1Inaugural EditorialBaofeng Yang12Prevention and control measures of the major cold-region diseases(hypertension)in ChinaZhenwei Pan, Yong Zhang, Tengfei Pan, Haihai Liang, Baofeng Yang3-83Hydrogen sulfide,microbiota,and sulfur amino acid restriction dietRui Wang9-164Discussion on the model of community management of chronic diseases in cold areasRui Jiang, Yuquan Zhao, Yongchen Wang17-225Traditional Chinese medicine in the treatment of high incidence diseases in cold areas:the thrombotic diseasesXueqing Tang, Xin Liu, Monayo Seth Mikaye, Hongrui Zhao, Yong Zhang23-446Tridepsides from the endophytic fungus colletotrichum gloeosporioides associated with a toxic medicinal plant tylophora ovataSen-Feng Sun, Shao Zhu, Hai-Yan Cao, Yun-Bao Liu, Shi-Shan Yu45-517Ablation of apoptosis-stimulating of p53 protein 1 protects mice from acute hepatic injury and dysfunction via NF-κB pathway in CCl4-induced hepatotoxicityTolessa Muleta Daba, Xiang Huang, Timur Yagudin, Ying Yang, Jiangang Wang, Xiaoyu Fu, Yue Zhao, Haiyu Gao, Yang Zhou, Zhenwei Pan, Xiangyu Zhong53-648COLD in Medicine is More Than Just Low Temperature……封3