Research progress on the role of insulin-like growth factor 1 in the pathogenesis of acne
YANG Yuying
FANG Yali
LI Yuan
Abstract：Acne is a common chronic,inflammatory disease of the pilosebaceous glands.Its pathogenesis is complex and affected by many factors.In recent years,the research on the patho-genesis of acne has been deepened.As a pleiotropic growth factor,insulin-like growth factor-1(IGF-1)plays an important role in the pathogenesis of acne.Studies have shown that IGF-1 can promote the proliferation and lipid synthesis of sebaceous gland cells by activating PI3K/Akt/mTORC1 signaling pathway,while also increasing androgen receptor sensitivity and aggravating se-baceous hypersecretion.This article reviews the current research progress on the role of IGF-1-me-diated inflammation in the pathogenesis of acne.
Keywords：acneinsulin-like growth factor-1pathogenesisresearch progress
Publication Date：2025-12-28
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 894-899 )