Abstract:Objective:To explore the clinical efficacy of herb-partitioned moxibustion on the navel in treat-ment of irritable bowel syndrome with diarrhea(IBS-D)induced by liver depression and spleen deficiency.Methods:Thirty patients with IBS-D induced by liver depression and spleen deficiency were selected and included in the herb-partitioned moxibustion on the navel group,and 30 healthy volunteers were included in the normal control group.Patients in the herb-partitioned moxibustion on the navel group received continuous treatment with herb-partitioned moxi-bustion on the navel for 2 months,while the normal control group received no intervention.The scores of the Irritable Bowel Syndrome Symptom Severity Scale(IBS-SSS)and clinical efficacy of patients in the herb-partitioned moxibustion on the navel group were observed before and after treatment,as well as the visceral sensitivity index(VSI)scale score and the levels of transient receptor potential vanilloid subtype 1(TRPV1),substance P(SP),and calcitonin gene-related peptide(CGRP)in serum of the included individuals in both groups.Results:After treatment,the score of each item and the total score of the IBS-SSS scale in the patients of the herb-partitioned moxibustion on the navel group were all lower than those before treatment,and the differences were statistically significant(P＜0.01).The total effective rate of the herb-partitioned moxibustion on the navel group was 100％.At the time of enrollment,the VSI scale score of the herb-partitioned moxibustion on the navel group was higher than that of the normal control group(P＜0.01);after treatment,the VSI scale score of the herb-partitioned moxibustion on the navel group decreased significantly compared with that at the time of enrollment(P＜0.01).At the time of enrollment,the levels of serum TRPV1,SP,and CGRP in the herb-partitioned moxibustion on the navel group were all higher than those in the normal control group(P＜0.01);after treatment,the levels of serum TRPV 1,SP,and CGRP in the herb-partitioned moxibustion on the navel group decreased significantly compared with those at the time of enrollment(P＜0.01).Conclusions:Herb-partitioned moxibustion on the navel can improve the clinical symptoms of patients with IBS-D induced by liver depression and spleen deficiency and reduce their visceral hypersensitivity.

Abstract:Objective:To observe the influence of Yixin Tongluo Decoction(益心通络汤)combined with individualized exercise rehabilitation training on cardiac function and physical fitness of patients after percutaneous coronary intervention(PCI)for acute myocardial infarction with qi deficiency,phlegm,and blood stasis syndrome.Methods:A total of 180 patients after PCI for acute myocardial infarction with qi deficiency,phlegm,and blood stasis syndrome were divided into a control group and a treatment group according to the random number table method,with 90 cases in each group.The patients in the control group received conventional western medicine treatment and indi-vidualized exercise rehabilitation training,and the patients in the treatment group took Yixin Tongluo Decoction on the basis of the treatment plan of the control group.Both groups were treated continuously for 4 weeks.The physical fitness,the six-minute walk test(6MWT)distance,the Chinese Quality of Life Questionnaire for Cardiovascular Patients(CQQC)score,the left ventricular ejection fraction(LVEF),the plasma brain natriuretic peptide(BNP)level,and the score of four diagnostic information of traditional Chinese medicine(TCM)were compared between the two groups.The curative efficacy of TCM syndromes was evaluated,and the adverse reactions of the two groups during the treatment were recorded.Results:After treatment,the 6MWT distance,the CQQC score,the plasma BNP level,and the score of four diagnostic information of TCM in both groups were better than those before treatment(P＜0.05),and the physical fitness level,the CQQC score,the plasma BNP level,the score of four diagnostic information of TCM,and the curative efficacy of TCM syndromes in the treatment group were better than those in the control group(P＜0.05).No serious adverse reactions occurred in both groups during the treatment period.Conclusions:Yixin Tongluo Decoction combined with individualized exercise rehabilitation training can significantly improve the physical fitness level,cardiac pump function,clinical symptoms,and exercise endurance of patients after PCI for acute myocardial infarction with qi deficiency,phlegm,and blood stasis syndrome.It can reduce the plasma BNP level of the patients and has high safety.

Abstract:In recent years,there have been increasing reports on the treatment of xerophthalmia by acu-puncture,and the mechanism of acupuncture treatment for xerophthalmia has gradually become a research hotspot.This article summarizes the mechanism of acupuncture therapy for xerophthalmia from the pers-pectives of western medicine and traditional Chinese medicine.From the perspective of western medicine,the mechanism of acupuncture in the treatment of xerophthalmia may be related to reducing inflammatory reactions,inhibiting signal transduction pathways,regulating hormone levels,regulating nerve functions,promoting the expression of mucin in tears,inhibiting apoptosis in lacrimal gland tissues,and increasing the content of lactoferrin,etc.From the perspective of traditional Chinese medicine,acupuncture mainly exerts its functions by dredging the meridians of the eyes and regulating qi and blood of the eyes through approaches such as soothing the liver and purging fire,nourishing the kidney and regulating the liver,nourishing the lung yin,and supplementing qi and nourishing yin,thereby alleviating the clinical symptoms of xerophthalmia.There are 48 references.

Abstract:Acupuncture and moxibustion has its unique advantages in the treatment of infertility,and its neurobiological mechanism is mainly related to the regulation of the hypothalamic-pituitary-ovarian(HPO)axis closely.However,there are few studies that explore the mechanism of acupuncture and moxibustion treatment for infertility from the perspective of"The uterine collaterals are interconnected with the kidney system".This paper deeply analyzes the biological mechanism of acupuncture and moxibustion in treating infertility from kidney,starting from the interconnections between meridian-viscera correlation theory and hypothalamic-pituitary-ovarian axis,so as to provide a scientific basis for the application of acupuncture and moxibustion in treating diseases of reproductive system.

Abstract:Chronic atrophic gastritis(CAG)is one of the common digestive diseases in clinical practice.Intestinal metaplasia(IM)refers to the pathological changes in which gastric mucosal epithelial cells are replaced by intestinal epithelial cells.Bile acids and intestinal flora axis maintain gastrointestinal homeostasis together,and bile acid-flora axis abnormalities are closely related to the occurrence and development of CAG with IM.Bile acid-flora axis is closely related to traditional Chinese medicine(TCM)liver and spleen function,and is the material basis for its normal function.The interaction between bile acid and intestinal flora also reflects the theory of liver and spleen correlation.Meanwhile,the dysfunction of liver and spleen is an important pathogenesis of CAG with IM.Therefore,this paper discusses the effect of bile acid-flora axis on CAG with IM based on liver and spleen disorders,in order to provide new thinking for the prevention and treatment of CAG with IM by combining TCM and western medicine.

Abstract:Objective:To observe the clinical efficacy of Yiqi Guanmai Tongxin Formula(益气冠脉通心方)combined with Baduanjin in the treatment of patients with chronic heart failure due to coronary heart disease,as well as its effects on myocardial fibrosis and inflammatory injury,etc.Methods:A total of 100 patients with chronic heart failure due to coronary heart disease were selected and divided into control group and observation group according to the random number table method,with 50 cases in each group.Both groups were given standardized western medical treatment simultaneously.The control group was treated with the Yiqi Guanmai Tongxin Formula,while the observation group was treated with the Yiqi Guanmai Tongxin Formula combined with Baduanjin.The changes of traditional Chinese medicine(TCM)syndrome scores and ventricular rate-related indicators before and after treatment in the two groups were observed.The indicators related to inflammatory response[Interleukin-17(IL-17A),Lipoprotein phospholipase A2(Lp-PLA2)]and vascular regeneration[vascular endo-thelial growth factor(VEGF),Hypoxia-Inducible factor 1α(HIF-1α)],and indicators related to myocardial fibrosis injury[C1q-tumor necrosis factor-related protein 3(CTRP3),hyaluronic acid(HA),type Ⅲ procollagen(PC Ⅲ)]before and after treatment were compared between the two groups.The left ventricular ejection fraction(LVEF),myocardial energy expenditure(MEE),and left ventricular myocardial mass index(LVMI)of the two groups before and after treatment were detected.And the clinical efficacy of the two groups was evaluated.Results:After treatment,the scores of each TCM syndrome in both groups were lower than those before the treatment,and the scores in the observation group were lower than those in the control group(P＜0.05).After treatment,the minimum,maximum and average ventricular rates in both groups were lower than those before treatment,and the rates in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of IL-17A,Lp-PLA2,HA and PC Ⅲ in both groups decreased compared with those before treatment,and the levels in the observation group were lower than those in the control group(P＜0.05).The levels of HIF-1α,VEGF and CTRP3 all increased compared with those before treatment,and those in the observation group were higher than those in the control group(P＜0.05).After treatment,the LVEF in both groups increased compared with that before treatment(P＜0.05),and the LVEF in the observation group was higher than that in the control group(P＜0.05).The MEE and LVMI in both groups were lower than those before treatment(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).The total effective rate of treatment in the control group was 80.00％,which was lower than 96.00％in the observation group.Comparison of the clinical efficacy between the two groups showed a statistically significant difference(P＜0.05).Conclusions:Yiqi Guanmai Tongxin Formula combined with Baduanjin can reduce inflammatory injury,myocardial fibrosis and vascular regeneration,improve atrial fibrillation,regulate ventricular remodeling and myocardial energy metabolism,alleviate the condition and enhance clinical efficacy in the treatment of patients with chronic heart failure due to coronary heart disease.

Abstract:The clauses related to phlegm and fluid retention in Treatise on Cold Pathogenic and Miscellaneous Diseases reflect the dynamic characteristics of the pathogenic factors of phlegm and fluid retention.For example,the flowing of phlegm and fluid retention in the body can cause movement,trembling,and shaking symptoms;the upward invasion of phlegm and fluid retention to the heart orifices can cause palpitations and restlessness;the upward rush of phlegm and fluid retention to the brain orifices can cause dizziness and difficulty in standing,etc.The characteristics of essential tremor(ET),such as limb tremors,sudden onset and cessation of symptoms,repeated illness,and lingering condition,are consistent with the dynamic characteristics of phlegm and fluid retention.Therefore,clinical treatment of ET can refer to the relevant clauses on phlegm and fluid retention in Treatise on Cold Pathogenic and Miscellaneous Diseases,aiming at eliminating phlegm and fluid retention and follow-ing the principle of"harmonization with warming medicines".In acute cases,relieve the exterior,dispel wind,and harmonize nutrient and defensive aspects.In chronic cases,support and promote simultaneously and regulate all the internal organs.

Abstract:Professor QI Yuanfu attaches great importance to the important role of toxic pathogens in the occurrence and development of lung cancer."Detoxification"is one of the characteristics of his treatment for lung cancer.Professor Qi classifies the toxic pathogens that cause lung cancer into four types:heat toxin,stagnation toxin,phlegm toxin,and blood stasis toxin.For those with heat toxin,the main treatment is clearing heat and detoxifying.For those with stagnation toxin,the main treatment is regulating qi and eliminating masses.For those with phlegm toxin,the main treatment is resolving phlegm and eliminating dampness.For those with blood stasis toxin,the main treatment is promoting blood circulation and resolving masses.The above-mentioned treatment methods often achieve good results in clinical practice.One proved case is attached.

Abstract:Professor WANG Yue believes that rheumatoid arthritis(RA)is primarily caused by wind,cold,dampness,heat,phlegm,and blood stasis,leading to blockage of the meridians and collaterals.Pungent medicinals have the efficacy characteristics of dispersing,circulating,transforming,moistening,dredging,and lifting.According to the etiology and pathogenesis of RA,Professor WANG is adept at using the compatibility and prescription of pungent medicinals to treat the disease,such as opening sweat pores with pungent medicinals,dispersing cold with pungent and warm medicinals,clearing heat with pungent and cold medicinals,resolving dampness with pungent and aromatic medicinals,and dredging collaterals with pungent and moistening medicinals.In clinical practice,based on the patient's condition,various combinations of the five flavors are employed:pungent and sweet,sour and pungent,pungent and salty,or pungent dispersing and bitter descending.By utilizing the compatibility of the five flavors,pathogenic qi is eliminated,the functions of the five zang-organs are harmonized,and the potential side effects of the primary medication are mitigated.One proved case is attached.

Abstract:There are numerous types of brain diseases,and their clinical diagnosis and treatment encounter significant challenges,necessitating innovative diagnostic and therapeutic approaches.Professor WANG Xinlu,a master of traditional Chinese medicine,proposed the theory of blood turbidity and applied it to the differentiation and treatment of brain diseases.He believes that the onset of brain diseases is related to internal injuries caused by the seven emotions,improper diet,and environmental pollution.The main patho-genesis is that turbid blood damages the marrow and the brain orifices are deprived of nourishment.He also proposed the treatment principles of clearing blood turbidity,nourishing the brain,and filling the marrow.At the same time,he emphasized the prevention before illness and the flexible use of supporting drugs.Currently,guided by this theory,the treatments of brain diseases through the internal administration of traditional Chinese medicine and the combination of acupuncture and medicine have achieved notably significant therapeutic effects,and research into the underlying mechanisms is ongoing.This article sorts out the pertinent literature on blood turbidity and reviews the recent advancements in the diagnosis and treatment of brain diseases,including ischemic stroke,vascular dementia,cerebral small vessel disease,migraine,and epilepsy,from the perspective of blood turbidity theory.The aim is to provide a valuable reference for the diagnosis and treatment of brain diseases using traditional Chinese medicine.There are 46 references.

Abstract:Adenomyosis(AM)is a common gynecological disorder,often detected in postmenopausal women,typically identified accidentally after surgery.The pathogenesis of AM remains unclear.In China,there is no established guideline or high-level consensus on the diagnosis and treatment of AM.To address this gap,a collection of expert opinions has been gathered to form this consensus.This consensus covers the pathogenesis of AM malignant lesions,diagnostic criteria,etiology,and disease cause,disease mechanism and syndrome differentiation of traditional Chinese medicine(TCM),as well as combined Chinese and Western medicine treatment protocols.The treatment strategies include staging therapy,surgery,systemic therapy,radiation therapy,TCM syndrome differentiation and treatment,and external therapies.All treatment protocols are based on expert consensus,derived from a comprehensive review of the literature,to ensure clinical applicability.

Abstract:Objective:To observe the clinical efficacy of Fangji Huangqi Decoction(防 己 黄 芪 汤)combined with Zhizhu Pill(枳术丸)in treating obesity in adolescent children of spleen deficiency and phlegm dampness type.Methods:Seventy cases of adolescents with simple obesity of spleen deficiency and phlegm dampness type were selected and randomly divided into a control group and a treatment group,with 35 cases in each group.The control group was given guidance to correct daily behavioral habits,while the treatment group received Fangji Huangqi Decoction combined with Zhizhu Pill with modifications,in addition to the correction of daily behavioral habits.Both groups were treated for 12 weeks.The clinical efficacy of the two groups was compared,along with changes in traditional Chinese medicine(TCM)syndrome scores,obesity indexes[body mass,body mass index(BMI)],and serum levels of high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),triacylglycerol(TG),and total cholesterol(TC)before and after treatment.Results:The total effective rate of the treatment group was 85.71％,which was higher than that of the control group at 61.54％,and the difference was statistically significant(P＜0.05).After treatment,both groups showed a reduction in TCM syndrome scores,body mass,BMI,LDL-C,TG,and TC compared to before treatment.The differences of TCM syndrome scores and BMI between the groups were also statistically significant(P＜0.05).Conclusion:Fangji Huangqi Decoction combined with Zhizhu Pill can effectively treat obesity in adolescent children,reduce body mass and BMI.

Abstract:Chronic gastritis(CG)is one of the most common digestive diseases.At present,a large number of clinical studies have shown that acupuncture has a significant effect on chronic gastritis,which can significantly relieve the stomach discomfort of CG patients and improve their quality of life.However,there is no unified conclusion on the mechanism of acupuncture in the treatment of CG.Based on"meridian-viscera correlation"theory,this study elaborates the internal relationship between stomach fu-organs and relevant meridians,and discusses and summarizes the mechanism of acupuncture in the treatment of chronic gastritis from the perspectives of acupuncture regulation of local microenvironment of acupoints,intervention of acupuncture on stomach itself,central and peripheral pathways of acupuncture action,etc.,in order to provide reference for the future clinical research on the mechanism of acupuncture in the treatment of CG.

Abstract:Objective:To observe the clinical effect of Dingxuan Tongluo Formula(定眩通络方)com-bined with transmoxibustion in the treatment of mixed cervical vertigo of phlegm-dampness blocking collaterals type.Methods:A total of 84 patients with mixed cervical vertigo of phlegm-dampness blocking collaterals type were selected and divided into the control group and the observation group according to random number table method,with 42 cases in each group.The control group was given conventional western medicine treatment and traction treatment,and the observation group was given Dingxuan Tongluo Formula combined with transmoxibustion treatment on the basis of the treatment of the control group.Traditional Chinese medicine(TCM)syndrome score,evaluation scale for cervical vertigo(ESCV)score,dizziness assessment rating scale(DARS)score before and after treatment were compared between the two groups.The domain frequency(MF)and the averaged electromyography(AEMG)of sternocleidomastoid muscle were detected before and after treatment.Serological parameters including phosphorylated-P38 mitogen-activated protein kinase(p-P38MAPK),tumor necrosis factor α(TNF-α),matrix metalloproteinase-14(MMP-14)and 5-hydroxytryptamine(5-HT)levels were compared between the two groups before and after treatment.The clinical efficacy of the two groups was compared.Results:After treatment,TCM syndrome scores and DARS scores in both groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group,the difference was statistically significant(P＜0.05).ESCV scores in both groups were higher than those before treatment,and the scores of the observation group were higher than those of the control group(P＜0.05).The MF of sternocleidomastoid muscle in two groups was higher than that before treatment,and the value of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The AEMG of sternocleidomastoid muscle in two groups was lower than that before treatment,and the value of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05).The levels of p-P38MAPK,TNF-α,MMP-14 and 5-HT in both groups were decreased compared with those before treatment,and the levels of the observation group were lower than those of the control group,the difference was statistically significant(P＜0.05).The total effective rate of the observation group was 97.62％,and that of the control group was 80.95％.The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).Conclusions:Dingxuan Tongluo Formula combined with transmoxibustion can inhibit inflammation,reduce the level of pain factors,improve myoelectric indexes and relieve vertigo symptoms,and enhance clinical efficacy in the treatment of vertigo of mixed cervical spondylosis of phlegm-dampness blocking collaterals type.

Abstract:Based on the theory of the mutual reinforcement between the kidney and the brain,as well as the circulation and structural connection of the governor vessel,the"brain-governor vessel-kidney"axis is proposed,and it is believed that the disorder of this functional system is the key pathogenesis of Parkinson's disease(PD).The disharmony of the brain orifices is the primary cause,the deficiency of the kidney and subsequent loss of nourishment is the root cause,and the damage to the governor vessel makes it impossible to connect the brain and the kidney.These three factors jointly contribute to the occur-rence and development of PD.In the acupuncture and moxibustion treatment based on the"brain-governor vessel-kidney"axis for PD,the governor vessel points on the head and neck,such as Baihui(GV20),Shenting(GV24),Yintang(EX-HN3),Fengfu(GV16),and Yamen(GV15),should be selected first to invigorate the brain and replenish the marrow,unblock the governor vessel and regulate the spirit,and relieve tremors by raising yang.Moreover,points such as Taixi(KI3),Yongquan(KI1),Dazhong(KI4),and Shenshu(BL23)should be combined to tonify the kidney and supplement essence,consolidate the foundation and unblock the governor vessel,and nourish yin and cultivate yang.In addition,points like Sanyinjiao(SP6),Guanyuan(CV4),and Qihai(CV6)are used to regulate and tonify qi and blood.For common complications associated with PD,such as depressive and other negative emotional disorders,sleep disorders,and defecation and urination disorders,emphasis is placed on the simultaneous regulation of both body and mind,and acupuncture is administered based on syndrome differentiation to eliminate all symptoms.

Abstract:Professor WANG Maosheng,based on the etiological and pathological characteristics of chronic leukemia,identifies the deficiency of liver and kidney yin essence as the foundation,the internal accumu-lation of toxic pathogens as the primary cause,and the obstruction by phlegm and blood stasis as the manife-station.He emphasizes the integration of disease differentiation by stage and syndrome differentiation and treatment,dividing chronic leukemia into the initial,middle,and final stages for diagnosis and treatment.In the initial stage,the syndromes are primarily characterized by the accumulation of marrow toxins and blood stasis.The treatment focuses on clearing and resolving the toxins and blood stasis,and the prescription is modified from Zhuyu Decoction(逐瘀汤).In the middle stage,the syndromes are primarily characte-rized by the intermingling of phlegm and blood stasis.The treatment focuses on eliminating phlegm and dispersing blood stasis,and the prescription is based on Shenqi Shabai Decoction(参芪杀白汤).If the intermingled toxins and blood stasis turn into heat,it is necessary to cool the blood,stop bleeding,and clear heat and detoxify.In the final stage,the syndromes are primarily characterized by liver-kidney yin deficiency.The treatment focuses on nourishing liver and kidney yin essence,and the prescription is based on Qinghao Biejia Decoction(青蒿鳖甲汤).Blood stasis exists in the initial,middle,and final stages,and promoting blood circulation to remove blood stasis runs through the treatment of the disease from beginning to end.Professor WANG properly handled the relationships between"manifestations"and"root causes","healthy qi"and"pathogenic qi","attacking"and"tonifying",and flexibly applies methods such as detoxifying,eliminating phlegm,dissipating blood stasis,and strengthening the body resistance to treat chronic leukemia,ultimately achieving the effects of enhancing efficacy,reducing toxicity,and improving prognosis.

Abstract:Discuss the etiology,pathogenesis and treatment strategies of premature ejaculation from three perspectives of form,qi and spirit.From the perspective of form,damp-heat,phlegm-dampness,kidney essence deficiency,and organic abnormalities,etc.are the key factors of premature ejaculation,and the treatment should follow the principle of"eliminating the causes of the disease and targetting the root causes".From the perspective of qi,factors such as stagnation of liver qi,failure of kidney qi to solidify,deficiency of heart and spleen qi,lung failing in regulating and controling,and disordered meridian qi are the internal factors leading to premature ejaculation,the treatment should follow the principle of"soothing the liver and relieving stagnation,regulating qi activity,solidifying and protecting kidney qi,nourishing the heart and spleen,and helping the lung in regulating and controlling".From the perspective of spirit,factors such as emotional disorders,disharmony between heart and kidney,and mental distraction are the fundamental causes of premature ejaculation,and the treatment should focus on"regulating emotions,maintaining the harmony between heart and kidney,and keeping spiritual introversion",which is conducive to the clinical examination of the disease to identify the causes of the disease,choose appropriate prescriptions,and provide new ideas for the clinical diagnosis and treatment of premature ejaculation,in order to better guide the clinical practice.

Abstract:This article aims to construct a series of reactions of the pathogenesis of Alzheimer's disease based on the correlation between the spleen and blood turbidity,namely"spleen disease,blood turbidity and spirit damage",to explore the disease process of Alzheimer's disease in depth.Combined with the concept of preventive treatment of disease,it proposes a treatment strategy of strengthening the spleen to prevent disease,eliminating turbidity to relieve the symptoms,and opening the orifices to treat the disease.It is proposed to use the modified formula of Kaixin Powder and Huazhuo Xingxue Decoction(开心散合化浊行血汤)to strengthen the spleen and improve intelligence in the treatment of Alzheimer's disease,so as to provide a theoretical basis for the treatment of Alzheimer's disease from the perspective of the spleen.One test case is attached.

Abstract:Objective:To explore the risk factors for postoperative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome based on Logistic regression analysis.Methods:A total of 140 patients with colorectal adenoma and spleen deficiency and blood stasis syndrome were divided into a recurrence group(68 cases)and a non-recurrence group(72 cases)according to whether there was recurrence one year after the operation.The basic information,traditional Chinese medicine(TCM)symptom and preoperative adenoma characteristics of the two groups were compared,and the risk factors for post-operative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome were analyzed by Logistic regression model.Results:There were significant differences in age,gender distribution,number of adenomas,and the diameter of the largest adenoma between the two groups(P＜0.05).Logistic regression analysis indicated that male(OR=2.106),age≥50 years old(OR=2.090),the number of adenomas≥3(OR=2.318),and the diameter of the largest adenoma ≥10 mm(OR=2.508)were risk factors for postoperative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome(P＜0.05).Conclusion:Postoperative male patients with colorectal adenoma and spleen deficiency and blood stasis syndrome,age ≥ 50 years old,having 3 or more than 3 adenomas,and the diameter of the largest adenoma≥10 mm,should undergo regular colonoscopy monitoring to prevent recurrence.

Abstract:Objective:To observe the clinical efficacy of acupoint application of Antai Zhixue Powder(安胎止血散)as an adjuvant therapy in the treatment of threatened abortion with kidney deficiency syndrome.Methods:A total of 100 patients with threatened abortion due to kidney deficiency were divided into an Antai Zhixue Powder acupoint application group and a placebo acupoint application group,with 50 patients in each group(1 case dropped out in the Antai Zhixue Powder acupoint application group,and 3 cases dropped out in the placebo acupoint application group).In the Antai Zhixue Powder acupoint application group,treatment was carried out using intramuscular injections of progesterone and oral admini-stration of dydrogesterone tablets combined with Antai Zhixue powder acupoint application at Shenque point(CV8)and bilateral Shenshu points(BL23).In the placebo acupoint application group,treatment was conducted using intramuscular injections of progesterone and oral administration of dydrogesterone tablets combined with specially prepared starch placebo acupoint application at Shenque point and bilateral Shenshu points.Both groups were treated continuously for 2 weeks.The hematometra area,gestational sac size,embryo size,and the levels of serum progesterone,human chorionic gonadotropin(HCG),and estradiol of the patients in both groups were observed before treatment,1 week after treatment,and 2 weeks after treatment.The clinical curative efficacy and the curative efficacy of traditional Chinese medicine(TCM)syndromes(lumbago,abdominal pain,and vaginal bleeding)in both groups were evaluated.The adverse reactions of both groups during the treatment were compared.Results:At 1 week and 2 weeks post-treatment,the gestational sac and embryo of the patients in both groups were larger than those before treatment(P＜0.05),and the levels of serum HCG and estradiol were higher than those before the treatment(P＜0.05).After 2 weeks of treatment,the hematometra area of the patients in Antai Zhixue Powder acupoint application group was smaller than that before treatment(P＜0.05),and was smaller than that in the placebo acupoint application group(P＜0.05).After treatment,the total clinical effective rate and the total effective rate of TCM syndromes in the Antai Zhixue Powder acupoint application group were higher than those in the placebo acupoint application group(P＜0.05).During the treatment period,no obvious adverse reactions were observed in either group.Conclusions:The acupoint application of Antai Zhixue Powder at the Shenque point and bilateral Shenshu points has the effect of tonifying kidney qi,preventing miscarriage,and stopping bleeding.This therapy can reduce hematometra in patients with threatened abortion due to kidney deficiency,alleviate symptoms such as lumbago,abdominal pain,and vaginal bleeding,and has no obvious influence on the hormone levels of patients.It is safer for clinical application.