Analysis of the Evaluation Value of Serum sTREM-1 and NF-κB in Disease Progression and Prognosis of Patients with Sepsis Acute Lung Injury

SUN Jing; DENG Qiufang; GAN Jincheng; YAO Yuling; ZHANG Li

doi:10.14033/j.cnki.cfmr.2026.005.004

Abstract：Objective:To explore and analyze the evaluation value of soluble Triggering Receptor Expressed on Myeloid cells-1(sTREM-1)and nuclear transcription factor-κ B(NF-κ B)in the disease progression and prognosis of patients with acute lung injury(ALI)caused by sepsis.Method:A total of 120 patients with ALI due to sepsis who were diagnosed and admitted to Nanxishan Hospital in Guangxi Zhuang Autonomous Region between March 2022 and March 2024.According to disease severity,they were stratified into a mild group(n=58),a moderate group(n=37),and a severe group(n=25).Levels of sTREM-1 and NF-κB,Sequential Organ Failure Assessment(SOFA)scores,and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores were compared among the patients.The Pearson method was used to analyze the correlations between serum sTREM-1,NF-κB and SOFA and APACHE Ⅱ scores.A 28-day follow-up was conducted to record survival outcomes.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of serum sTREM-1 and NF-κB levels for sepsis-induced ALI.Result:In patients with sepsis-induced ALI,serum levels of sTREM-1 and NF-κB,as well as SOFA and APACHE Ⅱ scores,showed a graded increase across severity groups:severe group＞moderate group＞mild group,with statistically significant differences(P＜0.05).The levels of serum sTREM-1 and NF-κB in patients with sepsis ALI were significantly positively correlated with the SOFA and APACHEII scores,and the difference was statistically significant(P＜0.05).Furthermore,serum sTREM-1 and NF-κB levels were significantly higher in the non-survivor group compared to the survivor group(P＜0.05).The area under the disease prediction curve(AUC)values,specific values and sensitive values of serum sTREM-1 and NF-κB for patients with sepsis and ALI were 0.861,85.57％,78.26％and 0.797,74.23％,73.91％,respectively.Conclusion:sTREM-1 and NF-κB can serve as important biomarkers for disease progression and prognosis in patients with acute lung injury caused by sepsis.By detecting the levels of sTREM-1 and NF-κB,disease progression can be detected at an early stage,providing a basis for clinical treatment.