Abstract:Objective To explore the specific impact of applying structure-process-outcome model combined health education in patients with contrast-enhanced ultrasound.Methods A total of 180 contrast-enhanced ultrasound patients admitted to Nanyang Central Hospital from January 2022 to June 2023 were included as the research subjects.They were randomly divided into a control group and an observation group,with 90 patients in each group.The control group received routine health education,while the observation group received structure process outcome model.The health knowledge mastery,contrast coordination,and contrast quality between the two groups were compared.Results At the end of the contrast-enhanced ultrasound,the health knowledge mastery,contrast coordination,and harmonic imaging quality score of the observation group were higher than those of the control group(P＜0.05).Conclusion The implementation of structure-process-result mode combined with health education can effectively improve the grasp of health information of contrast-enhanced ultrasound patients,enhance the coordination degree of examination,improve the quality of contrast.

Abstract:Objective To explore the effect of TCM nursing combined with exercise rehabilitation on exercise endurance and quality of life on patients with chronic heart failure.Methods A total of 82 patients with chronic heart failure treated in Chinese Medicine Hospital of Puyang from July 2022 to December 2023 were randomly grouped,with 41 cases in the observation group and the control group.The control group was received routine nursing and exercise rehabilitation intervention,and the observation group was received TCM nursing on the basis.The nursing intervention time was 3 months.Exercise endurance was evaluated by 6-minute walking test(6MWT)and rating of perceived exertion(RPE),quality of life was evaluated by Minnesota living with heart failure questionnaire(MLHFQ),and nursing satisfaction was compared.Results After nursing intervention,6MWT and RPE scores in both groups were improved,6MWT in the observation group was higher than the control group,and RPE scores were lower(P＜0.05).After nursing intervention,the dimension scores of body condition,emotional change and other dimension of MLHFQ in both groups were decreased,and the scores in the observation group were lower(P＜0.05).The nursing satisfaction in the observation group was higher(P＜0.05).Conclusion The application of TCM nursing combined with exercise rehabilitation could effectively improve the exercise endurance and quality of life of patients,and the nursing satisfaction was higher.

Abstract:Objective To discuss clinical characteristics,pathological features,treatment and prognosis of primary female genital tract malignant melanoma(PFGMM).Methods The data of 17 patients with PFGMM in the First Affiliated Hospital of Zhengzhou University from March 2015 to July 2023 were retrospectively analyzed.Kaplan-Meier test and log-rank test were used to analyze the relationship between related factors and prognosis.Results The median age of 17 patients was 52 years old(33-70 years).Vulva was the predominant site,followed by vagina and cervix.The main clinical manifestations were vulvar mass and irregular vaginal bleeding.All the patients received surgical treatment,and 3 of them did not receive adjuvant treatment.Median follow-up was 24 months(6-113 months).The 1-year,2-year,and 5-year progression-free survival rates were 80.5％,42.9％and 21.5％respectively,and the overall survival rates were 94.1％,63.2％and 24.6％respectively.International federation of gynecology and obste-tries stage was the main factor affecting prognosis,and patients with stage Ⅲ/Ⅳ had poorer prognosis than those with stage Ⅰ/Ⅱ(P=0.001).Conclusion PFGMM tends to occur in postmenopausal women,with a low incidence,but a high degree of malignancy and atypical clinical symptoms.Immunohistochemistry is very important for the identification of the disease.Surgical treatment combined with adjuvant therapy is the most popular clinical approach for malignant melanoma currently.Patients with late clinical stage tend to have a poor prognosis.

Abstract:Objective To study the difference of anatomic parameters of patent foramen ovale(PFO)by transesophageal echocardiography(TEE)in different grades of transthoracic contrast echocardiography(cTTE)and different anatomical types,and to explore the significance of anatomical features of PFO.Methods A total of 343 patients diagnosed with PFO in the First Affiliated Hospital of Xinxiang Medical University were retrospectively analyzed.According to the RLS grading results of cTTE,the patients were divided into grade Ⅰ,grade Ⅱ and grade Ⅲ group,and then divided into simple PFO and complex PFO or high-risk PFO and non-high-risk PFO according to different anatomical structures.The difference of anatomical parameters of different RLS grades and different types of PFO and the relationship between anatomical parameters and RLS grades were analyzed.Results During Valsalva maneuver,the inner diameter of the left atrial(LA)and right atrial(RA)surface of PFO in RLS Ⅲ group were greater than those in Ⅰ and Ⅱ groups,while the tunnel length of PFO was shorter(P＜0.05).The RA surface diameter of PFO during Valsalva maneuver was an independent risk factor for RLS classification.Age,inner diameter of the LA surface and tunnel length of PFO at rest and tunnel length of PFO during the Valsalva maneuver were greater in the complex subgroup than in the simple subgroup(P＜0.05).The inner diameter of the LA surface and tunnel length of PFO at rest,the inner diameter of the LA and RA surface of PFO and tunnel length of PFO during the Valsalva maneuver in the high-risk PFO were higher than those of non-high-risk PFO(P＜0.05).Conclusion The RA surface diameter of PFO during Valsalva maneuver was an independent risk factor for RLS classification.High-risk PFO contains more risk factors than complex PFO,which should be paid more attention to in clinic.TEE can effectively identify these high-risk factors in the assessment of PFO,and provide more help for clinical practice.

Abstract:Objective To observe the effects of respiratory training and acupoint application on pulmonary function,quality of life and exercise endurance in patients with chronic obstructive pulmonary disease(COPD).Methods Eighty-two patients with COPD admitted to Henan Provincial Hospital of Traditional Chinese Medicine from February 2024 to March 2025 were randomly divided into the observation group(41 cases)and the control group(41 cases).The control group received routine care,while the observation group was given respiratory exercises and acupoint application on the basis of routine nursing,the intervention period was 12 weeks.The pulmonary function indicators,quality of life,degree of dyspnea,exercise endurance and therapeutic effects before and after the intervention were compared between the two groups.Results Before the intervention,there was no significant difference in each index between the two groups(P＞0.05).After the intervention,the pulmonary function indicators in the observation group were(1.53±0.34)L,(58.44±8.30)％and(2.49±0.50)L,respectively,which were higher than those of the control group[(1.32±0.29)L,(55.15±7.97)％,(2.25±0.42)L](P＜0.05).The quality of life score of the observation group was lower than that of the control group(t=5.881,P＜0.05).The dyspnea severity was lower than that of the control group(t=9.852,P＜0.05).The exercise tolerance score was higher than that of the control group(t=4.133,P＜0.05).The total effective rate of treatment in the observation group was 92.68％,which was higher than 73.17％in the control group(P＜0.05).Conclusion Respiratory training combined with acupoint application therapy can significantly improve the pulmonary function,quality of life and exercise endurance of patients with COPD.It is a safe and effective non-pharmaceutical treatment method and is worthy of clinical promotion.

Abstract:Objective To compare the application effects of fiber reinforced all-crown(FCR)and endocrown(ECR)in the restoration of large area occlusal defects of mandibular first molars.Methods Ninety patients with extensive mandibular first molar surface defects who underwent oral restoration at the First Affiliated Hospital of Zhengzhou University from June 2021 to May 2023 were selected and randomly divided into FCR group and ECR group using a random number table method.The repair effect,biomechanical performance and complications were compared between two groups.Results After repair,the proportion of A-grade edge adaptability and adjacency relationship in the FCR group was higher than that in the ECR group(P＜0.05).After repair,there was no significant difference in the maximum Von Mises stress of vertical loads between the two groups(P＞0.05),the maximum Von Mises stress of oblique loads in FCR group was lower than that in ECR group(P＜0.05).There was no statistical significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion Compared with ECR,FCR can improve marginal adaptability and adjacency relationship in repairing large area defects of mandibular first molars after root canal treatment,and has more advantages in oblique stress.

Abstract:Objective To investigate the correlation between the expression of serum fibroblast growth factor 23(FGF23)and hypoxia inducible factor-1α(HIF-1α)and the occurrence of pulmonary arterial hypertension(PAH)in hemodialysis patients.Methods A retrospective analysis was conducted to collect clinical data of 148 patients who underwent maintenance hemodialysis in hospitals for more than 6 months from January 2021 to January 2024.Based on the results of pulmonary artery pressure measured by echocardiography at 6 months of hemodialysis,the patients were divided into PAH group(46 cases)and non PAH group(102 cases).At the same time,the PAH group was evaluated for disease severity based on the average pulmonary artery pressure value and divided into subgroups:mild group(14 cases),moderate group(22 cases),and severe group(10 cases).The data required for the study were reviewed and recorded,and the possible factors were included.Logistic regression was used to analyze the influencing factors of PAH in hemodialysis patients,and the relationship between serum FGF23,HIF-1α expression and PAH in hemodialysis patients was analyzed.Results During dialysis,the increase in body mass,serum FGF23,HIF-1α,blood phosphorus,and total parathyroid hormone levels in the PAH group were higher than those in the non PAH group,and hemoglobin was lower than that in the non PAH group(P＜0.05).Multivariate logistic regression analysis showed that the increase in body mass,FGF23,HIF-1α,hemoglobin during dialysis were associated with the occurrence of PAH in hemodialysis patients(P＜0.05).There was a positive interaction between serum FGF23 and HIF-1α levels in hemodialysis patients and the occurrence of PAH.The levels of serum FGF23 and HIF-1α in the severe group were higher than those in the moderate and mild groups,and the moderate group was higher than the mild group(P＜0.05).Conclusion The abnormal elevation of serum FGF23 and HIF-1α is related to the occurrence of PAH in hemodialysis patients,and there is an interaction between the two indicators.

Abstract:Objective To investigate the feasibility of percutaneous cement augmentation for treating adjacent vertebral stress fractures with pseudarthrosis in ankylosing spondylitis(AS).Methods The study selected patients with AS complicated by adjacent vertebral stress fractures and intervertebral pseudarthrosis,who were admitted to Zhengzhou Orthopedic Hospital from January 2015 to January 2021 and met the inclusion and exclusion criteria,as the research subjects.Among them,26 patients who received percutaneous bone cement fusion surgery were assigned to the experimental group,while 25 patients who received conservative treatment during the same period were assigned to the control group.Data recorded for all patients included age,gender,operative time,amount of polymethyl methacrylate(PMMA)bone cement injected,surgical complications,and hospital stay.Visual analog scale(VAS)pain scores and Oswestry disability index(ODI)scores were recorded preoperatively,at 1 day postoperatively,at 3 months postoperatively,and at the final follow-up.Therapeutic outcomes were assessed according to the MacNab criteria.Results All surgeries in the experimental group were successfully completed.The operative time was(54.81±14.52)min,the PMMA injection volume was(13.58±1.45)mL,and the hospital stay was(6.46±1.33)days.All patients exhibited good intervertebral bone cement fusion postoperatively,with no pseudarthrosis occurrence.According to the MacNab criteria,the excellent and good rate in the experimental group was higher than that in the control group(P＜0.05).VAS and ODI scores at 1 day postoperatively,3 months postoperatively,and the final follow-up were lower than preoperative scores in all patients(P＜0.05).At postoperative follow-ups,the VAS scores of patients in the experimental group were lower than those in the control group(P＜0.05),while the ODI scores were higher than those in the control group(P＜0.05).No related complications occurred postoperatively.Conclusion Percutaneous bone cement fusion can improve the functional status of AS patients with adjacent vertebral stress fractures and pseudarthrosis,providing lasting pain relief.It is an effective option for patients unsuitable for open surgical fixation and conservative treatment.

Abstract:Objective To explore the effect of PERMA-based spiritual care training among new nurses with high occupational stress.Methods This study belonged to quasiexperimental study with comparison before and after intervention.Thirty-eight new nurses with high occupational stress who recruited Henan Provincial Cancer Hospital in July 2023 were selected as the study subjects,they were divided into 4 groups,with 9 to 10 cases in each group,and the PERMA-based spiritual care training was carried out for 7 weeks.The training effects were compared with the Chinese nurses stressor scale(CNSS),10-item Connor-Davidson resilience scale(CD-RISC-10),and Chinese version of the meaning of life questionnaire(MLQ)before and after the training.Results The new nurses' occupational stress scores after training were lower than those before training,and the scores of psychological resilience and sense of meaning in life were higher than those before training(P＜0.05).Conclusion The PERMA-based spiritual care training can effectively alleviate new nurses' occupational stress,improve their mental health and enhance sense of meaning in life.

Abstract:Objective To explore the effects of Orem self-care mode on self-care ability,psychology,and quality of life in patients with aplastic anemia(AA)undergoing hematopoietic stem cell transplantation(HSCT).Methods Clinical data of 141 AA patients treated with HSCT in the Affiliated Cancer Hospital of Zhengzhou University from January 2020 to January 2024 were retrospectively collected.According to nursing plans,they were divided into a control group(70 cases,conventional nursing mode)and an observation group(71 cases,conventional nursing mode and Orem self-care mode),both of which completed a 3-month intervention.The self-care ability,psychological state,and quality of life were compared between two groups.Results After the intervention,the scores of exercise of self-care agency scale(ESCA)and functional assessment of cancer treatment-bone marrow transplant(FACT-BMT)in the two groups were all higher than before the intervention,and the subscale of anxiety and depression in hospital anxiety and depression scale(HADS)was lower than before the intervention,and the scores of ESCA and FACT-BMT in the observation group were higher than those in the control group,while the subscale of anxiety and depression in HADS was lower than that in the control group(P＜0.05).Conclusion The Orem self-care model can improve the self-care ability of AA patients after HSCT,improve their psychological state and quality of life.

Abstract:Objective To explore the effect of traditional Chinese medicine children's health management plan on the TCM physiological status score and growth and development of children with atopic dermatitis.Methods A total of 80 children with atopic dermatitis admitted to Henan Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to July 2024 were enrolled and divided into two groups by random drawing,with 40 cases in each group.The control group received routine intervention,while the observation group was given traditional Chinese medicine pediatric health management on the basis of the control group.The clinical efficacy,SCORing Atopic Dermatitis(SCORAD)score,TCM physical state score and growth and development status were compared between the two groups.Results Compared with the control group(80.00％),the total effective rate of the observation group(97.50％)was higher(P＜0.05).After intervention,the SCORAD score of the observation group[(35.68±5.54)points]was lower than that of the control group[(46.30±6.92)points](P＜0.05).After intervention,both groups showed an increase in body weight and height gain,with no statistically significant difference between two groups(P＞0.05).After intervention,the physiological status scores of both groups in traditional Chinese medicine(abdominal distension,loose stools,difficulty falling asleep,skin itching,and fatigue)decreased,and the observation group had even lower scores(P＜0.05).Conclusion Traditional Chinese medicine pediatric health management programs for children with atopic dermatitis can help improve the severity of the disease and clinical symptoms,promote growth and development to a certain extent,and are worthy of clinical promotion.

Abstract:Objective To explore the therapeutic effect difference between metoclopramide injection or neostigamine injection at Zusanli Acupoint combined with rhubarb enema in the treatment of severe patients with gastrointestinal dysfunction.Methods A total of 57 severe patients with gastrointestinal dysfunction who treated in the intensive care unit of Zhengzhou Second People's Hospital from January 2024 to May 2025 were randomly divided into the observation group and the control group.Both groups were received rhubarb enema treatment.The observation group(30 cases)was combined with the injection of metoclopramide needle at the Zusanli Acupoint,and the control group(27 cases)was combined with the injection of Neosmine needle at the Zusanli Acupoint.The recovery indicators of gastrointestinal function,nutritional indicators,classification of acute gastrointestinal injury(AGI)and adverse reactions were compared.Results The gastrointestinal function indicators of recovery time of bowel sounds and first defecation time in the observation group were all shorter than the control group(P＜0.05).After treatment,the nutritional indicators of serum albumin and prealbumin in both groups increased,and the levels in the observation group were higher than the control group(P＜0.05).The AGI grading in the observation group was better(P＜0.05).The incidence of adverse reactions in the observation group was lower(P＜0.05).Conclusion The treatment of metoclopramide injection at the Zusanli Acupoint combined with rhubarb enema has more advantages for patients with gastrointestinal dysfunction in severe patient.The treatment can effectively improve the nutritional indicators,promote the recovery of gastrointestinal function,alleviate clinical symptoms,and has good therapeutic safety.

Abstract:Objective To investigate the prevalence and distribution of the six respiratory viruses in pediatric patients attending the clinic of grade A tertiary hospital in Luoyang city.Methods The detection results of respiratory virus nucleic acid test kits using nasal swabs from pediatric patients admitted to the hospital in 2023 were analyzed.Results In 2 377 samples,the overall positive rate of infection was 39.88％,with the highest detection rates being adenovirus(ADV)(15.57％),respiratory syncytial virus(RSV)(10.39％),influenza virus(IF)A(5.97％),parainfluenza virus(PIV)3(4.75％),PIV1(3.87％)and IFB(1.14％).The overall infection rate was higher in males than in females(P＜0.05),and only PIV3 infection rate was associated with gender(P＜0.01),the infection rates of other viruses were not statistically associated with gender(P＞0.05).Across different age groups,except for IFB,the comparison of infection rates for each virus showed statistically significant differences(P＜0.05).Among them,RSV,PIV 1,and PIV3 had the highest infection rates in the 0-3 age group,while ADV and IFA had the highest infection rates in the 7-14 age group.In different seasons,the infection rates of the six viruses were also statistically significant(P＜0.05),with the highest detection rates of ADV and IFB in winter,RSV and IFA in spring,PIV1 in autumn,and PIV3 in summer.Conclusion Among the six common respiratory viruses in pediatric patients in Luoyang city,ADV had the highest infection rate.All six viruses were associated with season,five were associated with age,and only one was associated with gender.

Abstract:Objective To observe the effect of spasmodic correction acupuncture combined with extracorporeal shock wave therapy on the rehabilitation of middle-aged and elderly patients with upper limb spasms after ischemic stroke.Methods One hundred and thirty-five patients with upper limb spasms after ischemic stroke who received rehabilitation treatment in the hospital from January 2023 to May 2024 were selected and randomly divided into a control group(67 cases)and an observation group(68 cases)according to a random number table method.During the study period,both groups were excluded from dropout,and 64 patients were ultimately included in both groups.Both groups received routine rehabilitation treatment,the control group received extracorporeal shock wave therapy,and the observation group received spasmodic correction acupuncture on the basis of the control group.Both groups were treated for 4 weeks.The effects of 4 weeks of treatment were compared between the two groups,and the upper limb joint motion,upper limb motor function[simplified Fugl-Meyer assessment of motor function(FMA)]and daily living ability[modified Barthel index(MBI)score]were compared before treatment and 4 weeks of treatment.Results The total effective rate of the observation group(98.44％)was higher than the control group(87.50％)(P＜0.05).After 4 weeks of treatment,the range of motion of the shoulder joint,elbow joint,and wrist joint on the affected side increased in both groups,and the FMA score and MBI score increased,and the observation group was higher than the control group(P＜0.05).Conclusion The application of spasmodic correction acupuncture combined with extracorporeal shock wave therapy in the rehabilitation period of middle-aged and elderly patients with upper limb spasms after ischemic stroke has definite therapeutic effects,can increase the range of motion of upper limb joints,promote the improvement of upper limb function and daily living ability.

Abstract:Objective To investigate the predictive value of hemoglobin-to-red blood cell distribution width ratio(HRR)for 365-day all-cause mortality in patients with pulmonary arterial hypertension and identify its threshold effect.Methods Using the MIMIC-Ⅳ 3.1 database,3 261 adult pulmonary arterial hypertension patients with complete data during their first ICU admission were retrospectively enrolled.Patients were divided into three groups based on HRR tertiles:group 1 was HRR＜0.586 6;group 2 was 0.586 6 ≤ HRR≤0.796 2;group 3 was HRR＞0.796 2.The primary endpoint was 365-day all-cause mortality.Restricted cubic splines(RCS)were used to analyze the nonlinear relationship between HRR and mortality.Kaplan-Meier curves assessed cumulative survival rates at 365-day follow-up,with log-rank test for comparison.Multivariable Cox regression models analyzed the relationship between HRR and mortality in pulmonary arterial hypertension patients.Receiver operating characteristic(ROC)curves evaluated HRR's predictive ability for clinical mortality.Subgroup analysis aimed to test model robustness and identify interaction effects.Results HRR showed a significant nonlinear negative correlation with 365-day mortality,revealing a threshold effect(inflection point=0.42).For each 1-unit increase in HRR,mortality risk decreased by 98％(HR=0.02,95％CI:0-0.25)in the ≤0.42 segment and by 56％(HR=0.44,95％CI:0.29-0.67)in the＞0.42 segment.Kaplan-Meier curves demonstrated the highest cumulative survival rate in group 3(log-rank P＜0.001).Multivariable Cox analysis confirmed HRR as an independent protective factor(HR=0.36,95％CI:0.25-0.53,P＜0.001);mortality risks in groups 2 and 3 were reduced by 23％(HR=0.77,95％CI:0.66-0.90,P＜0.001)and 33％(HR=0.67,95％CI:0.56-0.79,P＜0.001),respectively,compared to group 1.ROC analysis showed an area under the curve of 0.605(95％CI:0.59-0.62)for HRR predicting mortality risk;subgroup analysis revealed stronger protective effects in hypertensive patients.Conclusion HRR demonstrates a significant nonlinear negative correlation with mortality in pulmonary arterial hypertension patients.As a simple and cost-effective biomarker,HRR holds important value in prognostic assessment of pulmonary arterial hypertension,aiding in the identification of high-risk patients and guiding clinical decision-making.

Abstract:Objective To evaluate the differences in short-term efficacy and safety between tislelizumab and sintilimab combined with chemotherapy in advanced non-small cell lung cancer(NSCLC).Methods A total of 90 patients with advanced NSCLC and negative driver genes who were treated at the Second Outpatient Department of Henan Province from January 2021 to April 2023 were enrolled.They were randomly divided into the tislelizumab plus chemotherapy group(control group,45 cases)and the sintilimab plus chemotherapy group(observation group,45 cases)using a random number table method.Both groups received the same chemotherapy regimen of paclitaxel(135 mg·m-2)combined with cisplatin(30 mg·m-2).Immunotherapy was administered via intravenous infusion with tislelizumab(200 mg)or sintilimab(200 mg),with a 21-day cycle repeated for 3 cycles.The primary endpoint was the disease control rate(DCR),while secondary endpoints included tumor marker levels,immune function indicators,total adverse reaction incidence,and 1-year survival rate.Results There was no statistically significant difference in disease control rates between the two groups(P＞0.05).Compared to pre-treatment levels,tumor marker levels decreased in both groups post-treatment;however,no statistically significant difference was observed in serum tumor marker levels between the two groups post-treatment(P＞0.05).Relative to pre-treatment,post-treatment levels of CD3+,CD4+,and CD4+/CD8+increased in both groups,while CD8+levels decreased;no statistically significant differences were found in post-treatment levels of CD3+,CD4+,CD8+,or CD4+/CD8+between the two groups(P＞0.05).The total incidence of adverse reactions was lower in the observation group than in the control group(P＜0.05).Kaplan-Meier survival curve analysis revealed no statistically significant difference in 1-year survival rates between the two groups(P＞0.05).Conclusion The short-term efficacy of tislelizumab or sintilimab combined with chemotherapy is similar for driver gene-negative advanced NSCLC.Compared to the tislelizumab plus chemotherapy regimen,sintilimab plus chemotherapy carries a lower risk of adverse reactions and demonstrates acceptable safety.

Abstract:Objective To compare the clinical efficacy of transurethral holmium laser enucleation of the prostate(HoLEP)and transurethral resection of the prostate(TURP)for the treatment of small-volume benign prostatic hyperplasia(BPH).Methods From January 2021 to January 2024,90 patients with small volume BPH admitted to Henan Provincial Hospital of Traditional Chinese Medicine were selected for a prospective single blind controlled study.They were randomly divided into a control group(45 cases)and a study group(45 cases)using a random number table method.The control group underwent TURP treatment,while the study group underwent HoLEP treatment.The surgical-related indicators,levels of traumatic inflammatory stress[C-reactive protein(CRP),interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1)],urinary function indicators[residual urine volume(RUV),maximum flow rate(Qmax),pressure-flow rate value(A-G value)],International prostate symptom score(IPSS score),benign prostatic hyperpla-sia-quality of life(BPH-QOL),and complications were compared between the two groups.Results The intraoperative blood loss of the study group was less than that of the control group,and the bladder irrigation time,catheter indwelling time and hospitalization time of the study group were shorter than those of the control group(P＜0.05).The levels of serum CRP,IL-6 and MCP-1 in the study group were lower than those in the control group at 3 days after operation(P＜0.05).At 3 months after operation,RUV,A-G value and IPSS score in the study group were lower than those in the control group,while Qmax,BPH-QOL score in the study group were higher than those in the control group(P＜0.05).There was no significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion Both HoLEP and TURP have good long-term efficacy and safety in the treatment of small-volume BPH patients,while the former can reduce tissue damage,reduce inflammatory response,and promote early postoperative recovery.

Abstract:Objective To investigate the clinicopathological features and diagnostic points of angiomatoid fibrous histiocytoma(AFH).Methods Immunohistochemical findings and EWSR1 gene fluorescence in situ hybridization results of two AFH cases admitted to Henan Chest Hospital from 2014 to 2024 and 68 AFH cases reported in literatures were collected.Clinical features,pathological subtypes,immunohistochemical profiles and EWSR1 molecular alterations were retrospectively analyzed.Results Among the two local cases,there was one female and one male patient aged 50 years and 13 years respectively.No postoperative recurrence was observed,and both cases were classified as solid subtype.Immunohistochemically,the tumor cells were diffusely positive for EMA,CD68,CD99,Desmin,Vimentin,Leu-7,Bcl-2 and CD31,while negative for CK,CK5/6,MyoD1,Myogenin,HMB45,CD34,S-100,SOX-10 and CD21.The Ki-67 proliferation index was 5％in both cases,and EWSR1 gene split signals were detected in all specimens.For the 68 literature-reported cases,there were 31 females and 37 males with an age range of 1 to 76 years.One patient died,two cases developed tumor recurrence,50 cases had no recurrence after surgery,two cases were lost to follow-up,and 13 cases lacked follow-up data.Pathological subtypes included 11 solid-type cases,5 myxoid-type cases,22 classical-type cases,and 30 cases with undetermined subtypes.Immunohistochemical positive rates were as follows:Vimentin(34/37),CD99(38/46),CD68(36/44),EMA(39/52),Desmin(36/52),α-SMA(24/52),ALK1(3/13),CD31(2/20),CD56(1/12),CD34(1/50)and CK(1/56).S-100(47/47),HMB45(21/21),CD117(11/11)and INI1(10/10)were consistently negative in all tested specimens.The Ki-67 proliferation index ranged from 2％to 20％.EWSR1 molecular testing was performed in 23 cases,including three cases with EWSR1-CREB1 fusion,two cases with EWSR1-ATF fusion,two cases with EWSR1-CREM fusion,and 16 cases with unclassified EWSR1 rearrangement.Conclusion AFH predominantly occurs in the young population,presenting distinctive histological morphology and immunophenotype.The majority of AFH cases harbor EWSR1 gene rearrangement.Comprehensive evaluation combining clinical manifestations,histopathology,immunohistochemistry and molecular detection can effectively improve the diagnostic accuracy of AFH.

Abstract:Objective To explore the application of psychological process"five-step"in the spiritual care of patients with colorectal cancer(CRC)and its influence on dignity and quality of life.Methods A total of 106 patients with CRC in the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital from March 2023 to April 2024 were included and assigned to two groups by random number table method,53 patients in the control group received routine nursing,and 53 patients in the observation group were given a spiritual care based on the psychological process"five-part"on this basis,the intervention time was 12 weeks.The patient dignity inventory(PDI),functional assessment of chronic illness therapy-spiritual(FACIT-Sp-12),mental vulnerability questionnaire(MvQ),and European Organization for research and treatment of cancer quality of life questionnaire core 30(EORTCQLQ-C30)were used to evaluate the changes of patients' sense of dignity,spiritual moderation,psychological vulnerability and quality of life before and after intervention.Results After intervention,the scores of PDI and MvQ in the observation group were lower than those in the control group,and the scores of FACIT-Sp-12 and EORTCQLQ-C30 were higher than those in the control group(P＜0.05).Conclusion The spiritual care based on the psychological course"five-step"helps to reduce the psychological vulnerability of patients,improve the sense of dignity and spiritual moderation,so as to improve the quality of life of CRC patients and find the meaning and value of life.

Abstract:Objective To study the overall situation and research hotspots of health science and technology layout in Henan Province,so as to provide reference for the reasonable planning and scientific layout of the project.Methods The unit category,project name,project category,project number,project amount and discipline category of Henan Provincial medical science and technology research program approved in 2019-2023 were extracted,and the overall situation,population and discipline distribution characteristics of the project were described by Excel 2019 software.Python 3.12 software was used to extract the disease names contained in the project name,and the disease co-occurrence network analysis was carried out by Gephi 0.10 software.Results From 2019 to 2023,a total of 6 665 medical science and technology research projects in Henan Province were approved,with a total investment of 261.59 million yuan and 786 kinds of diseases studied.The hospital projects and funds accounted for 95.14％and 95.85％,respectively,and they were the main undertaking unit of the project.The proportion of projects and funding among young people was higher than that of non-young people,but the funding intensity was lower than that of non-young people.The funding direction of the project was mainly concentrated in internal medicine,surgery,oncology,gynecology and pediatrics.The diseases with the highest frequency in the project were lung cancer,breast cancer,liver cancer,esophagenal carcinoma,stomach cancer,of which cancer accounted for 11 of the top 20 diseases in terms of frequency,which was one of the main research directions of the project.The disease co-occurrence network presented a core cluster of chronic diseases with diabetes,heart failure,stroke,chronic obstructive pulmonary disease,and functional impairment.Conclusion The implementation of Henan Province medical science and technology research plan is of great significance to strengthening the construction of the province's talent team and enhancing the province's scientific and technological innovation capabilities.In the future,we can focus on improving the funding of outstanding young talents in the province,strengthen the level of disciplines such as digestion,infection and parasitic diseases,support comorbidity research on cancer diseases,and optimize the project funding pattern,and contributes to the development of Healthy Central Plains.