Abstract:A case of morphea-like basal cell carcinoma is reported.A 37-year-old female pres-ented with a skin-colored,hard plaque on the medial side of her left eyelid,persisting for one year.Dermatological examination revealed a 3 cm×2 cm skin-colored plaque on the medial side of the left eyelid.The surface was smooth and felt firm upon palpation.Additionally,a 1 cm×1.5 cm reddish plaque was noted locally,exhibiting capillary dilation on the surface without ten-derness to palpation.Histopathology of the lesion revealed multiple tumor masses within the der-mis,composed of basophilic basaloid cells arranged in cord-like structures.The surrounding cells exhibited a palisading arrangement,accompanied by clefting artifacts.Proliferation of collagen fi-bers was evident in the interstitial spaces around the tumors.The diagnosis of morphea-like basal cell carcinoma was established.The patient＇s lesion was surgically excised.The patient recovered well after surgery and is currently under follow-up.

Abstract:Objective To investigate the therapeutic effects and mechanisms of blue light com-bined with gel for skin photoaging in mice.Methods Twenty-five male C57/BL6 mice were ran-domly divided into five groups:blank control,model,blue light,gel,and blue light+gel(com-bination)groups,with five mice per group.Except for the blank control group,a UVA and UVB synergistic irradiation method was used to establish a photoaging model.Mice were irradiated with 1 minimal erythema dose(MED)from week 1 to week 4,followed by 2 MEDs in weeks 5 and 6.Concurrently,starting from the third week,blue light combined with gel therapy was administered on the last day of each week.The control group received no treatment.The gel group received on-ly gel treatment for 6 minutes.The blue light group received only blue light irradiation for 6 mi-nutes.The combined group received gel treatment,followed immediately by blue light therapy.After 6 weeks,dorsal skin samples were collected for hematoxylin and eosin(HE),and Masson＇s trichrome staining.Both cutaneous and serum levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and tumor necrosis factor(TNF-α)were measured using ELISA.Results After 6 weeks:The mouse skin exhibited desquamation,dryness,roughness,lesions,leathery texture,and hyperpigmentation.Either the blue light or gel group showed no significant improve-ments in skin desquamation,dryness,roughness,or leathery texture compared with the model group.Moreover,expression levels of SOD,GSH-Px,and collagen were not significantly upregu-lated compared with the model group(P＞0.05).However,the combined group showed signifi-cant improvement in wrinkles,dryness,desquamation,and leathery texture.The expression levels of SOD and GSH-Px in the skin were significantly upregulated to levels comparable to normal(P＜0.05),accompanied by a significant increase in collagen(P＜0.001).TNF-αexpression in the skin,as well as the serum levels of SOD,GSH-Px,and TNF-α,remained no significant change(P＞0.05).Conclusions Blue light combined with gel can alleviate oxidation,reduce inflammation,and increase collagen in photoaged skin,providing experimental evidence for its clinical application in photoaging management.

Abstract:We report two cases of misdiagnosed subungual squamous cell carcinoma(SSCC).Case 1:A 50-year-old man presented with recurrent swelling and purulent discharge under the left middle fingernail for two years.The patient had been diagnosed with paronychia and pyogenic granuloma.Dermatological examination revealed a red,nodular,granulomatous lesion under the left middle fingernail,approximately 0.5 cm×0.3 cm×0.3 cm in size,with well-defined bor-ders.A partial nail unit excision was performed,and postoperative histopathology showed multiple tumor cell clusters in the dermis that were connected to the epidermis,accompanied by the forma-tion of squamous eddies and horn pearls.The tumor cells exhibited marked atypia and disordered arrangement.The diagnosis was subungual squamous cell carcinoma.Case 2:A 66-year-old woman presented with a painful subungual nodule on the left index finger for several months.She had been diagnosed with verruca vulgaris and subungual fibroma.Dermatological examination showed a red,soybean-sized nodule under the left index fingernail that protruded from the nail plate and the fingertip,with a rough and crusted surface.A partial nail unit excision was per-formed,and postoperative histopathology showed atypical tumor cell clusters connected to the epi-dermis,with the presence of mitosis and dyskeratosis.Postoperative diagnosis:Subungual squa-mous cell carcinoma.Both patients have been followed up after surgical excision and have not shown any signs of recurrence to date.

Abstract:Objective To elucidate the anti-inflammatory effects and underlying molecular mechanisms of recombinant ANKRD22 protein in dendritic cells,and to assess its therapeutic effi-cacy in mitigating the progression of psoriasis.Methods In vitro,mouse bone marrow cells isola-ted from femurs and tibias were induced into mature bone marrow-derived dendritic cells(BMDC)using GM-CSF.The BMDC were divided into four groups:PBS,IMQ,PBS+recombinant ANKRD22,and IMQ+recombinant ANKRD22.Each group was treated accordingly with PBS,IMQ,or recombinant ANKRD22 protein for 24 h.Quantitative reverse transcription PCR(qRT-PCR)was used to measure the expression levels of mRNA for IL23a,IL1 b,and ANKRD22,while Western blot was performed to detect the protein levels of key members of the noncanonical NF-κB signaling pathway.In vivo,an IMQ-induced mouse model of psoriasis was established(n=10)and divided into a PBS control group(n=5)and a recombinant ANKRD22 group(n=5).The changes in body weight and PASI scores were recorded daily.Histological changes and acanthosis area were evaluated by hematoxylin and eosin(H&E)staining.Flow cytometry was used to determine the proportions of neutrophils,Th17,and γδT17 cells,and qRT-PCR was used to quantify the expression levels of mRNA for IL1 b,IL23a,IL17a,IL17f,IL6 and TNF-α in the skin.Results In vitro,compared with the PBS group,expression levels of IL23a,IL1 b and ANKRD22 mRNA in the IMQ group significantly increased to 1.97±0.33(P=0.007),1.80±0.32(P=0.014)and 2.34±0.52(P=0.014)fold,accompanied by enhanced NIK accumulation and downstream p52/RelB nuclear translocation.In contrast,compared with the IMQ group,IL23a expression in the IMQ+recombinant ANKRD22 group was significantly reduced,from 1.97±0.33 to 1.17±0.19-fold(P=0.023),without significant differences in the expression levels of IL1 b and ANKRD22 mRNA.Concurrently,NIK accumulation and downstream p52/RelB nuclear translocation were markedly attenuated.In vivo,recombinant ANKRD22 significantly alle-viated psoriasis-like symptoms.On day 5,the PASI score was significantly lower in the recombi-nant ANKRD22 group than in the PBS group(6.10±0.65 vs.7.80±0.83,P=0.007),acan-thosis area was reduced from 0.08±0.01 to 0.04±0.01 mm2(P=0.001),and splenomegaly was mitigated with an increased body weight(20.24±0.51 g vs.19.06±0.45 g,P=0.005).The proportions of neutrophils,Th17,and γδT17 cells in the skin decreased from(21.00±3.07)%,(38.16±3.66)%,and(9.74±3.02)%to(6.48±1.96)%(P=0.001),(24.48±3.37)%(P=0.001),(6.42±1.55)%(P=0.030),respectively.The expression levels of mRNA for IL1 b,IL23a,IL17a,IL17f,IL6 and TNF-α in the skin were also reduced from(32.67±17.34)%to(67.37±25.43)%.Conclusions Recombinant ANKRD22 protein sup-presses IL-23 production by selectively inhibiting the noncanonical NF-κB signaling pathway in dendritic cells,thereby blocking the IL-23-Th17/γδT17 immune axis,promoting inflammatory resolution,and effectively ameliorating psoriasis progression.

Abstract:Objective To synthesize current evidence on wound management in patients with pemphigus,providing an evidence-based foundation for clinical nursing practice.Methods Ac-cording to the"6S"pyramid model,a systematic search of domestic and international databases,as well as relevant websites,was conducted for literature published from inception to April 2025 on wound management in patients with pemphigus.Following the assessment of the retrieved stud-ies,the content from eligible studies that met the quality standards based on the themes was ex-tracted and synthesized to form an evidence summary for wound management in patients with pem-phigus.Results A total of 15 studies were included,comprising 3 clinical decision aids,5 guidelines,2 systematic reviews,2 expert consensuses,and 3 randomized controlled trials.Thir-ty-four evidence statements were derived across five domains:wound assessment,wound cleansing techniques,management of bullae and erosion,selection and application of dressings,and nutri-tional support.Conclusions The evidence-based medical evidence integrated in this study can provide scientific reference for clinical healthcare professionals in developing wound management strategies for patients with pemphigus.

Abstract:Specialized pro-resolving mediators(SPMs)are endogenous lipid molecules that are biosynthesized from ω-3/ω-6 polyunsaturated fatty acids via key enzymes such as lipoxygenases and cyclooxygenases.By targeting specific receptors on the surfaces of immune cells,SPMs pre-cisely regulate inflammation resolution and play a crucial role in maintaining skin homeostasis.This review delineates the dynamic changes and regulatory roles of SPMs in various physiological and pathological processes,including psoriasis,atopic dermatitis,skin wound healing,and skin aging.Specifically,certain SPMs,such as RvD5 and PDx,are detectable in psoriatic lesions,while an imbalance between pro-inflammatory mediators and SPMs is observed in the skin of pa-tients with atopic dermatitis.During skin wound healing,the content of the resolvin D series in-creases,promoting inflammation resolution and tissue repair.In the process of skin aging,the downstream metabolism of EPA/DHA in aged skin fails to effectively produce active SPMs,lead-ing to a decline in the skin's ability to resolve inflammation.Furthermore,this article elucidates the role of SPMs in alleviating skin inflammatory symptoms such as pain,pruritus,edema,and er-ythema through mechanisms that include regulating transient receptor potential(TRP)channels,inhibiting the release of pro-inflammatory factors,and modulating vascular permeability.It pro-vides a theoretical basis for the clinical application of novel skin anti-inflammatory strategies based on SPMs or their analogs.

Abstract:Objective To assess the efficacy and safety of apremilast in the treatment of plaque psoriasis.Methods Fifty patients with plaque psoriasis were enrolled and categorized into mild,moderate,and severe groups based on disease severity.They received 12 weeks of treatment with apremilast.The psoriasis area and severity index(PASI)scores,as well as PASI50,PA-SI75,and PASI90,were recorded at weeks 0,4,8,and 12.Additionally,the incidence and se-verity of adverse events were recorded.Results Fifty patients included 12 mild cases,33 moder-ate cases,and 5 severe cases.At weeks 4,8,and 12,the PASI scores for mild(0.60±0.40,0.34±0.29,0.27±0.26),moderate(2.43±1.17,1.55±0.94,1.06±0.83),and severe(7.04±0.94,5.26±1.48,4.18±1.55)groups significantly decreased from baseline.The PA-SI50,PASI75,and PASI90 were highest in the mild group(PASI50:75%,100%,100%;PA-SI75:42%,75%,75%;PASI90:0,17%,50%),while they were lowest in the severe group.Fifty-six percent of patients reported at least one adverse event during the 12-week period,with the most common being diarrhea(30%),nausea(12%),and muscle pain(6%).Few patients ex-perienced depression,headache,stomachache,or toothache.No serious adverse events occurred.Conclusions Apremilast demonstrates good efficacy for mild to moderate plaque psoriasis.Diar-rhea is the most commonly reported adverse event and is generally well tolerated.

Abstract:Objective To analyze the epidemic trend and population distribution characteris-tics of syphilis in the Zhongshan City of Guangdong Province,so as to provide a scientific basis for formulating targeted prevention and control strategies.Methods Based on the data from the Na-tional Notifiable Infectious Diseases Reporting System between 2015 and 2024,the reported inci-dence rates of syphilis were stratified and organized by year,stage,gender,and age group.The Joinpoint regression model was used to analyze the annual percentage change(APC)and trend in-flection points.Results From 2015 to 2024,the reported incidence rate of syphilis decreased from 61.0 per 100,000 population to 56.7 per 100,000 population(AAPC=-2.2%,P=0.581),showing a continuous downward trend.Primary and secondary syphilis decreased by 83.8%and 35.1%,respectively,while latent syphilis increased by 22.0%,contrary to the trend(from 41.4 per 100,000 to 50.5 per 100,000),accounting for as much as 89.1%.The inci-dence rates decreased simultaneously in both genders,and the reported incidence rate among peo-ple aged 60 and above was significantly higher than that in other age groups.Conclusions The prevalence of syphilis in Zhongshan City,Guangdong Province,shows an overall controlled and slightly declining trend,while there is a notable increase in the number of asymptomatic carriers and a high incidence among the elderly aged 60 and above.This indicates the need to improve the three-level prevention and control system,strengthen monitoring and early intervention manage-ment for asymptomatic carriers,and curb hidden transmission.It is essential to focus on women and youth,promote knowledge about sexually transmitted disease prevention and control,and en-hance the risk awareness of key populations.Additionally,it is important to optimize and innovate prevention and control strategies for the elderly,develop accessible popular science materials tai-lored to older adults,strengthen health education,and increase public risk awareness and protec-tive capabilities accordingly.

Abstract:We report a case of kerion celsi caused by Microsporum canis in a child.A 2-year-old girl presented with multiple pustules,edematous plaques,scalp alopecia,and pustular scabs for more than 1 month.The fungal microscopic examination was positive.Fungal culture of the broken hair showed positive results for Microsporum canis.Molecular biology identified the fungus Microsporum canis,and the Brucella tube condensation test was positive++(1∶400).Diagnosis:①Kerion Celsi caused by Microsporum canis;②Brucellosis.After 8-week treatments with oral Griseofulvin combined with Compound Glycyrrhizin tablets,supplemented with ozone water rinses and standardized topical antifungal medication,the tinea capitis resolved,and follow-up tests showed negative fungal cultures.During six-month follow-up,there were no recurrences,and hair regrowth was satisfactory.The patient is currently continuing oral Mongolian medicine treatment for brucellosis.

Abstract:Objective To evaluate the awareness of the HPV vaccine among healthcare work-ers(HCWs)in dermatology(STD),infectious diseases,and related departments,their attitudes toward male vaccination and recommendation willingness,and to identify associated determinants.Methods This survey was conducted in Guangzhou and Shenzhen from October to November 2024.Electronic questionnaires were distributed via"questionnaire star"to HCWs in dermatology(STD),infectious diseases,and related departments.The instrument comprised three modules:(1)sociodemographic characteristics;(2)knowledge,attitudes,and behaviors regarding HPV and HPV vaccination;and(3)the current status of recommending HPV vaccination for males and willingness to recommend it.Results A total of 94 valid questionnaires were collected,primarily from doctors in infectious diseases and dermatology-STD departments at public hospitals(72.34%).Overall,HCWs demonstrated high awareness of HPV and the HPV vaccine,with the vast majority(91.49%)believing that males should be vaccinated.The HPV vaccination rate a-mong female HCWs was 56.25%(36/64),with a higher rate(65.38%,34/52)in those under 45 years old.No male HCWs had received the HPV vaccine.Most HCWs were willing to recom-mend the HPV vaccine to their partners(88.30%),children(87.23%),friends(92.55%),and male patients(95.74%).67.02%of the HCWs had recommended the HPV vaccine to male patients,with high patient acceptance(76.19%).82.98%of the HCWs had received HPV vac-cine-related inquiries,and 92.55%believed their knowledge could benefit patients.Conclusions HCWs among dermatology and infectious diseases have a relatively high awareness of HPV and its vaccines.They also show a strong willingness to recommend the HPV vaccine for males.How-ever,the vaccination rate among themselves still needs improvement.There is a need to enhance health education specifically aimed at increasing awareness of the necessity and importance of HPV vaccination for males,in order to improve the vaccination rate among this group.

Abstract:We present a case of cutaneous metastatic carcinoma that was initially misdiagnosed as herpes zoster.A 74-year-old male experienced painful erythemas,papules,and nodules on the right thoracic and dorsal regions for over two months.He had a history of small cell lung cancer with multiple lymph node metastases for more than two years.Prior to this visit,he had been re-ceiving anti-tumor treatment with adibelimab and docetaxel.Dermatological examination showed a band-like distribution of erythemas,papules,and nodules on the right chest and back.The le-sions appeared pale red to pink,smooth,and firm in texture,with some resembling a"pseudobul-lous"appearance.Histopathological examination of the skin lesion showed atypical cell infiltration in the subcutaneous fibrous stroma.Immunohistochemistry demonstrated CK(+)and P40(+).Diagnosis:Metastatic cutaneous squamous cell carcinoma(T4N3M1 Stage Ⅳ).The oncology de-partment administered IMRT radiotherapy to the thoracic and dorsal skin areas,at a dose of 60Gy/30f.A comprehensive assessment of the patient's multiple pulmonary metastases indicated end-stage cancer.Despite aggressive treatment,the disease was poorly controlled,leading to death.

Abstract:Objective To evaluate the clinical efficacy and safety of intralesional injection of heparin sodium versus carbon dioxide(CO2)laser ablation in the treatment of xanthelasma palpe-brarum.Methods A total of 38 patients with Grade Ⅰ-Ⅲ xanthelasma and normal blood lipid levels were retrospectively enrolled,and divided into two groups based on the treatment modality:the heparin sodium group(n=20)treated with intralesional injection of heparin sodium and the CO2 laser group(n=18)treated with CO2 laser ablation.The primary and secondary outcomes were compared between the two groups,including the therapeutic effect at 1 week post-treatment,the recurrence rate at 3 months,the incidence of adverse events during treatment and follow-up,and patient satisfaction.Results There was no significant difference in the overall therapeutic effect between the two groups(P=0.107).All patients in the CO2 laser group achieved excellent response(100%),while 80.00%of patients in the heparin sodium group achieved excellent re-sponse,and 20.00%achieved good response.Regarding patient satisfaction,the satisfaction rate was higher in the heparin sodium group than in the CO2 laser group(100%vs.83.33%,P=0.023).For adverse events,the incidence of scar formation(72.22%)and hypopigmentation(33.33%)in the CO2 laser group was significantly higher than that in the heparin sodium group(both P＜0.01).In contrast,the incidence of hyperpigmentation in the heparin sodium group was higher than that in the CO2 laser group(60.00%vs.5.56%,P＜0.001),and most cases of hyperpigmentation spontaneously resolved or improved within 6 months.No statistically significant difference was observed in the recurrence rates between the two groups(P=0.663).Conclusions Intralesional injection of heparin sodium for xanthelasma offers comprehensive advantages,in-cluding"definite efficacy,no risk of scarring,and high treatment satisfaction,"making it a po-tentially viable alternative for treating xanthelasma.

Abstract:Acne is a common chronic,inflammatory disease of the pilosebaceous glands.Its pathogenesis is complex and affected by many factors.In recent years,the research on the patho-genesis of acne has been deepened.As a pleiotropic growth factor,insulin-like growth factor-1(IGF-1)plays an important role in the pathogenesis of acne.Studies have shown that IGF-1 can promote the proliferation and lipid synthesis of sebaceous gland cells by activating PI3K/Akt/mTORC1 signaling pathway,while also increasing androgen receptor sensitivity and aggravating se-baceous hypersecretion.This article reviews the current research progress on the role of IGF-1-me-diated inflammation in the pathogenesis of acne.

Abstract:Vitiligo is a common depigmenting skin disorder with a complex pathogenesis,pri-marily resulting from the destruction,death,or dysfunction of melanocytes.In recent years,fer-roptosis,a novel iron-dependent form of cell death driven by lipid peroxidation,has been recog-nized as playing a significant role in the onset and progression of vitiligo.Factors such as iron ho-meostasis imbalance,lipid peroxidation accumulation,weakened antioxidant defenses,and activa-tion of immune inflammation collectively contribute to melanocyte damage.This review systemati-cally examines the physiological processes of iron metabolism,explores the molecular mechanisms of ferroptosis in melanocyte injury and its role in vitiligo pathogenesis,and summarizes potential therapeutic targets and drug interventions related to ferroptosis.An in-depth exploration of the in-teractions between ferroptosis and immune regulation provides novel insights and a strong theoreti-cal foundation for the precise prevention and treatment of vitiligo.

Abstract:Objective To explore the clinical application value of the"double-kite"flap for re-constructing lip skin defects.Methods A retrospective analysis was conducted on 20 patients who underwent excision of benign lip tumors at the Dermatology Hospital of Southern Medical Universi-ty from June 2024 to January 2025.Vancouver Scar Scale(VSS)scores were used to evaluate scar outcomes at 6 months post-operation,while healing pattern,postoperative complications,aes-thetic matching,texture and function were also recorded.Results Ten patients(Group A)re-ceived reconstruction with the"double-kite"flap,and ten patients(Group B)underwent conven-tional tension-reducing suturing.The median VSS score in Group A was significantly lower than that in Group B[0.5(1.0)vs.4.0(2.0),U=6.0,P＜0.001].In Group A,9 patients a-chieved primary healing,and 1 had secondary healing with mild hypertrophic scarring.In Group B,9 patients achieved primary healing,and 1 developed infection-related secondary healing,with a higher incidence of widened or hypertrophic scars.Group A showed better aesthetic matc-hing,texture,and functional recovery than Group B.No severe complications occurred in either group.Conclusions The"double-kite"flap makes full use of the"cat-ear"tissue formed during excision,significantly reducing suture tension and improving the appearance and texture of the scar.It also provides reliable blood supply and fewer complications,making it a safe and effective option for repairing lip defects.

Abstract:We report a case of pediatric Kimura's disease complicated by atopic dermatitis treated with dupilumab.An 11-year-old boy presented with a three-year history of a left facial mass that recurred more than a year after surgery.He also had a four-year history of"eczema".Dermatological examination revealed a subcutaneous,oval-shaped mass on the parotid region of the left face,measuring approximately 55 mm × 50 mm in size.Generalized red papules and scratches with post-inflammatory hyperpigmentation were present on the trunk and limbs.Ancillary examina-tions showed elevated levels of serum immunoglobulin E(IgE)and an increased percentage of eo-sinophils.Histopathological examination of the skin demonstrated either diffuse or nodular infiltra-tion of numerous lymphocytes and eosinophils in the deep dermis and subcutaneous adipose tissue.Focal eosinophilic micro-abscesses and multiple lymphoid follicle formations,with collagen and fi-broblast proliferation were observed between the lymphoid follicles.Diagnoses:① Kimura's dis-ease,② Atopic dermatitis.The patient was treated with an initial dose of 400 mg of dupilumab,followed by 200 mg every two weeks.At the four-month follow-up,the child's tumor had signifi-cantly decreased in size.The serum immunoglobulin IgE levels and the percentage of eosinophils also decreased.The child is currently still under follow-up.

Abstract:Objective To evaluate the training effectiveness of the dermatology course in the Guangdong Province Assistant General Practitioner Teacher Training Program based on the feed-back from participants,assess participants' needs for future courses,summarize training experi-ences,and provide a foundation for developing assistant general practitioner training and accelera-ting the construction of the general practitioner teaching team.Methods From January to Decem-ber 2024,the cluster sampling method was employed to conduct a questionnaire survey of the trai-nees participating in the 2024 Guangdong Province Assistant General Practitioner Teacher Training Program.The questionnaire included sections on the trainees' basic information,their perceived benefits of the courses for future teaching,satisfaction with the training course schedule,course design,assessment content and methods,overall satisfaction with the teacher training program,and their needs for future courses.Results A total of 169 questionnaires were distributed,with 159 valid responses collected,yielding a valid response rate of 94.08％.Regarding overall satis-faction with the training program,73.58％of trainees were very satisfied,while 26.42％were generally satisfied.Moreover,95.60％of the trainees believed that the courses related to skin dis-eases would be very helpful for their future teaching roles.In terms of the schedule for the training program,66.04％of participants were very satisfied,with only 1.88％expressing dissatisfaction due to the perception that the course schedule was too tight and that the duration of the courses was insufficient.In terms of course design,99.37％of participants reported being very satisfied.Re-garding the assessment content and methods,98.74％of participants were very satisfied;only 1.26％found the assessment content to be overly challenging or the format to be unengaging.When asked about desired future courses,86.79％of participants expressed interest in dermatolo-gy outpatient scenario-based teaching,57.23％in courses on new media and online teaching tech-nologies,and 54.72％in narrative medicine.Additionally,some participants hoped for courses on interpreting the latest guidelines(27.04％),the general practice concept in dermatology teach-ing(18.24％),PBL(Problem-Based Learning)course design(13.21％),and the integration of ideological and political elements in teaching activities(11.95％).Conclusions The Assistant General Practitioner Teacher Training Program in Guangdong Province is well-organized,with a reasonable course design and practical content.Participants have reported significant benefits from the training.The program's courses related to dermatology have received high satisfaction ratings and achieved good training outcomes.This provides valuable experiences and references for the development of the general practitioner teaching workforce.

Abstract:Objective To construct a combination model integrating seasonal autoregressive integrated moving average(SARIMA)and generalized regression neural network(GRNN)to pro-vide a new methodological approach for predicting the incidence trend of syphilis in Jiangsu Prov-ince.Methods Monthly syphilis incidence data from Jiangsu Province from January 2005 to De-cember 2019 were used to establish SARIMA and SARIMA-GRNN combined models,with a com-parative analysis of their fitting accuracy and predictive performance.Results The optimal SARI-MA model parameters were SARIMA(0,1,1)(0,1,1)12,and the best smoothing parameter(spread)for the SARIMA-GRNN combined model was 0.11.In the prediction of syphilis inci-dence in 2019,the root mean square errors(RMSE)for the SARIMA model and the SARIMA-GRNN combination model were 0.336 and 0.287,respectively,while the mean absolute percent-age errors(MAPE)were 10.43％and 8.83％,respectively.And the mean absolute errors(MAE)were 0.278 and 0.245,respectively.Compared to the SARIMA model,the SARIMA-GRNN combination model reduced the RMSE by 14.58％,the MAPE by 15.33％,and the MAE by 11.87％,indicating that the SARIMA-GRNN combination model outperformed the SARIMA model in prediction accuracy.Conclusions The SARIMA-GRNN combination model is more pre-cise than the SARIMA model in fitting monthly syphilis incidence data in Jiangsu Province and has higher prediction accuracy,making it suitable for predicting syphilis incidence in this province.

Abstract:The invasion of Treponema pallidum can affect multiple structures of the eyes,thereby leading to the development of ocular syphilis.The pathogenesis of ocular syphilis is closely related to the activity of mucopolysaccharide enzymes on the surface of Treponema pallidum.The clinical manifestations are complex and diverse,and often lack specificity.It may present as con-junctivitis,keratitis,uveitis,optic neuritis,etc.Diagnostic methods include ophthalmic function-al examinations,ophthalmic morphological examinations,ophthalmic imaging studies,and labora-tory tests.Treatment primarily relies on the use of antibiotics,and corticosteroids may occasionally be added.There is a close connection between ocular syphilis and neurosyphilis,and in cases of co-infection with HIV,the prognosis of patients is usually poor.This article reviews the progress in the diagnosis and treatment of ocular syphilis,providing reference for clinical diagnosis and treatment.

Abstract:Objective To observe the clinical efficacy of glycolic acid combined with skin bar-rier function repair in patients with facial melasma.Methods Sixty-four patients with facial melasma treated at the Department of Dermatology,Yantian District People's Hospital,Shenzhen from January 2024 to June 2024 were randomly divided into two groups(32 patients per group).The control group was treated with glycolic acid once every four weeks.The treatment group re-ceived a combined therapy of glycolic acid and skin barrier function repair,with glycolic acid treatment once every 4 weeks and desensitization treatment once every two weeks.After 16 weeks of treatment,the changes in the melasma area and severity index(MASI)scores were evaluated,and the effective rate and patient satisfaction were compared between the two groups.Results Af-ter 16 weeks of treatment,the MASI score in both groups was decreased,with a more prominent decrease in the treatment group(P=0.035 vs.the control group).The effective rate in the treat-ment group was higher than that in the control group(87.50％vs.71.88％,P＜0.05),and pa-tient satisfaction rate was also higher in the treatment group than in the control group(87.50％vs.75.00％,P＜0.05).Conclusion The combination of skin barrier function repair and glycolic acid has a good therapeutic effect on melasma,along with a higher patient satisfaction rate.