Malignant myopericytoma of thoracic vertebra:report of a case
JIANG Yan-hong
ZHANG Jing
YANG Xiang-shan
Abstract：Objective To investigate the clinical and pathological features, immunohistochemical phenotype, and differential diagnosis of malignant myopericytoma. Methods A retrospective analysis was conducted on the clinical manifestations, imaging, postoperative histopathological morphology, and immunophenotype of a rare case of malignant myopericytoma in the vertebral body, along with a review of relevant literature. Results Under the microscope, tumor cells were distributed in a diffuse nest-like or sheet-like pattern around blood vessels, showing invasive growth, nuclear atypia, approximately 7-8 mitotic figures per 10 HPF, local vascular invasion, and infiltration into surrounding bone tissue and skeletal muscle. Immunohistochemistry showed positive expression of SMA and Caldesmon, partial expression of BCL-2 and CD99; CD31 and CD34 showed intravascular tumor emboli. Postoperative follow-up for 36 months showed no recurrence or metastasis. Conclusion Malignant myopericytoma of the thoracic vertebra is an extremely rare soft tissue tumor. The histopathological morphology needs to be differentiated from malignant glomus tumor, malignant peripheral nerve sheath tumor, and leiomyosarcoma. Definitive diagnosis relies on pathological examination, and surgical resection may be the only effective treatment currently.
Keywords：VertebraMalignant myopericytomaImmunohistochemistryPathological diagnosisDifferential diagnosis
Publication Date：2025-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 618-620 )