Exploring the Relationship Between Circadian Rhythm and Polycystic Ovary Syndrome(PCOS)from the Perspective of the"Ziwu Liuzhu"(Midnight-Noon Ebb-Flow)Theory and Its Therapeutic Implications
DU Yao
ZHANG Yang
Abstract：Polycystic Ovary Syndrome(PCOS)is a common endocrine and metabolic disorder among women of reproductive age,characterized by ovulatory dysfunction,hyperandrogenism,and insulin resistance.Its pathogenesis is closely linked to genetic predisposition,environmental factors,and circadian rhythm disruption.Modern medical research indicates that PCOS has a complex and multifaceted etiology involving genetic susceptibility,environmental influences,and disturbances in biological rhythms.From the perspective of Traditional Chinese Medicine(TCM),the"Ziwu Liuzhu"(Midnight-Noon and Ebb-Flow Doctrine)theory profoundly elucidates the intrinsic connection between the body's Qi-blood circulation and the natural day-night rhythm.This theory posits that the flow of Qi and blood in the twelve primary meridians follows a cyclical pattern of waxing and waning throughout the twelve two-hour periods of the day,synchronizing with the natural rise and decline of Yin and Yang.The pathological basis of PCOS is associated with kidney essence deficiency,spleen deficiency with phlegm-dampness,and liver Qi stagnation.These pathological changes ultimately lead to dysfunction in the"Kidney-Tian Gui-Chong Ren-Uterus"reproductive axis,manifesting as typical symptoms such as menstrual irregularities and infertility.Modern molecular biology research provides scientific support for these traditional theories.Studies have confirmed that clock genes(such as BMAL1 and PER2)regulate reproductive endocrine function via the hypothalamic-pituitary-gonadal(HPG)axis.Disruptions in circadian rhythms can exacerbate glucose and lipid metabolism disorders,obesity,and hyperandrogenism in PCOS patients.
Keywords：polycystic ovary syndromecircadian rhythmZiwu Liuzhu
Publication Date：2026-01-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：5( 68-72 )