A simple and convenient synthesis of pyrrolo[3,4-b]quinolin-1-one derivatives
ZHANG Hong
WANG Jianyuan
LI Cheng
SUN Mingyang
Abstract：A simple and concise construction of a series of new quinoline-based isoindolin-l-ones,namely N-substituted-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones,wherein the benzene moiety of isoindolin-l-one is replaced by a quinoline ring has been achieved via a two-step procedure,involving the one-step synthesis of ethyl 2-chloromethyl-quinoline-3-carboxylate followed by its one-pot reaction with various amines in a refluxing EtOH-AcOH(v/v,10:1)solvent system.These newly synthesized compounds could be good candidates for the development of lead compounds for use in medicinal chemistry.
Keywords：quinolineaminesnucleophilic substitution reactioncyclization
Publication Date：2024-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 21-31 )