Analysis of the Relationship between Blood Levels of hs-CRP, MB, cTnI, D-Dimer and Cardiac Function and Prognosis in Patients with Coronary Heart Disease and Heart Failure

doi:10.3969/j.issn.1674-3245.2025.02.035

Abstract：Objective: To analyze the relationship between blood levels of high-sensitivity C-reactive protein (hs-CRP), myoglobin (MB), cardiac troponin I (cTnI), and D-dimer (D-D) with cardiac function and prognosis in patients with coronary heart disease and heart failure. Methods: A retrospective analysis was conducted on the clinical data of 100 patients with coronary heart disease and heart failure admitted to Funan County People's Hospital from January 2022 to May 2023. According to the prognosis after one year of treatment, the patients were divided into two groups: the good prognosis group (69 cases) and the poor prognosis group (31 cases). The general data, blood indicators (hs-CRP, MB, cTnI, D-D), and cardiac function indicators [left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), mean wall stress (MWS), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), N-terminal pro-B-type natriuretic peptide (NT-ProBNP)] were compared between the two groups. Pearson correlation analysis was used to evaluate the correlation between blood indicators and cardiac function indicators. ROC curve analysis was used to assess the predictive value of the different blood indicators for patient prognosis. Results: The proportion of patients with NYHA functional class II was higher in the good prognosis group than in the poor prognosis group (39.13% vs. 16.13%), with a statistically significant difference (Z=5.251, P=0.022). The levels of hs-CRP, MB, cTnI, and D-D in the poor prognosis group were (14.65±2.03) mg/L, (225.76±18.34) ng/ml, (15.42±1.61) ng/ml, and (1.29±0.25) µg/L, respectively, which were all higher than those in the good prognosis group [(8.97±1.14) mg/L, (146.39±19.28) ng/ml, (8.15±1.01) ng/ml, (0.48±0.09) µg/L], with statistically significant differences (t=17.861, 19.323, 27.441, 23.811, P<0.05). The levels of LVEDV, LVESV, MWS, LVMI, and serum NT-ProBNP in the poor prognosis group were (147.52±13.97) ml, (74.21±10.13) ml, (37.94±4.26) kPa, (90.21±17.35) g/m², and (1036.73±105.72) pg/ml, respectively, which were all higher than those in the good prognosis group [(135.86±14.19) ml, (54.36±9.58) ml, (28.95±4.31) kPa, (64.58±5.06) g/m², (723.47±68.40) pg/ml], with statistically significant differences (t=3.818, 9.414, 9.681, 11.306, 17.743, P<0.05); the LVEF level in the poor prognosis group was (42.85±3.61)%, which was lower than that in the good prognosis group (53.61±4.27%), with a statistically significant difference (t=12.199, P<0.05). Pearson correlation analysis showed that the levels of blood hs-CRP, MB, cTnI, and D-D were positively correlated with LVEDV, LVESV, MWS, LVMI, and serum NT-ProBNP levels (r=0.526, 0.534, 0.579, 0.634, 0.625; 0.531, 0.516, 0.568, 0.575, 0.524; 0.537, 0.581, 0.605, 0.568, 0.569; 0.602, 0.604, 0.612, 0.546, 0.573; P<0.05), and negatively correlated with LVEF (r=-0.377, -0.642, -0.423, -0.458, P<0.05). ROC curve analysis showed that the levels of blood hs-CRP, MB, cTnI, and D-D had good predictive value for the prognosis of patients with coronary heart disease and heart failure (AUC=0.695, 0.724, 0.782, 0.778, P<0.05). Conclusion: The levels of blood hs-CRP, MB, cTnI, and D-D in patients with coronary heart disease and heart failure are positively correlated with LVEDV, LVESV, MWS, LVMI, and NT-ProBNP levels, and negatively correlated with LVEF levels. Therefore, monitoring the levels of blood hs-CRP, MB, cTnI, and D-D can provide good predictive value for the prognosis of these patients.