Clinical Study on Acupoint Application of Antai Zhixue Powder(安胎止血散)as Adjuvant Therapy in Treatment of Threatened Abortion with Kidney Deficiency Syndrome

CHEN Huihui; CHEN Hui; FENG Wentu; KANG Min; WANG Qingyi; CHEN Yingting

doi:10.16295/j.cnki.0257-358x.2025.01.014

Abstract：Objective:To observe the clinical efficacy of acupoint application of Antai Zhixue Powder(安胎止血散)as an adjuvant therapy in the treatment of threatened abortion with kidney deficiency syndrome.Methods:A total of 100 patients with threatened abortion due to kidney deficiency were divided into an Antai Zhixue Powder acupoint application group and a placebo acupoint application group,with 50 patients in each group(1 case dropped out in the Antai Zhixue Powder acupoint application group,and 3 cases dropped out in the placebo acupoint application group).In the Antai Zhixue Powder acupoint application group,treatment was carried out using intramuscular injections of progesterone and oral admini-stration of dydrogesterone tablets combined with Antai Zhixue powder acupoint application at Shenque point(CV8)and bilateral Shenshu points(BL23).In the placebo acupoint application group,treatment was conducted using intramuscular injections of progesterone and oral administration of dydrogesterone tablets combined with specially prepared starch placebo acupoint application at Shenque point and bilateral Shenshu points.Both groups were treated continuously for 2 weeks.The hematometra area,gestational sac size,embryo size,and the levels of serum progesterone,human chorionic gonadotropin(HCG),and estradiol of the patients in both groups were observed before treatment,1 week after treatment,and 2 weeks after treatment.The clinical curative efficacy and the curative efficacy of traditional Chinese medicine(TCM)syndromes(lumbago,abdominal pain,and vaginal bleeding)in both groups were evaluated.The adverse reactions of both groups during the treatment were compared.Results:At 1 week and 2 weeks post-treatment,the gestational sac and embryo of the patients in both groups were larger than those before treatment(P＜0.05),and the levels of serum HCG and estradiol were higher than those before the treatment(P＜0.05).After 2 weeks of treatment,the hematometra area of the patients in Antai Zhixue Powder acupoint application group was smaller than that before treatment(P＜0.05),and was smaller than that in the placebo acupoint application group(P＜0.05).After treatment,the total clinical effective rate and the total effective rate of TCM syndromes in the Antai Zhixue Powder acupoint application group were higher than those in the placebo acupoint application group(P＜0.05).During the treatment period,no obvious adverse reactions were observed in either group.Conclusions:The acupoint application of Antai Zhixue Powder at the Shenque point and bilateral Shenshu points has the effect of tonifying kidney qi,preventing miscarriage,and stopping bleeding.This therapy can reduce hematometra in patients with threatened abortion due to kidney deficiency,alleviate symptoms such as lumbago,abdominal pain,and vaginal bleeding,and has no obvious influence on the hormone levels of patients.It is safer for clinical application.