Progress in the diagnosis and treatment of ocular syphilis
XU Yating
LI Shanshan
XU Yuxuan
DAI Jun
HE Fanghua
LI Jingjing
WU Minzhi
JIAO Qingqing
Abstract：The invasion of Treponema pallidum can affect multiple structures of the eyes,thereby leading to the development of ocular syphilis.The pathogenesis of ocular syphilis is closely related to the activity of mucopolysaccharide enzymes on the surface of Treponema pallidum.The clinical manifestations are complex and diverse,and often lack specificity.It may present as con-junctivitis,keratitis,uveitis,optic neuritis,etc.Diagnostic methods include ophthalmic function-al examinations,ophthalmic morphological examinations,ophthalmic imaging studies,and labora-tory tests.Treatment primarily relies on the use of antibiotics,and corticosteroids may occasionally be added.There is a close connection between ocular syphilis and neurosyphilis,and in cases of co-infection with HIV,the prognosis of patients is usually poor.This article reviews the progress in the diagnosis and treatment of ocular syphilis,providing reference for clinical diagnosis and treatment.
Keywords：ocular syphilisneurosyphilisinterstitial keratitisuveitis
Publication Date：2025-11-28
Online Publishing Date：2025-12-29(First online date of this platform, not the publication date of the document)
Pages：9( 821-829 )