Abstract:The aging mouse models could be divided into two categories:natural aging models and artificial aging models.This paper reviewed the aging mouse models established by nature,D-galactose,β-amyloid protein injection,accelerated senescence,γ ray irradiation,ozone,thymectomy and transgene.The principles,methods,indicators of evaluation,advantages and disadvantages of each method were elaborated to provide reference for researches with different purposes,including the establishment of oral mucosal aging model

Abstract:Objective:To investigate the changes of Oral Health-Related Quality of Life in elderly edentulous patient swith com plete denture and analyse the responsiveness of the C hinese version of the O ral health im pact profile-14 (O H IP-14) in the treatm ent of edentulous patients by com paring the subjective attitudes of elderly patients tow ard com plete dentures. Methods:1050 edentulous patients w ere invited to fill in the questionnaire of O H IP-14 before com plete denture prosthesis replacem ent.O ne m onth later,they w ere invited to finish the questionnaire of O H IP-14 and the satisfaction survey.SPSS 17.0 softw are package w as used for data analysis. Results: (1)T he score of each dom ain and the total O H IP-14 score decreased significantly after treatm ent, respectively (P<0.01). (2) T here w as a negative correlation betw een the O H IP-14 score and the satisfaction in both pre- and post-treatm ent groups. Conclusion: T he O H IP-14 possesses reasonable responsiveness in the effect and patientsatis faction of complete dentureres toration,and thus can beused in the evaluation of the clinicalresults ofcom plete denture prosthesis.

Abstract:Objective:To compare the clinical efficacy of ultrasonic scaling and manual subgingival scaling 84 elderly patients with chronic periodontitis who were treated with basic periodontal therapy in our hospital were randomly divided into two groups after supragingival scaling.Group A was treated with manual subgingival curettage (group A) and group B with ultrasonic subgingival curettage (group B).Periodontal examination records were recorded before treatment and 6 weeks,3 months and 6 months after treatment in both groups,and the changes ofPD,BI,AL and PLI were observed and the results were analyzed.Results:the periodontal index of the two groups improved significantly before and after treatment (P＜0.05),and there was no significant difference in periodontal index between the two groups (P＞0.05).Conclusion:there is no significant difference in the clinical effect of Ultrasonic scalingin the treatment of the elderly chronic periodontitis and subgingival scaling.