Study on the Effect of Low-Dose Colchicine Combined with Traditional Chinese Medicine Sihuang San for External Treatment of Patients with Acute Gout Attacks

LI Quan; LAN Qian

doi:10.14033/j.cnki.cfmr.2026.04.034

Abstract：Objective:To compare and analyze the therapeutic effects of low-dose colchicine combined with traditional Chinese medicine Sihuang San on patients with acute gout attacks.Method:A total of 120 patients with acute attack of gout treated in Jianning County General Hospital from January 2024 to March 2025 were divided into control group and treatment group by random number table method,with 60 cases in each group.The control group was treated with western medicine and small dose of colchicine.The treatment group was treated with external application of traditional Chinese medicine Sihuang powder on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy,Visual Analogue Scale(VAS)score,pain relief time,Traditional Chinese Medicine(TCM)syndrome score,serum indexes and adverse reactions of the two groups were compared and analyzed.Result:Compared with the control group,the treatment group had a higher treatment effectiveness rate,lower VAS scores and TCM syndrome scores,shorter pain relief time,and more significant decrease in serum indicators after treatment,all of which were statistically significant(P<0.05).There was no statistically significant difference in the comparison of adverse reactions between the two groups(P>0.05).Conclusion:The research results show that the combination of low-dose colchicine and traditional Chinese medicine Sihuang San for external use is more effective in treating acute gout attacks than using low-dose colchicine alone.It can shorten the pain relief time.The efficacy is higher and the safety is comparable,with high clinical application value.