Research Progress on the Mechanism of Cistanche Glycosides in the Prevention and Treatment of Parkinson's Disease
XU Zhipeng
HUO Dongsheng
Abstract：Parkinson's disease(PD)is a common progressive neurodegenerative disease,characterized by motor symptoms such as reduced movement,muscle rigidity,and tremors,as well as non motor symptoms such as decreased sense of smell,sleep disorders,and cognitive impairment.It seriously affects the quality of life of patients.The complex pathogenesis of PD poses significant challenges in clinical practice,including the inability to make a clear diagnosis in the early stages and difficulty in controlling symptoms in the later stages.Furthermore,there is currently no treatment that can slow down the progression of neurodegenerative diseases.Drug development targeting the pathogenesis may become a means of preventing and treating PD.Cistanche deserticola,a plant of the Ledanceae family,is one of the precious medicinal herbs commonly used in clinical practice.Glycosides of Cistanche(GCs)are its main active ingredients,which have a wide range of pharmacological activities and exert neuroprotective effects on PD.Therefore,this article provides a systematic review of the pathogenesis of PD and the mechanism of action of GCs in preventing and treating PD,providing a theoretical basis and basis for the prevention and treatment of PD or other neurodegenerative diseases with traditional Chinese and Mongolian medicine.
Keywords：glycosides of cistancheParkinson's diseasepathogenesis
Publication Date：2025-11-20
Online Publishing Date：2026-07-17(First online date of this platform, not the publication date of the document)
Pages：6( 86-91 )