Abstract:Objective:To explore the therapeutic effect of Sihuang San cold compress on conjunctivitis.Method:A total of 60 patients with conjunctivitis admitted to Renhuai Traditional Chinese Medicine Hospital from January 2023 to December 2024 were selected as the study sample.The grouping was determined using a random number table,with the control group(n=30,conventional symptomatic treatment)and the observation group(n=30,conventional treatment+Si Huang San cold compress)designated accordingly.The symptom and sign scores,symptom relief time,clinical efficacy,Schirmer test,tear break-up time(BUT),and incidence of adverse reactions were compared between the two groups.Result:Prior to treatment,no significant difference was observed in conjunctival edema and conjunctival hyperemia scores between the two groups(P>0.05).After treatment ended,the two groups showed a significant reduction in scores,the observation group demostrated lower scores than the control group,and the difference was statistically significant(P<0.05).In terms of burning sensation,conjunctival hyperemia,foreign body sensation,conjunctival edema,and duration of discharge,the observation group exhibited shorter durations compared to the control group,with the difference being statistically significant(P<0.05).Regarding the overall treatment efficacy rate,the observation group achieved a higher rate compared to the control group,with the difference being statistically significant(P<0.05).For Schirmer test values and BUT scores,no statistically significant differences were observed between the two groups before treatment(P>0.05).After treatment completion,the two groups showed improvements in these parameters,the observation group demostrated higher values than the control group,and the difference was statistically significant(P<0.05).In terms of adverse reaction incidence,the observation group had a lower incidence rate compared to the control group,with no statistically significant difference between the two groups(P>0.05).Conclusion:Cold compress with Sihuang San can improve the clinical efficacy of conjunctivitis,effectively improve symptoms such as conjunctival edema,shorten the duration of symptoms,promote the recovery of conjunctival related functions,and has good safety.

Abstract:Objective:This study aims to assess the effect of the nursing management model under the Plan-Do-Check-Act(PDCA)cycle on the postoperative recovery of patients who have undergone laparoscopic surgery.Method:From January 2023 to January 2025,90 patients who underwent laparoscopic surgery at the Honghu Traditional Chinese Medicine Hospital were enrolled in this study.After screening based on the inclusion and exclusion criteria,they were randomly assigned to the experimental group and the control group,with 45 patients in each group.The control group received conventional nursing measures,while the experimental group was managed to use a nursing model centered on the PDCA cycle.The clinical conditions of the two groups,namely the duration of bed rest and the time of first defecation were recorded and compared,the incidence of postoperative adverse events was calculated.In addition,the Visual Analogue Scale(VAS)was used to compare the pain levels of the two groups at 2 hours and 8 hours after surgery.Result:The duration of bed rest and the time of first defecation in the research group were significantly shorter than those in the control group.The VAS scores at 2 hours and 8 hours after surgery were lower than those in the control group,and the probability of adverse events was also lower in the research group,with statistically significant differences(P<0.05).Conclusion:The application of the PDCA cycle based nursing management model in patients undergoing laparoscopic surgery can effectively alleviate the patients'pain and has a positive significance for promoting their postoperative recovery.

Abstract:Objective:To explore the clinical value of integrated intervention protocols based on the biopsychosocial medical model for correcting breech presentation in late pregnancy,and to analyze their potential impact on maternal comfort and perinatal outcomes.Method:A prospective cohort study was conducted from August 2021 to December 2023,enrolling 74 singleton breech presentation pregnant women undergoing prenatal check-ups at the Maternal and Child Health Care Hospital of Xiangtan City.Participants were divided into an intervention group(n=40)and a control group(n=34).The study group received a structured intervention program comprising positional correction(modified breech adjustment technique),birthing dance(designed based on biomechanical principles),prenatal yoga(incorporating pelvic floor muscle training),and mindfulness meditation(12 min/day).The control group received conventional knee-chest positioning.The fetoposition conversion rates,intervention adherence(measured using a 5-point Likert scale),perinatal outcome parameters,and neonatal prognosis indicators were compared and evaluated between the two groups.Result:After intervention,the fetal position reversal rate in the study group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).The comfort level in the study group was significantly superior to that in the control group,with a statistically significant difference(P<0.05).The natural delivery rate in the study group was significantly higher than that in the control group,and the weight gain during pregnancy was also higher than that in the control group,with statistically significant differences(P<0.05).There were no statistically significant differences between the study group and the control group in terms of neonatal asphyxia rates and postpartum hemorrhage rates(P>0.05).Conclusion:Integrated interventions combining biomechanical adjustments and mind-body regulation can effectively enhance the efficacy of breech version.The underlying mechanism likely involves multidimensional synergistic effects,including optimization of fetal movement space,maternal pelvic structural adaptation,and sympathetic-parasympathetic nervous system balance.This model offers a novel clinical pathway for obstetric positional correction.

Abstract:Objective:To investigate the intervention effects of implementing Green Model-based infection early warning management for patients with urinary tract infections.Method:90 patients with urinary tract infections admitted to the First Affiliated Hospital of Bengbu Medical University from January 2022 to October 2024 were enrolled.The patients were divided into two groups using a convenience sampling method.The control group(n=45)received routine care,while the research group(n=45)received Green Model-based infection early warning management.The pain level,infection symptoms,self-care ability,positive and negative emotions,and nursing satisfaction were compared between the two groups.Result:After the intervention,the Numerical Rating Scale(NRS)and the Infection-Related Symptom Scale(IRS)scores of the research group were lower than those of the control group.The self-care ability of the research group improved compared with that of the control group after the intervention.After the intervention,the positive emotions of the research group were higher than those of the control group,while the negative emotions were lower than those of the control group.The nursing satisfaction of the research group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion:Implementing Green Model-based infection early warning management for patients with urinary tract infections can improve infection symptoms,reduce pain levels,enhance self-care ability,and has significant practical value.

Abstract:Objective:To understand the distribution of thyroid cancer inpatients at a hospital in Fujian Province and analyze preoperative and postoperative serum-related indicators and their clinical significance.Method:Data and serological indicators of thyroid cancer inpatients at Putian University Affiliated Hospital from January 2020 to December 2023 were collected.Serum levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),carcinoembryonic antigen(CEA),and calcitonin(Ctn)were measured before and after surgery.The positive rates for thyroglobulin(Tg)and thyroid-related antibodies were statistically analyzed.Result:A total of 2,237 hospitalized thyroid cancer patients were enrolled,with a male-to-female ratio of 1∶4.34.The mean age was(49.1±12.0)years,and the proportion of hospitalized patients aged 50 years or older showed a year-on-year increasing trend.Postoperative levels of FT3,FT4,TSH,CEA,and Ctn were all lower than preoperative levels,with statistically significant differences(P<0.05).The serum Tg positivity rate was higher postoperatively than preoperatively,while the antithyroglobulin antibody(TGAb)positivity rate was lower postoperatively than preoperatively,with both differences being statistically significant(P<0.05).There was no statistically significant difference in the antithyroid peroxidase antibody(TPOAb)positivity rate between pre-and postoperative periods(P>0.05).Conclusion:Women and middle-aged and elderly individuals are key populations for thyroid cancer prevention.Thyroid-related hormones,antibodies,serum Ctn,and CEA hold significant clinical value for the diagnosis,treatment,and postoperative follow-up of thyroid cancer.

Abstract:Objective:To analyze the factors influencing volume management behaviors in maintenance hemodialysis(MHD)patients and propose corresponding interventions.Method:A retrospective analysis was conducted on clinical data from 180 MHD patients at Zunyi First People's Hospital between January and December 2023.Volume management behavior was assessed using a volume management behavior scale,while general data including gender,age,marital status,household monthly income,dialysis duration,and complications were collected.Univariate and multivariate analyses were performed to identify factors affecting MHD patients'volume management behaviors.Result:The mean volume management behavior score for the 180 MHD patients was(17.26±2.31)points.Univariate analysis showed there were no statistically significant differences in scores for age,gender,marital status,dialysis frequency,living alone status,and complications(P>0.05).The Univariate analysis showed that there were statistically significant differences in the capacity management behavior scores among different leves of education,self-efficacy,monthly family income,and medical payment methods.(P<0.05).Multivariate linear regression analysis revealed that high school education or below,self-efficacy scores<24 points,unemployment,household income<5 000 yuan,out-of-pocket payments,and dialysis duration≥3 years were all high-risk factors for poor volume management behavior.Conclusion:MHD patients exhibit low levels of volume management behavior,which correlates with education level,self-efficacy,household income,and payment methods.Clinical interventions should be scientifically designed to improve these behaviors.

Abstract:Objective:To investigate the efficacy of levonorgestrel intrauterine sustained-release system(LNG-IUS)combined with goserelin in the treatment of adenomyosis,and to analyze the effects of the combination therapy on patients'estrogen-progesterone levels and ovarian function.Method:A total of 88 patients with adenomyosis of uterus admitted to the Fifth People's Hospital of Huai'an City from February 2022 to February 2025 were selected as the research objects.The patients were randomly divided into a monotherapy group(n=44,treated with goserelin)and a combination group(n=44,treated with LNG-IUS combined with goserelin)by the random envelope method.The total effective rate of treatment,transblood loss chart(PBAC)score,estrogen and progesterone[estradiol(E2),progesterone(P)],ovarian function[luteinizing hormone(LH),follicle-stimulating hormone(FSH),anti-Mullerian hormone(AMH)],and the incidence of adverse reactions were compared between the two groups.Result:After 6 months of medication,the total effective rate in the combination group was higher than that in the monotherapy group,with a statistically significant difference(P<0.05).Compared with baseline levels,the PBAC scores in both groups decreased,with the combination group showing a lower reduction than the monotherapy group.The levels of E2,P,LH,FSH,and AMH in both groups decreased compared to baseline,with the combination group exhibiting a higher AMH level than the monotherapy group,and the differences were statistically significant(P<0.05).There were no significant differences were observed in the levels of E2,P,LH,and FSH between the two groups(P>0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion:The application of LNG-IUS combined with goserelin in the treatment of patients with adenomyosis can improve the therapeutic effect,reduce menstrual flow,stabilize the levels of estrogen and progesterone,protect ovarian function,and does not increase adverse reactions.

Abstract:Atrial fibrillation(AF)is one of the common arrhythmias.It has attracted extensive attention from clinical scholars due to its increasing prevalence year by year and often accompanied by serious complications.Previous studies have shown that obesity and inflammation are related to the occurrence and severity of AF.Some studies have also shown that epicardial adipose tissue(EAT)may be related to the occurrence of AF.However,the specific role of EAT in AF remains unclear.At present,it has become a consensus among clinical scholars to evaluate EAT using medical imaging to further explore the association between EAT and AF.However,traditional imaging has limitations.If there are emerging technologies to evaluate EAT more accurately,it will provide great help for its research.Based on this,this article will explore the clinical assessment methods and emerging technologies of EAT,and at the same time elaborate the mechanism of EAT on the occurrence of AF.

Abstract:Objective:To explore the impact of the Intensive Care Nursing Scoring System(ICNSS)on the clinical outcomes,cardiac function,and adverse events of patients with severe heart failure under the joint nurse hierarchical responsibility nursing model.Method:82 patients with severe heart failure admitted to the First Affiliated Hospital of Bengbu Medical University from June 2023 to June 2025 were selected and divided into two groups using a random number table method,with 41 patients in each group.The control group received routine nursing care,while the observation group received nurse level responsibility nursing care.Both groups were intervened for one week,and the clinical symptoms,changes in condition,changes in cardiac function,and incidence of adverse events were compared between the two groups.Result:After intervention,the Memorial Heart Failure Symptom Assessment Scale(MSAS-HF)and Acute Physiology and Chronic Health Status II(APACHE II)scores in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The left ventricular ejection fraction(LVEF)value of the observation group was higher than that of the control group,and the left ventricular end diastolic diameter(LVEDD)value was lower than that of the control group,with a statistically significant difference(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,with a statistically significant difference(P<0.05).Conclusion:ICNSS evaluation combined with nurse hierarchical responsibility nursing can effectively alleviate clinical symptoms,reduce the severity of the condition,improve cardiac function,and reduce the incidence of adverse events in patients with severe heart failure.

Abstract:Objective:To observe and compare the clinical effect of prophylactic ileostomy with single-lumen stoma and double-lumen stoma in laparoscopic anterior rectal resection.Method:90 patients who underwent laparoscopic anterior resection of the rectum at the Sanming First Hospital from June 2021 to June 2024 were randomly divided into two groups,with 45 cases in each group.Prophylactic ileum single-lumen stoma was used in the observation group and double-lumen ileum stoma was used in the control group.The differences between the two stoma methods in terms of operation time,blood loss,total incidence of postoperative complications,length of hospital stay,and total hospital cost were compared.Result:The operation time and blood loss during the operation of the observation group were compared to those of the control group,with no statistically significant differences(P>0.05).The total incidence of postoperative complications,length of stay and total hospitalization cost of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion:Laparoscopic anterior rectal resection prophylactic single-lumen stoma is safer and more reasonable than double-lumen stoma.

Abstract:The clinical application of Traditional Chinese Medicine nursing in chronic obstructive pulmonary disease(COPD)is reviewed.Progress in its application is explored from the perspectives of TCM nursing's holistic concept,syndrome differentiation and treatment,and disease prevention.This approach provides comprehensive TCM nursing care for COPD patients,thereby enhancing nursing satisfaction.

Abstract:Objective:To investigate the correlation of lymphocyte to monocyte ratio(LMR)and Toll-like receptor 4(TLR4)expression with the prognosis and pathological features of patients undergoing surgery for colorectal cancer.Method:A retrospective study was conducted on 321 colorectal cancer patients admitted to the Nanchang County Hospital of Traditional Chinese Medicine between January 2019 and May 2022.All patients underwent laparoscopic total mesorectal excision.Postoperative clinical characteristics were observed and overall survival rates were recorded during follow-up.The optimal cut-off point for LMR was determined using a time-dependent receiver operating characteristic(ROC)curve.Participants were categorised into a high LMR level group(LMR>3.12,228 cases)and a low LMR level group(LMR≤3.12,93 cases)based on this optimal cut-off point.TLR4 expression was assessed via immunohistochemistry,with patients categorised into low-expression(≤4 points,177 cases)and high-expression(≥5 points,144 cases)groups based on immunohistochemical scoring.Postoperative clinical characteristics were observed in both high-and low-LMR groups alongside high-and low-TLR4 expression cohorts to evaluate prognostic outcomes.Result:All 321 patients underwent successful surgery.Among TNM stage III patients,six cases demonstrated localised poor intestinal anastomotic blood supply and excessive anastomotic tension during operation,with significant intestinal congestion and oedema.These patients underwent prophylactic double-lumen ileostomy at the terminal ileum.The remaining patients underwent primary anastomosis.The postoperative complication rate was 5.61%.Low-,medium-,and high-grade differentiated adenocarcinomas comprised 99,132,and 90 cases respectively.TNM staging revealed 90 cases at stage I,144 at stage II,and 87 at stage III.The overall survival rate at follow-up was 64.49%.The proportion of low-grade differentiation and TNM stage III disease was significantly higher in the low LMR level group and high TLR4 expression group compared to the high LMR level group and low TLR4 expression group,with statistically significant differences(P<0.05).The survival rate in the high LMR group was 67.11%,higher than the 58.06%survival rate in the low LMR group,and the survival rate in the high TLR4 expression group was 58.33%,lower than the 69.49%survival rate in the low TLR4 expression group,with statistically significant differences(P<0.05).Conclusion:Colorectal cancer patients with higher levels of LMR have a lower percentage of postoperative hypodifferentiation,TNM stage III,and a higher survival rate,while patients with higher levels of TLR4 expression have a higher percentage of postoperative hypodifferentiation,TNM stage III,and a lower survival rate.The levels of LMR and TLR4 expression can be used as specific indicators of clinical prognosis.

Abstract:Objective:To investigate the impact of combining nursing emergency plans with emergency procedures on patients with severe multiple traumatic fractures in emergency departments.Method:A retrospective analysis was conducted on clinical data from 120 patients admitted to Beijing Jishuitan Hospital from December 2022 to October 2024.Patients were divided into two groups based on intervention methods:60 patients receiving conventional emergency procedures formed the control group,while 60 patients implementing combined nursing emergency plans with emergency procedures formed the observation group.The two groups were compared in terms of emergency response efficiency,prognosis,and adverse events.Result:The observation group showed shorter admission-to-treatment time,waiting time at hospital entrance,and time from calling for help to pre-hospital emergency treatment compared to the control group,with statistically significant differences(P<0.05).Post-intervention,the observation group scored lower on all items of the International Classification of Functioning,Disability and Health(ICF)rehabilitation scale than the control group,with statistically significant differences(P<0.05).The incidence of adverse events in the observation group was also lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:Combining nursing emergency plans with emergency procedures can improve emergency response efficiency,reduce adverse events,and enhance prognosis for patients with severe multiple traumatic fractures in emergency departments.

Abstract:Objective:To explore the application effect of infection intervention based on the Diagnosis-related Grouping(DRG)model in patients with chronic obstructive pulmonary disease(COPD)and its impact on the incidence of nosocomial infections.Method:A prospective cohort study was conducted.200 inpatients from the Department of Respiratory Medicine and ICU of the Second Hospital of Nanping City from December 2023 to January 2025 were selected as the subjects.Among them,100 cases received early intervention with infection control measures(early intervention group),and 100 cases received conventional treatment(conventional group).For the two groups of patients,whether hospital infection occurred was taken as the exposure factor respectively.Patients who experienced hospital-acquired infections were included in the early intervention group,while the remaining patients were included in the conventional group.The average length of hospital stay,total hospitalization cost,DRG enrollment at discharge,drug proportion,incidence of complications and patient satisfaction were compared between the two groups.Result:Different methods of intervention were given to the conventional group and the early intervention group.Eventually,21 cases were included in the early intervention group and 179 cases in the conventional group.The average length of hospital stay,total hospitalization cost and the proportion of drug use in the early intervention group were lower than those in the conventional group,and the difference was statistically significant(P<0.05).The enrollment rate of DRG and the incidence of complications in the early intervention group after discharge were lower than those in the conventional group,and the difference was statistically significant(P<0.05).The satisfaction of patients in the early intervention group after lower sensory intervention under the DRG model was higher than that in the conventional group,and the difference was statistically significant(P<0.05).Conclusion:The DRG model for lower infection intervention has a good effect in patients with COPD.It can shorten the average length of hospital stay,reduce the total hospitalization cost,lower the proportion of DRG enrollment and medication at discharge,help reduce the incidence of complications,and improve patient satisfaction.

Abstract:Objective:To investigate the incidence and influencing factors of community-acquired pneumonia in elderly communities.Method:One hundred and ten elderly patients with community-acquired pneumonia admitted to the sample hospital from January 2020 to January 2025 were selected as the observation group,and 110 elderly non-community-acquired pneumonia patients matched by community and gender during the same period were selected as the control group.Age,BMI,nutritional status(albumin level),history of dust occupation,smoking status,alcohol consumption,history of pneumonia within 1 year,history of cardiovascular disease,respiratory disease,diabetes mellitus,hypertension,and malignancy were compared between the two groups to analyse the factors influencing the occurrence of community-acquired pneumonia in the elderly by logistic regression.Result:There were no statistically significant differences between the two groups in terms of age,body mass index(BMI),alcohol consumption,history of cardiovascular or cerebrovascular disease,hypertension,or malignant tumours(P>0.05).The proportion of participants in the observation group with albumin levels<35 g/L,occupational exposure to dust,smoking history,history of pneumonia within the past year,respiratory diseases,and diabetes was higher than that in the control group,with statistically significant differences(P<0.05).Logistic regression analysis revealed that albumin<35 g/L,occupational exposure to dust,smoking status,history of pneumonia within the past year,respiratory diseases,and diabetes mellitus were significant risk factors for community-acquired pneumonia in the elderly.Conclusion:The occurrence of community-acquired pneumonia in the elderly is strongly influenced by a number of factors,including basic personal circumstances,living habits and diseases,which can be used as a reference for the development of preventive and control measures for the disease.

Abstract:Objective:To compare and analyze the therapeutic effects of low-dose colchicine combined with traditional Chinese medicine Sihuang San on patients with acute gout attacks.Method:A total of 120 patients with acute attack of gout treated in Jianning County General Hospital from January 2024 to March 2025 were divided into control group and treatment group by random number table method,with 60 cases in each group.The control group was treated with western medicine and small dose of colchicine.The treatment group was treated with external application of traditional Chinese medicine Sihuang powder on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy,Visual Analogue Scale(VAS)score,pain relief time,Traditional Chinese Medicine(TCM)syndrome score,serum indexes and adverse reactions of the two groups were compared and analyzed.Result:Compared with the control group,the treatment group had a higher treatment effectiveness rate,lower VAS scores and TCM syndrome scores,shorter pain relief time,and more significant decrease in serum indicators after treatment,all of which were statistically significant(P<0.05).There was no statistically significant difference in the comparison of adverse reactions between the two groups(P>0.05).Conclusion:The research results show that the combination of low-dose colchicine and traditional Chinese medicine Sihuang San for external use is more effective in treating acute gout attacks than using low-dose colchicine alone.It can shorten the pain relief time.The efficacy is higher and the safety is comparable,with high clinical application value.

Abstract:Objective:To investigate the effectiveness of emotional nursing combined with acupoint moxibustion in the care of patients with stomach pain and spleen-stomach deficiency-cold syndrome.Method:60 patients with stomach pain and spleen-stomach deficiency-cold syndrome admitted to Bijie City Traditional Chinese Medicine Hospital from May 2024 to May 2025 were randomly divided into a control group(30 cases)and an observation group(30 cases).The control group received acupoint moxibustion,while the observation group received emotional nursing combined with acupoint moxibustion.The negative emotions,TCM syndrome scores,and pain levels of both groups were compared.Result:After intervention,Hamilton Anxiety Rating Scale(HAMA),Hamilton Depression Rating Scale 17 items(HAMD-17),TCM syndrome scores,and Visual Analog Scale(VAS)scores of the observation group were significantly lower than those of the control group,with statistically significant differences(P<0.05).Conclusion:Emotional nursing combined with acupoint moxibustion can effectively alleviate negative emotions in patients with stomach pain and spleen-stomach deficiency-cold syndrome,improve TCM syndrome scores,and reduce pain levels.

Abstract:Objective:To explore the effect of psychological and enteral nutrition intervention on patients with abdominal infection.Method:A retrospective study was conducted to select the clinical data of 104 patients with abdominal infection admitted to the 910th Hospital of the Joint Logistics Support Force from January 2022 to December 2024.According to the patient's intervention plan,they were divided into observation group(psychological+early enteral nutrition intervention,54 cases)and control group(general enteral nutrition intervention,50 cases).The use of antibiotics and hospitalization days were recorded and compared between the two groups.The levels of nutritional and inflammatory indexes[serum total protein(TP),albumin(ALB),C-reactive protein(CRP),procalcitonin(PCT)]were compared between the two groups at 1 week of intervention,and the satisfaction questionnaires of patients and their families were analyzed.Result:After intervention,the use of antibiotics and hospitalization days in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After intervention,the levels of TP and ALB in the two groups were higher than those before intervention,and the levels of CRP and PCT were lower than those before intervention.After intervention,the satisfaction questionnaires of patients and their families in the observation group was higher than the control group,with statistically significant differences(P<0.05).Conclusion:Psychological and enteral nutrition intervention can effectively improve the nutritional level of patients with abdominal infection in general surgery,reduce the body's inflammatory response,promote the rehabilitation of patients,shorten the time of medication and hospitalization,and improve the satisfaction of family nursing.

Abstract:Objective:To explore the clinical effect of vertebroplasty combined with posterior pedicle internal fixation in the treatment of patients with thoracolumbar spinal osteoporotic fractures and its influence on their stress response.Method:A total of 98 patients with thoracolumbar osteoporotic spinal fractures admitted to the hospital from July 2022 to September 2024 were selected.By random number table method,they were divided into 49 cases in each group.The control group was treated with posterior transpedicle internal fixation,while the observation group was treated with vertebroplasty combined with posterior transpedicle internal fixation.The stress index levels of the two groups before the operation and 7 days after the operation,the pain status[Visual Analogue Scale(VAS)scores]before the operation and 7 days after the operation,the lumbar function[Oswestry Disability Index(ODI)]scores before the operation and 2 months after the operation,and the relevant treatment indicators(kyphosis Cobb Angle,spinal stenosis rate,anterior edge compression rate of the vertebral body)before the operation and 2 months after the operation,and the postoperative complications were compared.Result:On the 7th day after operation,the observation group epinephrine level,β-endorphin level,and cortisol level were lower than control group(P<0.05).VAS score of the observation group,and the lumbar function score was lower 2 months after operation(P<0.05).Two months after operation,the kyphosis Cobb Angle of the observation group,the spinal canal stenosis rate and the anterior vertebral compression rate were better than control group(P<0.05).Six months after the operation,compared with the control group,the incidence of complications in the observation group was lower(P<0.05).Conclusion:Vertebroplasty combined with posterior pedicle internal fixation in the treatment of thoracolumbar spinal osteoporotic fractures can effectively reduce the stress response of patients,relieve pain,improve lumbar function and fractured indicators,and has few complications.

Abstract:Objective:To explore the relationship between adenosine triphosphate binding cassette transporter B subfamily member 1(ABCB1),plasmin activator inhibitor 1(PAI-1)and the risk of steroid-induced femoral head necrosis in Uyghur patients with autoimmune diseases.Method:25 patients with hormone-induced femoral head necrosis due to autoimmune diseases who were treated in the First People's Hospital of Kashgar Prefecture from January 2022 to May 2024 were selected as the study group,and 29 patients without hormone-induced femoral head necrosis due to autoimmune diseases were selected as the control group.The clinical data of the two groups were analyzed,and the differences in the polymorphisms of ABCB1 and PAI-1 genes were determined by first-generation sequencing.Result:There was no statistically significant difference in the general clinical data such as gender,age and BMI between the two groups(P>0.05).The comparison of polymorphisms at the rs1045642 locus of the ABCB1 gene in the two groups showed statistically significant differences(P<0.05).The proportion of C/C genotypes at the rs1045642 locus of the ABCB1 gene in the two groups reached 68.00%.The comparison of polymorphisms at the rs1799768 locus of the PAI-1 gene in the two groups.There was no statistically significant difference(P>0.05).Conclusion:The polymorphism of the ABCB1 gene is associated with the occurrence of steroid-induced femoral head necrosis in patients with autoimmune diseases,while the polymorphism of the PAI-1 gene has no significant relationship with the occurrence of steroid-induced femoral head necrosis.Further verification is needed in a larger sample.