Abstract:Objective To understand the status of cancer-related fatigue in patients with lung cancer, analyze its influencing factors and the relationship with quality of life, provide reference basis for the treatment of lung cancer.Methods According to the overall score of Piper Fatigue Scale (PFS), 120 patients with lung cancer were divided into non-fatigue group, mild fatigue group, moderate fatigue group and severe fatigue group.The influencing factors of cancer-related fatigue were analyzed and the quality of life of patients were evaluated, and the correlation between cancer-related fatigue and quality of life of patients with lung cancer were analyzed.Results Among 120 cases of lung cancer, 92 cases (76.67％) had cancer-related fatigue.The scores of somatic dimension in lung cancer patients were significantly higher than those of behavioral dimension, cognitive dimension and emotional dimension (P<0.05).The PFS scores of lung cancer patients with aged 60 years above, high school and above, TNM stage III-IV and adverse reactions were respectively higher than those of lung cancer patients with age <60 years old, middle school and below TNM stage I-II and without adverse reactions (P<0.05).Multivariate logistic regression analysis showed that education level (OR=1.374), TNM stage (OR=1.647) and adverse reactions (OR=2.391) were independent risk factors for cancer-related fatigue in lung cancer patients (P<0.05).With the increase of fatigue in lung cancer patients, the scores of SF-36 decreased gradually (P<0.05).Spearman correlation analysis showed that there was a negative correlation between SF-36 scores and PFS score in lung cancer patients (P<0.05).Conclusion The incidence of cancer-related fatigue in patients with lung cancer is higher, and the quality of life of patients is decreased, which is related to the degree of fatigue.Educational level, TNM stage and adverse reactions are independent risk factors for cancer-related fatigue in patients with lung cancer.