Simple way to synthesize halogenated salicyladehydes
Abstract：Salicylaldehyde（1） was brominated using liquid bromine as brominating agent in the presence of ethanol as solvent at 10 ℃ to afford mono-substituted 5-bromosalicylaldehyde（2） in 82.7% yield.When NBS（N-bromosuccinimide） was used as a brominating agent in the presence of PEG-400 as solvent at room temperature,the disubstituted 3,5-dibromosalicylaldehyde（3） was obtained in 74.1% yield.Similarly,when NBS was replaced with NCS（N-chlorosuccinimide） as a chlorination agent under the same reaction conditions,the corresponding 3,5-dichlorosalicylaldehyde（4） was obtained in 34.8% yield.
Keywords：synthesis5-bromosalicylaldehyde35-dibromosalicylaldehyde5-dichlorosalicylaldehyde
Publication Date：2012-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 32-36 )