Abstract:Objective:This study aimed to explore the relationship between nasal microbiota characteristics and postoperative recurrence in patients with chronic sinusitis with nasal polyps(CRSwNP),providing new insights for controlling disease progression and preventing recurrence.Methods:The clinical data of 101 patients with CRSwNP ad-mitted to tianjin first central hospital from June 2020 to January 2021 were collected.According to the improvement of postoperative symptoms,endoscopic examination and imaging results,they were divided into non-recurrent group(85 cases)and recurrent group(16 cases).Nasal swab samples were collected during the operation,and 16S ribosomal RNA(16S rRNA)gene high-throughput sequencing and bioinformatics analysis were performed.Results:There is no significant difference between the α and β diversity indexes of nasal flora in patients with recurrence and those without recurrence,but the overall composition of the microbiota differed.The abundance of Acinetobacter,Rhodopseudomonas and Kestrella in recurrent group was significantly higher than that in non-recurrent group.Further linear discriminant analysis indicated that digestive cocci were also enriched in the recurrent group.The composition of nasal flora is signifi-cantly related to clinical variables,among which the abundance of Acinetobacter is positively related to age,body mass index(BMI),serum total immunoglobulin E(IgE)level and 20 items of rhinosinusitis outcome test(SNOT-20)score,and the difference of flora is related to the severity of the disease.Conclusion:The nasal microbiota structure dif-fers significantly between non-recurrent and recurrent CRSwNP patients,which may be associated with postoperative recurrence.An increased abundance of acidobacteria may be correlated with both postoperative recurrence and disease severity in CRSwNP.

Abstract:Objective:To find the optimal prophylactic dose of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)injection by comparing the efficacy,safety,and economicity of its different doses(3 mg and 6 mg)for the secondary prevention with an intermediate risk of chemotherapy-induced neutropenia.Meth-ods:From January 2023 to January 2025,398 patients with malignant solid tumor who received chemotherapy in Jincheng People's Hospital and used pegylated recombinant human granulocyte stimulating factor injection for secondary prevention of neutropenia or deficiency were selected and divided into two groups:3 mg(n=169)and 6 mg(n=229).The effectiveness,safety and economy of the two groups in preventing neutropenia and deficiency were compared by SPSS 24.0 software.Results:The overall incidence of neutropenia in the 3 mg and 6 mg groups was 11.83％(20/169)and 9.61％(22/229)respectively,with no statistical significance(P＞0.05).The incidence of grade 3 and grade 4 granulocytopenia in 6 mg group was lower than that in 3 mg group,which were 3.49％(8/229)and 3.55％(6/169)respectively,but the difference was not statistically significant(P＞0.05).There were no serious adverse reactions in the two groups,and the incidence of general adverse reactions such as bone pain and fever was similar in the two groups,which were 2.37％(4/169)and 2.62％(6/229)respectively,with no statistical significance(P＞0.05).The direct economic cost(680 yuan)of the 3 mg group was lower than that of the 6 mg group(1360 yuan),and the differ-ence between the two groups was statistically significant(P＜0.05).The ratio of single treatment expense to hospitali-zation expense in 3 mg group was(12.89±3.95)％,which was lower than that in 6 mg group(16.15±6.28)％,but there was no statistical difference between the two groups(P＞0.05).Conclusion:For the secondary prevention of neu-tropenia or deficiency in non-obese patients(with BMI in the normal range)receiving chemotherapy regimens with an intermediate risk of chemotherapy-induced neutropenia,the effectand safety of the 3mg dose of PEG-rhG-CSF was similar to the 6mg dose,while be more economical.

Abstract:Objective:To explore the effect of risk management based on the modified early warning score in the ob-servation of patients with acute bronchitis.Methods:A total of 100 patients with acute bronchitis under observation who were diagnosed and treated in hospital from December 2022 to October 2024 were selected and divided into two groups according to the random number table method,with 50 cases in each group.The conventional group was given the conventional management mode,while the observation group was given risk screening intervention.The rehabilita-tion process,nursing quality,quality of life and incidence of complications were compared between the two groups.Re-sults:The time for fever to subside,cough to disappear,wheezing to disappear,lung moist rales to disappear,blood oxy-gen saturation(SpO2)to stabilize and observation time in the observation group were shorter than those in the control group,and the difference was statistically significant(P＜0.05).The identification rate of high-risk patients,the qual-ified rate of respiratory tract management,and the medication compliance in the observation group were all higher than those in the conventional group.The screening response time was shorter than that in the conventional group,and the clinical deterioration rate was lower than that in the conventional group(P＜0.05).The scores of each dimension of the comprehensive quality of life questionnaire(GQOLI-74)in the observation group were all higher than those in the conventional group(P＜0.05).The incidence of complications in the observation group was lower than that in the con-ventional group(P＜0.05).Conclusion:Risk screening intervention has a better effect on promoting the rehabilitation process of patients under observation for acute bronchitis.It can effectively improve the quality of nursing,enhance the quality of life of patients,and reduce the incidence of complications.

Abstract:Objective:To compare the efficacy of transoral endoscopic vestibular approach(TOETVA)and endo-scopic thoracic breast approach(ETCBA)in the treatment of patients with papillary thyroid carcinoma(PTC).Meth-ods:A total of 88 patients with PTC in puyang hospital of traditional chinese medicine from January 2021 to March 2024 were selected,and they were randomly divided into observation group and control group using a random number table method.Patients in the observation group were treated with TOETVA,while patients in the control group were treated with ETCBA.The perioperative related indexes,pain degree,scar aesthetics,stress response level and complica-tion rate were compared between the two groups.Results:The number of central lymph node dissection in the observa-tion group was more than that in the control group,the postoperative drainage and blood loss were less than those in the control group,and the operation time was longer than that in the control group,with statistical significance(P＜0.05).The visual analogue scale(VAS)in the observation group was lower than that in the control group on the 1st,3rd and 7th day after operation,with statistical significance(P＜0.05).The vancouver scar scale(VSS)scores in the observa-tion group were lower than those in the control group at 1 month,2 months and 3 months after operation,with statisti-cal significance(P＜0.05).The serum serum norepinehrine(NE),adrenaline(E)and cortisol(Cor)levels in observation group were higher than control group,but with no significant difference(P＞0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion:There is no significant difference be-tween TOETVA and ETCBA in the treatment of PTC patients in terms of surgical safety and stress response to the body,but TOETVA can reduce pain,improve scar aesthetics,increase the number of central lymph node dissection,re-duce postoperative drainage and intraoperative blood loss,and ETCBA is more helpful to shorten the operation time.

Abstract:Objective:To explore the clinical effect of traditional chinese medicine syndrome differentiation in the treatment of early patients with diabetes nephropathy,and analyze the influence of traditional chinese medicine syn-drome differentia tion on their urine metabolomics.Methods:A total of 120 patients with early stage diabetic nephrop-athy admitted to jiujiang hospital of traditional chinese medicine from November 2023 to November 2024 were randomly divided into the observation group and the control group,60 cases in each group.The control group was treated accord-ing to standard protocols,while the observation group was treated according to the previous traditional chinese medi-cine syndrome differentiation types.The traditional chinese medicine symptom score,renal function index,urine meta-bonomics index of the two groups were observed and compared,and the value of traditional chinese medicine syndrome differentiation combined with metabolomics in diabetic nephropathy patients was analyzed.Results:After treatment,the symptoms of fatigue,edema,anorexia and limb edema,serum creatinine,urea ni-trogen,24h urinary protein quantification,arachidonic acid,lactic acid and glucose in both groups were lower than those before treatment,and the observation group was lower than that in the control group.The levels of taurine,valine,glutamine,octade-canedioic acid and fructose in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,with statistical significance(P＜0.05).The effective rate of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).Conclusion:The early clinical effect of TCM syndrome differentia tion in treating diabetic nephropathy is good,which can reduce the TCM symptom score of patients,improve renal function,and effectively adjust the indicators of urine metabonomics.

Abstract:Objective:To explore the efficacy and safety of laparoscopic mesh implantation(LMI)and autologous tissue repair(ATR)in the treatment of severe pelvic organ prolapse,and to provide clinical basis for optimizing the surgical plan.Methods:All 120 patients with severe pelvic organ prolapse treated in Puyang Oilfield General Hospital from January 2020 to December 2024 were randomly divided into ATR group(60 cases)and LMI group(60 cases),and the efficacy and safety of the two operations were compared in terms of anatomical reduction success rate,functional im-provement and postoperative complications.Results:Six months after operation,the success rate of anatomical reduction in LMI group(96.7％)was significantly higher than that in ATR group(87.0％)(P＜0.05).The scores of interna-tional urinary incontinence advisory committee questionnaire(ICIQ-SF)and dysdefecation scale(CSS)in LMI group were significantly lower than those in ATR group(P＜0.05).There was no significant difference between the two groups in the scores of female sexual function index scale(FSFI)and the incidence of infection,hematoma formation and deep vein thrombosis(DVT)(P＞0.05),but the proportion of visual analogue scale(VAS)≥4in LMI group was higher(P＜0.05).Conclusion:Laparoscopic mesh implantation provides superior anatomical and functional outcomes compared to autologous tissue repair,but is associated with a higher incidence of postoperative pain.Autologous tissue repair,with no foreign material implantation,offers more postoperative comfort.Individualized treatment plans should be formulated based on patient-specific factors to optimize surgical outcomes.

Abstract:Objective:To evaluate the clinical efficacy and safety of Sacubitril/Valsartan,an angiotensin receptor-neprilysin inhibitor(ARNI),in patients with acute coronary syndrome(ACS)and concomitant heart failure(HF).Methods:All 100 patients with ACS complicated with HF admitted to pingxiang people's hospital from September 2020 to September 2021 were selected and divided into observation group(n=50)and control group(n=50)according to treatment methods.Both groups received routine treatment of ACS.On this basis,the observation group was given shakubatravalsartan tablets and the control group was given valsartan.The adverse clinical outcome,cardiac function in-dex,renal function index and adverse reactions of the two groups were observed.Results:The incidence of adverse clini-cal outcomes and adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the left ventricular ejection fraction(LVEF),serum creatinine(Cr)and blood urea nitrogen(BUN)in the two groups increased with time,and the observation group was higher than the control group at the same time.Left ventricular end-diastolic diameter(LVEDD),N-terminal pro-natriuretic peptide(NT-proBNP)and glomerular filtration rate(eGFR)decreased with time,and the observation group was low-er than the controp group at the same time,and the difference was statistically significant(P＜0.05).Conclusion:Sacu-bitril/Valsartan significantly enhances cardiac function,reduces rehospitalization and mortality,and demonstrates better safety than Valsartan in ACS complicatde with HF patients,offering an optimized therapeutic approach.

Abstract:Objective:This study uses a diagnostic—formative—summative—value—added integrated evaluation system to explore how the integrated evaluation system can better improve students' academic performance and drive students' independent learning under the new three-center teaching model.Methods:Some nursing undergraduate students in the 2023 and 2024 grades of the systematic anatomy course of fenyang college of shanxi medical university were selected as the research subjects.150 students in the 2023 grade were the control group,and 154 students in the 2024 grade were the observation group.The observation group adopted the new three center teaching model,and the control group followed the traditional teaching model.Results:The observation group was higher than the control group in the completion of micro—lesson preview,the scores of small lectures and chapter tests,the final theoretical scores of summative evaluation,and the value-added evaluation of students' autonomous learning ability and literacy,with statis-tical significance(P＜0.05).The completion of micro—course preview,the scores of small lectures and chapter tests are positively correlated with the final theoretical scores.The autonomous learning ability,learning motivation,learning strategy,learning behavior,learning reflection score and total score of the observation group were higher than those of the control group,and the difference was statistically significant(P＜0.05).Conclusion:The use of diagnostic—forma-tive—summative—value—added integrated evaluation under the new three—center teaching model has significantly promoted knowledge internalization and independent learning abilities.

Abstract:Objective:This study aimed to explore the predictive and diagnostic value of Caprini score combined with dynamic monitoring of D—dimer(D—D)for postoperative deep vein thrombosis(DVT)in patients with severe traumatic brain injury.Methods:A total of 144 patients with severe traumatic brain injury were enrolled as research subjects and divided into the observation group(51 cases with DVT)and the control group(93 cases without DVT)based on whether DVT occurred postoperatively.D—D level was detected before operation and 1 day,3 days and 7 days after operation,and Caprini score was made.The area under receiver operating characteristic curve(ROC)area under curve(AUC)was used to evaluate the diagnostic value of Caprini score and D—D in the formation of DVT after severe craniocerebral trauma.Results:There was no significant difference in the overall risk distribution of low-risk,medium—risk,high—risk and extremely high—risk between the two groups before operation,1 day after operation and 7 days after operation(P＞0.05),but there was significant difference between the two groups at 3 days after operation(P＜0.05).The proportion of extremely high risk in the preoperative observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).One day after operation,the proportion of low risk in the observation group was significantly lower than that in the control group,and the proportion of extremely high risk was significantly higher than that in the control group,with statistical significance(P＜0.05).Three days af-ter operation,the proportion of critical patients in the observation group was significantly lower than that in the control group,and the proportion of extremely high—risk patients was significantly higher than that in the control group,with statistical significance(P＜0.05).Seven days after operation,there was no significant difference among all the stratified groups(P＞0.05).The preoperative D—D levels in both groups were normal,and there was no statistical difference between the two groups(P＞0.05).The level of D—D in both groups was higher than that before operation,and reached the highest level at 3 days after operation.The level of D—D in the observation group was higher than 500 μg/L at 3 days after operation,indicating that it was in hypercoagulable state at this time,while the level of D—D in the control group did not reach hypercoagulable state.The level of D—D in the observation group was significantly higher than that in the control group on the 1st,3rd and 7th day after operation,with statistical significance(P＜0.05).The AUC of the combined diagnosis of the two indexes was significantly higher than that of Caprini score and plasma D—D single test,with statistical significance(P＜0.05).Conclusion:Caprini score combined with dynamic monitoring of D—D can assess perioperative coagulation changes in patients with traumatic brain injury,and has effective diagnostic value for postoperative DVT in patients with severe traumatic brain injury in clinical practice.

Abstract:Objective:To explore the effect of four seeds cooling compress on preoperative anxiety and postoperative recovery of hemorrhoidectomy patients.Methods:Eighty-four patients who were admitted to the first affiliated hospi-tal of yangtze university from December 2024 to March 2025 were randomly divided into control group and observation group,with 42 patients in each group.Before operation,the control group was given routine care,and the observation group was given four seeds of cooling compress on the basis of the control group.The preoperative anxiety,postopera-tive recovery and nursing satisfaction were compared between the two groups.Results:After nursing,the human anti mouse antibodies(HAMA)score in the observation group was lower than that in the control group,with statistical sig-nificance(P＜0.05).The first drinking time,first eating time and first getting cut of bed time of patients in the obser-vation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in nursing satisfaction between the two groups(P＞0.05).Conclusion:Four seeds cooling compress is helpful to relieve preoperative anxiety and promote postoperative rehabilitation.

Abstract:Objective:To explore the application effect of levonorgestrel intrauterine contraceptive system combined with medroxyprogesterone acetate in the treatment of patients with abnormal uterine bleeding during perimenopause by hysteroscopic resection.Methods:A total of 80 patients with abnormal uterine bleeding during the perimenopause peri-od who were treated in Nanyang Second People's Hospital from January 2024 to December 2024 were selected and divid-ed into a control group and an observation group,with 40 cases in each group.The control group was treated with me-droxyprogesterone acetate,and the observation group was treated with levonorgestrel intrauterine birth control system combined with medroxyprogesterone acetate.The menstrual volume[pictorial blood loss assessment chart(PBAC)score],endometrial thickness the levels of sex hormones[follicle stimulating hormone(FSH),estradiol(E2)and lute-inizing hormone(LH)],the incidence of complications and disease recurrence rate were compared between the two groups.Results:Before treatment,there was no significant difference in PBCA score,endometrial thickness and FSH,E2 and LH levels between the two groups(P＞0.05).After treatment,the PBAC score,the endometrial thickness,FSH,E2 and LH levels were lower than those in the control group,with statistical significance(P＜0.05).The incidence of complications and disease recurrence rate in the observation group were lower than those in the control group,with statistical significance(P＜0.05).Conclusion:The use of levonorgestrel intrauterine contraceptive system combined with medroxyproges-terone acetate in the treatment of abnormal uterine bleeding during perimenopause can effectively improve patients' clinical bleeding symptoms and sex hormone levels,reduce the incidence of complications and disease recurrence.

Abstract:Objective:To compare the clinical outcomes of minimally invasive burr hole drainage and minimally inva-sive microcraniotomy with microendoscopic hematoma evacuation in patients with intracerebral hemorrhage.Methods:From October 2023 to December 2024,62 patients with cerebral hemorrhage were randomly divided into observation group(n=31)and control group(n=31)according to the software lottery method.Patients in the control group un-derwent minimally invasive small bone window craniotomy with microscopic hematoma evacuation,while those in the observation group underwent minimally invasive drilling and drainage.The residual hematoma rate,rebleeding rate,mortality rate,postoperative activities of daily living(ADL)classification,complication rate,operation time,intraopera-tive blood loss,and hospital stay were compared between the two groups.Results:There was no significant difference in the residual rate of hematoma,mortality,ADL classification and incidence of complications between the two groups(P＞0.05).The rebleeding rate in the control group was lower than that in the observation group,and the operation time,blood loss and hospitalization time in the observation group were less than those in the control group,with statistical significance(P＜0.05).Conclusion:Minimally invasive drilling and drainage and minimally invasive small bone window craniotomy under microscope are used to treat patients with cerebral hemorrhage,and the mortality and complications are similar,which can effectively remove hematoma and improve the ability of daily living.Minimally invasive small bone window craniotomy under microscope can reduce the rate of rebleeding,and minimally invasive drilling and drain-age can reduce the amount of blood loss during operation and shorten the operation time and hospitalization time.

Abstract:Objective:To explore the clinical effect of Jin Hu Tonglin Capsule combined with finasteride in patients undergoing transurethral bipolar plasmakinetic prostatectomy(TUPKP).Methods:All 100 patients with benign prosta-tic hyperplasia admitted to urology department of Chuxiong Hospital of Traditional Chinese Medicine from June,2022 to December,2024 were divided into observation group and control group according to treatment methods,with 50 cases in each group.The control group was treated with finasteride,while the observation group was treated with finasteride combined with jinhu tonglin capsule.The perioperative indicators,residual urine in bladder(PVR),maximum urine flow rate(Qmax),quality of life score(QOL),international prostate symptom score(IPSS)and the effective rate were com-pared between the two groups.Results:The total effective rate of the observation group was slightly higher than that of the control group,but the difference was not statistically significant(P＞0.05).There was no significant difference in operation time,tissue quality,between the two groups(P＞0.05).The amount of intraoperative bleeding,intraoperative irrigation and postoperative irrigation in the observation group were significantly less than those in the control group,and the postoperative irrigation time was significantly shorter than that in the control group,there was significient difference(P＜0.05).After treatment,both groups of patients showed an increase in Qmax and a significant decrease in PVR compared to preoperative levels,and the Qmax in the observation group was significantly higher than that in the control group,and the PVR was significantly lower than that in the control group(P＜0.05).After treatment,the IPSS and QOL scores of both groups of patients decreased compared to preoperative levels,and the IPSS and QOL scores of the observation group were significantly lower than those of the control group(P＜0.05).Conclusion:The combined application of jinhu tonglin capsule and finasteride in patients with BPH before and after TUPKP operation can signifi-cantly reduce intraoperative bleeding,irrigation volume and postoperative PVR,improve postoperative Qmax and improve patients' quality of life.

Abstract:Objective:To analyze the clinical characteristics,diagnosis and treatment process,and prognosis of a pa-tient with intestinal obstruction combined with small intestinal fistula caused by small intestine metastasis of lung canc-er,in order to accumulate experience in the diagnosis and treatment of this disease.Methods:Clinical data of a patient with intestinal obstruction combined with small intestinal fistula caused by small intestine metastasis of lung cancer were collected,and literature review and study were conducted.Results:The patient was admitted to hospital due to'chest tightness and high fever,accompanied by nausea and vomiting after eating for more than one day'.The patient had a previous diagnosis of lung squamous cell carcinoma.The initial diagnosis was acute intestinal obstruction combined with acute peritonitis.After emergency exploratory laparotomy,the patient was discharged.The diagnosis was corrected based on preoperative and postoperative pathology as:infiltrative squamous cell carcinoma of the lower lobe of the left lung,small intestinal squamous cell carcinoma,small intestinal fistula,acute peritonitis,and small intestinal obstruction.Conclusion:Acute conditions of intestinal obstruction combined with small intestinal fistula caused by small intestine metastasis of lung cancer are extremely rare clinically.When patients with lung cancer present with abdominal symp-toms,intestinal metastasis should be considered,indicating hematogenous spread and poor prognosis.Early correspond-ing treatment measures should be taken to relieve patient suffering and reduce medical burden.

Abstract:Objective:To analyse the effect of corona virus disease-19(COVID-19)on clinical test indexes and prognosis of haematological oncology patients.Methods:The clinical data of 101 patients with novel coronavirus infec-tion admitted to the Department of Haematology of the First Affiliated Hospital of Xi'an Jiaotong University from De-cember 2022 to February 2023 were retrospectively analyzed,and they were divided into transplantation group(25 ca-ses)and the non-transplantation group(76 cases)according to whether hematopoietic stem cell transplation.Labora-tory parameters and clinical outcomes were compared between the two groups before infection and at 1 week post-in-fection,＞1 week post-infection,and among patients who cleared the infection,within each group.Results:At 1 week post-infection,the transplant group exhibited higher neutrophil(NE)counts than the non-transplant group(P＜0.05),while D-dimer(D-D)levels were lower in the transplant group(P＜0.05).After＞1 week of infection,the trans-plant group had higher lymphocyte(LYM)counts than the non-transplant group(P＜0.05),while fibrinogen(FIB)and interleukin-6(IL-6)levels were lower in the transplant group(P＜0.05).After nucleic acid clearance,the non-transplant group had higher platelet(PLT)counts than the transplant group(P＜0.05).Compared with before no-vel coronavirus infection,LYM and PLT decreased,and FIB,C-reactive protein(CRP)and IL-6 increased in the transplanted group after infection,with statistical significance(P＜0.05).White blood cells(WBC),LYM,NE and PLT decreased,while FIB,D-D and CRP increased in the non-transplanted group,with statistical significance(P＜0.05).The mortality rate of transplantation group was 12.00%(3/25),which was slightly higher than that of non-transplantation group(11.84%,9/76),but there was no statistical difference between the two groups(P=0.983).There were 16 cases(72.73%,16/22)in transplantation group and 37 cases(68.52%,37/54)in non-transplantation group,and there was no statistical difference between the two groups(χ2=0.389,P=0.533).Conclusion:corona virus disease-19 have a greater impact on laboratory markers and clinical outcomes in haematological oncology patients,with transplanted patients having a higher mortality rate than non-transplanted patients and transplanted patients having a longer duration of neo-coronavirus infections.

Abstract:Objective:To explore the correlation between the detection of irregular antibodies in the Rh system of pregnant women during the perinatal period and hemolytic disease of the newborn.Methods:A retrospective selection was made of 136 perinatal pregnant women with positive irregular antibodies from August 2020 to December 2024 as the research subjects,and the specific distribution of Rh irregular antibodies was statistically analyzed.The relationship between Rh blood group irregular antibodies in perinatal pregnant women and the occurrence of hemolytic disease of the newborn was also analyzed.Results:Among 136 pregnant women with positive irregular antibodies during the perinatal period,86 cases were found to have Rh blood type irregular antibodies,including 30 cases(22.05%)of IgG anti-E,40 cases(29.41%)of IgG anti-D,9 cases(6.61%)of IgG anti-C,and 7 cases(5.14%)of IgG anti-cE.There was no statistical significant difference in the detection of Rh irregular antibodies among pregnant women with different preg-nancies,parity,and transfusion histories during the perinatal period(P＞0.05).Among 86 pregnant women with Rh blood type irregular antibodies during the perinatal period,45 newborns gave birth to hemolytic disease,including 14 ca-ses(16.28%)of IgG anti-D,27 cases(31.40%)of IgG anti-E,and 4 cases(4.65%)of IgG anti-C.The propor-tion of Rh blood type irregular antibodies IgG anti-D and IgG anti-E in the affected group was higher than that in the non affected group,with statistical significant differences(P＜0.05).Conclusion:The positive detection of irregular an-tibodies in Rh system serum of pregnant women during the perinatal period is related to the occurrence of hemolytic disease in newborns,which is helpful for the early assessment of hemolytic disease in newborns in clinical practice.

Abstract:Objective:To explore the main interfering factors of pre-transfusion compatibility testing in multiple myeloma(MM)patients and stratified treatment strategies.Methods:The data of 201 transfusion compatibility tests of 36 MM patients who received treatment in the people's hospital of chuxiong yi autonomous prefecture from September 2022 to December 2024 were included,and the tests were performed using a fully automated blood typing instrument and a blood-matching instrument,and the abnormal results(n=99)were analyzed by the test-tube method of re-peated testing,the saline replacement method,the 37℃and 4℃treatments,the coagulant amine method,the 2-mer-captoethanol(2-Me)pretreatment method,and irregular antibody specificity identification method to deal with inter-fering factors in a hierarchical manner so as to complete the pre-transfusion related tests.Results:CD38 monoantibody interference accounted for 61.62％(61/99),followed by blood group antibody attenuation[18.18％(18/99)]and pro-tein agglutination[12.12％(12/99)].The success rate of blood matching was significantly improved after treatment with coagulant amine method and 2-Me.Conclusion:There are many interfering factors in transfusion compatibility testing in MM patients,and there are many challenges in blood matching,among which CD38 monoclonal antibody is the main factor of interference.The establishment of standardized procedures and stratified processing in the transfusion department can improve the efficiency of transfusion compatibility testing and the safety of blood transfusion.

Abstract:Objective:To explore the therapeutic effects of stroke formula No.1 combined with acupuncture at du meridian acupoints on patients who suffering from ischemic stroke of the qi-deficiency and blood stasis pattern.Meth-ods:All 130 patients with qi-deficiency and blood stasis type ischemic stroke admitted to jiangxi hospital of integrated traditional chinese and western medicine from January 2023 to December 2024 were randomly divided into control group and observation group,with 65 cases in each group.The control group received conventional western medicine interven-tions,while the observation group was treated with stroke formula No.1 combined with acupuncture at du meridian acupoints in addition to the conventional treatment.Clinical efficacy,neurological function indicators,electroencephalo-gram(EEG)-related indicators,and traditional Chinese medicine(TCM)syndrome scores of both groups were com-pared before and after treatment.The adverse reactions throughout the treatment period were also evaluated between the two groups.Results:A total of 60 cases in each group completed the study.After treatment,the clinical efficacy and the score of Montreal Cognitive Scale(MoCA)in the observation group were higher than those in the control group(P＜0.05).After treatment,the scores of national institute of health stroke scale(NIHSS),brain symmetry index(BSI)and the ratio of(δ+θ)wave to(α+β)wave(DTABR)in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The combination of stroke formula No.1 and acu-puncture at du meridian acupoints significantly improves patients'neurological function,EEG-related indicators,and TCM symptoms,enhances clinical efficacy,and is safe.Clinicians can flexibly select this combined treatment regimen based on the specific conditions of patients to improve their health status.

Abstract:Objective:To explore the impact of strategy optimization concepts combined with safety warnings on the quality of pharmaceutical drug management.Methods:All 100 kinds of drugs managed by the pharmacy department of youyang county people's hospital in chongqing from January 2024 to December 2024 were selected as the research ob-ject,and were randomly divided into control group and observation group,with 50 kinds in each group.The control group received routine management,while the observation group received strategy optimization combined with safety warning management.The quality scores,time consumption,and incidence of adverse events during drug storage,dis-pensing,and supply were compared between the two groups.Results:The quality scores of drug storage,dispensing,and supply management in the observation group were higher than those in the control group,the management time for drug storage,dispensing,and supply in the observation group were shorter than those in the control group,the incidence of adverse events during drug use in the observation group was lower than that in the control group,there was significient difference(P＜0.05).Conclusion:The combination of strategy optimization concept and safety warning has a positive impact on improving the quality and efficiency of pharmaceutical drug management,and can also ensure the safety of drug use.

Abstract:Objective:To explore and analyze the clinical effect of using recombinant bovine basic fibroblast growth factor gel(bFGF)combined with xenogeneic acellular dermal matrix(ADM)in the repair of deep second-degree burn wounds.Methods:A total of 120 patients with deep second-degree burn wounds treated in Jiujiang First People's Hos-pital from January 2023 to January 2024 were selected as the observation subjects.According to the random number ta-ble method,the 120 cases were divided into the study group(bFGF combined with ADM),control group 1(ADM a-lone),and control group 2(bFGF alone),with 40 cases in each group.The wound healing time,wound healing rate,wound infection rate,post-healing scar condition[vancouver scar scale(VSS)],drug adverse reactions,reoperation rate,and white blood cell count(WBC)were compared among the three groups.Results:The wound healing time in the study group was shorter than that in control group 1 and control group 2,and the statistical were significant(P＜0.05).The wound healing rates in the study group on the 7th,14th,and 21st days after medication were higher than those in con-trol group 1 and control group 2,and the statistical were significant(P＜0.05).The wound infection rates in the study group on the 7th,14th,and 21st days after medication were lower than those in control group 1 and control group 2,and the statistical were significant(P＜0.05).The VSS scores in all dimensions in the study group at 6 months after repair were lower than those in control group 1 and control group 2(P＜0.05).After treatment the WBC levels in the study group were lower than those in control group 1 and control group 2,and the control group 1 lower than control group 2(P＜0.05).The incidence of drug adverse reactions and reoperation rate in the study group were lower than those in control group 1 and control group 2(P＜0.05).Conclusion:The use of bFGF combined with ADM in the repair of deep second-degree burn wounds can significantly shorten the wound healing time,reduce the wound infection rate and reo-peration rate,alleviate the inflammatory response,promote wound healing,and improve the aesthetic appearance of the repair,with high safety.