Effect of Bile Acid-Flora Axis on Chronic Atrophic Gastritis with Intestinal Metaplasia from Liver and Spleen Disorders
WANG Wenxiu
WANG Yujuan
YU Lili
LI Xiuli
BAI Shijie
JIA Tianrui
Abstract：Chronic atrophic gastritis(CAG)is one of the common digestive diseases in clinical practice.Intestinal metaplasia(IM)refers to the pathological changes in which gastric mucosal epithelial cells are replaced by intestinal epithelial cells.Bile acids and intestinal flora axis maintain gastrointestinal homeostasis together,and bile acid-flora axis abnormalities are closely related to the occurrence and development of CAG with IM.Bile acid-flora axis is closely related to traditional Chinese medicine(TCM)liver and spleen function,and is the material basis for its normal function.The interaction between bile acid and intestinal flora also reflects the theory of liver and spleen correlation.Meanwhile,the dysfunction of liver and spleen is an important pathogenesis of CAG with IM.Therefore,this paper discusses the effect of bile acid-flora axis on CAG with IM based on liver and spleen disorders,in order to provide new thinking for the prevention and treatment of CAG with IM by combining TCM and western medicine.
Keywords：chronic atrophic gastritisintestinal metaplasialiver and spleen disorderbile acid metabolismintestinal florabile acids-intestinal flora axis
Publication Date：2025-04-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 405-409,415 )