Abstract:Objective:To explore the influencing factors of infection after bleeding from open skin injuries and con-struct a column chart prediction model.Methods:A total of 375 patients with open skin injury and bleeding who were treated in hospital from February 2021 to March 2023 were enrolled in the modeling group.According to whether infec-tion occurred,they were divided into the occurrence group(n=45)and the non-occurrence group(n=330).Addition-ally,160 patients with the same type of injury admitted to Beihai Skin Disease Prevention Hospital from April 2023 to April 2024 were included in the validation group,which was similarly divided into the occurrence group(n=20)and the non-occurrence group(n=140).The general data of the modeling group were analyzed retrospectively,and the inde-pendent influencing factors of infection were screened by univariate and multivariate Logistic regression analysis.Based on the screening results,a nomogram prediction model was constructed,and the model was verified by calibration curve and ROC curve.Results:Univariate analysis showed that there was no significant difference in sex,weight index,smok-ing and drinking,injury site,dressing type and wound number between the two groups(P＞0.05).There were signifi-cant differences in age,underlying diseases,use of antibiotics,injury area,wound depth and time from injury to debride-ment(P＜0.05).ROC curve analysis showed that the area of injury,the depth of wound and the time from injury to de-bridement had certain predictive value for the infection after bleeding of patients with open skin injury,and the AUC of the modeling group was 0.817,0.737 and 0.880,respectively(P＜0.05).Logistic regression analysis showed that age,injury area,wound depth and time from injury to debridement were independent influencing factors of infection after bleeding of open skin injury(P＜0.05).The consistency index(C-index)of modeling group is 0.942(0.908～0.975),DCA results show that when the risk threshold is greater than 0.22,the model can provide standardized net in-come.Conclusion:Age,injury area,wound depth and time from injury to debridement are the independent influencing factors of infection after bleeding of open skin injury.Constructing nomogram prediction model can effectively predict the risk of infection,help to make accurate clinical decisions and take targeted preventive measures to reduce the inci-dence of infection.

Abstract:Objective:To explore the impact of cognitive behavioral intervention based on the information motivation behavioral skills(IMB)model on the psychological resilience and recurrence rate of glaucoma patients.Methods:Ac-cording to the random number table method,90 glaucoma patients who visited Tingzhou Hospital from July 2021 to De-cember 2023 were divided into conventional group and IMB group,45 cases in each group.The intraocular pressure in-tervention time,psychological resilience and self-management ability were compared between the two groups.Followed up for half a year,the recurrence blindness rate and quality of life of the two groups were compared.Results:The inter-vention time for intraocular pressure in the IMB group was shorter than that in the conventional group(P＜0.05).The scores of various dimensions in the concussion decision rules(CD-RISC)psychological resilience scale,the scores of various items in the glaucoma self-management behavior questionnaire and the life scale score of low vision quality of the IMB group were higher than those of the conventional group(P＜0.05).The recurrence rate of glaucoma in the IMB group was lower than that in the conventional group(P＜0.05).There was no significant difference in the blind-ness rate of glaucoma between the two groups(P＞0.05).Conclusion:Cognitive behavioral intervention based on IMB model can improve self-management ability and quality of life of glaucoma patients,shorten intraocular pressure con-trol time,enhance patients' psychological resilience,and reduce recurrence rate.

Abstract:Objective:To explore the effect of two stent placement methods in preventing ureteral stricture after int-racavitary lithotripsy for incarcerated ureteral stones.Methods:All 120 patients with embedded ureteral stones who un-derwent intracavitary lithotripsy in enshi central hospital were selected and included from January 2023 to June 2024.They were divided into two groups according to different stent placement methods:a control group of 62 cases(with 1 D-J tube placed after surgery)and an observation group of 58 cases(with 2 D-J tubes placed after surgery).The perioperative indicators,postoperative recovery,incidence of stenosis and stent-related complications were observed in the two groups.Results:There was no significant difference in postoperative hospitalization time,stent placement time,postoperative residual stone rate,postoperative pain,and the chinese version of wisconsin stone quality of life question-naire(C-WISQOL)score and the incidence of complications related to stent tubes between the two groups(P＞0.05).The incidence of ureteral stricture in the observation group(5.17％)was significantly lower than that in the control group(17.74％)(P＜0.05).Conclusion:For patients with embedded ureteral stones,placing two D-J tubes after int-racavitary lithotripsy can reduce the risk of ureteral stricture without affecting postoperative recovery.

Abstract:Objective:To compare the efficacy and safety of Celecoxib and other non-steroidal anti-inflammatory drugs(ibuprofen)in the treatment of rheumatoid arthritis(RA).Methods:All 120 patients with RA admitted to the Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanxi University of Traditional Chinese Medicine from January 2023 to April 2024 were randomly divided into control group and observation group,with 60 pa-tients in each group.The control group was treated with ibuprofen,while the observation group was treated with cele-coxib,and the clinical effects of different treatment schemes were analyzed.Results:After treatment,the scores of joint pain and joint swelling,the duration of morning stiffness and the number of joint tenderness in the two groups were less than before treatment,and the observation group was less than the control group,with statistical significance(P＜0.05).After treatment,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-re-active protein(CRP)],erythrocyte sedimentation rate(ESA)and immune indicators[serum immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)]in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P＜0.05).Conclusion:Celecoxib can improve the clinical symptoms of RA patients,reduce inflammatory reaction and improve im-mune function,with few adverse reactions.

Abstract:Objective:The influence of the popularization of rational drug use knowledge on improving the quality of basic pharmaceutical care.Methods:From March 1,2024 to June 30,2024,500 patients with hypertension and diabetes(before popularization of science),aged 45～65,were selected from the Department of Internal Medicine and the De-partment of Traditional Chinese Medicine of the Second Peoplés Hospital of Urumqi Economic and Technological Develop-ment Zone(Toutunhe District)in Xinjiang.From July 1,2024 to October 31,2024,500 patients with hypertension and diabetes who were hospitalized in the Department of Internal Medicine and Chinese Medicine of the Second People's Hospital of Urumqi Economic and Technological Development Zone(Toutunhe District)in Xinjiang(after being popu-larized by pharmacists)were selected,aged45～65.Various popular science means such as electronic equipment,special lectures,network platforms,consultation service desks,distribution of medication guides and knowledge manuals have been used to carry out activities to popularize the knowledge of rational drug use.Results:In-patients' cognitive level of safe drug use and behavioral accuracy increased from 51.2％(256 cases)to 92.2％(461 cases),patients' awareness of clinical pharmacists and prescription pharmacists increased from 30.2％(151 cases)to 85.6％(428 cases),and patients' satisfaction with these two kinds of pharmacists also jumped from 50.2％(251 cases)to 89.The compliance rate of pa-tients increased from 59.6％(298 cases)to 97.0％(485 cases),and the incidence of clinically reported adverse drug re-actions decreased from 5.0％(25 cases)to 1.2％(6 cases).Conclusion:Before the experiment and after the selection of patient samples in cognition,number,age,gender,disease diagnosis and so on various aspects,the diversification of ra-tional drug use knowledge popularization activities,enhance the understanding of our inpatient drug science,to ensure the safe and safe,laid the foundation for the follow-up work of pharmaceutical knowledge popularization and guide the path.

Abstract:Objective:To analyze the clinical characteristics,diagnosis and treatment plan,and prognostic factors of a patient with relapsed thrombotic thrombocytopenic purpura(TTP),to provide more clinical evidence for the precise diagnosis and treatment of this rare disease.Methods:The clinical data of a patient with relapsed TTP who had previ-ously undergone standardized treatment were collected,including clinical manifestations and auxiliary examination re-sults,along with a review of relevant literature.Results:The patient was a 46-year—old male admitted to the hospital due to'discovery of thrombocytopenia for over 11 months'.based on clinical manifestations and related laboratory tests,he was diagnosed with relapsed TTP.After emergency treatment with plasma exchange,corticosteroids,and rit-uximab,his condition improved,and he was discharged.Conclusion:For acute TTP,emergency treatment with plasma exchange combined with corticosteroids should be initiated without waiting for laboratory results.Additionally,restar-ting anti-CD20 therapy for relapsed TTP patients appears to be a long-term treatment option for immune-mediated TTP(iTTP),which may reduce adverse risks during hospitalization.This approach is of significant importance in mini-mizing disease recurrence and mortality risks.

Abstract:Objective:To explore the value of CT radiomics technology in assisting the differentiation of solid myco-plasma pneumoniae pneumonia(MPP)and pneumococcal pneumonia(SPP)in children under 5 years of age.Methods:Children under 5 years of age clinically diagnosed with solid MPP and SPP were collected and divided into the MPP group(n=42)and the SPP group(n=40).All children underwent chest CT examinations,and radiomic features were extracted from the CT images.Correlation analysis and feature selection methods were used to screen for features with differential significance and to establish a radiomics model.The general data and radiomic feature differences between the two groups of patients were compared,and the differential efficacy of the model was evaluated.Results:The fever time in MPP group was longer than that in SPP group,and the difference was statistically significant(P＜0.05).The dry cough in MPP group was more than that in SPP group,and the difference was statistically significant(P＜0.05).The white blood cell count and C reactive protein level in MPP group were lower than those in SPP group,and the difference was statistically significant(P＜0.05).In the comparison of morphological features,the volume of pulmona-ry consolidation areas in the SPP group was larger than that in the MPP group,and the sphericity of the consolidation areas in the SPP group was smaller than that in the MPP group,with statistically significant differences(P＜0.05).In the comparison of texture features,the contrast of the gray-level co-occurrence matrix in the MPP group was lower than that in the SPP group,with a statistically significant difference(P＜0.05).The short run emphasis parameter of the gray-level run-length matrix in the MPP group was higher than that in the SPP group,with a statistically signifi-cant difference(P＜0.05).Through the analysis of imageology,the characteristics with discriminating value were screened out,and the imageology model was established.It has high discrimination accuracy,sensitivity and specificity for MPP and SPP.Conclusion:CT radiomics technology can provide valuable information for the differential diagnosis of solid MPP and SPP in children under 5 years of age,which helps with early accurate diagnosis and rational treatment in clinical practice.

Abstract:Objective:To analyze the influencing factors of prognosis in patients with systemic lupus erythematosus(SLE)using the random forest model and the Logistic regression model respectively,and to provide a basis for the se-lection of treatment plans and prognosis judgment.Methods:All 182 patients with SLE diagnosed in the dermatology and rheumatology departments of Linfen People's Hospital from January 2022 to June 2023 were selected as the re-search subjects.Random forest and Logistic regression models were entered to analyze the influencing factors of the lat-er disease recovery of SLE patients and evaluate the predictive effects of the two models.Results:The relevant data of the random forest model suggest that the top five in terms of importance are complement C3,whether combined with kidney disease,infection,anti-double-stranded DNA antibody(anti-dsDNA antibody),and whether there is neuro-logical related damage.The Logistic regression model showed that the order was complement C3,whether there was neurosystem-related damage,infection,anti-dsDNA antibody,and whether there is any damage related to nervous system.Conclusion:Complement C3,whether combined with kidney disease,infection,anti-DSDNA antibody,and whether neurological damage occurs are relatively important factors affecting the prognosis of SLE patients.Both the random forest and Logistic regression models have their own advantages and disadvantages.In practical applications,the two can be used in combination.

Abstract:Objective:To explore the diagnostic value of magnetic resonance imaging(MRI)and serum carbohy-drate antigen 125(CA125)levels in ovarian endometriosis.Methods:A total of 84 patients with suspected ovarian en-dometriosis who were treated in hospital from April 2023 to May 2024 were collected as the research subjects.After ad-mission,they all underwent MRI examination and serum CA125 level testing.The results of laparoscopic examination were used as the"gold standard"to analyze the diagnostic value and efficacy of MRI examination and serum CA125 for ovarian endometriosis,and the MRI indicators and serum CA125 levels between positive and negative patients were compared.Results:Using the results of laparoscopic examination as the gold standard,the results showed that among 84 patients suspected of having ovarian endometriosis,61 patientswere positive and 23 patientswere negative.The MRI di-agnosis results showed that 50 cases were positive and 34 cases were negative.The serum CA1 2 5 diagnosis results showed that 48 cases were positive and 36 cases were negative.The combined diagnosis results showed that 60 cases were positive and 24 cases were negative,the diagnostic sensitivity and accuracy of MRI combined with CA125 were 95.08％and 94.05％,respectively,which were higher than those of MRI alone(sensitivity 80.33％,accuracy 84.52％)and CA125 alone(sensitivity 75.41％,accuracy 79.76％).The missed diagnosis rate was 4.92％,which was lower than that of MRI(19.67％)and CA1 25(24.59％),and the difference was statistically significant(P＜0.05).The propor-tion of high signal intensity on T1WI and T2WI in positive patients was lower than that in negative patients,and the proportion of ovarian phase matching,intracystic septation,and fluid-fluid level in positive patients was higher than that in negative patients,with statistically significant differences(P＜0.05).The serum CA125 level in positive patients was higher than that in negative patients,and the difference was statistically significant(P＜0.05).Conclusion:MRI combined with serum CA125 level has high diagnostic value for ovarian endometriosis,and can be used for early screen-ing and diagnosis in clinical practice to improve diagnostic accuracy.

Abstract:Objective:To examine the impact of integrating micro—lessons with scenario simulation training on the psychological wellbeing,occurrence of complications,and overall quality of life among patients who have undergone uri-nary tract ostomy surgery.Methods:Sixty patients who underwent urostomy surgery in our hospital from June 2022 to June 2024 were randomly selected and divided into two groups using a random number table method(control group and observation group).The control group received routine nursing interventions,while the observation group received mi-cro lessons combined with scenario simulation training.The adverse psychological mood,incidence of complications,quality of life and self-care ability of urostomy patients before and after nursing were compared between the two groups.Results:Compared with before nursing,the self rating anxiety scale(SAS)and self rating depression scale(SDS)scores of both groups of patients with urinary tract ostomy decreased after nursing,but the observation group was lower than the control group(P＜0.05).The incidence of complications in the observation group of patients with urinary tract ostomy was lower than that in the control group(P＜0.05).After nursing,the quality of life score(SF-36)of patients with urinary tract ostomy in the observation group was higher than that in the control group(P＜0.05).Compared with before nursing,the self-care ability scale(ESCA)score of the observation group after nursing was higher than that of the control group(P＜0.05).Conclusion:Micro lessons combined with scenario simulation training can improve the psychological state of patients with urinary tract ostomy,reduce the incidence of complications,and enhance their quality of life and self-care ability.

Abstract:Objective:To analyze the effects of six Sigma on the rate of pathogenic examination and the quality of microbial samples before antibiotics treatment.Methods:A total of 15 835 patients who were hospitalized in Xingguo Hospital Affiliated to Gannan Medical University and used antibiotics from January 2024 to December 2024 were select-ed as the study objects.They were divided into 9 180 cases before Six Sigma management mode intervention(January 2024 to June 2024),as the control group,and 6 655 cases after six sigma management mode intervention(July 2024 to December 2024),as the intervention group.The rate of pathogenic examination before treatment with restricted grade and special grade antibiotics,the rate of pathogenic examination before treatment with hospitalized patients combined with key antibiotics,the rate of pathogenic examination related to nosocomial infection diagnosis,the incidence of drug-resistant bacterial infection,the rate of unqualified specimens,the proportion of sterile specimens,the rate of various pathogenic items,the length of hospital stay,and the cost of antibacterial drugs were evaluated.Results:In the interven-tion group,the rate of pathogenic examination before treatment with restricted grade and special grade antibiotics,the rate of pathogenic examination related to hospital infection diagnosis was higher than that of the control group,the inci-dence of drug-resistant bacterial infection was lower than that of the control group,the rate of unqualified specimens was lower than that of the control group,the proportion of sterile specimens was higher than that of the control group,and the rate of various pathogenic items was higher than that of the control group.The duration of hospitalization was shorter than that of control group,and the cost of antibiotics was lower than that of control group(P＜0.05).Conclu-sion:The evidence-based control strategy of six sigma management can improve the rate of pathogenic detection before treatment with antibiotics,reduce the incidence of drug-resistant bacteria infection and the rate of unqualified speci-mens,and reduce the length of hospital stay and hospital expenses of patients,which is worth promoting.

Abstract:Objective:To explore the effect of applying mindfulness-based stress reduction(MBSR)and stepwise reinforcement training in the recovery period of patients with acute cerebral infarction(ACI).Methods:A total of 64 ACI recovery patients from March 2021 to March 2023 who were admitted in Putian University Affiliated Hospital were selected,and randomly divided into the intervention group(32 cases,MBSR and stepwise reinforcement training intervention)and the control group(32 cases,routine intervention).The neurological function,cognitive function,mind-fulness level,and limb function in both groups were compared.Results:After the intervention,the score of NIHSS in the intervention group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The scores of mini mental state examination scale(MMSE),mindful attention awareness scale(MAAS)and fugel-meyer motor function rating scale(FMA)of interevention group were higher than those of the control group,and the difference was statistically significant(P＜0.05).Conclusion:The application of MBSR and stepwise reinforcement training in the recovery intervention of ACI patients can improve neurological and cognitive function,promote limb function recovery,and enhance mindfulness level.

Abstract:Objective:Based on the regional specialty alliance unit,to understand the health literacy level of patients with permanent enterostomy and analyze its influencing factors.Methods:Convenient sampling method was used to se-lect the patients who underwent permanent enterostomy in the tertiary hospitals of the specialized alliance in Mianyang area as the study objects.General data questionnaire and enterostomy health literacy scale were used to investigate the results,and statistical analysis was conducted.Results:The total score of health literacy of patients with permanent en-terostomy was(108.5±23.92).Univariate analysis showed that age,education level,place of residence,marital status and occupation had influence on the health literacy of patients with permanent enterostomy(P＜0.05).Multiple linear regression analysis showed that education level and marital status were the main factors affecting the health literacy of patients with permanent enterostomy(P＜0.05).Conclusion:The survey results regarding the current status of health literacy among patients with permanent enterostomy in the region indicate that there is a need to enhance patients' health literacy.This can be achieved by promoting comprehensive disease management for patients with permanent en-terostomy within specialized alliance units,implementing regular postoperative health education,expanding the scope of health education content,and offering diversified health education approaches.These measures aim to reduce the inci-dence of stoma-related complications and improve the quality of life for patients.

Abstract:Objective:To investigate the effect of quetiapine in the treatment of elderly organic mental disorders and its effect on the mental status of patients.Methods:All 90 elderly patients with organic mental disorders who presented to Guizhou Second People's Hospital from May 2023 to September 2024 were divided into two groups by random num-ber chart,45 cases in each group.The control group was treated with olanzapine and the observation group was treated with quetiapine.Clinical efficacy,cognitive function,mental status,glucose and lipid metabolism,and adverse effects were compared between the two groups.Results:The total response rate of the observation group was higher than that of the control group,with a statistical difference(P＜0.05).After treatment,the scores of the montreal cognitive as-sessment scale(MoCA)in the observation group were higher than those in the control group,and the scores of the brief mental assessment scale(BPRS)were lower than those in the control group,with statistical significance(P＜0.05).After treatment,the low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)and fasting glucose(GLU)in the two groups were higher than before treatment,but the observation group was lower than the control group,with statistical significance(P＜0.05).After treatment,the high-density lipoprotein cholester-ol(HDL-C)in the two groups was lower than that before treatment,but the observation group was higher than that in the control group,with statistical significance(P＜0.05).The incidence of adverse reactions in the two groups was similar,with no statistical difference(P＞0.05).Conclusion:Compared with olanzapine,quetiapine has a higher thera-peutic effect in the treatment of elderly patients with organic mental disorders,which can promote the improvement of patients' mental status and cognitive function,and has a lower impact on patients' glucose and lipid metabolism level,so the medication is safer.

Abstract:Objective:Discuss the necessity,implementation status and existing problems of integrating course ideol-ogy and politics into nursing clinical teaching,put forward improvement suggestions and future research direction,and contribute to the cultivation of high-quality nursing talents and the development of healthcare careers.Methods:Through a systematic review of relevant studies in recent years,we analyze the current status of the development of course ideology and politics in nursing clinical teaching from three aspects,namely,teaching form,faculty construction,and evaluation of teaching effect,and summarize the current key problems by combining the literature analysis method and problem summarization method.Results:The study found that the rich form of teaching in the clinic promotes the overall development of students.However,there are some problems,such as:at the teaching level,the combination of the course ideology and politics teaching and the specialty characteristics of the department is relatively small,the lack of a systematic training system for teachers' course ideology and politics teaching ability,and insufficient awareness of course ideology and politics among teachers,the lack of a perfect evaluation system of the teaching effect.At the student level,insufficient attention to the course ideology and politics and lack of learning initiative;students' individualized differences lead to different degrees of acceptance of the course ideology and politics.Conclusion:The in-depth integra-tion of course ideology and politics and clinical teaching is a key initiative for the implementation of foster virtue through education,and the current development of course ideology and politics in clinical teaching promotes the overall development of students to a certain extent,but some challenges need to be solved.

Abstract:Objective:To explore the current situation of expected sadness in stroke patients with hemiplegia and analyze its influencing factors.Methods:From August 2023 to May 2024,165 patients with Jinjiang Hospital(Fujian Hospital of Shanghai Sixth Peoples Hospital)were selected.The general information,expected sadness,psychological resilience and social support of patients were investigated by questionnaire,and Pearson correlation coefficient was used to analyze the correlation between the scores of expected sorrow scale(AGS)and social support rating scale(SSRS)and psychological resilience rating scale(CD-RISC).Multiple linear regression was used to analyze the related factors of expected sadness in stroke patients with hemiplegia.Results:A total of 165 questionnaires were distributed in this stud-y,and 160 valid questionnaires were recovered.The AGS score of 160 stroke patients with hemiplegia was(81.02±13.14).The AGS scores of stroke patients with different gender,age and average family income were significantly different(P＜0.05).Pearson correlation coefficient analysis showed that AGS score was negatively correlated with CD-RISC and SSRS scores(r=-0.405/-0.492,both P＜0.05).The results of multiple linear regression analysis showed that psychological resilience,age,social support and average family income were the influencing factors of expected sadness in stroke patients with hemiplegia(P＜0.05).Conclusion:The expected sadness of stroke patients with hemiplegia is at a high level,and age,average family income,psychological resilience and social support are its influencing factors.Clini-cal medical staff should take personalized intervention measures from the perspective of improving patients' psychologi-cal resilience and social support,so as to reduce the degree of expected sadness.

Abstract:Objective:To explore the mechanism of midbrain astrocyte-derived neurotrophic factor(MANF)in the occurrence and development of acute renal insufficiency(ARI)after cardiopulmonary bypass(CPB)by regulating clas-sical activated M1 macrophages.Methods:The animal model of ARI after CPB and the model of cell hypoxia in vitro were established.The changes of renal function,MANF protein and M1 macrophage were detected by enzyme-linked immunosorbent assay(ELISA),flow cytometry and western blot.Results:Serum creatinine,urea nitrogen,tumor nec-rosis factor—α(TNF—α)and interleukin-1β(IL-1β)in CPB+ARI group and CPB+ARI+MANF group were higher than those in sham operation group,and the CPB+ARI group was higher than the CPB+ARI+MANF group,and the difference was statistically significant(P＜0.05).The expression of MANF protein in CPB+ARI group was lower than that in sham operation group,and the expression of MANF protein in CPB+ARI+MANF group was higher than that in CPB+ARI group,with statistical significance(P＜0.05).Inducible nitric oxide synthase antibody(iN-OS),CD86 and M1 macrophages in CPB+ARI group and CPB+ARI+MANF group were higher than those in pros-thetic hand group,and the difference was statistically significant(P＜0.05).The percentage of iNOS,CD86 and M1 macrophages in cell model group and MANF over expression group was higher than that in blank group,and the differ-ence was statistically significant(P＜0.05).Conclusion:MANF may play a protective role on ARI after CPB by regula-ting M1 macrophages,which provides a new idea for clinical treatment.

Abstract:Objective:To explore the clinical efficacy and safety of radiotherapy combined with puji disinfecting drink in the treatment of advanced esophageal cancer in elderly people.Methods:A total of 60 elderly patients with ad-vanced esophageal cancer admitted to Ganzhou Tumor Hospital from January 2021 to January 2023 were randomly as-signed to either the radiotherapy group(control group)or the radiotherapy combined with puji disinfecting drink group(observation group)using a random number table method,30 cases in each group.The objective remission rate(ORR),progression—free survival(PFS),overall survival(OS),tumor markers,immune function,KPS score,nutritional indi-cators and adverse reactions were compared between the two groups.Results:The ORR in the observation group was significantly higher than that in the control group,with statistical significance(P＜0.05).The median PFS in the ob-servation group was 13.33 months,which was higher than that in the control group(10.00 months),with statistical significance(P＜0.05).There was no significant difference between the two groups of OS(P＞0.05).After treat-ment,the squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)in both groups were lower than those before treatment,and the difference was statistically significant(P＜0.05).After treatment,the levels of SCC and CA19-9 in the observation group were significantly lower than those in the control group(P＜0.05).There was no significant difference between CEA and CA125 between the two groups(P＞0.05).There was no significant difference in CD4+,CD8+and CD4+/CD8+levels in the control group before and after treatment(P＞0.05).After treatment,the levels of CD4+,CD8+and CD4+/CD8+in the observation group were significantly higher than those before treatment,and CD4+and CD4+/CD8+in the observation group were higher than those in the control group,with statistical significance(P＜0.05).There was no significant difference in CD8+level between the two groups(P＞0.05).After treatment,the hemoglobin(Hb)of the control group and the Hb,transferrin(TRF)and albumin(ALB)of the observation group were higher than those before treatment,and the observation group was higher than the control group,and the difference was statistically significant(P＜0.05).After treatment,the TRF and ALB of the control group were slightly higher than before treatment,but the difference was not statistically significant.The incidence of radiation esophagitis in the observation group was signifi-cantly lower than that in the control group(P＜0.05).Conclusion:Radiotherapy combined with puji disinfecting drink can significantly improve the objective remission rate and progression—free survival of elderly patients with advanced e-sophageal cancer,reduce tumor marker levels,attenuate toxic side effects of radiotherapy,and improve immune function and quality of life.

Abstract:Objective:To explore the intervention effects of embodied cognition on anxiety,depression,and psycho-logical resilience among clinical nurses with children.Methods:All 38 pregnant nurses from Lyuliang People's Hospital were included in the observation group,and 39 pregnant nurses were included in the control group.Before the study(t0)and at the end of the study(t,),the anxiety level,depression level and resilience level of China adults were evalua-ted by generalized anxiety disorder scale(GAD—7),the patient health questionnaire—9(PHQ—9),and the resilient trait scale for chinese adults(RTSCA)respectively.Results:The levels of anxiety,depression and resilience in the con-trol group at t1 were higher than those at t0,but there was no significant difference(P＞0.05).The level of anxiety and depression in the observation group at t1 was lower than that at t0,while the level of psychological resilience was higher than that at t0,and the difference was statistically significant(P＜0.05).At t1,the level of anxiety and depression in the observation group was lower than that in the control group,and the level of psychological resilience in the observa-tion group was higher than that in the control group,with statistical significance(P＜0.05).Conclusion:Embodied cognition intervention can effectively alleviate the levels of anxiety and depression among clinical nurses with children and enhance their level of psychological resilience.

Abstract:Objective:This study examines the role of medical libraries in supporting scientific research services.Methods:Analyzing the information needs of researchers,and exploring the practical measures and achievements of medical libraries in supporting scientific research services using peking university medical library and china medical a-cademy library as examples.The study also proposes strategies for medical libraries to support scientific research serv-ices.Results:Findings indicate that medical libraries have significant room for improvement in areas such as information resources,information retrieval and processing,academic exchanges and cooperation,and personalized and customized services.Conclusion:Medical libraries need to start by optimizing information resource development,innovating infor-mation service models,strengthening information literacy education,and expanding cooperation and communication to continuously enhance their scientific research support capabilities and contribute to medical research in China.