Efficient synthesis of N1 -substituted 3 ,4 -dihydropyrimidone -2(1H) -onescatalyzed by ferric(Ⅲ) chloride under solvent -free conditions
WANG Min
ZHANG Shun
JIANG Hong-xu
Abstract：A series of N1-substituted 3,4-dihydropyrimidone -2(1H)-ones were synthesized by an one -pot three-component condensation of aromatic aldehydes ,β-ketone esters and monosubstituted (thio)urea in the presence of FeCl 3 · 6H2 O under solvent -free conditions at 80℃.The effects of the ratio of the raw materials , the amount of the catalyst and thereaction temperature on the yields were investigated .The optimal conditions are as follows:naldehyde:nester:nurea =1:1:1, FeCl3 · 6H2 O is 3 mol％, reaction temperature is 80℃.The reactions of various aromatic aldehydes , ethyl acetoacetate (methyl acetoacetate ) and monosubstituted (thio)urea were investi-gated .Eight new compounds were synthesized .All products were characterized by IR ,1 H NMR, 13 C NMR and ele-mental analysis .The probable catalytic mechanism was proposed .The method has the advantages of simple proce-dure, the avoidance of the use of organic solvents , mild conditions, inexpensive catalyst and extensive substrates .
Keywords：34-dihydropyrimidinonesferric( III) chloridesolvent-freeBiginelli reaction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 289-294 )