.The patients with successful first-stage lithotripsy were divided into group A(30 cases),and the patients with second-stage lithotripsy were divided into group B(90 cases).According to the timing of the second-stage surgery of the patients,they were further divided into the 2-week group(Group a),the 3-week group(Group b),and the 4-week group(Group c),with 30 cases in each group.The general information of Group A and Group B were compared.The stone clearance rates of group a,Group b and Group c were compared.The renal function[serum creatinine(SCR)]of the three groups before the operation,1 day after the operation and 7 days after the operation were compared.The incidence of postoperative complications of the three groups was also compared.Result:logistic regression analysis showed that holmium laser energy(1.0 to 1.5 J)was an independent protective factor for secondary lithotripsy in patients,and the difference was statistically significant(P＜0.05).Body mass index(BMI)≥ 24 kg/m2,stones located in the middle/lower calyces,the angle between the renal pelvis and funnel＜90°,and severe hydronephrosis are independent risk factors for stage Ⅱ lithotripsy,and the differences are statistically significant(P＜0.05).The stone clearance rate in group c was higher than that in groups a and b,and the difference was statistically significant(P＜0.05).Before the operation,there was no statistically significant difference in the t-test and F-test of SCR levels among the three groups(P＞0.05).The F-test results of the three groups at 1 day and 7 days after the operation were statistically different(P＜0.05).One day after the operation,the SCR levels in all three groups increased compared with before,but those in group c were lower than those in the other two groups,and the difference was statistically significant(P＜0.05).At 7 days after the operation,the SCR levels in all three groups were lower than those at 1 day after the operation,and the SCR level in group c was lower than that in the other two groups,with statistically significant differences(P＜0.05).The incidence of complications in group c was lower than that in groups a and b,and the difference was statistically significant(P＜0.05).Conclusion:Among patients with 2 to 4 cm upper urinary tract calculi undergoing one-time electronic flexible ureteroscopic staged lithotripsy,holmium laser energy(1.0～1.5 J)is an independent protective factor for the second-stage lithotripsy.The independent risk factors that lead to the need for secondary lithotripsy in patients are BMI≥24 kg/m2,the stone located in the middle/lower calyx,the Angle between the renal pelvis and infunnelium＜90°,and severe hydronephrosis,which can provide a reference for the selection of treatment plans for different patients.Meanwhile,in patients with stage Ⅱ lithotripsy,postponing the operation to 4 weeks can increase the stone clearance rate of patients,promote the recovery of postoperative renal function,and also shorten the operation time and hospital stay,reducing the incidence of postoperative complications.

Abstract:Objective:To explore the improvement effect of structured nursing intervention(compared with conventional nursing)on the quality of life(QoL)and functional score of patients with permanent pacemaker implantation for coronary heart disease,and to analyze the correlation between the two,providing evidence-based basis for optimizing postoperative care.Method:A retrospective design was adopted.A total of 117 patients with coronary heart disease pacemaker implantation admitted to the Department of Cardiovascular Medicine of Beijing Aerospace General Hospital from February 2021 to December 2024 were selected and randomly divided into the observation group(59 cases,structured care:standardized health education+individualized rehabilitation training+systematic follow-up)and the control group(58 cases,routine care).The primary outcome measures included the total score of the Short Form 36-item Health Survey(SF-36)for assessing quality of life,the Barthel Index(BI)for assessing basic living abilities,and the Lawton Instrumental Activities of Daily Living(IADL)for assessing higher-order functions.Secondary outcomes involved complication rates,readmission rates and satisfaction.Result:The total score of SF-36 in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.001).The Barthel index and Lawton IADL score also improved significantly,and the difference was statistically significant(P＜0.001).The change value of the total score of SF-36 was strongly correlated with the change value of Barthel index,and the difference was statistically significant(r=0.712,P＜0.001),and moderately correlated with the change value of IADL,and the difference was statistically significant(r=0.486,P＜0.001).The total incidence of complications in the observation group was lower than that in the control group,and the patient satisfaction was higher.The difference was statistically significant(P＜0.001).Conclusion:Structured nursing can significantly improve the quality of life and functional status of patients with coronary heart disease pacemakers,and reduce the risks of complications and readmission.The improvement of quality of life is moderately to strongly correlated with functional scores,supporting the integration of multi-dimensional assessment into the clinical nursing pathway.

Abstract:Objective:Discuss the improvement effect of the early comprehensive rehabilitation model centered on nursing on the multi-dimensional functions of children with autism.Method:A total of 54 children with autism spectrum disorder treated at the outpatient clinics and inpatient wards of the Department of Rehabilitation Medicine,Pediatric Specialty Campus of Fuzhou First General Hospital between November 1,2022 and December 31,2024 were enrolled in this study.The participants were randomly assigned,using a random number table,to an observation group or a control group,with 27 children in each group.The control group received routine nursing care,whereas the observation group received early comprehensive rehabilitation nursing in addition to routine care.This integrated nursing model comprised early behavioral intervention nursing,early sensory integration stimulation nursing,nursing focused on language and communication skills,emotional regulation and sleep management nursing,early training in activities of daily living,and early family-centered nursing guidance.After a 3-month nursing intervention,the two groups were compared with respect to simple reaction time,attention,information processing speed,scores on the Autism Behavior Checklist(ABC),the Psychoeducational Profile-Third Edition(PEP-3),the Pittsburgh Sleep Quality Index(PSQI),and overall nursing satisfaction.Result:After the intervention,simple reaction time was significantly shortened and information processing speed was markedly improved in both groups compared with baseline,with the observation group demonstrating superior improvements relative to the control group;these differences were statistically significant(P＜0.05).The ABC and PEP-3 scores in both groups decreased significantly after the intervention,and all post-intervention scores in the observation group were significantly lower than those in the control group(P＜0.05).In addition,the mean scores across all six PSQI dimensions were significantly lower in the observation group than in the control group following the intervention(P＜0.05).Nursing satisfaction was also significantly higher in the observation group compared with the control group(P＜0.05).Conclusion:The early comprehensive rehabilitation model centered on nursing can effectively improve the reaction speed,attention,and information processing ability of children with autism,enhance behavioral and cognitive functions,and improve sleep quality.

Abstract:Objective:To explore the application effect of parent-adult-child(PAC)psychological resilience care in improving the quality of safety management for hemodialysis patients.Method:110 hemodialysis patients who received maintenance hemodialysis(MHD)treatment at the Hemodialysis Center of Tongzhou District People's Hospital in Nantong City from January 2022 to December 2022 were selected as the research subjects.They were divided into the control group and the experimental group according to the random number table method,with 55 cases in each group.The control group was given routine nursing content.The experimental group implemented nursing intervention guided by the PAC psychological resilience theory on the basis of the nursing intervention in the control group.The incidence of complications,adverse events and the quality of nursing were compared between the two groups.Result:The total incidence of complications in the experimental group during the study period was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).The total incidence of adverse nursing events in the experimental group during the study period was significantly lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the scores of basic nursing and specialized nursing between the two groups after the study(P＞0.05).However,the quality of nursing in the experimental group after the study period was higher than that in the control group in terms of nursing communication,awareness of nursing risks and total score,and the difference was statistically significant(P＜0.05).Conclusion:Providing flexible PAC care to dialysis patients can effectively reduce the incidence of complications and adverse events during dialysis,and also effectively enhance nursing communication and patients' risk awareness,ultimately achieving a significant improvement in the quality of nursing safety management.

Abstract:Objective:Xinjiang,as a typical extreme arid area,has regional specificity in the influence of climatic factors(temperature,humidity,wind speed)on respiratory diseases.This study focuses on the Urumqi and Changji areas to explore the association between climatic factors and the number of asthma cases.Method:Based on the number of asthma patients visiting Changji People's Hospital and Urumqi Military Region General Hospital from 2019 to 2023,as well as the average monthly temperature,average monthly humidity,and average monthly wind speed during the same period,Pearson correlation analysis and time series analysis were used to explore the correlation between climatic factors and the number of asthma cases.Result:The peak period of asthma onset in both places was in spring(March to May),and the low peak period was in winter(December to February of the following year).During the period from 2019 to 2023,the number of female patients with bronchial asthma visiting Changji People's Hospital was higher than that of male patients,and the total number of patients was on the rise.The number of male patients visiting the General Hospital of the Urumqi Military Region is greater than that of female patients.The number of patients with bronchial asthma visiting Changji People's Hospital increased significantly in March,and the number of patients visiting Urumqi Military Region General Hospital also increased significantly in March and September.The Pearson correlation coefficient showed that the average monthly number of bronchial asthma patients in Changji People's Hospital was positively correlated with the average monthly temperature and average monthly wind speed(P＞0.05),but negatively correlated with the average monthly humidity(P＜0.01).The average monthly number of bronchial asthma patients in the General Hospital of Urumqi Military Region was positively correlated with the average monthly temperature and average monthly wind speed,and negatively correlated with the average monthly humidity(P＞0.05).Conclusion:The prevalent season of bronchial asthma in Xinjiang region is spring(March to May).Among the climatic factors in Xinjiang region,the average temperature and average wind speed are positively correlated with the number of cases of bronchial asthma,while the average humidity is negatively correlated with the number of cases of bronchial asthma.That is,the higher the average temperature and average wind speed,the more people will fall ill,the lower the average humidity,the more people will fall ill.

Abstract:Objective:To investigate and compare the safety and clinical efficacy of transurethral bipolar plasma kinetic resection of the prostate(PKRP)versus transurethral bipolar plasma enucleation of the prostate(TUPEP)combined with PKRP in patients with benign prostatic hyperplasia(BPH)complicated with calculi.Method:A retrospective analysis was conducted on the dataof 82 patients with BPH and stones treated at the Third Hospital of Baotou Steel Group between December 2021 and February 2025.According to different treatment modalities,the patients were divided into observation and control groups(41 cases each).The control group received PKRP alone,while the observation group received TUPEP combined with PKRP.Clinical efficacy,safety,prostate symptom scores,maximum urinary flow rate(Qmax),quality of life,and incidence of complications were compared between the two groups.Result:Compared with the control group,the observation group exhibited shorter operative time and higher clinical efficacy(P＜0.05).Furthermore,the observation group demonstrated lower prostate symptom scores,higher Qmax,improved quality of life scores,and lower complication rates compared with the control group(P＜0.05).Conclusion:TUPEP combined with PKRP in the treatment of BPH patients with calculi has shorter operation time and bladder irrigation time,is safer,helps improve clinical efficacy,relieve prostate symptoms of patients,increase their maximum urine flow rate,promote the improvement of patients'living standards,and reduce the incidence of complications.

Abstract:Objective:To explore the clinical efficacy and safety of intravesical traditional Chinese medicine perfusion in patients with kidney deficiency and damp-heat type overactive bladder(OAB).Method:A total of 73 patients diagnosed with OAB in the Department of Urology of Rongchang District Hospital of Traditional Chinese Medicine in Chongqing from January 2022 to September 2024 were selected as the study objects and randomly enrolled in the Yisang Liquid group and the Solinaxin group respectively according to the random number table method.Both groups were orally administered Solina succinate tablets.In the Yisang Liquid group,a self-designed traditional Chinese medicine formula(Yisang Liquid)was added for bladder perfusion twice a week,with the perfusion retained for 1 hour.The TCM syndrome score,OABSS\,OAB-Q short form,clinical efficacy evaluation and incidence of adverse reactions of patients with OAB in the two groups after 8 weeks of treatment were analyzed.Result:Before treatment,there was no statistically significant difference in the TCM syndrome score,OABSS,and OAB-q short form between the two groups(P＞0.05).After treatment,the TCM syndrome score,OABSS,and OAB-q short form of the two groups of patients were all improved compared with those before treatment.Moreover,the Yisang Liquid group had a significant advantage over the solifenaxin group,and the difference was statistically significant(P＜0.05).Moreover,the adverse reaction rate in the Yisang Liquid group(16.67％)did not increase significantly.Conclusion:Intravesical infusion of traditional Chinese medicine(Yisang Liquid)can effectively improve the symptoms of kidney deficiency and damp-heat type overactive bladder(OAB),with good safety.It provides a new treatment method for the clinical treatment of OAB and is worthy of further research and promotion.

Abstract:Objective:To explore the effect of dexmedetomidine(Dex)combined with ropivacaine in patients undergoing subcostal transversus abdominis plane block(TAPB)for radical resection of colorectal cancer(CRC).Method:A total of 100 patients with subcostal TAPB who underwent radical CRC resection and were admitted to Gutian County Hospital from October 2022 to September 2024 were selected as the research subjects.They were divided into the study group(n=50)and the control group(n=50)according to the random number table method.The control group was treated with ropivacaine,and the study group was treated with Dex combined with ropivacaine.The dosage of anesthetic drugs,hemodynamic indicators,sedative effects,pain degrees and adverse reactions were compared between the two groups.Result:The dosage of remifentanil,the dosage of propofol,and the number of compressions of patient-controlled intravenous analgesia(PC I A)in the study group were less than those in the control group,and the first compression time of PCIA was longer.The differences were statistically significant(P＜0.05).Before plane block(T1),at the beginning of the surgery(T2),and 30 minutes after the start of the surgery(T3),the heart rate(HR)and mean arterial pressure(MAP)in both groups showed a trend of first decreasing and then increasing,and the study group was higher than the control group,with statistically significant differences(P＜0.05).The Ramsay sedation score(RSS)of the study group 2 hours after the operation was lower than that of the control group,and the difference was statistically significant(P＜0.05).The RSS scores of the study group at 6 hours and 1～2 hours after the operation were higher than those of the control group,and the difference was statistically significant(P＜0.05).At 2 hours,6 hours and 12 hours after the operation,the Numerical Rating Scale(NRS)scores in the resting and active states of the two groups showed an upward and then downward trend,and the score of the study group was lower than that of the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:For patients with subcostal TAPB after radical CRC surgery,the use of Dex combined with ropivacaine can reduce the dosage of anesthetic drugs,improve the sedative effect,alleviate postoperative pain,promote hemodynamic stability,and has relatively high safety.

Abstract:Objective:To explore the application effect of hyperbaric oxygen combined with transcranial magnetic stimulation rehabilitation mode in the rehabilitation period of cerebral infarction.Method:A retrospective analysis was conducted on 100 patients in the rehabilitation period of cerebral infarction admitted to the First Hospital of Longyan City,Fujian Province from January 2022 to December 2024.According to the different treatment measures received by the research subjects,the above research subjects were evenly divided into the conventional treatment group(48 cases)and the combined treatment group(52 cases).Among them,the conventional treatment group received conventional treatment combined with hyperbaric oxygen therapy.The combined treatment group was treated with transcranial stimulation on the basis of the above-mentioned treatment mode.The Mini-Mental State Examination(MMSE)scores,Modified Barthel Index(MBI)scores,P300 detection parameters,Activities of Daily Living(ADL)scores,Hamilton Anxiety Scale(HAS)scores of the two groups of research subjects were compared,as well as the incidence of complications after intervention in both groups.Result:After treatment,the MMES and MBI of the two groups of research subjects increased compared with those before treatment,and the observation group was higher than the control group,with statistically significant differences(P＜0.05).After treatment,the P300 latency parameter of the two groups of research subjects decreased compared with that before treatment,and the value of the combined treatment group was lower than that of the conventional treatment group,with statistically significant differences(P＜0.05).Meanwhile,the amplitude increased compared with that before treatment.The combined treatment group was higher than the conventional treatment group,and the difference was statistically significant(P＜0.05).In addition,after receiving treatment,the ADL score increased compared with that before treatment,and the combined treatment group was higher than the conventional treatment group.Meanwhile,the HAS score was lower than that before treatment,and the combined treatment group was lower than the conventional treatment group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion:The rehabilitation model of hyperbaric oxygen combined with transcranial magnetic stimulation applied to patients in the rehabilitation period of cerebral infarction can effectively improve their cognitive impairment and activities of daily living,and enhance their self-care ability and relieve negative emotions.

Abstract:Objective:To investigate the effects of Bifidobacterium Triple Viable Combined with Ulinastatin and Levofloxacin on inflammatory factors and intestinal mucosal barrier function in patients with acute pancreatitis.Method:A total of 100 patients with acute pancreatitis admitted to the Affiliated Hospital of Putian University from July 2023 to June 2025 were randomly divided into control group and observation group(50 cases each).The control group received ulinastatin and levofloxacin,while the observation group was additionally treated with Bifidobacterium triple viable,with no sample loss during the study.Clinical efficacy,inflammatory factors,D-lactic acid,diamine oxidase(DAO),endotoxin(ET),amylase(AMY),lipase(LPS),insulin(INS),blood glucose(GLU)and adverse reactions were compared between the two groups.Result:The clinical efficacy of the observation group was higher than that of the control group.After treatment,the levels of C-reactive protein(CRP),Procalcition(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),D-lactic acid,DAO,ET,AMY,LPS and GLU in the observation group were lower,while the INS level was higher than those in the control group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:Bifidobacterium triple viable combined with ulinastatin and levofloxacin can reduce inflammatory factor levels,improve intestinal mucosal barrier function with favorable safety,and promote the recovery of pancreatic function in patients.

Abstract:Objective:This study analyzes the current research status and development trend of traditional Chinese medicine in the treatment of acute lung injury based on knowledge graphs,providing references and suggestions for future research directions.Method:The study retrieved domestic and foreign literatures on the treatment of acute lung injury with traditional Chinese medicine included in the China National Knowledge Infrastructure(CNKI)and the Web of Science Core Collection database from January 1,2013 to February 13,2023,and plotted the annual number of published papers.The Citespace software was used to visually display the contents such as countries,institutions,authors and keywords,and to analyze the current situation and development trend of traditional Chinese medicine in the treatment of acute lung injury.Result:After screening,a total of 232 relevant Chinese literatures and 313 relevant English literatures were included.The results show that the annual number of published articles has shown a fluctuating upward trend.The country with the strongest number of published articles and centrality is China.The authors who have published the largest number of Chinese and English documents are Liu Enshun and Chen Daofeng.The institutions that have published the largest number of Chinese and English documents are Tianjin University of Traditional Chinese Medicine and Nanjing University of Traditional Chinese Medicine.The keyword cluster analysis of Chinese literature shows that the research hotspots of traditional Chinese medicine in the treatment of acute lung injury mainly lie in the theory of traditional Chinese medicine treatment methods,experimental research and molecular mechanisms,and traditional Chinese medicine therapies.The keyword cluster analysis of English literature shows that the research hotspots mainly lie in the mechanism research of traditional Chinese medicine in the treatment of ALI and the clinical treatment research of traditional Chinese medicine.Conclusion:The treatment of acute lung injury with traditional Chinese medicine has been in a stage of steady development in the past decade.The visualization of knowledge graphs visually and vividly presents the development trends and research hotspots in this field,providing a basis for future research.