Clinical study on the repair of deep second-degree burn wounds with bFGF combined with ADM
CAO Qing
CHEN Xiuhuang
BAI Shiping
PAN Yongjun
HE Xiafei
Abstract：Objective:To explore and analyze the clinical effect of using recombinant bovine basic fibroblast growth factor gel(bFGF)combined with xenogeneic acellular dermal matrix(ADM)in the repair of deep second-degree burn wounds.Methods:A total of 120 patients with deep second-degree burn wounds treated in Jiujiang First People's Hos-pital from January 2023 to January 2024 were selected as the observation subjects.According to the random number ta-ble method,the 120 cases were divided into the study group(bFGF combined with ADM),control group 1(ADM a-lone),and control group 2(bFGF alone),with 40 cases in each group.The wound healing time,wound healing rate,wound infection rate,post-healing scar condition[vancouver scar scale(VSS)],drug adverse reactions,reoperation rate,and white blood cell count(WBC)were compared among the three groups.Results:The wound healing time in the study group was shorter than that in control group 1 and control group 2,and the statistical were significant(P＜0.05).The wound healing rates in the study group on the 7th,14th,and 21st days after medication were higher than those in con-trol group 1 and control group 2,and the statistical were significant(P＜0.05).The wound infection rates in the study group on the 7th,14th,and 21st days after medication were lower than those in control group 1 and control group 2,and the statistical were significant(P＜0.05).The VSS scores in all dimensions in the study group at 6 months after repair were lower than those in control group 1 and control group 2(P＜0.05).After treatment the WBC levels in the study group were lower than those in control group 1 and control group 2,and the control group 1 lower than control group 2(P＜0.05).The incidence of drug adverse reactions and reoperation rate in the study group were lower than those in control group 1 and control group 2(P＜0.05).Conclusion:The use of bFGF combined with ADM in the repair of deep second-degree burn wounds can significantly shorten the wound healing time,reduce the wound infection rate and reo-peration rate,alleviate the inflammatory response,promote wound healing,and improve the aesthetic appearance of the repair,with high safety.
Keywords：recombinant bovine basic fibroblast growth factor gelxenogeneic acellular dermal matrixdeep second-degree burn wounds
Publication Date：2026-01-10
Online Publishing Date：2026-01-15(First online date of this platform, not the publication date of the document)
Pages：5( 3-7 )