Research Progress on Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Abstract：Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, characterized histopathologically by myocyte hypertrophy, myocyte disarray, and myocardial fibrosis. It is also the leading cause of sudden cardiac death in adolescents and athletes, with a prevalence of 0.2% to 0.5% [1, 2]. Myocardial fibrosis and myocardial hypertrophy are the main myocardial changes in HCM, which can lead to the occurrence of chest pain, heart failure, and risks of supraventricular and ventricular arrhythmias, even sudden cardiac death (SCD). Myocardial fibrosis (MF) is mainly caused by the proliferation of fibroblasts and excessive deposition of extracellular matrix (ECM) proteins, including type I and III collagen [3]. During the progression of HCM, myocardial hypertrophy and myocardial fibrosis are both characteristic pathological changes and the pathological basis and main causes of ventricular arrhythmias and sudden cardiac death in patients.
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Publication Date：2025-03-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 378-380,384 )