Comparison of efficacy and safety between intralesional injection of heparin sodium and CO2 laser ablation in the treatment of xanthelasma
JI Liyue
QIU Xiaonan
WANG Xijuan
ZHAN Kui
ZHANG Yixin
ZHANG Jing
Abstract：Objective To evaluate the clinical efficacy and safety of intralesional injection of heparin sodium versus carbon dioxide(CO2)laser ablation in the treatment of xanthelasma palpe-brarum.Methods A total of 38 patients with Grade Ⅰ-Ⅲ xanthelasma and normal blood lipid levels were retrospectively enrolled,and divided into two groups based on the treatment modality:the heparin sodium group(n=20)treated with intralesional injection of heparin sodium and the CO2 laser group(n=18)treated with CO2 laser ablation.The primary and secondary outcomes were compared between the two groups,including the therapeutic effect at 1 week post-treatment,the recurrence rate at 3 months,the incidence of adverse events during treatment and follow-up,and patient satisfaction.Results There was no significant difference in the overall therapeutic effect between the two groups(P=0.107).All patients in the CO2 laser group achieved excellent response(100%),while 80.00%of patients in the heparin sodium group achieved excellent re-sponse,and 20.00%achieved good response.Regarding patient satisfaction,the satisfaction rate was higher in the heparin sodium group than in the CO2 laser group(100%vs.83.33%,P=0.023).For adverse events,the incidence of scar formation(72.22%)and hypopigmentation(33.33%)in the CO2 laser group was significantly higher than that in the heparin sodium group(both P＜0.01).In contrast,the incidence of hyperpigmentation in the heparin sodium group was higher than that in the CO2 laser group(60.00%vs.5.56%,P＜0.001),and most cases of hyperpigmentation spontaneously resolved or improved within 6 months.No statistically significant difference was observed in the recurrence rates between the two groups(P=0.663).Conclusions Intralesional injection of heparin sodium for xanthelasma offers comprehensive advantages,in-cluding"definite efficacy,no risk of scarring,and high treatment satisfaction,"making it a po-tentially viable alternative for treating xanthelasma.
Keywords：xanthelasmaheparin sodiumCO2 laser
Publication Date：2025-12-28
Online Publishing Date：2026-01-13(First online date of this platform, not the publication date of the document)
Pages：6( 852-857 )