1Calculation method of patent term extension of Chinese innovative medicineGENG Wen-jun, DING Jin-xi2641-26462Research on the legal definition of rare diseases and drugs and devices for rare diseasesYANG Dian-zheng, XU Wen-xiu, LI Zhuang-qi, YANG Yue2647-26533Research on post-marketing drug risk management measures of FDA and its implication for China:a case of thalidomideCHEN Jin-min, LIU Peng-cheng, YU Zheng2654-26594Pharmacological and clinical evaluation of calaspargase pegol-mknl-a L-asparaginase specific enzymeYANG Xue, NI Qian, LI Ting, PEI Yi-fang, LI Shao-qiang2660-26635General considerations on bio-waiver using quality assessment of azacitidine injectionCHEN Ai-ping, HE Wu2664-26676Research progress of bioequivalence of acarboseLI Min, LI Fang, WANG Yu-zhu, YANG Jin-bo2668-26717Research progress in the determination of free concentration of antibacterial drugsWU A-long, XU Bing-fa2672-26768Research progress of bevacizumab in the treatment of ovarian cancerGUO Chong-zhen, QU Lian-yue, DU Rong-rong, YAN Cheng-da, LIN Jian-yang2677-26829Advances of dermato-pharmacokinetic in the bioequivalence assessment of topical formulationLIU Xiao-lin, DING Liang, GUAN Yan-ping, HUANG Min, ZHONG Guo-ping2683-268910The role of a new generation of TKI ripretinib in gastrointestinal stromal tumor treatment and its research progressZHANG Yi-wen, PAN Zong-fu, YE Qiang, LIU Yu-jia, SUN Jiao, LI Li, HUANG Ping2690-269411Research progress of preclinical study of edaravone in the treatment of amyotrophic lateral sclerosisLI Tian-lei, HAN Zun-sheng, ZHANG Chi, QI Yan, YAN Ting, WU Song2695-269912Efficacy and safety of dexamethasone on postoperative multimodal analgesia in patients undergoing thoracoscopic radical resection for lung cancerZHANG Yun-xiao, LI Zong-chao, CHEN Ji-heng2700-270413Bioequivalence and safety evaluation of dabigatran capsule in humanYANG Wei, YU Shuang, XU Zhong-nan, GAO Zhen-yue, LI Hao, YANG Hai-miao2705-271114"Precision medicine" innovational clinical trial design master protocol:concept,design,and examplesYU Ya-nan, DU Pei-yan, LIU Jun, WANG Zhong2712-271715Research and analysis of clinical trial fundingGUO Shao-jie, ZHAO Xiu-li, CAO Cai2718-272216The effect of compound Qima capsule on blood pressure and related vasoactive factors in different hypertensive rat modelsYANG Jiu-mei, CHEN Yu-xing, GAN Hai-ning, HUANG Xue-jun, CAI Da-ke, HUANG Dan-e, WANG Qing-hai2723-272817Molecular mechanism of honeysuckle against H1N1 influenza based on network pharmacology and molecular dockingGAO Kai, SONG Yan-ping2729-273718Protective effects of Lycium barbarum polysaccharides on epilepsy in rat hippocampal cell model and its mechanismMA Lin, ZUO Di, ZHANG Chun, REN Xiao-fan, HE Zhen-quan, DING Na, WANG Feng2738-274319Quantitative determination of gluconate in calcium gluconate injection by ion chromatographyLI Jie, HAN Chun-xia, HUANG Hai-wei, ZHANG Yan-chen, HE Lan2744-274720Analysis of the utilization of national essential medicines in the emergency department of medical institution in six cities of China during 2013-2017REN Yi, HU Xin, PEI Yi-fang, SHI Lu-wen2748-2755 