Abstract:Objective To preliminarily explore the toxicity of the new Ti-6Al-4V-3Cu antibacterial implant material implanted in New Zealand white rabbits,and to provide experimental evidence for the clinical experiment of this implant material.Methods Eighteen adult female New Zealand white rabbits weighted 2.5-3.0 kg were randomly divided into three groups including experimental group,control group and blank group containing six rabbits in each group,where the Ti-6Al-4V-3Cu(TC4-3Cu)antibacterial implant and Ti-6Al-4V(TC4)implant were respectively implanted into the experimental group and control group in the present work.Gross observations were conducted on days 1,3,7 postoperatively,and complete blood count and blood biochemistry were analyzed preoperatively and on days 1,3,7 of post-surgery.One month after surgery,the rabbits were euthanized,and tissue samples were collected from major organs,including the heart,lungs,liver,kidneys,and spleen.Hematoxylin-eosin staining was employed to evaluate cellular morphology in these organs across experimental groups.Results All the experimental animals exhibited the good wound healing on days 1,3,7 of post-surgery.The TC4-3Cu and TC4 implants showed the negative effect on and the relative expression of compared to the blank group.One month after implantation,histological analysis revealed that there was the normal cellular morphology in the target tissues including heart,lung,liver,kidney and spleen without the inflammatory cell infiltration.Conclusion A novel Ti-6Al-4V-3Cu antibacterial biomaterial implanted into the New Zealand white rabbits without acute toxicity in vivo.

Abstract:Objective To compare the bond strength of two universal adhesives containing 10-Methacryloyloxydecyl Dihydrogen Phosphate(10-MDP)on enamel,dentin,and sclerotic dentin in elderly patients,aiming to provide clinical guidance for adhesive selection in restorative treatments for this population.Methods Forty non-carious,intact premolars extracted from elderly patients due to periodontitis were selected and randomly divided into an enamel group(Group A)and a dentin group(Group B),with 20 teeth each group.An additional 20 premolars were collected from elderly patients exhibiting cervical wedge-shaped defects and grade IV sclerotic dentin,and designated as the sclerotic dentin group.Each group was further divided into two subgroups(a Single Bond Universal adhesive subgroup and a Meiytin adhesive subgroup),with 10 teeth per subgroup.The buccal surface of each tooth was prepared for bonding.The teeth in the three Single Bond Universal subgroups were treated with Single Bond Universal adhesive,and the teeth in the three Meiytin subgroups were treated with Meiytin adhesive,followed by incremental placement of composite resin.The micro-tensile strength of specimens from each group was tested using a universal testing machine,and the failure modes were analyzed by stereomicroscope.The micro-tensile strength of 2 kinds of adhesives were performed using Two-way ANOVA analysis,with multiple comparisons conducted using the SNK-q test.The Kruskal-Wallis H test was used to compare the influence of the two adhesives on the failure modes in enamel,dentin,and sclerotic dentin.Results The bond strength results indicated that both Single Bond Universal and Meiytin Universal adhesives achieved clinically acceptable bond performance in the enamel,dentin,and sclerotic dentin groups.Furthermore,no statistically significant differences(P>0.05)were observed in the bond strength or fracture modes between the two adhesives at the three different dental hard tissue interfaces.Conclusion Universal adhesive systems containing MDP demonstrate equivalent bond performance in the enamel,dentin,and sclerotic dentin of elderly patients.This study provides experimental evidence to support the selection of restorative materials for the treatment of severe tooth wear in the aged population.

Abstract:Sjogren's syndrome(SS)is a chronic autoimmune disease characterized by the immune-mediated dysfunction of exocrine glands,particularly the salivary and lacrimal glands..The etiology of SS is multifactorial,involving a complex interplay of genetic predisposition,hormonal influences,environmental triggers,and epigenetic modifications.The hallmark clinical features are xerophthalmia and xerostomia.In more advanced stages of the disease,a subset of patients may develop systemic complications,with an increased risk of malignant transformation,particularly to B-cell non-Hodgkin lymphoma,including mucosa-associated lymphoid tissue(MALT)lymphoma.In recent years,the role of environmental and epigenetic factors in autoimmune diseases has gradually attracted attention.Environmental factors(such as viral infections,vitamin D deficiency,smoking,etc.)and abnormal epigenetic regulation(such as DNA methylation,histone modification,etc.)play a key role in the occurrence and carcinogenesis of SS.Environmental factors may promote changes in epigenetic modifications by inducing oxidative stress,chronic inflammation,and abnormal immune activation,thereby affecting B cell proliferation,apoptosis escape,and malignant transformation.This article aims to review the research progress of environmental and epigenetic factors in SS and related lymphomas.

Abstract:Objective To analyze the research hot spots and development frontiers of English literature related to Oral Frailty.Methods From the establishment of the database to September 2023,by searching for published English literature related to oral frailty in PubMed,Embase and Scopus databases,extracting information such as keywords,authors,and institutions that published the literature,and using Cite Space 6.2.R4 and VOS viewer software to analyze the research related to oral frailty,the distribution of related authors,countries/institutions,co-citation of literature,and clustering,emergence,and time-superimposed mapping analysis of keywords were conducted.Results A total of 1167 valid references were retrieved through the database for visual analysis.The author co-author network analysis indicated that:At present,the core author team in the research field is not close;The network analysis of research institutions suggests that the inter-institutional cooperation mainly exists between universities and hospitals,and between hospitals.Keywords visualization research tips:Cite Space high-frequency keywords are divided into Frailty,oral health,the elderly,risk factors,a total of four categories,based on VOS viewer co-word cluster analysis can be divided into seven clusters.Conclusion Through visual analysis,the main research focus is to explore the interaction between factors affecting Oral Frailty and chronic diseases.It is suggested to increase communication and cooperation between research teams in different regions in the field,and strive to explore the treatment mode of multi-mode Oral Frailty.

Abstract:Objective To systematically assess the oral health literacy level of elderly patients with dental arch defects and thoroughly investigate its influencing factors,so as to provide a basis for developing precise oral health education and intervention measures.Methods A total of 578 elderly patients with dental arch defects treated in who attended the Department of Stomatology at Peking University People's Hospital from January 2024 to June 2025 were enrolled through convenience sampling.Basic patient information was collected using a general information questionnaire,and oral health literacy was assessed using the short-form Health Literacy Dental Scale(HeLD-14).Univariate analysis was used to compare HeLD-14 scores among elderly patients with different characteristics,and a multiple linear regression model was employed to identify key influencing factors.Results The mean HeLD-14 score among 578 elderly patients with dentition defects was 44.15±10.80.Univariate analysis revealed statistically significant differences in HeLD-14 total scores according to medical insurance type,educational level,annual income,smoking status,and duration of dentition defect(all P<0.05).Subsequent multiple linear regression analysis identified educational level,annual income,smoking habit,and duration of dentition defect as independent predictors significantly associated with oral health literacy levels in this population(P<0.05).Conclusion The oral health literacy of elderly patients with dental arch defects is at a moderate level,with a total HeLD-14 score of[(44.15±10.80)points].Education level,annual income,smoking habit,and duration of dental arch defects are key predictors.It is recommended to build a precise oral health intervention system focusing on education empowerment,behavior correction,and timeliness of restoration,forming a multi-factor collaborative intervention pathway.

Abstract:Objective To compare the clinical outcomes of digital and traditional impression in single implant restoration for elderly patients aged over 60 years.Methods A total of 40 elderly patients aged over 60 years who underwent single implant restoration in the Implant Department of Stomatological Hospital of Jilin University from October 2023 to October 2024 were selected and randomly divided into the experimental group(digital impression,20 patients)and the control group(traditional silicone rubber impression,20 patients).The impression-taking time,crown seating time,occlusal adjustment time,denture seating accuracy,rework rate,and patient satisfaction were compared between the two groups.Results The impression-taking time,crown seating time,and occlusal adjustment time in the experimental group were all shorter than those in the control group(P<0.05).The experimental group demonstrated significantly higher scores across all five aspects of denture fitting accuracy compared to the control group(P<0.05).Additionally,the impression rework rate in the experimental group was markedly lower than that in the control group(0.5%vs.25%,P<0.05).Patient satisfaction scores in the experimental group were also significantly higher across all five evaluated dimensions(P<0.05).Conclusion Digital impression can significantly improve the efficiency,accuracy,and comfort of implant restoration for elderly patients,and is worthy of clinical promotion.

Abstract:Patients with head and neck cancer frequently experience oral disease symptoms that are caused or exacerbated by oral health complications during radiotherapy.The occurrence of radiotherapy complications can cause chewing and swallowing dysfunction,affect patients'nutritional intake,and impact their postoperative recovery and mental health.Therefore,performing a comprehensive oral health assessment prior to radiotherapy,identifying potential risks for patients,implementing timely interventions,and ensuring long-term follow-up and maintenance after treatment can effectively reduce the incidence of complications and alleviate disease-related symptoms,thereby enhancing patients'quality of life.Although scholars at home and abroad have paid attention to the oral complications of head and neck malignancy patients before and after radiotherapy,there are still differences in the timing of intervention and the application of treatment plans.This article summarizes the existing oral treatment strategies for head and neck malignancy patients before and after radiotherapy by domestic and foreign scholars for clinical reference.

Abstract:Objective To explore the influencing factors of oral infection in elderly patients with complete dentition loss after oral implant restoration,construct a predictive model,and formulate targeted prevention and treatment strategies.Methods A total of 176 elderly patients with dentition loss admitted to the hospital from September 2021 to December 2023 were prospectively selected as the modeling set,and divided into an infected group(58 cases)and a non-infected group(118 cases)according to whether oral implant restoration was complicated by oral infection.A total of 44 elderly patients with dentition loss from January 2024 to April 2024 were selected as the validation set.The baseline data of the patients were collected and statistically significant differences were obtained by univariate Logistic analysis.A Nomogram prediction model for oral infection complicated by dental implant restoration in elderly patients with dental loss was established and verified by receiver operating curve(ROC).Results Univariate analysis showed that there were significant differences in smoking,diabetes mellitus,periodontal disease,bone density in the implant area,preoperative oral health index and gingival bleeding index between the two groups(all P<0.05).Multivariate analysis showed that smoking,diabetes mellitus,periodontal disease,bone mineral density in the implant area,preoperative oral hygiene index and gingival bleeding index were the influential factors for oral infection complicated by dental implant repair in elderly patients with missing dentition(all P<0.05).Internal verification showed that the area under ROC curve of the constructed Logistic model was 0.810(95%CI:0.740-0.880),the sensitivity was 67.2%,and the specificity was 84.7%.External verification showed that the area under the curve was 0.783(95%CI:0.646-920),the sensitivity was 86.7%,and the specificity was 65.5%.The average absolute error of theoretical value and actual value of calibration curve is 0.028,which has a good agreement.Conclusion Diabetes,smoking,reduced bone density,periodontal disease,poor preoperative oral hygiene,and elevated gingival bleeding index are significantly associated with increased risk of oral infection after implant restoration in edentulous elderly patients.The proposed nomogram model demonstrates favorable predictive accuracy and clinical applicability,supporting its use for preoperative risk stratification.It is recommended that clinicians implement targeted preventive measures,including glycemic control,smoking cessation programs,oral hygiene optimization,and bone augmentation when indicated,to reduce postoperative infection rates.

Abstract:Zirconia ceramics and lithium disilicate ceramics are extensively utilized in all-ceramic crown restorations.Zirconia-based all-ceramic crowns exhibit superior mechanical strength,whereas lithium disilicate-based crowns demonstrate excellent aesthetic outcomes and enhanced bonding properties.Clinicians should carefully evaluate patient-specific factors that may influence clinical outcomes and select the most appropriate all-ceramic restoration accordingly.This article systematically examines the mechanical and aesthetic characteristics of zirconia-based and lithium disilicate-based all-ceramic crowns,conducting a comprehensive evaluation of surface treatment methods and bonding techniques for these restorations.It further explores current clinical application strategies and recent advancements in zirconia and lithium disilicate all-ceramic crowns,aiming to provide clinicians with evidence-based guidance for the selection of appropriate restorative materials.

Abstract:In the contemporary era,as fixed dental restoration becomes increasingly prevalent,removable partial dentures(RPD)continue to occupy an indispensable role in the management of partially edentulous arches among elderly patients with multiple chronic conditions,owing to their advantages including minimal invasiveness,cost-effectiveness,and broad indications.However,in the face of elderly and frail patients,wearing of RPD not only changes the ecological balance of the local oral microenvironment,triggers denture stomatitis,caries of the remaining teeth and periodontitis,but may also have an impact on systemic health through microbial-host interactions.This paper discusses the potential impact of changes in oral bacterial structure and function after RPD wearing and the potential impact of related microbial ecological changes on systemic diseases,and discusses the cutting-edge progress such as surface modification,digital design and production of RPD materials,aiming to provide ideas for the application of removable denture materials,solution design and process improvement.

Abstract:Osteochondroma is typically located at the metaphyseal region of long bones.Its occurrence in the jawbone,particularly in the coronoid process,is exceedingly rare.This article reports a case of osteochondroma of the right mandibular coronoid process in a 63-year-old female.The patient presented with"a painless mass on the right cheek for more than 5 months and a new mass for 1 month".CT revealed a mass in the right coronoid process area.A modified preauricular-zygomatic arch approach was used for expanded resection of the tumor and partial coronoid process resection.During the procedure,the facial nerve branches were fully protected,and zygomatic arch osteotomy,reduction,and titanium plate fixation were performed.Postoperative pathology confirmed osteochondroma.The patient's facial appearance and mouth opening improved,and the prognosis was good.This article focuses on the selection of surgical approaches for lesions located deep to the coracoid process,highlighting the advantages of the modified preauricular-zygomatic arch approach in achieving adequate surgical exposure,ensuring facial nerve preservation,and facilitating osteotomy and reduction.This case serves as a valuable reference for the diagnosis and management of coracoid osteochondroma and the refinement of surgical strategies.

Abstract:Objective This article examines the clinical association between periodontitis in the elderly population and the elevated risk of various cancers,providing a systematic elaboration from three perspectives:epidemiological characteristics,underlying biological mechanisms,and multidimensional prevention and treatment strategies.Current evidence indicates that periodontitis may contribute to carcinogenesis through mechanisms such as oral microbial translocation,chronic immune-inflammatory responses,activation of key signaling pathways(e.g.,NF-κB,Wnt/β-catenin,IL-6/STAT3),and epigenetic regulation.Based on these findings,this article advocates for the implementation of an integrated prevention and control strategy centered on oral health in the elderly population.The proposed strategy encompasses enhancing oral health literacy,establishing a cancer risk early warning system,promoting stepwise periodontal therapy,facilitating comprehensive management of systemic comorbidities,and strengthening interdisciplinary collaboration among departments of stomatology,oncology,and geriatrics.Such an approach offers a promising pathway for early intervention and holistic disease management in elderly cancer care.

Abstract:Periodontitis is a chronic inflammatory disease characterized by progressive destruction of periodontal tissues,primarily caused by multiple pathogenic microbial communities.It has been increasingly recognized as a potential contributor to the development and progression of various systemic conditions.Hypothyroidism is a common endocrine disease,usually caused by reduced synthesis of thyroid hormones or resistance to their effects.If left untreated,it may result in severe complications,affecting multiple physiological functions.Although studies have demonstrated a correlation between periodontitis and hypothyroidism,the causal relationship and underlying mechanisms remain unclear.This paper reviews the current research progress on the correlation and possible mechanisms between periodontitis and hypothyroidism from five aspects:epidemiology and clinical research,animal experiments,related treatments,possible mechanisms and common risk factors,aiming to provide a theoretical basis for integrated clinical management strategies targeting both diseases.

Abstract:Objective To compare the efficacy of implant site anesthesia with that of conventional local infiltration anesthesia in single posterior maxillary tooth implantation surgery.Methods Sixty patients aged 20～70 years who underwent single tooth implant surgery in the maxillary posterior region at our hospital's Department of stomatology from February to June 2025 were randomly assigned to either the experimental group or the control group,with 30 patients in each group.The experimental group received site-specific implant anesthesia,whereas the control group received conventional local anesthesia.Parameters compared included pain scores during injection,pre-and post-anesthesia heart rate changes,and incidence of adverse anesthetic reactions.Results Pain scores during injection were significantly lower in the experimental group than in the control group(3.63±1.19 vs.4.33±1.21,P=0.03).No statistically significant difference was observed in heart rate changes between the two groups(P=0.34).In the elderly subgroup(60～70 years,n=20),pain scores and heart rate changes were lower in the experimental group compared to the control group,but the differences were not statistically significant(P=0.28、P=0.24).The overall incidence of adverse reactions was 3.33%in the experimental group and lower than the control group(10.00%).Conclusion When performing single posterior tooth implant surgery under local anesthesia,the use of implant site anesthesia techniques can effectively reduce patient discomfort during the anesthetic procedure.No significant differences were observed between the two methods with respect to heart rate variability or the incidence of adverse reactions.

Abstract:This study presents a rare case of a bilateral second mandibular molar with eight cusps,with pulp infection observed in the left mandibular second molar secondary to dental caries.To investigate the clinical characteristics and treatment approaches for malformed teeth,comprehensive assessments were conducted using intraoral examinations,dental model measurements,radiographic imaging,and digital oral scanning.Following root canal therapy,the buccolingual diameter of the crown was reduced to minimize the occlusal load and achieve optimal occlusal harmony.At the six-month follow-up,the fillings and the condition of the teeth were satisfactory,with no signs of periodontal complications.The patient's symptom of biting the cheek had disappeared,indicating a successful treatment outcome.This study has accumulated valuable clinical experience in the diagnosis and management of rare dental malformations.It indicates that modifying crown morphology can enhance the retention of multi-cusped molars with supernumerary cusps following root canal therapy,and highlights the importance of general dentists utilizing digital technologies in managing complex cases.

Abstract:Objective This study aims to investigate the current status of knowledge,attitude,practice(KAP)of implant denture patients concerning maintenance,providing evidence for developing targeted patient education programs.The goal is to improve the level of implant denture maintenance and extend the lifespan of implant dentures.Methods Convenience sampling was adopted to select 180 elderly patients with oral implants from the Department of Stomatology of the First Medical Center of the PLA General Hospital from September 2024 to March 2025 for a questionnaire survey.A questionnaire survey is conducted using the"Implant Denture Patients'Oral Health Knowledge,Attitudes,and Practice Questionnaire"to assess patients'knowledge and attitudes toward implant denture maintenance.The questionnaire includes sections on patients'demographic information,maintenance knowledge,attitudes,and practice.Descriptive statistical analysis is used to assess the levels of KAP,and the relationship between knowledge and attitudes is explored.Results The scores of maintenance knowledge and attitude towards dental implants among female patients were higher than those among male patients(P<0.01).With the improvement of educational level,patients'scores increased(P<0.05).With the increase of age,patients'scores decreased(P<0.01).The scores of maintenance knowledge and attitude towards dental implants among patients without a smoking history were higher than those among patients with a smoking history(P<0.01).The scores of non-implant patients were lower than those of implant patients(P<0.01).Univariate analysis showed that age,gender,educational level,smoking history,and implantation time of elderly patients were all independent influencing factors for the KAP scores of elderly dental implant patients(P<0.05).The results of multiple linear regression analysis showed that age,gender,educational level,smoking history,and implantation time of elderly patients were independent influencing factors for the KAP scores of elderly dental implant patients.Conclusion There is an obvious positive correlation among knowledge,behavior,and attitude regarding dental implant maintenance in elderly patients.Age,gender,educational level,smoking history,and implantation time are influencing factors for the KAP scores of elderly dental implant patients.It is necessary to strengthen the education of maintenance knowledge for elderly dental implant patients,improve their awareness of dental implant maintenance,optimize their maintenance behaviors,and enhance the long-term success rate of dental implants.

Abstract:Tantalum-based materials are a class of materials in which tantalum serves as the primary component or core structural element,modified through alloying,composite formation,or specialized processing techniques to meet specific application requirements.With mechanical properties closely matching those of human bone,exceptional long-term stability,intrinsic osteoinductive potential,unparalleled corrosion resistance,antithrombogenicity,and surface functionalization capabilities,they demonstrate tremendous promise in orthopedics,oral medicine,and interventional vascular medicine.This paper presents a systematic review of the biological foundations,current applications,and future prospects of tantalum-based materials in the medical field,offering a scientific reference for their further clinical translation.

Abstract:Pemphigus vegetans is a rare subtype of pemphigus.The diagnosis and the treatment of the disorder is difficult.We analyzed the clinical data of a case of pemphigus vegetans,which mainly affected oral mucosa,and treated with thalidomide and Nd:YAG laser.The treatment effect was good and stable.This report is expected to provide experience for clinical diagnosis and treatment.

Abstract:Objective This study aims to analyze the differences between the microRNA(miRNA)of the jawbone and the long bone of rats under the action of zoledronic acid.Methods Male rats were selected and randomly divided equally into:the normal saline(NS)group and the zoledronic acid(ZA)group.After treating for 12 weeks,all rats were sacrificed after 4 weeks of discontinuation,and 4 groups of samples were obtained from the mandible and femur,and the expression differences were analyzed by histological staining,miRNA sequencing,functional enrichment,and qRT-PCR on the bones of the four groups.Results The jawbone in the ZA group showed early osteonecrosis than the NS group.Under the action of ZA,miRNAs underwent specific changes in the jawbone were mainly related to the synthesis,secretion and function of parathyroid hormone,nuclear factor kappa-B signaling pathway,and apoptosis.Conclusion Under the action of zoledronic acid,jawbone histological osteonecrosis manifests earlier than clinically,and some miRNAs only undergo specific changes in the jawbone and may be related to BRONJ occurrence.

Abstract:Objective To quantify the labial cortical thickness of maxillary central incisors in individuals aged≥60 years using cone-beam computed tomography(CBCT)and to provide an anatomical basis for risk assessment before immediate implant placement in the anterior maxilla.Methods From the radiologic archive of Beijing Tongren Hospital,120 CBCT scans containing the anterior maxilla were screened.After applying inclusion criteria(age≥60 years,intact labial tooth structure),100 subjects(200 maxillary central incisors)were enrolled.ITK-SNAP 3D reconstruction was performed,and the sagittal plane was standardized and extracted using Photoshop.The thickness of the labial bone plate at 1/2 of the root length,the root apex,1,3,and 5 mm apical to the alveolar crest,and 3 and 5 mm below the cemento-enamel junction(CEJ)was measured.The proportion of alveolar bone resorption and the total width of the labial and lingual diameters were also recorded.Results The thickness of the labial bone plate at 1/2 of the root length was 0.45(0.24,0.66)mm,with 92%being less than 1 mm and 57%less than 0.5 mm.The thickness of the labial cortical bone at the apical region is 1.07(0.68,1.57)mm.46%of the samples have a thickness less than 1 mm,and 18%have a thickness less than 0.5 mm.Thickness 1 mm,3 mm and 5 mm apical to the alveolar crest was 0.84,0.84 and 0.72 mm,respectively;proportions<1 mm were 68%,65%and 74%.At 3 mm and 5 mm apical to the CEJ,65%of sites exhibited thickness<1 mm.The labial bone plate was consistently thinner than the lingual bone plate at all subcrestal levels.Conclusion In individuals≥60 years,the labial cortical plate of the maxillary central incisor is generally thin,with almost half of mid-root sites<0.5 mm,indicating a high esthetic risk for immediate implant placement.The lingual bone plate was relatively abundant.Preoperative CBCT evaluation is mandatory,and patient-specific planning that considers individual anatomy and occlusal conditions is recommended.