Efficacy of VMAT Radiotherapy in the Treatment of Locally Advanced Cervical Cancer
ZHANG Hui
ZHAO Kaijie
LIU Wenju
Abstract：Objective To observe and analyze the efficacy of volumetric modulated arc therapy(VMAT),as well as the acute adverse reactions and dosimetry differences after treatment in patients with locally advanced cervical cancer.Methods A retrospective analysis was performed for 96 patients with locally advanced cervical cancer admitted to Henan Provincial People's Hospital,from April 2022 to March 2024,and the short-term efficacy,acute adverse reactions and dosimetry differences between the two groups were compared according to different treatment regimens,including the reference group[48 cases,receiving intensity-modulated radiation therapy(IMRT)]and the study group(48 cases,receiving VMAT).Results There was no significant difference in short-term efficacy between the two groups(P＞0.05),and there was no significant difference in the irradiation dose of V107 and D98％ between the two groups(P＞0.05),and there was a significant difference in V100,D2％,D50％,D90％,D95％,Dmax,Dmean,uniformity index(HI)and conformal index(CI)(P＜0.05).There was a significant difference in the dose distribution of bladder in the V10 parameter(P＜0.05),but there was no significant difference in the other organs(P＞0.05).In the V20 parameter there was a significant difference in the dose distribution of bladder,pelvis,small intestine,femoral head and rectum(P＜0.05).In the V30 parameter,there was a significant difference in the dose distribution of pelvis,small intestine and femoral head(P＜0.05).There was no significant difference in rectal dose distribution(P＞0.05),bladder dose distribution in V40 parameters(P＜0.05),and other organs(P＞0.05),and bladder,pelvis,small intestine,femoral head and rectum in Dmax and Dmean parameters(P＜0.05).In the reference group,7 cases(14.58％),6 cases(12.50％)developed radiation proctitis,and 11 cases developed bone marrow suppression(22.92％),compared with 5 cases of radiation cystitis(10.42％),4 cases of radiation proctitis(8.33％),and 7 cases of bone marrow suppression(14.58％)in the study group,the complication rate was higher and the difference was not obvious(P＞0.05).Conclusion Both IMRT and VMAT radiotherapy can achieve good short-term efficacy,but VMAT has significant advantages in reducing the incidence of acute adverse reactions,and can better protect the target area and threatened organs.
Keywords：locally advanced cervical cancervolumetric modulated arc therapyintensity-modulated radiation therapyacute adverse reactionsexposure dose
Publication Date：2026-08-28
Online Publishing Date：2026-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 2895-2899 )