Abstract:Objective To compare the mechanical performance of fully threaded and partially threaded sacroiliac screws in the treatment of Tile C1.3 type pelvic fractures through finite element analysis,providing a theoretical reference for clinical fixation strategy selection.Methods Three groups of Tile C1.3-type pelvic fracture internal fixation models were established:group A(S1 and S2 fully threaded screws),group B(S1 partially threaded screw,S2 fully threaded screw),and group C(S1 and S2 partially threaded screws).Finite element analysis was performed to simulate standing still,standing with forward bending,and standing with left rotation,analyzing the total displacement and Von-Mises stress distribution of the fracture fragments and the internal fixation devices.Results Under three physiological conditions,the total deformation of the pelvis,sacral fracture fragment,and screws in group A was the lowest among the three groups,indicating the strongest posterior pelvic ring stability.Group C had the highest total deformation overall,showing the poorest stability.The total deformation in group B was between groups A and C,closer to group C.In terms of stress distribution,the peak equivalent stress of the pelvis,fracture fragment,and screws in group A was the lowest among the three groups,while group C had the highest peak equivalent stress.The peak equivalent stress in group B was significantly lower than in group C but slightly higher than in group A,showing no mechanical advantage.Under the forward bending posture,both the total deformation and equivalent stress indicators were highest in all three models.Conclusion Fully threaded sacroiliac screws are significantly better than partially threaded sacroiliac screws in controlling fracture end displacement,optimizing stress distribution,and reducing the risk of screw failure,making them a more ideal minimally invasive fixation option for treating Tile C1.3 type pelvic fractures.

Abstract:Objective To explore the effect of dynamic closed-loop education combined with ABC-X emotion management on negative emotions,disease uncertainty,and coping styles in patients with liver cancer.Methods A total of 80 patients with liver cancer admitted to Kaifeng Central Hospital from January 2023 to February 2025 were divided into two groups using a random number table method.On the basis of routine nursing,the control group(40 cases)received dynamic closed-loop education,while the observation group(40 cases)received dynamic closed-loop education combined with ABC-X emotion management.The scores of the positive and negative affect scale(PANAS),Mishel's uncertainty in illness scale(MUIS),and medical coping modes questionnaire(MCMQ)were compared between the two groups.Results After intervention,the positive emotion scores increased and the negative emotion scores decreased in both groups,with significantly greater changes in the observation group(P＜0.05).After intervention,MUIS scores decreased in both groups,with the observation group showing significantly lower scores(P＜0.05).After intervention,the yields and avoidance scores in MCMQ decreased,while confrontation scores increased in both groups,with significantly greater changes in the observation group(P＜0.05).Conclusion Dynamic closed-loop education combined with ABC-X emotion management can effectively regulate negative emotions,alleviate disease uncertainty,and improve coping styles in patients with liver cancer,demonstrating clinical application value.

Abstract:Objective To investigate the postoperative bleeding after endoscopic mucosal resection(EMR)in patients with colonic flat polyps and to explore its influencing factors.Methods A total of 200 patients with colonic flat polyps who underwent EMR in the Third People's Hospital of Henan Province from June 2023 to May 2024 were selected as the study subjects.Clinical data of the patients were collected,and they were divided into a bleeding group and a non-bleeding group based on whether postoperative bleeding occurred within 3 months after surgery.Clinical data were compared between the two groups,and logistic multivariate regression analysis was used to identify the influencing factors for postoperative bleeding after EMR for colonic flat polyps,followed by ranking of importance.Results Among the 200 patients with colonic flat polyps after EMR,17 developed postoperative bleeding,with an incidence of 8.50％.Univariate analysis showed statistically significant differences between the non-bleeding group and the bleeding group in terms of preoperative antithrombotic medication,maximum resected polyp diameter,intraoperative blood loss,intraoperative electrocoagulation hemostasis,and postoperative recovery diet time(P＜0.05).Logistic multivariate regression analysis revealed that patients with colonic flat polyps who received preoperative antithrombotic medication had a 2.088-fold higher risk of postoperative bleeding after EMR than those without preoperative antithrombotic medication;those with a maximum resected polyp diameter＞1 cm had a 2.717-fold higher risk than those with a maximum resected polyp diameter≤ 1 cm;those with intraoperative blood loss＞50 mL had a 5.346-fold higher risk than those with intraoperative blood loss ≤50 mL;and those with postoperative recovery diet time＞48 h had a 0.659-fold higher risk than those with postoperative recovery diet time ≤48 h(P＜0.05).The ranking of importance showed that intraoperative blood loss(＞50 mL)ranked first,followed by maximum resected polyp diameter(＞1 cm),preoperative antithrombotic medication,and postoperative recovery diet time(＞48 h).Conclusion Postoperative bleeding after EMR in patients with colonic flat polyps is associated with various factors,including disease condition,medication use,and postoperative diet.Medical staff can optimize controllable variables based on these findings to guide clinical application.

Abstract:Objective To evaluate the efficacy of sintilimab combined with chemotherapy in advanced gastric adenocarcinoma and its impact on peripheral blood levels of signal transducer and activator of transcription-3(STAT-3),STAT-5 and interleukin(IL)-17A.Methods A total of 80 patients with advanced gastric adenocarcinoma admitted to Xinyang Hospital of Traditional Chinese Medicine from October 2021 to September 2023 were randomly divided into control group and observation group according to a random number table.The control group(40 cases)received conventional chemotherapy,whereas the observation group(40 cases)received sintilimab in combination with conventional chemotherapy,21 days for one cycle,and continued treatment for 6 cycles.The short-term efficacy of the two groups was compared.Peripheral blood STAT-3,STAT-5,IL-17A,tumor markers,quality of life,and adverse reactions prior to and following treatment were compared between the two groups.Results The observation group had higher objective response rate(ORR)and disease control rate(DCR)than the control group(P＜0.05).After treatment,the expression levels of STAT-3,STAT-5,IL-17A,serum levels of glucose carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),and tumor supplied group of factors(TSGF)were reduced relative to pretreatment values in both groups,with the observation group showing lower levels than the control group(P＜0.05).After treatment,the score on the European organisation for research and treatment of cancer quality of life questionnaire-stomach cancer module(EORTC QLQ-STO22)was higher in the observation group than in the control group(P＜0.05).The incidence of adverse reactions did not differ significantly between the two groups(P＞0.05).Conclusion Combined sindilitumab in the treatment of advanced gastric adenocarcinoma can effectively improve the efficacy,regulate the expression levels of STAT-3,STAT-5 and IL-17A,tumor marker levels can be reduced and patients' quality of life improved,without an increase in adverse reactions.

Abstract:Objective To explore the predictive value of ultrasound blood flow parameters combined with the detection of serum high mobility group box 1(HMGB-1)and uromodulin(UMOD)for renal injury in patients with essential hypertension.Methods A total of 143 patients with essential hypertension admitted to the Second Affiliated Hospital of Zhengzhou University from December 2022 to December 2024 were selected and divided into the renal injury group(52 cases)and the non-renal injury group(91 cases)according to the renal injury conditions.General data such as the patients' gender,age,body mass index(BMI),duration of hypertension,and smoking history were collected.The biochemical indicators such as serum creatinine(SCr),blood urea nitrogen(BUN),triglycerides(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)of the patients were detected.The renal blood flow parameters such as the resistance index(RI),peak systolic velocity(PSV),and end-diastolic velocity(EDV)of the interlobar artery(IRA),segmental renal artery(SRA),and main renal artery(MRA)of the patients were detected.The levels of serum HMGB-1 and UMOD were detected.Spearman rank correlation analysis was used to evaluate the correlations of renal injury with renal blood flow parameters and serum levels of HMGB-1 and UMOD in patients with essential hypertension.Logistic regression model was employed to identify the risk factors for renal injury,and receiver operating characteristic(ROC)curve was utilized to analyze the predictive value of the above indicators for renal injury.Results The duration of hypertension,IRA-RI,MRA-RI and serum HMGB-1 levels in the renal injury group were higher than those in the non-renal injury group,while the IRA-EDV and serum UMOD levels were lower than those in the non-renal injury group(P＜0.05).Renal injury in patients with essential hypertension was positively correlated with the levels of serum HMGB-1,and negatively correlated with the levels of IRA-EDV and serum UMOD(P＜0.05).The level of serum HMGB-1 was a risk factor for renal injury in patients with essential hypertension,while the levels of IRA-EDV and serum UMOD were protective factors for renal injury in patients with essential hypertension(P＜0.05).The areas under the curve(AUC)of IRA-EDV,serum HMGB-1 level,serum UMOD level and the combined prediction of renal injury in patients with essential hypertension by the three indicators were 0.740,0.728,0.745 and 0.861,respectively.The Youden indices were 0.429,0.341,0.363 and 0.596,respectively.Conclusion The ultrasound renal blood flow parameter IRA-EDV and the levels of serum HMGB-1 and UMOD are the influencing factors of renal injury in patients with essential hypertension.IRA-EDV,serum HMGB-1 level,and serum UMOD level can be used as auxiliary predictive indicators for renal injury in patients with essential hypertension.

Abstract:Objective To observe the clinical effect and safety of Banxia Juzhu Granule in the treatment of chronic gastritis(intermingled cold and heat syndrome).Methods A total of 116 patients with chronic gastritis(intermingled cold and heat syndrome)admitted to Henan General Hospital and the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from July 2023 to June 2024 were enrolled and randomly divided into an observation group(72 cases)and a control group(36 cases).The observation group was treated with Banxia Juzhu Granule,and the control group was treated with Yangweishu Granule.The effective rate,changes in traditional Chinese medicine syndrome scores,levels of serum pepsinogen Ⅰ (PG Ⅰ),pepsinogen Ⅱ(PG Ⅱ),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),and the incidence of adverse reactions were observed in both groups.Results After treatment,the total effective rate of traditional Chinese medicine syndrome improvement in the observation group was 95.82％(69/72),which was higher than 80.56％(29/36)in the control group(P＜0.05).Compared with before treatment,the traditional Chinese medicine syndrome scores(epigastric distress,belching,epigastric pain,acid regurgitation)and the levels of PG Ⅰ,PG Ⅱ,and IL-6 were all decreased in both groups after treatment(P＜0.05),and no adverse reactions occurred.Conclusion Banxia Juzhu Granule can effectively reduce the serum inflammatory levels and pepsinogen levels in patients with chronic gastritis of intermingled cold and heat syndrome,alleviate clinical symptoms,and has a high safety profile,which is worth promoting.

Abstract:Objective To explore the application of failure mode and effect analysis(FMEA)in hospital infection management of traditional Chinese medicine(TCM)medical technology.Methods To form an assessment team,risk assessment of hospital infection management in traditional Chinese medical technology was carried out by using FMEA method,and intervention measures were taken for high-risk projects,and changes before and after intervention were compared.Results The key points to be improved were inadequate disinfection of skin,non-replacement of cotton swabs at each point,premature opening of acupuncture needles,low compliance of hand hygiene and non-standard disinfection process of cupping.After intervention,the risk priority number(RPN)value of each item decreased significantly,the compliance rate of hand hygiene,the standard rate of aseptic technique operation,the standard rate of disinfection process increased(P＜0.05),and the correct rate of hand hygiene increased,but there was no statistical significance(P＞0.05).Conclusion The risk assessment based on FMEA has a good effect of prevention and control for the determination and intervention of risk points of hospital infection in TCM medical technology.

Abstract:Objective To explore the influencing factors of excessive daytime sleepiness(EDS)in stroke patients and construct a logistic regression model,so as to provide reference for guiding the development of clinical intervention plans.Methods A total of 175 stroke patients diagnosed and treated in the Third Provincial People's Hospital of Henan Province from March 2021 to March 2024 were selected as the research objects.These patients were categorized into an occurrence group and a non-occurrence group based on whether they developed EDS during the recovery phase.The clinical data of the two groups were compared to analyze the risk factors for EDS in stroke patients,and a logistic regression model was constructed.The receiver operating characteristic(ROC)curve,calibration curve,Hosmer-Lemeshow test,and consistency index(C-index)were used to evaluate the predictive performance of the logistic regression model.Results Stroke location,depressive state,degree of neurological impairment,pre-stroke fatigue,post-stroke sleep disturbance,taking more than 2 medications,and levels of serum glial fibrillary acidic protein(GFAP),soluble intercellular adhesion molecule-1(sICAM-1),homocysteine(Hcy),and stress-induced protein 2(Sestrin2)were identified as independent risk factors for EDS in stroke patients(P＜0.05).The area under the curve(AUC)of this model for predicting EDS in stroke patients was 0.914(95％CI:0.862-0.951),and the calibration curve showed a high degree of fit with the ideal curve.The Hosmer-Lemeshow test yielded x2=7.441,P=0.093,and the consistency index(C-index)was 0.716.Conclusion Stroke location,depressive state,degree of neurological impairment,pre-stroke fatigue,post-stroke sleep disturbance,taking more than two medications,and serum levels of GFAP,sICAM-1,Hey,and Sestrin2 are independent risk factors for EDS in stroke patients.The logistic regression model established based on these risk factors has good predictive value for EDS in stroke patients.Clinically,targeted intervention plans can be formulated according to the corresponding risk factors to reduce the occurrence of EDS.

Abstract:Objective To investigate and identify the risk factors for stroke associated with patent foramen ovale(PFO).Methods This study retrospectively selected 858 PFO patients admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2021 to August 2024,and divided them into a stroke group of 193 cases and a non stroke group of 665 cases based on whether they experienced stroke.Collect two sets of clinical data and use logistic regression analysis to screen for independent risk factors associated with PFO related stroke.Results In the stroke group,the proportions of age,body mass index(BMI),systolic and diastolic blood pressure,homocysteine(Hcy)levels,male sex,hypertension,diabetes,previous stroke history,and smoking were significantly higher compared to the non-stroke group(P＜0.05).Conversely,the proportion of migraine was lower in the stroke group than in the non-stroke group(P＜0.05).Additionally,the stroke group exhibited greater PFO channel length and width(P＜0.05),as well as higher proportions of atrial septal protrusion,increased secondary septal thickness,excessively long inferior vena cava valve,Chiari network,resting right-to-left shunt,and large right-to-left shunts compared to the non-stroke group(P＜0.05).Multivariate logistic regression analysis revealed that in PFO patients,elevated systolic blood pressure,longer PFO channel length,and the presence of resting right-to-left shunt were independent risk factors for stroke occurrence.Conclusion This study identified systolic blood pressure,PFO channel length,and resting right to left shunt as independent risk factors for stroke in PFO patients through multiple logistic regression analysis.These results provide important evidence for clinical assessment of stroke risk in PFO patients,helping to identify high-risk patients early and take targeted preventive measures.

Abstract:Objective To evaluate the impact of nursing interventions based on the theory of knowledge,belief,and practice on disease management in patients with angina pectoris.Methods A prospective randomized controlled trial design was adopted,and 100 patients with angina pectoris who were treated in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2023 to January 2024 were recruited and randomly divided into a control group and an observation group.The control group received routine nursing care,while the observation group received further nursing interventions based on the knowledge,belief,and practice theory on the basis of the control group.The intervention effects between the two groups were compared.Results Compared with the control group,the observation group had lower frequency of angina attacks and degree of pain(P＜0.05).The scores of knowledge,belief,and behavior theory,quality of life,and self-management ability were higher in the observation group than in the control group(P＜0.05).The readmission rate of the observation group was lower than that of the control group(P＜0.05).Conclusion The nursing intervention combined with the theory of knowledge,belief,and practice can improve the quality of life and self-management ability of patients,reduce the risk of readmission,and confirm the important application potential of this comprehensive intervention model in clinical nursing.

Abstract:Objective To investigate the application value of vascular drainage localization and CT-guided coil localization in thoracoscopic wedge resection of lung.Methods A total of 99 patients undergoing thoracoscopic wedge resection of lung in the First Affiliated Hospital of Henan Medical University from January 2023 to December 2024 were selected and divided into drainage group(49 cases)and conventional group(50 cases)according to the random number table method.The drainage group received vascular drainage localization,and the conventional group received CT-guided coil localization.The operation conditions,perioperative conditions,lung function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)]before and 3 months after surgery,and complications were compared between the two groups.Results There were no significant differences in the success rate of first resection,the rate of secondary resection,the rate of conversion to thoracotomy,the distance of incision margin,and the drainage volume at 24 h after operation between the two groups(P＞0.05).The operation time in the drainage group was(139.52±38.71)min,which was longer than(102.63±34.58)min in the conventional group,and the blood loss was(60.16±13.29)mL,which was more than(36.84±7.51)mL in the conventional group(P＜0.05).At 3 months after surgery,there were no significant differences in FEV1,FVC,and PEF between the two groups(P＞0.05).The incidence of preoperative localization-related complications in the drainage group was 0,which was lower than 16.00％in the conventional group(P＜0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P＞0.05).Conclusion Both localization schemes are effective auxiliary techniques for thoracoscopic wedge resection of the lung.The vascular drainage method can reduce preoperative localization-related complications and has higher safety,while CT-guided coil localization can shorten operation time and reduce intraoperative blood loss.Both have their own advantages and disadvantages,and should be selected according to the specific clinical situation.

Abstract:Objective To investigate the relationship between serum lactate dehydrogenase(LDH),calcium ion and chemotherapy response and prognosis of multiple myeloma(MM)patients.Methods A total of 115 MM patients who received chemotherapy in the First Affiliated Hospital of Henan University of Science and Technology from June 2020 to October 2023 were selected as the study objects,and were divided into an effective group(97 cases)and an ineffective group(18 cases)according to their chemotherapy efficacy.Serum LDH and calcium ion levels of the two groups were compared.Logistic regression analysis was used to evaluate whether serum LDH and calcium ions were related to chemotherapy response in MM patients.Subsequently,97 patients who responded effectively to chemotherapy were followed up until October 31,2024,with a median follow-up time of 12.5 months(from 6 to 18 months).They were divided into good prognosis group and poor prognosis group according to the follow-up prognosis.Clinical data of the two groups were compared,and the risk factors affecting the poor prognosis of MM patients were analyzed by logistic regression.Receiver operating characteristic(ROC)curve was drawn to evaluate the predictive efficacy of serum LDH and calcium ions on poor prognosis in MM patients.Results Compared with the effective chemotherapy group,the serum LDH and calcium ionized water in the ineffective group were higher(P＜0.05).Logistic regression analysis showed that serum LDH and calcium ion were closely related to chemotherapy response in MM patients(P＜0.05).There were significant differences in the proportion of hemoglobin,albumin,calcium ion,LDH,β2 microglobulin and bone marrow plasma cells between the good prognosis group and the poor prognosis group(P＜0.05).Multivariate logistic regression analysis showed that hemoglobin＜90 g·L-1 and albumin＜35 g·L-1,calcium ion≥2.7 mmol·L-1,LDH≥ 240 U·L-1,β2 microglobulin ≥3.5 mg·L-1,marrow plasma cell ratio≥10％were independent risk factors for poor prognosis in MM patients(P＜0.05),that is,it was associated with poor prognosis in MM patients.ROC curve results showed that the sensitivity,specificity and area under the curve(AUC)of the combination of serum LDH and calcium ions in predicting poor prognosis of MM patients were 90.20％,72.50％and 0.901,respectively,indicating good predictive efficacy.Conclusion Serum LDH and calcium ions can be used as simple and reliable evaluation indexes for chemotherapy efficacy and prognosis of MM patients,and have certain guiding significance for improving clinical remission rate and prognosis of MM patients.

Abstract:Objective To explore the influence of optimized emergency intervention process on hemostasis time and complications in patients with liver cancer complicated with gastrointestinal bleeding.Methods A retrospective analysis was conducted on the data of 113 patients with liver cancer complicated with gastrointestinal bleeding who visited the Emergency Department of Henan Provincial People's Hospital from May 2024 to June 2025.They were divided into a control group(63 cases)and a study group(50 cases)according to intervention methods.The control group received conventional emergency treatment process,while the study group received optimized emergency intervention process.The treatment efficiency(gastroscopy preparation time,assessment time,hemostasis time),treatment effective rate,in-hospital mortality rate,complications(rebleeding,renal injury,hyponatremia),recovery time(time to stable vital signs,hospital stay),and short-term prognosis(mortality rate at 28 days after discharge)of the two groups were compared.Results The gastroscopy preparation time,evaluation time,and hemostasis time in the study group were shorter than those in the control group(P＜0.05).The total treatment effective rate was higher,and the in-hospital mortality rate and total incidence of complications were lower compared with the control group(P＜0.05).The time to stable vital signs and hospitalization time were also shorter in the study group(P＜0.05).No significant difference was exhibited in the mortality rate at 28 days after discharge between the two groups(P＞0.05).Conclusion The optimized emergency intervention process can enhance the treatment efficiency and effective rate in patients with liver cancer complicated with gastrointestinal bleeding,reduce complications,shorten recovery time,and help to reduce the in-hospital mortality rate.

Abstract:Objective To investigate the factors influencing the prognosis of alteplase(rt-PA)thrombolysis in patients with acute ischemic stroke(AIS).Methods This retrospective study included 187 consecutive AIS patients treated at Xuchang Municipal Hospital from July 2022 to February 2025 who underwent rt-PA thrombolysis.Patients were grouped based on the occurrence of poor prognosis within 3 months post-treatment:poor prognosis group and favorable prognosis group.Clinical data between the favorable and unfavorable prognosis groups were compared.Variable selection was performed using LASSO regression.Multivariate logistic regression models analyzed factors influencing rt-PA thrombolysis outcomes in AIS patients.Additionally,receiver operating characteristic(ROC)curves were constructed to assess the predictive value for adverse outcomes at 3 months post-treatment.Results This study included clinical data from 187 AIS patients.Statistical analysis revealed that 62 patients had an mRS score ≥3,with a poor prognosis rate of 33.16％,who were assigned to the poor prognosis group.The remaining 125 patients with an mRS score＜3 were assigned to the good prognosis group.Comparison of clinical data between the poor prognosis and favorable prognosis groups revealed significant differences in infarct size,National Institutes of health stroke scale(NIHSS)score at admission,time from onset to thrombolysis,trial of ORG 10172 in acute stroke treatment(TOAST)classification,and length of hospitalization(P＜0.05).C-reactive protein(CRP),brain natriuretic peptide(BNP),and homocysteine(Hey)levels were higher in the poor prognosis group than in the favorable prognosis group(P＜0.05).The incidence of qi deficiency with blood stasis syndrome was higher in the poor prognosis group(54.84％)than in the favorable prognosis group(10.40％)(P＜0.05).LASSO regression identified six characteristic variables for model construction:admission NIHSS score,time from onset to thrombolysis,CRP,BNP,Hey,and qi deficiency with blood stasis syndrome.Multivariate logistic regression revealed that NIHSS score at admission,CRP,BNP,and qi deficiency with blood stasis syndrome were independent predictors of poor prognosis at 3 months post-treatment in AIS patients(P＜0.05).ROC curve analysis revealed the following area under the curve(AUC)values for predicting poor prognosis at 3 months post-treatment:0.850(95％CI:0.791-0.909),0.632(95％CI:0.544-0.721),0.722(95％CI:0.641-0.803),and 0.746(95％CI:0.681-0.812),respectively,indicating their predictive value in assessing the prognosis of AIS patients undergoing rt-PA thrombolysis.Conclusion Patients with acute ischemic stroke may experience poor outcomes following rt-PA thrombolysis.This study identified admission NIHSS score,CRP,BNP,and qi deficiency with blood stasis syndrome as significant prognostic factors.Therefore,constructing a risk prediction model for rt-PA thrombolysis outcomes in AIS patients is feasible and may provide evidence for optimizing subsequent clinical treatment.

Abstract:Objective To compare the short-term effects of ultrasound-guided radiofrequency ablation and conventional thyroidectomy on thyroid function,hormone levels,inflammatory stress indicators,and quality of life in patients with hyperthyroidism.Methods This study was based on a prospective,non randomized controlled principle.A total of 71 patients with hyperthyroidism admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from December 2021 to December 2024 were selected as the research subjects.They were divided into a conventional group(35 cases)and an observation group(36 cases)according to the surgical plan.The conventional group of patients received conventional thyroidectomy treatment,while the observation group received ultrasound-guided radiofrequency ablation treatment.The surgical related indicators,thyroid function and hormone levels,inflammation and stress indicators,and prognosis quality of life levels of the two groups of patients were compared.Results The observation group had a shorter surgical time and less intraoperative bleeding compared to the control group(P＜0.05).The pain level of the observation group patients was milder than that of the control group,and the postoperative hospitalization time was shorter than that of the control group(P＜0.05).After one month of surgery,the serum levels of free thyroxine(FT4)and free triiodothyronine(FT3)in the observation group were lower than those in the control group,and the level of thyroid stimulating hormone(TSH)was higher than that in the control group(P＜0.05).After one week of surgery,the levels of C-reactive protein(CRP),interleukin-6(IL-6),and cortisol(COR)in the observation group were lower than those in the control group(P＜0.05).After one month of surgery,the physiological dimension,appearance dimension,and physical symptom scores of the observation group were lower than those of the control group(P＜0.05).Conclusion After ultrasound-guided radiofrequency ablation treatment for hyperthyroidism patients,serum thyroid hormones decreased and thyroid stimulating hormone returned to normal.Minimally invasive intervention can accurately regulate endocrine function,effectively regulate inflammatory response and stress levels,and improve prognosis and quality of life.

Abstract:Objective To explore the influence of multi-dimensional psychological intervention under the empowerment theory on the physical and mental state and quality of life of patients after intracranial aneurysm surgery.Methods Using the random number table method,124 patients with intracranial aneurysms who underwent endovascular interventional therapy in Henan Provincial People's Hospital from January to December 2024 were evenly divided into two groups.On the basis of the routine care of the control group(62 cases),multi-dimensional psychological intervention under the empowerment theory was given to the observation group(62 cases).The scores of the depression anxiety and stress scale(DASS-21),the self rated abilities for health practices scale(SRAHP),and the generic quality of life inventory-74(GQOLI-74)were compared between the two groups.Results After the intervention,the scores of depression,anxiety and stress in DASS-21 of both groups decreased,and the scores of depression,anxiety and stress in DASS-21 of the observation group were lower(P＜0.05).After the intervention,the SRAHP scores of both groups increased,and the SRAHP score of the observation group was higher(P＜0.05).After the intervention,the scores of physical function,psychological function,social function,material life status and overall quality of life in GQOLI-74 of both groups increased,and the scores of physical function,psychological function,social function,material life status and overall quality of life in GQOLI-74 of the observation group were higher(P＜0.05).Conclusion The multi-dimensional psychological intervention under the empowerment theory can effectively improve the physical and mental state,health behaviors and quality of life of patients after intracranial aneurysm surgery,and has application and promotion value.

Abstract:Objective To investigate the application effect of implant nail assisted retraction of upper anterior teeth in orthodontic patients with bimaxillary protrusion extraction.Methods A total of 100 cases of orthodontic patients with bimaxillary protrusion extraction received in the First Affiliated Hospital of Zhengzhou University from January 2020 to June 2022 were retrospectively selected.According to the 1∶1 matching principle,50 cases of patients who received implant nail assisted retraction of upper anterior teeth were selected as implant nail group and received conventional G6 protocol.After a significant"roller coaster"effect,50 patients who were assisted by implant nail were included in the conventional group.The orthodontic satisfaction after 1 year of treatment and the changes of labial bone before and after 1 year treatment were statistically analyzed between the two groups.Results After 1 year of treatment,upper incisor to Sella-Nasion plane angle(U1-SN),lower incisor to vertical reference line(U1-VRL),incisor mandibular plane angle(IMPA),upper incisor to vertical reference line(L1-VRL)were lower than before treatment,and upper incisor to lower incisor angle(U1-L1)was higher than before treatment(P＜0.05).The difference of U1-SN,upper incisor to the horizontal reference line(U1-HRL)and U1-L1 in implant nail group before and after treatment were lower than those in conventional group(P＜0.05).Compared with the conventional group(82.00％),the orthodontic satisfaction of implant nail group(96.00％)was higher(P＜0.05).Conclusion The orthodontic patients with bimaxillary protrusion extraction treated by implant nail assisted retraction of upper anterior teeth can improve the appearance of labial bone and improve orthodontic satisfaction.

Abstract:With the study of the mechanism of autoimmune diseases(AID),the detection and application of AID and autoantibodies have attracted more and more clinical attention.However,clinicians in primary hospitals have not enough understanding of AID,and the clinical laboratory of primary hospitals has carried out less corresponding tests.In order to promote the development of clinical immunology in Henan province,the Society of Microbiology and Immunology Branch of Henan Medical Association and the Clinical Micaorbiology Division of Henan society of Microbiology organized experts to compile this consensus.The consensus mainly includes three parts:autoantibody detection methodology,performance verification and quality control,clinical significance and result interpretation.Due to limited space,this consensus mainly introduces the characteristics and differences of different detection methods,and provides recommendations for autoantibody laboratory testing in hospitals at all levels in Henan Province,especially primary hospitals,so that hospitals at all levels can standardize their use and better serve patients.

Abstract:Objective To observe and analyze the efficacy of volumetric modulated arc therapy(VMAT),as well as the acute adverse reactions and dosimetry differences after treatment in patients with locally advanced cervical cancer.Methods A retrospective analysis was performed for 96 patients with locally advanced cervical cancer admitted to Henan Provincial People's Hospital,from April 2022 to March 2024,and the short-term efficacy,acute adverse reactions and dosimetry differences between the two groups were compared according to different treatment regimens,including the reference group[48 cases,receiving intensity-modulated radiation therapy(IMRT)]and the study group(48 cases,receiving VMAT).Results There was no significant difference in short-term efficacy between the two groups(P＞0.05),and there was no significant difference in the irradiation dose of V107 and D98％ between the two groups(P＞0.05),and there was a significant difference in V100,D2％,D50％,D90％,D95％,Dmax,Dmean,uniformity index(HI)and conformal index(CI)(P＜0.05).There was a significant difference in the dose distribution of bladder in the V10 parameter(P＜0.05),but there was no significant difference in the other organs(P＞0.05).In the V20 parameter there was a significant difference in the dose distribution of bladder,pelvis,small intestine,femoral head and rectum(P＜0.05).In the V30 parameter,there was a significant difference in the dose distribution of pelvis,small intestine and femoral head(P＜0.05).There was no significant difference in rectal dose distribution(P＞0.05),bladder dose distribution in V40 parameters(P＜0.05),and other organs(P＞0.05),and bladder,pelvis,small intestine,femoral head and rectum in Dmax and Dmean parameters(P＜0.05).In the reference group,7 cases(14.58％),6 cases(12.50％)developed radiation proctitis,and 11 cases developed bone marrow suppression(22.92％),compared with 5 cases of radiation cystitis(10.42％),4 cases of radiation proctitis(8.33％),and 7 cases of bone marrow suppression(14.58％)in the study group,the complication rate was higher and the difference was not obvious(P＞0.05).Conclusion Both IMRT and VMAT radiotherapy can achieve good short-term efficacy,but VMAT has significant advantages in reducing the incidence of acute adverse reactions,and can better protect the target area and threatened organs.

Abstract:Objective To investigate the effect of ultra-early(＜6 h)and early(6-24 h)neuroendoscopic surgery on patients with thalamic hemorrhage with ventricular extension and its influence on inflammatory factors,nerve injury factors and rebleeding risk.Methods The clinical data of 61 patients with thalamic hemorrhage with ventricular extension who underwent neuroendoscopic surgery in Henan Second People's Hospital from January 2024 to June 2025 were retrospectively analyzed.According to the timing of surgery,30 patients with onset to operation time＜6 h were included in the ultra-early group,and 31 patients with onset to operation time between 6 and 24 h were included in the early group.The routine indexes of operation and hematoma clearance were compared between the two groups,as well as the inflammatory indexes[C-reactive protein(CRP),white blood cell count,systemic immune inflammatory index(SII)],and neuron-specific enolase(NSE),S100β protein(S100β),matrix metalloproteinase-9(MMP-9)before operation,1 d and 3 d after operation.The complications during hospitalization and the modified Rankin scale(mRS)score within 3 months after operation were counted.Results The operation time of the ultra-early group was(129.86±21.40)min,which was longer than(102.75±26.96)min of the early group.The indwelling time of the external ventricular drainage tube and the hospitalization time were(6.53±1.27)d and(18.40±4.66)d,which were shorter than(8.01±1.64)d and(24.03±3.29)d of the early group(P＜0.05).The incidence of rebleeding and the total incidence of complications in the ultra-early group were 26.67％and 3.33％,respectively,compared with 6.45％and 12.90％in the early group,the difference was not statistically significant(P＞0.05).The complete clearance rate,near complete clearance rate and most clearance rate of hematoma in the ultra-early group were 70.00％,26.67％and 3.33％,respectively,which were better than 25.81％,58.06％,and 16.13％in the early group(P＜0.05).The CRP,white blood cell count and SII index of patients in the ultra-early group were lower than those in the early group at 1 d and 3 d after operation(P＜0.05).The levels of NSE,S100β and MMP-9 in the ultra-early group were lower than those in the early group at 1 d and 3 d after operation(P＜0.05).The good prognosis rate of patients in the ultra-early group was 86.67％,which was higher than 54.84％in the early group(P＜0.05).Conclusion For patients with thalamic hemorrhage breaking into the ventricle,neuroendoscopic ultra early surgery(＜6 hours)at the very early stage of the disease may increase the operation time and the risk of rebleeding compared with early surgery(6-24 hours),but it can be controlled through more thorough hematoma removal,secondary inflammation and nerve damage,without increasing the incidence of complications,and can shorten the recovery time and obtain better prognosis.