Research progress on the association between periodontitis and hypothyroidism
HAO Zhaoxue
YUAN Shaozhong
Abstract：Periodontitis is a chronic inflammatory disease characterized by progressive destruction of periodontal tissues,primarily caused by multiple pathogenic microbial communities.It has been increasingly recognized as a potential contributor to the development and progression of various systemic conditions.Hypothyroidism is a common endocrine disease,usually caused by reduced synthesis of thyroid hormones or resistance to their effects.If left untreated,it may result in severe complications,affecting multiple physiological functions.Although studies have demonstrated a correlation between periodontitis and hypothyroidism,the causal relationship and underlying mechanisms remain unclear.This paper reviews the current research progress on the correlation and possible mechanisms between periodontitis and hypothyroidism from five aspects:epidemiology and clinical research,animal experiments,related treatments,possible mechanisms and common risk factors,aiming to provide a theoretical basis for integrated clinical management strategies targeting both diseases.
Keywords：periodontitishypothyroidismthyroid hormonebone metabolism
Publication Date：2026-01-20
Online Publishing Date：2026-02-04(First online date of this platform, not the publication date of the document)
Pages：6( 74-79 )