Research progress on the role of ferroptosis in the pathogenesis of vitiligo
ZHUO Xiujuan
HUANG Xiuyun
SHI Xiaowei
LIU Han
ZHANG Jialin
FENG Jinlian
Abstract：Vitiligo is a common depigmenting skin disorder with a complex pathogenesis,pri-marily resulting from the destruction,death,or dysfunction of melanocytes.In recent years,fer-roptosis,a novel iron-dependent form of cell death driven by lipid peroxidation,has been recog-nized as playing a significant role in the onset and progression of vitiligo.Factors such as iron ho-meostasis imbalance,lipid peroxidation accumulation,weakened antioxidant defenses,and activa-tion of immune inflammation collectively contribute to melanocyte damage.This review systemati-cally examines the physiological processes of iron metabolism,explores the molecular mechanisms of ferroptosis in melanocyte injury and its role in vitiligo pathogenesis,and summarizes potential therapeutic targets and drug interventions related to ferroptosis.An in-depth exploration of the in-teractions between ferroptosis and immune regulation provides novel insights and a strong theoreti-cal foundation for the precise prevention and treatment of vitiligo.
Keywords：vitiligoferroptosisiron metabolismimmune regulationmelanocytes
Publication Date：2025-12-28
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：10( 900-909 )