The role of specialized pro-resolving mediators in skin inflammation
WANG Yuying
LIN Simin
WANG Xiaoying
WEI Yun
WANG Fuming
XIAO Yue
HUANG Hu
WANG Jing
Abstract：Specialized pro-resolving mediators(SPMs)are endogenous lipid molecules that are biosynthesized from ω-3/ω-6 polyunsaturated fatty acids via key enzymes such as lipoxygenases and cyclooxygenases.By targeting specific receptors on the surfaces of immune cells,SPMs pre-cisely regulate inflammation resolution and play a crucial role in maintaining skin homeostasis.This review delineates the dynamic changes and regulatory roles of SPMs in various physiological and pathological processes,including psoriasis,atopic dermatitis,skin wound healing,and skin aging.Specifically,certain SPMs,such as RvD5 and PDx,are detectable in psoriatic lesions,while an imbalance between pro-inflammatory mediators and SPMs is observed in the skin of pa-tients with atopic dermatitis.During skin wound healing,the content of the resolvin D series in-creases,promoting inflammation resolution and tissue repair.In the process of skin aging,the downstream metabolism of EPA/DHA in aged skin fails to effectively produce active SPMs,lead-ing to a decline in the skin's ability to resolve inflammation.Furthermore,this article elucidates the role of SPMs in alleviating skin inflammatory symptoms such as pain,pruritus,edema,and er-ythema through mechanisms that include regulating transient receptor potential(TRP)channels,inhibiting the release of pro-inflammatory factors,and modulating vascular permeability.It pro-vides a theoretical basis for the clinical application of novel skin anti-inflammatory strategies based on SPMs or their analogs.
Keywords：specialized pro-resolving mediatorsskin inflammationskin homeostasis
Publication Date：2025-12-28
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 910-915 )