1Review of the cases on the implementation of drug patent compulsory license from the international perspectiveCAO Lei, LIU Zhao, ZHAO Kun, LIU Yue-hua1441-14482The evolution of patent examination criteria for medical use inventions in Europe and comparisons of examination practices between Europe and ChinaWU Li, XUE Yang1449-14553Considerations on the estimation of the starting dose design for a new drug in first-in-human studyZHANG Feng-qin, SUN Tao, WANG Hai-xue, WANG Qing-li1456-14634Pharmaceutical continuous manufacturing and recent regulatory statusHU Yan-chen1464-14685Non-inferiority clinical trial: summary and considerationLI Xin-xu, ZHOU Jun, GAO Li-li, WANG Jun1469-14776Regulatory factors of PD-1 expression associated with cancer immunotherapyHE Qing, GAO Hua, WANG Jun-zhi1478-14847Cardiotoxicity assessment of cinobufotalin injectionLI Min, HUANG Li-hua, SHAO Shu-ming, CUI Tian-tian, HUANG Ming-shu, WANG Xi-jie, LI Hua, MA Jing1485-14948Potential biosafety risks of typical dual-use biotechnologyZHANG Xin, WANG Ying, LIU Jing, LI Ping-ping, SUN Yan-rong1495-15009Policy evaluation of biomedical industry based on PMC indexXU Li-ying, QIAO Han, LI Xu, CHU Shu-zhen1501-150710The pharmacological effect, application prospect and pharmaceutical monitoring of remdesivirZHAI Li-jie, ZHAO Zhi-gang1508-151311Cytokine storm warning and treatment progress on COVID-19WANG Yu-hang, CAI Yun, LIANG Bei-bei, WANG Jin, WANG Rui1514-151912DL-3-n-butylphthalide improves cerebral hypoperfusion caused by cerebral artherosclerotic stenosisCHEN Da-wei, SHI Jin, WANG Ke-hua, YIN Yan-wei, YANG Fen, ZHAO Fa-guo, SONG Chen, LI Wen-ping, LI Jin-hua1520-152713The effect of orlistat on proliferation and apoptosis of SMMC-7721 hepatoma cells and its mechanismCHEN Liang, SHI Qian, ZHANG Cong, ZHENG Guo-hua, QIU Zhen-peng1528-153414Comparison of nebulization characteristics of different formulations for ambroxol hydrochloride inhalation solutionWANG Zhen, WEI Ning-yi, ZHOU Ying, NING Bao-ming1535-153915Determination of residual solvent in the assignment of impurity reference substanceYAO Shang-chen, LIU Ying, TIAN Ye, YANG Qing, FENG Yan-chun, MA Bu-fang, ZHANG Xia, HU Chang-qin1540-154416Dissolution determination of alfacalcidol soft capsulesCHEN Xi, YUAN Song, YU Li-ju, HUANG Hai-wei, NING Bao-ming, ZHANG Qing-sheng1545-154817Simultaneous determination of leuprolide acetate and endogenous testosterone using HPLC-MS/MS in rats: application in pharmacokinetics and pharmacodynamics studyWANG Hai-juan, LIU Fang-jie, SHA Chun-jie, LENG Guang-yi, LIU Wan-hui, YOU Chun-na1549-155518Literature analysis of adverse drug reactions induced by sacubitril/valsartanSHU Bing, SHEN Ai-zong1556-1560 