Clinical Study on Herb-Partitioned Moxibustion on Navel in Treatment of Irritable Bowel Syndrome with Diarrhea Induced by Liver Depression and Spleen Deficiency

MA Fengjun; LIU Fang; ZHANG Wei; LIU Tong; LI Xinrui; MA Yuxia

doi:10.16295/j.cnki.0257-358x.2025.01.012

Abstract：Objective:To explore the clinical efficacy of herb-partitioned moxibustion on the navel in treat-ment of irritable bowel syndrome with diarrhea(IBS-D)induced by liver depression and spleen deficiency.Methods:Thirty patients with IBS-D induced by liver depression and spleen deficiency were selected and included in the herb-partitioned moxibustion on the navel group,and 30 healthy volunteers were included in the normal control group.Patients in the herb-partitioned moxibustion on the navel group received continuous treatment with herb-partitioned moxi-bustion on the navel for 2 months,while the normal control group received no intervention.The scores of the Irritable Bowel Syndrome Symptom Severity Scale(IBS-SSS)and clinical efficacy of patients in the herb-partitioned moxibustion on the navel group were observed before and after treatment,as well as the visceral sensitivity index(VSI)scale score and the levels of transient receptor potential vanilloid subtype 1(TRPV1),substance P(SP),and calcitonin gene-related peptide(CGRP)in serum of the included individuals in both groups.Results:After treatment,the score of each item and the total score of the IBS-SSS scale in the patients of the herb-partitioned moxibustion on the navel group were all lower than those before treatment,and the differences were statistically significant(P＜0.01).The total effective rate of the herb-partitioned moxibustion on the navel group was 100％.At the time of enrollment,the VSI scale score of the herb-partitioned moxibustion on the navel group was higher than that of the normal control group(P＜0.01);after treatment,the VSI scale score of the herb-partitioned moxibustion on the navel group decreased significantly compared with that at the time of enrollment(P＜0.01).At the time of enrollment,the levels of serum TRPV1,SP,and CGRP in the herb-partitioned moxibustion on the navel group were all higher than those in the normal control group(P＜0.01);after treatment,the levels of serum TRPV 1,SP,and CGRP in the herb-partitioned moxibustion on the navel group decreased significantly compared with those at the time of enrollment(P＜0.01).Conclusions:Herb-partitioned moxibustion on the navel can improve the clinical symptoms of patients with IBS-D induced by liver depression and spleen deficiency and reduce their visceral hypersensitivity.