Abstract:Objective Based on the literature data,this paper analyzes the prescription medication rules of traditional Chinese medicine in the treatment of asthma-COPD overlap syndrome,and develops new ideas for clinical treatment.Methods Traditional Chinese medicine prescriptions for asthma-COPD overlapping syndrome were searched from CNKI,Wanfang and Vip databases,and a database was established after screening and standardized treatment.Through the inheritance assistance platform(V2.5)system,the characteristics and taste,channel normalization,frequency of medication,combination of new prescriptions and drug correlation degree were analyzed,so as to explore the rules of their formulation.Results A total of 29 prescriptions were selected to meet the requirements,including 107 flavors of traditional Chinese medicine.The four qi were mainly warm,cold and flat,among which the frequency of warm drugs was the highest(49%).The five tastes were mainly sweet,bitter and spicy,and the frequency of sweet drugs was the highest,up to 32%;The meridian belongs to the lung meridian the most,which was used 218 times.The top 3 drugs were Pinellia,Tuckahoe and Glycyrrhiza.23 core drug combinations and 7 new prescriptions were obtained.Conclusion Based on the in-depth excavation of literature data,the core prescription and medication rules summarized can open up new ideas and provide new references for the clinical treatment of TCM syndrome differentiation and prescription medication.

Abstract:Kaixin Powder is a traditional Chinese medicine prescription first recorded in"Jiyan Fang",composed of Yuanzhi,Ginseng,Acorus tatarinowii,and Poria cocos.It possesses effects such as nourishing the heart and opening orifices,strengthening the spleen and calming the mind,and communicating the heart and kidney.Clinically,it is used to treat symptoms such as forgetfulness,sorrow,palpitations,fear,and timidity.Recent studies have shown that Kaixin Powder has significant effects in treating brain diseases,including Alzheimer's disease,vascular dementia,depression,anxiety,and sleep disorders.This article reviews the clinical applications and mechanisms of action of Kaixin Powder in the treatment of brain diseases,including neuroprotection,improvement of monoamine neurotransmitter systems,regulation of neurotrophic factors,modulation of the cholinergic system,melatonin system,impact on the HPA axis and activation of the PI3K signaling pathway,antioxidant stress effects,and inhibition of inflammatory factor expression.These studies provide a scientific basis for further research on Kaixin Powder in the field of brain disease treatment.Future research should expand the clinical application range of Kaixin Powder and explore its mechanisms of action in depth to optimize its clinical use and provide new insights for the treatment of brain diseases.

Abstract:The heart is the master of the five internal organs and six viscera.Professor WANG Huiwu has conducted in-depth research on the classic theory of the Yellow Emperor's Inner Canon,combined with decades of clinical practice experience,and innovatively developed the academic thought of"mind and spirit guiding the way",systematically expounding the core position and pathological mechanism of the"heart"in human health.This idea emphasizes that maintaining health requires two major conditions:"understanding"and"making the way clear".If the obstruction of the Dao is caused by insufficient innate endowment,improper postnatal care,or obstruction of evil qi,many diseases and syndromes resulting from it belong to the category of"heart disease".Professor WANG Huiwu divides"heart disease"into neurological,emotional,and bloodline diseases,advocating the principle of"communication"as the treatment principle:neurological diseases focus on"treating annoyance"and are treated based on the differentiation of deficiency heat and excess heat;emotional disorders are based on the viewpoint of"prolonged illness leads to depression"and"depression is a heart disease",emphasizing the importance of"resolving depression through communication";For blood related diseases,prevention is emphasized,and interventions are carried out based on the pathological types of chest obstruction,dizziness,stroke,etc.In clinical treatment,the concept of equal emphasis on traditional Chinese medicine and non pharmacological therapies should be upheld,and multiple pathways should be used to promote rehabilitation by unblocking the meridians.This theory has established a new framework for the diagnosis and treatment of mental illnesses,and has demonstrated unique value in both theoretical research and clinical practice.

Abstract:Percutaneous coronary intervention(PCI)effectively restores coronary blood flow and alleviates symptoms such as chest pain;however,it still carries a high risk of postoperative adverse cardiovascular events.This is primarily due to unresolved phlegm-dampness,which leads to persistent and even intensified issues of blood stasis and phlegm turbidity during the postoperative period.Current traditional Western medical methods have achieved some efficacy in treating conditions after PCI,yet the underlying etiology and pathological products remain inadequately addressed.In contrast,traditional Chinese medicine(TCM)has shown significant efficacy in managing adverse symptoms after PCI.TCM proposes a series of targeted therapeutic strategies based on its unique principle of evidence-based treatment.This article focuses on the phlegm-stasis syndrome commonly occurring in patients after PCI,analyzing the theoretical basis of TCM treatment and its practical application.

Abstract:Polycystic Ovary Syndrome(PCOS)is a common endocrine and metabolic disorder among women of reproductive age,characterized by ovulatory dysfunction,hyperandrogenism,and insulin resistance.Its pathogenesis is closely linked to genetic predisposition,environmental factors,and circadian rhythm disruption.Modern medical research indicates that PCOS has a complex and multifaceted etiology involving genetic susceptibility,environmental influences,and disturbances in biological rhythms.From the perspective of Traditional Chinese Medicine(TCM),the"Ziwu Liuzhu"(Midnight-Noon and Ebb-Flow Doctrine)theory profoundly elucidates the intrinsic connection between the body's Qi-blood circulation and the natural day-night rhythm.This theory posits that the flow of Qi and blood in the twelve primary meridians follows a cyclical pattern of waxing and waning throughout the twelve two-hour periods of the day,synchronizing with the natural rise and decline of Yin and Yang.The pathological basis of PCOS is associated with kidney essence deficiency,spleen deficiency with phlegm-dampness,and liver Qi stagnation.These pathological changes ultimately lead to dysfunction in the"Kidney-Tian Gui-Chong Ren-Uterus"reproductive axis,manifesting as typical symptoms such as menstrual irregularities and infertility.Modern molecular biology research provides scientific support for these traditional theories.Studies have confirmed that clock genes(such as BMAL1 and PER2)regulate reproductive endocrine function via the hypothalamic-pituitary-gonadal(HPG)axis.Disruptions in circadian rhythms can exacerbate glucose and lipid metabolism disorders,obesity,and hyperandrogenism in PCOS patients.

Abstract:Postmenopausal osteoporosis(PMOP)is a bone metabolism disorder caused by a decrease in estrogen levels in menopausal women,characterized by decreased bone density,microstructural damage,and increased bone fragility.Although modern medical drugs,such as hormone replacement therapy,have significant therapeutic effects in improving bone metabolism indicators,long-term use may lead to adverse reactions and higher treatment costs.Based on the traditional Chinese medicine theories of"kidney governs bone and generates marrow"and"spleen governs transportation and transformation",traditional Chinese medicine has demonstrated unique advantages in the prevention and treatment of PMOP through multidimensional strategies such as drug intervention,non drug therapy,and lifestyle management.Systematically combed the basic research mechanism and clinical application results,combined with classical theory and modern practice,the mechanism of Chinese medicine regulating bone metabolism signal pathway,acupuncture and moxibustion improving bone microenvironment,and Chinese medicine fumigation promoting local circulation was emphatically explained.Ultimately,a comprehensive intervention strategy integrating traditional Chinese medicine formulas,physical therapy,and exercise lifestyle management is proposed to provide a more comprehensive and scientific theoretical basis for the prevention and treatment of PMOP with traditional Chinese medicine.

Abstract:Colorectal cancer,as a common malignant tumor,is closely related to the imbalance of the internal and external environment of the human body in its occurrence and development.This article is based on the theory of six meridians differentiation in the classic Chinese medicine"Treatise on Cold Damage",and explores in depth the prevention and treatment strategies for colorectal cancer.From the perspective of the differentiation of the six meridians,the formation of colorectal cancer is not only related to the invasion of external pathogens and the imbalance of the internal environment caused by the transmission of the six meridians,but also closely related to pathological mechanisms such as muscle and pulse congestion,blood stasis and internal structure,as well as the generation of pathogenic heat and obstruction of organ qi.In addition,cold heat cementation and endogenous dampness are also important pathogenic factors that cannot be ignored.In treatment,emphasis should be placed on warming yang and strengthening the body to prevent the spread of diseases.At the same time,it is necessary to promote blood circulation and remove blood stasis to facilitate ventilation,clear heat and eliminate accumulation to unblock the organs and qi,and restore the balance of the body by regulating cold and heat and clearing the three burners.This prevention and treatment strategy for colorectal cancer based on the differentiation of six meridians embodies the holistic concept and characteristic of traditional Chinese medicine,and is expected to provide new treatment ideas and methods for modern medicine.

Abstract:Objective To explore the mechanism of Gancao Xiexin Tang in treating chemotherapy-induced nausea and vomiting(CINV)using traditional Chinese medicine network pharmacology methods combined with molecular docking technology.Methods The active compounds and their targets of Gancao Xiexin Tang were obtained from the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform TCMSP.Perl software was used to match the standard gene symbols corresponding to the targets in the UniProt database.CINV related disease target genes were retrieved from five databases:GeneCards,OMIM,PharmGKB,Therapeutic Target Database,and DrugBank.Using R software to screen the intersection genes between the targets of Gancao Xiexin Tang and CINV,a"drug ingredient target disease"interaction network diagram was drawn using Cytoscape 3.10.3 software.A protein-protein interaction network was constructed based on the STRING platform to perform molecular docking between key active ingredients and core targets to verify their binding activity.Gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using R 4.2.2 software.Results Based on oral bioavailability(OB)and drug likeness(DL)threshold screening,118 de duplicated active ingredients were obtained from Gancao Xiexin Tang.Gancao Xiexin Tang has 31 common targets with CINV.GO enrichment analysis showed a total of 1831 significant entries,including 1621 for biological processes,79 for cellular components,and 131 for molecular functions;KEGG pathway analysis identified 128 relevant pathways.The main active ingredients of Gancao Xiexin Tang are quercetin,β-sitosterol,baicalein,kaempferol,and hesperetin;The core targets are AKT1,IL-1 β,ICAM1,TP53,EGFR,PTGS2,BCL2,ESR1,and CTNNB1.Molecular docking showed that the active ingredient(such as quercetin)binds stably to the core target PTGS2,and its mechanism of action involves biological processes such as exogenous stimulus response,glial cell proliferation,and apoptosis.It exerts anti CINV effects by regulating signaling pathways such as PI3K-Akt,HIF-1,JAK-STAT,etc.Conclusion Gancao Xiexin Tang acts on multiple targets such as Akt1 and PTGS2 through active ingredients such as quercetin,β-sitosterol,and baicalein,regulating inflammatory response,cell apoptosis,and related signaling pathways,thereby treating nausea and vomiting after chemotherapy.

Abstract:Objective To investigate the clinical efficacy of narrow-band ultraviolet B combined with traditional Chinese medicine fumigation in the treatment of blood heat syndrome in psoriasis vulgaris,based on the combination of conventional oral Chinese medicine and external moisturizing preparations.Methods 116 patients with blood heat syndrome of psoriasis vulgaris admitted to the Dermatology Clinic of Foshan Traditional Chinese Medicine Hospital from July 2022 to July 2023 were randomly divided into three groups.There were 38 cases in the narrowband ultraviolet B(NB-UVB)treatment group(Group A),40 cases in the traditional Chinese medicine fumigation treatment group(Group B),and 38 cases in the traditional Chinese medicine fumigation combined with NB-UVB treatment group(Group C).All cases were treated with the combination of oral administration of traditional Chinese medicine Qingre Liangxue Formula and external application of our hospital's cod liver oil ointment for moisturizing.Compare the total effective rate of three treatment groups,as well as the psoriasis area and severity index(PASI)score,dermatology life quality index(DLQI)score,and squamous cell carcinoma antigen(SCCA)level before and after treatment.Results After treatment,the total effective rate of group C was higher than that of group A and group B.The PASI score,DLQI score,and serum SCCA level were all lower than those of group A and group B,and the difference was statistically significant(P<0.05).Conclusion In clinical practice,the use of traditional Chinese medicine fumigation combined with narrow-band ultraviolet radiation has a significant therapeutic effect on patients with blood heat syndrome in psoriasis vulgaris.

Abstract:Objective To investigate the clinical efficacy and safety of directional seton placement using a disposable fistula cutting and ligation device in the treatment of adenogenic ischiorectal space abscess.Methods A prospective randomized controlled study was conducted.Ninety patients with adenogenic ischiorectal space abscess admitted to The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine(Liaoning Provincial Anorectal Hospital)between July 2024 and February 2025 were selected and randomly divided into two groups based on the odd or even number of their visit numbers,with 45 patients in each group.The treatment group underwent directional seton placement using the disposable fistula cutting and ligation device,while the control group received conventional incision and seton treatment.The clinical outcomes(total effective rate),false healing rate,operation time,postoperative wound healing time,and Wexner incontinence scores were observed and compared between the two groups.Results The total effective rate was 100%(45/45)in the treatment group and 91.1%(41/45)in the control group,with no statistically significant difference(P>0.05).The false healing rate in the treatment group(4.4%)was significantly lower than that in the control group(22.2%),and the difference was statistically significant(P<0.05).The operation time in the treatment group was significantly shorter than that in the control group(P<0.05).The postoperative wound healing time in the treatment group was shorter than that in the control group,but the difference was not statistically significant(P>0.05).The postoperative Wexner incontinence score in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Directional seton placement using the disposable fistula cutting and ligation device for adenogenic ischiorectal space abscess demonstrates definite clinical efficacy while effectively preserving anal function.This method offers advantages such as convenience,minimal invasiveness,and a low false healing rate.By reducing tissue damage through minimized trauma,and lowering the false healing rate via precise lesion management and adequate drainage,it fundamentally shortens recovery time and reduces hospital stay.Furthermore,it enhances treatment efficiency by simplifying procedural steps,saving operation time for both surgeons and patients,and reducing surgical difficulty,demonstrating comprehensive advantages in clinical practice.

Abstract:Osteoporosis(OP)is a skeletal system disease that primarily affects middle-aged and elderly individuals.Its main characteristics are reduced bone density and bone destruction,which can easily lead to fractures and movement disorders.The pathogenesis of this disease is an imbalance between bone formation and bone resorption,falling under the category of"Gu Wei"(bone paralysis)in traditional Chinese medicine.The underlying mechanism can be summarized as deficiency in the spleen and kidney,blood stasis,phlegm stagnation,and qi stagnation.Data mining analysis has revealed that diuretic and dampness-resolving herbs appear frequently in effective prescriptions for treating OP.Therefore,based on the pathogenesis of osteoporosis,this article explores the significance of combining diuretic and dampness-resolving herbs.The study finds that these herbs have the following effects in treating osteoporosis:nourishing without stagnation to prevent being nourishing and greasy;replenishing deficiency and eliminating excess to enhance the treatment of paralysis;regulating both blood and water to promote diuresis and activate blood circulation;promoting diuresis and resolving phlegm to eliminate dampness and turbidity;promoting qi circulation to assist in the transformation of body fluid;and replenishing yang and promoting yang to treat both the body and mind.Additionally,this article discusses the modern pharmacological effects of diuretic and dampness-resolving herbs in treating OP,clarifying their dual efficacy of promoting bone formation and inhibiting bone resorption,thus providing a theoretical basis for the clinical application of these herbs in treating osteoporosis.

Abstract:Osteoporotic vertebral compression fracture(OVCF)and paraspinal muscle atrophy are two common spinal diseases that affect the health of elderly people.Clinical observations have found a comorbidity between paraspinal muscle atrophy and OVCF,and the two may interact and be mutually causal.Research suggests that these two diseases may have similar pathogenesis and pathological processes.There are various treatment options for OVCF,but there is currently no optimal treatment plan.Paravertebral muscle atrophy is the main manifestation of sarcopenia in the spinal region,and there is currently no effective drug treatment for sarcopenia.Traditional Chinese Medicine classifies OVCF and sarcopenia into categories such as"lower back pain","muscle weakness",and"fatigue",and has a deep understanding of their interrelationships.The phrase'disease in the spleen,Yu in the spine'succinctly summarizes the state of muscle bone comorbidity,believing that spleen kidney deficiency is its common pathological basis,spleen disease transmission to the kidneys is an important mechanism for the onset of OVCF,and tonifying the spleen and kidneys is the basic principle of treatment.

Abstract:Chronic subdural hematoma(CSDH)is a high incidence nervous system disease in the elderly.Its incidence rate increases significantly with age,and the incidence rate of people over 70 years old reaches 76.5～127.1 million.The traditional view is that CSDH is mainly caused by ruptured bridging veins due to head trauma,but about 30%to 50%of patients have no clear history of trauma,indicating that aging and related vascular degenerative diseases play a central role in the pathogenesis.According to traditional Chinese medicine theory,kidney essence is the material basis of life activities,mainly responsible for growth and development,as well as the filling of the marrow sea.During the aging process,the kidney essence gradually decreases,the qi and blood flow are insufficient,and the marrow sea is not nourished,resulting in the loss of brain collaterals,weak absorption,and blood overflowing outside the veins to form hematomas.At the same time,depletion of kidney essence can lead to qi stagnation and blood stasis,internal generation of phlegm turbidity,and further damage to collaterals,forming a vicious cycle of"deficiency stasis damage".This article is based on the theory of"essence deficiency and collateral damage"in traditional Chinese medicine,and systematically explores the impact of kidney essence deficiency and its resulting collateral damage on CSDH during the aging process.It proposes that the onset of CSDH may be the result of the combined effects of aging-related kidney essence deficiency and collateral damage.At the same time,starting from the integrated traditional Chinese medicine treatment strategy of tonifying the kidney and nourishing essence,removing blood stasis,and solidifying collaterals,a new approach has been provided for the prevention and treatment of elderly CSDH by regulating vascular homeostasis and inhibiting pathological leakage.

Abstract:The dampness that does not dissolve in the spleen and the cold that frequently affects the stomach often accumulate,leading to the development of cold dampness syndrome.The spleen and stomach are the hub for regulating the body's qi system.When cold and dampness are stagnant,the qi system becomes blocked,which in turn affects other organs and leads to complex complications.Cold dampness and qi stagnation syndrome is a common complication in the treatment of cold dampness syndrome,which is a composite disease syndrome formed by the combination of cold dampness and qi stagnation.The traditional divide and treat model often leads to poor therapeutic effects due to neglecting the interaction between the two.Professor Gu Song believes that this syndrome has both the characteristics of cold dampness causing damage to yang and cold dampness causing disease and consuming qi,as well as the inability to distribute body fluids due to the long-term mixing of cold dampness,resulting in"yin deficiency".Based on Professor Gu Song's clinical experience,the concept of"Cold Dampness Stagnation Qi Syndrome"was systematically proposed for the first time.Based on the theory of"Stagnation Qi"in the"Synopsis of Jin Kui",Li Dongyuan's warming method and the four reverse dispersing method were integrated to create the Warm Middle Flowing Qi Drink.Professor Gu Song pays attention to the diagnosis and treatment of symptoms and causes,with mutual reference between pulse and syndrome.He follows the treatment principles of pungent herbs dispersing stagnation,warming and dispelling cold,flexibly tailoring his own formula,and has repeatedly achieved good results.Through three typical medical cases,this article elaborates on the key points of syndrome differentiation,prescription and medication,as well as clinical experience,in order to provide a reference for the diagnosis and treatment of cold dampness combined with qi stagnation diseases.

Abstract:Traditional Chinese medicine refers to insomnia as"insomnia",which is a sleep disorder caused by problems with sleep time or sleep quality.Traditional Chinese medicine believes that the core pathogenesis of insomnia is"yang not entering yin",which means that the yang energy in the body is difficult to enter the yin division normally,leading to yin-yang imbalance.This article focuses on the theory of"yang does not enter yin"and explores the pathogenesis and treatment strategies of insomnia in traditional Chinese medicine.Through a comprehensive analysis of the pathogenic factors,pathological mechanisms,and traditional Chinese medicine treatment plans of insomnia,this article elaborates on the methods of syndrome differentiation and treatment of insomnia from the perspectives of disharmony between yin and yang,imbalance between yin and yang,and emotional disorders.Given the crucial role of the"yang does not enter yin"theory in the treatment of insomnia in traditional Chinese medicine,we are committed to exploring multiple perspectives of TCM insomnia treatment strategies,in order to explore new ideas for clinical treatment,improve treatment effectiveness,and effectively improve patients'sleep quality.

Abstract:Parkinson's disease(PD)is a common progressive neurodegenerative disease,characterized by motor symptoms such as reduced movement,muscle rigidity,and tremors,as well as non motor symptoms such as decreased sense of smell,sleep disorders,and cognitive impairment.It seriously affects the quality of life of patients.The complex pathogenesis of PD poses significant challenges in clinical practice,including the inability to make a clear diagnosis in the early stages and difficulty in controlling symptoms in the later stages.Furthermore,there is currently no treatment that can slow down the progression of neurodegenerative diseases.Drug development targeting the pathogenesis may become a means of preventing and treating PD.Cistanche deserticola,a plant of the Ledanceae family,is one of the precious medicinal herbs commonly used in clinical practice.Glycosides of Cistanche(GCs)are its main active ingredients,which have a wide range of pharmacological activities and exert neuroprotective effects on PD.Therefore,this article provides a systematic review of the pathogenesis of PD and the mechanism of action of GCs in preventing and treating PD,providing a theoretical basis and basis for the prevention and treatment of PD or other neurodegenerative diseases with traditional Chinese and Mongolian medicine.

Abstract:Objective Study on the regulation of lipopolysaccharide(LPS)-induced autophagy and related mechanisms in human bronchial epithelial cells(16HBE)by Yishen Chuanning Decoction.Methods The experiment was divided into 5 groups:normal group,model group,traditional Chinese medicine group,dexamethasone group,and traditional Chinese medicine+dexamethasone group.Cell counting kit-8 assay(CCK-8)was used to detect cell proliferation activity and screen for the optimal dose of Yishen Chuanning decoction;Observation of cellular damage using lactate dehydrogenase(LDH)release assay;Observation of changes in autophagosomes by transmission electron microscopy;Autophagy double labeled adenovirus experiment was used to detect changes in autophagic flux;UNEL staining was used to observe the apoptosis rate of cells;Immunofluorescence detection of cysteine dependent aspartate specific protease-1(Caspase-1)expression;Western blot was used to detect the protein expression of interleukin-1 β(IL-1β),interleukin-18(IL-18),Caspase-1,caspase-3,Beclin-1,and autophagy related protein 5(Atg-5).Results The CCK-8 experiment showed that the concentration of Yishen Chuanning decoction freeze-dried powder was 20%,and the best effect was achieved after 48 hours of cultivation.Observation by transmission electron microscopy showed that the normal group had normal cell morphology,intact cell membrane,clear mitochondrial cristae structure,and more autophagosomes;Model group,with normal mitochondrial morphology and fewer autophagosomes;The traditional Chinese medicine group showed mitochondrial shrinkage,reduced cristae,increased membrane density,and an increase in autophagosomes compared to the model group;The dexamethasone group showed mitochondrial swelling,reduced cristae,and a similar number of autophagosomes as the traditional Chinese medicine group;The group treated with traditional Chinese medicine and dexamethasone showed mitochondrial swelling,reduced cristae,and a decrease in the number of autophagosomes compared to the group treated with traditional Chinese medicine.The autophagy double labeled adenovirus experiment showed that the model group had significantly fewer yellow spots,autophagosomes,and lysosomes than the other groups,and the yellow spots were fewer than the red spots,indicating lower autophagy activity;The red and yellow spots in the traditional Chinese medicine group were reduced compared to the normal group and the traditional Chinese medicine+dexamethasone group,indicating a decrease in autophagosomes and autophagosomes.LDH and inflammatory factor detection showed that compared with the model group,the LDH leakage rate,IL-18,IL-1β,and Caspase-1 were significantly reduced in the normal group,traditional Chinese medicine group,dexamethasone group,and traditional Chinese medicine+dexamethasone group(P<0.01);The apoptosis rate,Atg-5,Beclin-1,and Caspase-3 significantly increased(P<0.01);Compared with the traditional Chinese medicine group,the LDH leakage rate in the normal group and the group treated with traditional Chinese medicine and dexamethasone was significantly reduced(P<0.01),while the apoptosis rate,Atg-5,Beclin-1,and Caspase-3 were significantly increased(P<0.01).Conclusion Yishen Chuanning Decoction can inhibit the survival rate of human bronchial airway epithelial cells,reduce cell autophagy and pyroptosis,and promote cell apoptosis.

Abstract:Diabetic kidney disease(DKD),one of the common microvascular complications of diabetes mellitus,not only seriously endangers patients'physical and mental health but also increases the societal healthcare burden.Multiple risk factors influence the occurrence and progression of DKD through different mechanisms.Among these,factors such as blood glucose,blood pressure,blood lipids,uric acid,and vitamin deficiencies are modifiable,while gender,disease duration,and age are non-modifiable.Therefore,early identification of the risk factors for DKD,implementing intensive treatment and lifestyle adjustments for modifiable factors,and paying closer attention to non-modifiable factors can effectively reduce its incidence and mortality risk.This article aims to clarify the risk factors for DKD onset and provide new insights for the prevention and treatment of the disease.

Abstract:Herpes zoster is caused by the reactivation of the varicella-zoster virus,which lies dormant in the dorsal root ganglia or cranial nerve ganglia,leading to skin and nerve damage.It is characterized primarily by pain,which is often persistent and difficult to alleviate.Integrating the"theory of latent toxins"and the"theory of collateral disease",this paper proposes that"latent toxins damaging collaterals"is the core pathogenesis of herpes zoster neuralgia."Latent toxins"originate from hidden pathogens and virulent toxins,referring to the varicella-zoster virus that remains dormant in the body and becomes activated when the body's Zhengqi(vital energy)is deficient or triggered by external factors."Collateral disease"aligns with the pattern of"chronic illness entering the collaterals",where pathogenic toxins block the fine and tortuous collaterals,leading to the mutual binding of phlegm and blood stasis.This triggers a vicious cycle of"latent toxins remaining in the collaterals,collaterals damaged,inability to expel pathogens,worsening pathogenic toxins".Based on this core pathogenesis,the fundamental treatment principles of"expelling pathogens"and"unblocking collaterals"are established.For expelling pathogens,patients with wind-toxin invasion are treated with modified Chuanxiong Chatiao San to dispel wind and detoxify,while those with heat-toxin invasion are treated with modified Huodan Fang to clear heat and activate blood circulation.For unblocking collaterals,formulas such as Taohong Siwu Tang are selected for syndromes of qi stagnation and blood stasis to promote blood circulation and remove stasis.For syndromes of qi deficiency and blood stasis,Buyang Huanwu Tang is used to tonify qi and unblock collaterals.In cases of severe pathogenic toxins,insect-based medicines such as scorpion and centipede can be added to search and eliminate toxins from the collaterals.External treatments,including surrounding acupuncture with fine needles,bloodletting puncture,and fire needle therapy,can be combined to enhance efficacy by dredging meridians and expelling pathogenic toxins.Clinical case verification has shown that the above syndrome differentiation and treatment protocol can effectively alleviate pain,promote skin lesion healing,improve sleep and emotional states,and reduce the incidence of postherpetic neuralgia(PHN).This study enriches the clinical connotation of the theory of"latent toxins damaging collaterals"and provides a systematic Traditional Chinese Medicine treatment approach for herpes zoster neuralgia,offering significant reference value for improving clinical efficacy.

Abstract:Atopic dermatitis(AD)is a skin disease characterized by chronic,recurrent,and itchy features.Chronic AD often recurs in autumn,and patients often present with symptoms such as dry skin,flaking,and severe itching.Modern medical research has shown that the pathogenesis of AD can be explored from aspects such as skin barrier disorders,immune dysfunction,and microbial imbalance.According to traditional Chinese medicine theory,dryness and evil are present throughout the course of chronic Alzheimer's disease.Therefore,the moistening dryness method is established as the basic treatment principle,and combined with methods such as nourishing qi,blood,and yin according to specific circumstances.Research has found that treating chronic AD patients with dryness theory has a definite therapeutic effect,which can effectively alleviate clinical symptoms and delay disease progression.This article reviews the research progress of traditional Chinese medicine and modern medicine in treating AD through the theory of dryness,including the explanation of the pathogenic theory of dryness,clinical treatment,and exploration of modern biological mechanisms.The aim is to reveal the scientific essence of the differentiation and treatment of AD based on dryness syndrome,and provide scientific basis for the treatment of dryness syndrome in traditional Chinese medicine.