Abstract:Objective To investigate the clinical effect of percutaneous curved vertebroplasty(PC VP)in the treatment of osteoporotic vertebral compression fractures(OVCF).Methods The clinical data of 230 patients with OVCF who underwent surgical treatment in the Department of Orthopedics,Civil Aviation General Hospital from January 2020 to June 2023 were collected and retrospectively analyzed.According to the different surgical methods,they were divided into the control group(120 cases)and the observation group(110 cases).The control group was treated with traditional unilateral percutaneous vertebroplasty,and the observation group was treated with PCVP.The dosage and distribution of bone cement,visual analogue scale(VAS)scores of low back pain and Oswestry disability index(ODI)scores before operation and at 24 hours,3 months and 6 months after operation were compared between the two groups.Results The amount of bone cement and the excellent rate of bone cement distribution in the observation group were higher than those in the control group[(4.7±0.7)ml vs(3.4±0.7)ml,81.8％(90/110)vs 57.5％(69/120)](both P＜0.01).The VAS and ODI scores of the two groups at 24 hours,3 months and 6 months after operation were significantly lower than those before operation(all P＜0.05).However,there was no significant difference between the two groups after operation(all P＞0.05).Conclusions The two surgical methods in the treatment of OVCF can quickly relieve pain,improve the quality of life of patients,and the curative effect is reliable.PCVP and traditional surgery have similar efficacy.PCVP consumes more bone cement,has better bone cement distribution,and performs better in bone support.

Abstract:Objective To investigate the effects of dexmedetomidine on perioperative neurocognitive disorders and inflammatory mediators in patients undergoing laparoscopic colorectal cancer surgery.Methods A total of 76 patients who underwent laparoscopic colorectal cancer surgery in the Eighty-second Army Group Hospital of the Chinese People's Liberation Army from June 2021 to January 2023 were selected.According to the random number table method,the patients were divided into the control group and the observation group,with 38 cases in each group.The control group was given 0.9％sodium chloride injection by intravenous pump before anesthesia induction.The observation group was given dexmedetomidine intravenous pump before anesthesia induction.The cognitive function was compared between the two groups before anesthesia(T0),at recovery(T1),when leaving the postanesthesia care unit(T2)and 24 h after operation(T3).The levels of neurological function and inflammatory mediators in the two groups were detected.Results The Montreal Cognitive Assessment scores of the two groups at T1 and T2 were lower than those at T0,and the scores of the observation group were higher than those of the control group[(24.5±1.8)vs(22.4±2.2),(25.7±1.5)vs(23.3±2.0)](all P＜0.001).The levels of central nervous system specific protein β and neuron specific enolase at T1 and T2 in the two groups were higher than those at T0,and those in the observation group were lower than those in the control group(all P＜0.05).The levels of C-reactive protein,tumor necrosis factor-α and interleukin-6 at T,,T2 and T3 in the two groups were higher than those at T0,and those in the observation group were lower than those in the control group(all P＜0.05).Conclusion Dexmedetomidine can effectively improve cognitive function and neurological function and reduce the level of inflammatory mediators in patients undergoing laparoscopic colorectal cancer surgery.

Abstract:Primary Immune Thrombocytopenia(ITP)is an autoimmune disease mediated by platelet autoantibodies.Most ITP patients have antiplatelet antibodies against the immunoglobulin G(IgG)subtype,which interact with glycoproteins on platelets and megakaryocytes to increase platelet destruction and inhibit platelet production.Neonatal Fc receptor(FcRn)is used to maintain the homeostasis of IgG levels in the human body.Targeting FcRn by FcRn inhibitors can reduce pathogenic IgG in the blood,proving its efficacy in the treatment of ITP and other autoimmune diseases,and improving platelet counts in ITP patients to some extent.Both efgartigimod and Rozanolixizumab can bind to FcRn and lead to the reduction of circulating IgG.FcRn inhibitors can also indirectly prolong the half-life of romiplostim to improve the therapeutic effect.This review briefly summarizes the mechanism of inhibition of platelet destruction and production in ITP,the molecular mechanism of FcRn and FcRn inhibitors,the application of FcRn inhibitors in ITP,and the association of FcRn with romiplostim and intravenous Ig.

Abstract:Mitophagy is an autophagy process in cells that can remove damaged mitochondria and maintain the health of cells.Kidney is an organ with high energy consumption.Mitochondria plays an important role in kidney function,and kidney diseases are usually associated with mitochondrial dysfunction.Recent studies have shown that mitochondrial damage and dysfunction in renal tubular cells may lead to renal tubular injury and decreased glomerular filtration rate,and mitophagy can remove these damaged mitochondria,thereby protecting renal cells from autophagy.In addition,mitophagy is also involved in the occurrence and development of kidney diseases,such as glomerulosclerosis and renal tubulointerstitial fibrosis.Therefore,mitophagy plays an important role in the prevention and treatment of kidney diseases.This article reviews the role of mitophagy in kidney diseases,and provides new ideas and strategies for mitochondrial targeted therapy in the future.

Abstract:Complications after cardiac surgery are common and have a significant impact on the clinical prognosis of patients.Patients who need cardiovascular surgery due to heart disease are often complicated with ischemic heart disease,hypertension and diabetes.Therefore,these patients often need to take long-term renin-angiotensin system blockers,namely angiotensin-converting enzyme inhibitors(ACEI)and/or angiotensin Ⅱ receptor blockers(ARB)drugs.At present,there is no consensus on whether and when ACEI/ARB should be discontinued before surgery in patients with a history of long-term use of ACEI/ARB drugs.Published clinical trials and observational studies even have conflicting results.In this review,we will discuss the application of ACEI/ARB drugs in the perioperative period of cardiac surgery,focusing on the effect of their use on postoperative renal complications,in order to provide clear clinical guidance for patients taking these drugs.

Abstract:Diabetic kidney disease is a common clinical chronic complication of diabetes mellitus,which has become the main cause of chronic kidney disease and end-stage renal disease.Traditional Chinese medicine believes that the core of the disease is the kidney,which is caused by the damage of the kidney body,the loss of kidney use,and the failure of the nephron.In Huangdi Neijing,it is recorded that"the kidney is bitter and dry,and the acute food is bitter to moisten it","the kidney wants to be strong,and the acute food is bitter to strengthen it,and it is bitter to tonify it,and the salt reduces it".This article investigated the connotation of the theory of"bitter to fill and reduce"of kidney in Huangdi Neijing,and combined with the current mainstream treatment of diabetic kidney disease in traditional Chinese medicine,it is proposed that the differentiation and treatment of diabetic kidney disease in traditional Chinese medicine should focus on the kidney.The kidney dryness should be moistened by spicy,the kidney deficiency should be strengthened by bitterness,and the kidney is solid should be salty and reduced.In order to provide theoretical origin for the treatment of diabetic kidney disease with integrated traditional Chinese and western medicine,and provide new ideas and methods for the differentiation and treatment of diabetic kidney disease with traditional Chinese medicine.

Abstract:Objective To investigate the relationship between elevated thyroid stimulating hormone(TSH)level and elevated blood pressure in women of childbearing age in a community of Urumqi.Methods In this study,cluster random sampling method was used to select 866 women of childbearing age with complete data from 2 561 subjects who participated in an epidemiological survey of chronic diseases in a community of Urumqi in May 2020,and the age ranged from 20 to 49 years.The height,body mass,abdominal circumference,hip circum-ference,blood pressure,fasting blood glucose and TSH levels were measured.Logistic regression method was used to analyze the relationship between elevated TSH level and elevated blood pressure.Results A total of 866 women of childbearing age were included in this study.According to the blood pressure status before pregnancy,they were divided into normal blood pressure group(424 cases,49.0％)and elevated blood pressure group(442 cases,51.0％).Age,abdominal circumference,hip circumference,waist-hip ratio,body mass index and TSH level[(3.4±2.8)mIU/L vs(2.9±2.1)mIU/L]in the elevated blood pressure group were significantly higher than those in the normal blood pressure group(all P＜0.05).The blood pressure level(0=normal,1=elevated)was used as the dependent variable,and age,abdominal circumference,hip circumference,body mass index,fasting blood glucose,and TSH were used as independent variables.Model 1(without controlling other variables)and model 2(controlling age,waist circumference,hip circumference,body mass index and fasting blood glucose)were used to explore the relationship between TSH level and elevated blood pressure.The results showed that elevated TSH level was associated with elevated blood pressure regardless of whether other factors were controlled.Elevated TSH level may be a risk factor for elevated blood pressure(model 1:odds ratio=1.53,95％confidence interval:1.09-2.13,P=0.012;model 2:odds ratio=1.45,95％confidence interval:1.03-2.04,P=0.030).Conclusion Elevated TSH level is associated with elevated blood pressure in women of childbearing age,and elevated TSH level may be a risk factor for elevated blood pressure.

Abstract:Phosphodiesterase 4 is the main enzyme that metabolizes cyclic adenosine monophosphate in inflammatory cells and plays a crucial role in regulating the balance of second messengers.As the key signal transduction regulation factor,phosphodiesterase 4 in a variety of diseases shows a promising pharmacological target,the inhibitors have been used as a treatment drug.This article reviews the mechanism,efficacy and adverse reactions of phosphodiesterase 4 inhibitors in the treatment of dermatosis.

Abstract:Objective To analyze the medication rules of traditional Chinese medicine in the treatment of intervertebral disc degeneration(IVDD)based on data mining,and to explore the mechanism of core drug combi-nation in the treatment of IVDD using network pharmacology.Methods Apriori algorithm was used to analyze the association rules of the data based on CNKI,Wanfang database and VIP journal database.On this basis,the mechanism of core drugs in the treatment of IVDD was analyzed by network pharmacology,and the interaction between core components and key targets was verified by molecular docking.Results A total of 167 articles were included,and 52 compound formulas were screened,involving 109 Chinese herbs.Association rule analysis showed that the core drug combination was"safflower-peach kernel-Chuanxiong-Angelica".Network pharmacology analysis identified 27 core active ingredients,including quercetin,luteolin,kaempferol,baicalein,β-carotene,β-sitosterol,etc.There were 73 core targets,mainly vascular endothelial growth factor A(VEGFA),cellular tumor antigen p53(TP53),tumor necrosis factor(TNF),matrix metalloproteinase 9(MMP-9),etc.A total of 164 signaling pathways were involved,mainly interleukin-17 pathway,TNF signaling pathway,cancer signaling pathway,etc.Molecular docking results showed that the core targets predicted by network pharmacology could stably bind to the key active components of the core drug group.Conclusions Quercetin,luteolin,kaempferol,baicalin and other components in the drug combination of"safflower-peach kernel-Chuanxiong-Angelica"may be the material basis for the treatment of IVDD,which can act on VEGFA,TP53,TNF,MMP-9 and other targets.1t plays a role in the treatment of IVDD by regulating TNF signaling pathway,IL-17 signaling pathway,cancer signa-ling pathway and other pathways to reduce inflammatory response,control the apoptosis of nucleus pulposus cells,and regulate the metabolism of extracellular matrix.

Abstract:Objective To investigate the correlation between preoperative serum bile acid level and clinical indicators and prognosis in patients with colorectal cancer.Methods A total of 253 patients diagnosed with colorectal cancer in Tianjin Union Medical Center from January 2018 to August 2022 were collected as the observation group.During the same period,248 cases of mixed hemorrhoids without other serious diseases were collected as the control group for retrospective study.According to the clinical data of these patients,Logistic regression method was used to analyze the influencing factors of colorectal cancer occurrence.The changes of serum bile acid levels before and after surgery were compared.Spearman correlation analysis was used to analyze the correlation between preoperative serum bile acid level and tumor markers,lymphocyte subsets,interleukin-6(IL-6),as well as tumor necrosis factor α(TNF-α).The Kaplan-Meier method was used to draw survival curves and compare the prognostic differences of patients with different levels of serum bile acid.The differences of lesion location and pathology in patients with different serum bile acid levels were compared.Results Logistic regression analysis showed that higher serum bile acid level was a risk factor for colorectal cancer(odds ratio=1.102,95％confidence interval:1.022-1.189,P=0.012).The postoperative serum bile acid level was lower than that before operation(P＜0.05).The preoperative serum bile acid levels were positively correlated with carcinoembryonic antigen,IL-6,and TNF-α levels(all P＜0.05).Survival analysis showed that patients with higher levels(≥4.7 μmol/L)of serum bile acid had shorter recurrence free survival time than those with lower levels(＜4.7 µmol/L)(Log-rank x2=9.711,P=0.002),recurrence and metastasis rate was higher[55.6％(15/27)vs 25.8％(17/66)](P＜0.05).The proportion of low and moderate differentiation was higher and the proportion of lesions located in the right colon was lower in the high level of serum bile acid group than those in the low level of serum bile acid group(all P＜0.05).Conclusions Preoperative high level of serum bile acid is a risk factor for colorectal cancer,which is positively correlated with some tumor markers and inflammatory factors,and is related to tumor location,pathology and prognosis of patients.It has certain value in guiding the clinical diagnosis and treatment of patients with colorectal cancer.

Abstract:Stroke is one of the leading causes of disability in the global adult population.The number of post-stroke patients requiring rehabilitation is growing every year.Traditional rehabilitation methods have limited effect on the recovery of limb motor function,especially for severe motor dysfunction.In recent years,emerging intelligent rehabilitation technologies,such as biofeedback technology,brain-computer interface technology,robot-assisted,wearable technology,remote rehabilitation and non-invasive brain stimulation,have become new options to improve patients' functional outcomes.With its advanced scientific and technological means,these technologies provide more personalized and comprehensive rehabilitation support for stroke patients,and effectively promote the recovery of motor function and the improvement of quality of life of patients.This article aims to review the research status of intelligent rehabilitation technology in recent years,so as to provide reference for future research direction and clinical application.

Abstract:Objective To evaluate the efficacy and safety of live combined bacillus subtilis enteric-coated capsules in the treatment of irritable bowel syndrome(IBS)by Meta-analysis.Methods PubMed,Embase,CBM,CNKI,Wanfang,VIP,Cochrane Library and other databases were systematically searched until June 2023.The observation group was treated with live combined bacillus subtilis enteric-coated capsules alone or combined with other drugs,and the control group was treated with other drugs alone or combined.RevMan 5.4.1 software was used for Meta-analysis.Results Meta-analysis showed that the total effective rate of the observation group was better than that of the control group(relative risk=1.20,P＜0.001),and the incidences of abdominal pain and diarrhea symptoms were lower than those of the control group(all P＜0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(odds ratio=0.80,P=0.28).Subgroup analysis showed that the total effective rates of the observation group were higher than those of the control group in diarrhea-predominant IBS and constipation-predominant IBS(both P＜0.05).Conclusion Based on the current literature evidence,live combined bacillus subtilis enteric-coated capsules are effective and safe in the treatment of IBS.

Abstract:As an increasingly serious global health disease,metabolic associated fatty liver disease(MAFLD)has a rising incidence in young people,which seriously endangers human health and brings heavy economic burden to social development.In recent years,it has been found that hepatocyte senescence plays a non-negligible role in promoting liver lipid deposition,aggravating liver injury,and causing lipid metabolism disorders.At present,a summary review on the in-depth mechanism and drug intervention of hepatocyte senescence affecting the course of MAFLD is still insufficient,and the development of clinical treatment strategies is relatively lagging behind.This article focuses on the research progress of the regulatory mechanism of hepatocyte senescence in MAFLD from the perspective of the regulation of autophagy,DNA methylation changes,ferroptosis,effects on liver regeneration and drug mechanisms.This article aims to provide a reference for in-depth basic research,and provide a new perspective and practical guidance for the clinical treatment and drug development of MAFLD.

Abstract:Hyperuricemia(HUA)is common in patients with cardiovascular disease,and aspirin is the most widely used antiplatelet drug in cardiovascular disease.HUA is closely related to the occurrence and development of cardiovascular diseases.Aspirin may interfere with the production and excretion of uric acid,thereby affecting the level of serum uric acid.This paper reviews the effect of aspirin on HUA and blood uric acid level,to further explore the mechanism of action of aspirin affect uric acid generation and discharge,implement merge HUA individualized,accurate treatment of cardiovascular disease in patients with aspirin,improve cardiovascular disease prevention effect is of great significance.

Abstract:Objective To investigate the diagnostic value of serum apolipoprotein C1(APOC1),inter-leukin-6(IL-6)and squamous cell carcinoma antigen(SCC)in cervical cancer.Methods A total of 74 patients with cervical cancer who were treated in the Provincial Hospital Affiliated to Shandong First Medical University from April 2023 to June 2024 were selected as the cervical cancer group,and 60 healthy people were selected as the control group.The levels of APOC1,IL-6 and SCC in the two groups were compared,and the relationship between serum APOC1,IL-6 and SCC levels and clinicopathological parameters in patients with cervical cancer was analyzed.The receiver operating characteristic curve was used to evaluate the diagnostic value of single and combined detection of APOC1,IL-6 and SCC for cervical cancer,and the risk degree of cervical cancer in patients with different serum expression levels was compared.Results The levels of APOC1,IL-6 and SCC in cervical cancer group were higher than those in control group[89.00(64.67,169.17)mg/L vs 46.84(27.78,64.15)mg/L,65.49(39.88,125.20)ng/L vs 34.04(22.28,55.35)ng/L,1.81(1.03,4.03)μg/L vs 1.01(0.76,1.50)μg/L](Z=6.130,5.096,4.779,all P＜0.001).The serum APOC1 and IL-6 levels in International Federation of Gynecology and Obstetrics(FIGO)stage Ⅲ patients were significantly higher than those in FIGO stage Ⅰ-Ⅱpatients.The serum APOC1 level in poorly differentiated patients was significantly higher than that in moderately well differentiated patients.The SCC level in squamous cell carcinoma patients was higher than that in adenocarci-noma patients(all P＜0.05).The area under the curve of combined detection of APOC1,IL-6 and SCC in the diagnosis of cervical cancer was larger than that of any one of them alone(0.900 vs 0.809,0.757,0.741),and the sensitivity and specificity of combined detection of the three markers were also higher than those of single detection(all P＜0.05).The risk of cervical cancer in patients with high levels of APOC1,IL-6 and SCC was 9.76,5.94 and 3.92 times higher than those with low levels of APOC1,IL-6 and SCC.Conclusions The serum levels of APOC1,IL-6 and SCC are significantly increased in patients with cervical cancer.The serum levels have certain predictive value for tumor stage,tumor type and differentiation degree.The combined detection of APOC1,IL-6 and SCC can improve the diagnostic efficiency of cervical cancer.

Abstract:Objective To develop a model based on the Medical Information Mart for Intensive Care(MIMIC)database to predict in-hospital mortality in patients with congestive heart failure and cardiogenic shock(CS),and evaluate its clinical efficacy.Methods This retrospective study included 2 090 patients diagnosed as congestive heart failure complicated with CS from 2008 to 2019 from the MIMIC-Ⅳ database.All patients were divided into non-death group(1 434 cases)and death group(656 cases)according to whether there was in-hospital death.Data on clinical characteristics,vital signs,laboratory results,and system scores were collected.Lasso regression was used to select relevant variables,and multivariate logistic regression analysis was employed to identify independent predictors and construct a nomogram model for predicting in-hospital mortality.Internal validation was performed using the Bootstrap method.The model was evaluated using the receiver operating charac-teristic(ROC)curve and decision curve analysis(DCA).Results Multivariate Logistic regression analysis showed that peripheral oxygen saturation[odds radio(OR)=0.968,95％confidence interval(CI):0.949-0.987,P=0.001]and serum albumin(OR=0.764,95％CI:0.626-0.932,P=0.008)were independent protection factors for patients in-hospital death,and age(OR=1.043,95％CI:1.034-1.051,P＜0.001),female(OR=1.304,95％CI:1.052-1.615,P=0.015),body temperature＜36 ℃(OR=1.720,95％CI:1.284-2.304,P＜0.001),chronic obstructive pulmonary disease(OR=1.404,95％CI:1.131-1.744,P=0.002),hemodi-alysis(OR=2.210,95％CI:1.710-2.856,P＜0.001),serum lactate levels(OR=1.149,95％CI:1.100-1.200,P＜0.001)and sequential organs failure assessment(SOFA)score(OR=1.113,95％CI:1.080-1.146,P＜0.001)were independent risk factors.Based on multivariate Logistic regression analysis,a nomogram risk model of nosocomial death in patients with congestive heart failure complicated with CS was constructed.The nomogram model demonstrated an area under the ROC curve of 0.766,with a sensitivity of 72.6％and specificity of 66.9％.Internal validation showed good agreement between the predicted and actual values on the calibration curve.Decision curve analysis indicated that the model provided significant clinical net benefit.Conclusions Based on the MIMIC-Ⅳ database,this study developed a nomogram model incorporating age,gender,chronic obstructive pulmonary disease,peripheral oxygen saturation,body temperature＜36 ℃,hemodialysis,serum albumin,serum lactate,and SOFA score to predict in-hospital mortality in patients with CS complicated by congestive heart failure cardiogenic shock.The model demonstrated high discriminative ability,calibration,predictive performance,and clinical net benefit,enabling early identification of high-risk patients and optimization of treatment decisions.

Abstract:Infection can lead to the adverse progression of liver cirrhosis and increase the mortality rate,while the development of liver cirrhosis to the end stage will increase the susceptibility of patients to infection,thus forming a vicious circle.Patients with liver cirrhosis have impaired immune function,intestinal barrier dysfunc-tion,changes in the composition and function of intestinal flora,bacterial translocation,and are prone to infection.Antibiotics are the most commonly used means of anti-infection,but traditional empirical antibiotic therapy or irrational antibiotic use may promote the spread of multi-drug resistant bacteria,destroy intestinal microecology,and further increase the susceptibility to infection.Therefore,new methods for the prevention and treatment of liver cirrhosis complicated with infection need to be paid attention.This article aims to explore the relationship between liver cirrhosis complicated with infection and intestinal microecology,and focuses on the application of intestinal microecology regulation,such as probiotics,prebiotics,new antibiotics,intestinal metabolites,fecal microbiota transplantation and traditional Chinese medicine regulation in liver cirrhosis complicated with infection,in order to provide new ideas for the prevention and treatment of liver cirrhosis complicated with infection.

Abstract:Objective To explore the value of dulaglutide combined with Bifidobacterium quadruple live bacterial tablets in reducing the risk of cardiovascular diseases in patients with type 2 diabetes mellitus(T2 DM).Methods A total of 60 patients with T2DM admitted to the Department of Endocrinology,Zhangjiakou First Hospital,Hebei Province from March 2021 to March 2022 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 30 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with dulaglutide combined with Bifidobacterium quadruple live bacterial tablets on the basis of the control group.Both groups received diet and exercise intervention.The blood glucose level,islet function index and inflammatory factor index of the two groups were detected,and the risk of cardiovascular disease was compared between the two groups.Results After treatment,the fasting blood glucose,glycosylated hemoglobin and average blood glucose levels of the two groups were lower than those before treatment,and the blood glucose level of the observation group was lower than that of the control group(all P＜0.05).After treatment,the steady-state model islet β cell function index,0.5 h insulin production index and 2 h insulin production index of the two groups were higher than those before treatment,and the steady-state model insulin resistance index was lower than that before treatment;compared with the control group,the observation group had greater changes(all P＜0.05).After treatment,the levels of interleukin-6,high-sensitivity C-reactive protein and lipopolysaccharide in the two groups were lower than those before treatment,and the levels of each index in the observation group were lower than those in the control group(all P＜0.05).After treatment,the Framingham risk score and 10-year risk of cardiovascular disease in the observation group were lower than those before treatment,and lower than those in the control group[(12.0±0.6)vs(13.1±0.8),(4.1±2.3)％vs(6.2±5.3)％](all P＜0.05).Conclusion Dulaglutide combined with Bifidobacterium quadruple live bacterial tablets in the treatment of T2DM can reduce insulin resistance,improve islet β cell function,control inflammatory response,and reduce the risk of cardiovascular events.

Abstract:Objective To investigate the diagnostic value of inflammatory markers in peripheral blood for hepatocellular carcinoma(HCC).Methods A total of 431 patients with HCC who were admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2019 to April 2022 were collected as the research objects(HCC group),and 153 patients with hepatic hemangioma were enrolled as the control group.The peripheral blood neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),lymphocyte to monocyte ratio(LMR),lymphocyte to C-reactive protein ratio(LCR),C-reactive protein to albumin ratio(CAR),albumin to total bilirubin ratio(ABR),fibrinogen to albumin ratio(FAR),fibrinogen to prealbumin ratio(FPR)were calculated.Logistic regression analysis was used to evaluate the risk factors and protective factors for distinguishing HCC from hepatic hemangioma.The receiver operating characteristic(ROC)curve was drawn to analyze the auxiliary diagnostic value of the above indicators in the differential diagnosis of HCC and hepatic hemangioma.Results Logistic regression analysis showed that male,age,NLR,CAR and FPR were risk factors for the development of hepatic hemangioma into HCC(odds ratios=11.710,1.110,1.998,1.035,7.989,all P＜0.05);ABR,PLR,LMR and FAR were protective factors for the development of hepatic hemangioma into HCC(odds ratios=0.686,0.978,0.670,0.798,all P＜0.05).The results of ROC curve analysis showed that LMR,CAR,ABR,and FPR showed good diagnostic efficacy in the differential diagnosis of HCC and hepatic hemangioma[area under the curve(AUC)＞0.7],among which the protective factor LMR had the highest diagnostic efficacy,with an AUC of 0.761.The AUC of combined detection of NLR,PLR,LMR,LCR,CAR,ABR,FAR,and FPR was 0.946,which had the highest diagnostic efficiency.Conclusions NLR,PLR,LMR,LCR,CAR,ABR,FAR and FPR have certain value in the diagnosis of HCC.Among them,NLR,CAR and FPR are risk factors of HCC,and ABR,PLR,LMR and FAR are protective factors of HCC.The combined detection of the above indicators can improve the diagnostic efficiency of HCC.

Abstract:Hydroxychloroquine,as an antimalarial drug,has low toxicity,anti-inflammatory,immuno-modulatory,immunosuppressive and thromboprophylaxis effects.It is not only used in the treatment of malaria,but also in the treatment of rheumatic immune diseases.As the research progressed,it is discovered that hydroxychloro-quine can mitigate kidney damage by inhibiting the cascade of inflammatory signaling,suppressing autophagy,and preventing the formation of immune response complexes,thereby reducing or delaying the occurrence of proteinuria.Hence,it is utilized for the management of kidney diseases associated with inflammatory responses,such as IgA nephropathy and lupus nephritis.Moreover,hydroxychloroquine has demonstrated a superior safety profile in comparison to other immunosuppressants for treating kidney diseases.Furthermore,the therapeutic efficacy of hydroxychloroquine in additional kidney conditions like diabetic nephropathy and membranous nephropathy is highly esteemed,warranting further investigation into its mechanism of action and potential safety considerations.