Abstract:Acne is a chronic inflammatory skin disease of hair follicles and sebaceous glands,that commonly occurs in adolescents,and may result in post-inflammatory pigmentation and permanent scar.There is a close relationship between the occurrence and development of acne and skin barrier function.In the pathogenesis of acne,sebum secretion,hair follicle hyperkeratosis,Propionibacterium pathogenic colonization,inflammation and other factors will cause the damage of barrier function of skin,and skin barrier function damage will aggravate acne conversely.Therefore,repair of skin barrier function is an important part of acne prevention and treatment.

Abstract:ObjectiveTo evaluate the clinical effect and safety of activating blood and removing toxin decoction (huoxue jiedu decoction, HXJDD for short) in the treatment of psoriasis vulgaris of Blood stasis syndrome.MethodsThe randomized and controlled study was applied to 80 cases with psoriasis vulgaris. The treatment group was treated with HXJDD and control group was treated with placebo. The treatment lasted for 8 weeks and the efifcacy and safety were assessed. Main evaluation index included psoriasis area and severity index(PASI) score, main clinical symptoms of TCM, dermatology life quality index (DLQI) and safety indicators. ResultsThe total effective rate of HXJDD group was 86.84%, better than the control group 50.00%, and the difference was statistically signiifcant (P<0.05). Compared with control group after treatment, PASI score and DLQI score of the experimental group signiifcantly reduced, and the difference was statistically signiifcant (P<0.05). Signiifcant differences were found between the two groups of erythema and inifltration. Moreover, no serious adverse reactions occurred in the both groups.ConclusionHuoxue Jiedu decoction is safe and effective for psoriasis vulgaris of Blood stasis syndrome.

Abstract:ObjectiveTo investigate the related risk factors for melasma, and to provide scientiifc data for the prevention and treatment of melasma.MethodsTwo hundred patients from Shenzhen people's hospital were questioned by the matched case-control study. Risk factors were analyzed by logistic regression.ResultsThe age (OR=0.131), family history (OR=1.650), seasonal variation (OR=12.995), stress (fatigue) (OR=0.269), sunlight (OR=36.460), gestation (OR=78.075), and sensitive skin (OR=14.695) were signiifcant in multiple-regressionof risk factors for melisma. Sunscreen was an independent protect factor for melasma. TheOR was 0.101.ConclusionThrough this epidemiological survey, some factors, i.e. age, family history, seasonal variation, stress (fatigue), sunlight, sunscreen, gestation, and sensitive skin were conifrmed to be the risk factors for melisma in Shenzhen; sunscreen application, good mood could prevent occurrence of melasma. Some other factors were proved to be non-irrelevant: sleep quality, lack of sleep, contraception and cosmetic.

Abstract:Objective To explore a new way to improve the clinical ability of medical students by administrating the problem-originated clinical medical curriculum (PCMC) mode in combination with multimedia courseware in dermatology and venerology teaching. Methods Four classes in grade 2012, including 108 undergraduates of clinical medicine, were randomly selected and assigned in a 1:1 ratio into two groups which received PCMC teaching mode in combination with multimedia courseware or traditional mode, and both of the two groups were educated by the same teachers. At the end of the courses, tests of clinical abilities and theory were taken to evaluate the improvement of the students. Questionnaires were also used to investigate the students' acceptance of the two teaching modes. Results In the PCMC teaching group, the average score of clinical ability test was 91.9 points, significantly higher than 78.7 points of the traditional group(P<0.05), whereas, there was no significant difference of the theory test between the 2 groups. Student satisfaction survey results showed that the PCMC group(82.7%) was higher than that of the traditional group(75%) with no significant difference(P>0.05). Conclusion Application of PCMC teaching mode in combination with multimedia courseware is conducive to students' understand of the abstract theory knowledge in dermatology teaching process, and may fully mobilize the students' learning initiative.

Abstract:Severe drug eruption is a common cutaneous adverse drug reactions in clinical, including erythema multiforme drug eruption (EMDE), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), exfoliative dermatitis drug eruption (EDDE), and drug hypersensitivity syndrome (DHS), Which has a high morbidity and mortality. Detailed medical history, typical clinical manifestations, physical examination, and laboratory and auxiliary examinations are helpful for the early diagnosis of the disease. Two aspects of severe drug eruption, pathogenesis and clinical manifestations, are outlined in this article.

Abstract:Prurigo nodularis is a kind of chronic and recurrent nodular lesion with acute itching. Current researches suggested that nerve and immune factors played important roles in the onset of the disease. Obvious hyperplasia of nervous tissue was found in the skin lesion as well as a variety of neural peptides (e.g. substance P, calcitonin gene related peptide). At the same time, the disease was related to psychological factors, infection factors and some systemic diseases. The speciifc etiology and pathological mechanism still need further research. For the treatment, there are a variety of ways of treatments such as local external use, local injection, oral administration and physical therapy and so on. In order to obtain satisfactory curative effect, combined treatment of two or more ways is used in clinical.

Abstract:Objective To investigate the correlation between physiological alopecia, androgenetic alopecia, alopecia areata and sleep quality and emotional factors. Methods Patients from the outpatient dermatology of Daping Hospital from August 2011 to August 2012 diagnosed as physiological alopecia, androgenetic alopecia, alopecia areata and healthy collators were assessed by the pittsburgh sleep quality index (PSQI) and self rating anxiety scale (SAS). Results The total score of PSQI and SAS gradually increased with age in all the three kinds of hair loss and the normal control, which showed a statistically signiifcant difference between the different age groups (P<0.01). Alopecia areata score greater than 7 implied the problem of sleep disorder. Among the seven components of PSQI, three kinds of hair loss groups and the normal control had following differences;the quality of sleep, sleep time, sleep efifciency and sleep disorders in the youth group (15 to 29 years old) were different(P<0.01);the sleep quality, sleep latency, sleep disorders and daytime dysfunction in the middle-aged group (30 to 44 years old) were different (P<0.05);the sleep time, sleep efifciency and sleep disorders in the older-aged group (>45 years old) had differences (P<0.05). SAS score of alopecia areata and androgenetic alopecia in the youth group were higher than the national norm of China. Female patients had a greater inlfuence than male in PSQI and SAS. The pearson product moment related analysis (r=0.487, P=0.000) indicated that sleep quality and anxiety situation positively related. Conclusion Hair loss diseases, especially alopecia areata was affected by sleep quality and mental factors, so it is important to restore the good life habit and adjust emotion to prevent the onset of alopecia areata.

Abstract:Sensitive skin is a clinical syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, and tingling sensation) in response to normal stimuli. Sensitive skin can affect all body locations, commonly the young female face. Recent years, the incidence and social attention of this syndrome is increasing. Many endogenous and exogenous factors can induce unpleasant symptoms, which affects the patients' quality of life. The possible pathogenesis of sensitive skin includes disturbed barrier, neurogenic inflammation and related immune cells. This review summarizes current knowledge on the epidemiology, pathogenosis, diagnosis and therapy of sensitive skin.

Abstract:The aetio-pathogenic mechanisms of vitiligo are still poorly understood, which holds back the progress in the diagnosis and treatment of the disease. Up until now, treatment guidelines have been developed at national levels, but no common European viewpoint has emerged. This guideline for the treatment of segmental and nonsegmental vitiligo has been developed by the members of the Vitiligo European Task Force and other colleagues. It summarizes evidence-based and expert-based recommendations.

Abstract:Objective To detect and type human papillomavirus(HPV) by the method of dot blot hybridization reverse-gene chip for investigating their infections in women and their roles in the prevention and treatment in cervical cancer. Methods 1 478 patients from different age were enrolled and the HPV were detected and typed by dot blot hybridization reverse-gene chip. The infection rate of low-risk and high-risk types were compared and the relationship with age were analyzed. Results The total HPV infection rate was 26.05%in 1 478 cervical cell samples, the HPV infection rate of a single type was 19.4%. The predominant type from single infection with HPV was type 16(8.80%) secondly type 58(4.4%). The HPV infection rate of single type, double type and multiple type were 19.4%, 5.1%and 1.6%respectively;the HPV infection rate of high-risk type, low-risk type and mixed type were 17.9%, 4.6%and 3.5%respectively. The positive rate of HPV were 1.2%, 24.0%, 28.8%, 30.0%and 16.0%along with the age group of ≤20, 21 ~ 30, 31, 40, 41 ~ 50 and>50 years respectively, subsequently four age women in the HPV single, double and multiple infection rate difference were statistically signiifcant (χ2=26.475, P<0.01). High-risk and low-risk type infection rate difference were statistically signiifcant (χ2=25.887, P<0.01). Conclusion HPV 16, 58 are the main genotypes of 1 478 women in Beijing district. Gene chip technology had high sensitivity and speciifcity in detecting multiple HPV genotypes in cervical epithelium, which is useful for the prevention and etiology study of cervical cancer.