Abstract:Polycystic ovary syndrome(PCOS),a common reproductive endocrine metabolic disorder among women of childbearing age,is characterized by hyperandrogenemia,ovulatory dysfunction,and the presence of multiple cystic ovaries.The pathogenesis of PCOS is complex and unclear.The clinical manifestations of PCOS are highly heterogeneous,and treatment mainly focuses on alleviating clinical symptoms.In recent years,with the in-depth study of the relationship between the gut microbiota and PCOS,the application of probiotics in the treatment of PCOS has gradually gained attention.Probiotics can adjust the intestinal microbiome,reduce cholesterol through bile acid deconjugation,regulate body weight and serum lipid levels,lower blood pressure,and prevent and treat infections.Probiotics can improve insulin resistance,regulate hormonal disorders,alleviate oxidative stress and inflammation,improve abnormal lipid metabolism and reproductive function,and enhance mental health levels,all of which have therapeutic effects on PCOS patients.

Abstract:Nausea and vomiting of pregnancy(NVP)is the most common complication among pregnant women.The pathogenesis is related with genetics,hormones,Helicobacter pylori,and social psychological factors in the theory of Western medicine.Doxylamine/pyridoxine and other oral drugs are commonly used for treatment,including promethazine,metoclopramide,ondansetron,gabapentin,and glucocorticoids.Although these drugs can significantly alleviate NVP symptoms,the potential impact on the health of both mother and fetus has raised the concern among pregnant women,especially regarding the use of these medications in the first trimester.It is considered by Traditional Chinese Medicine(TCM)that the main etiology and pathogenesis of NVP is adverse rising of Chongqi,and disharmong of stomach qi.Based on the principle of regulating qi and harmonizing the middle,lowering counterflow and stopping vomiting in TCM treatment which not only prescribe oral decoction of TCM "varies from person to person" through syndrome differentiation but also flexibly use external treatment methods,such as acupuncture,acupoint injection,acupoint application,acupressure,auricular point pressing with bean,moxibustion and rectal instillation,have showed the remarkable efficacy.However,the relatively small sample sizes of clinical studies on TCM therapies have limited the in-depth exploration of these distinctive treatment approaches.In the future,it is imperative to further deepen the collaborative research between Western medicine and TCM to provide more scientific and personalized options for the diagnosis and treatment of NVP.

Abstract:Polycystic ovary syndrome(PCOS),a common multisystem disorder in women of reproductive age,is typically associated with metabolic and reproductive abnormalities.In recent years the attention to the psychological disturbances,adverse pregnancy outcomes,and long-term complications in PCOS patients has been growing.Quercetin(QUE)as a natural flavonoid exhibits the unique therapeutic potential for PCOS management.In terms of metabolic regulation,QUE can improve insulin resistance and modulates glucose/lipid metabolism through multiple pathways.Regarding reproductive endocrinology,QUE can significantly reduce serum androgen level,mitigate follicular atresia and promote follicular maturation,thereby restore normal ovarian function and alleviae ovulatory dysfunction.As for reproductive outcomes,QUE may reduce miscarriage risk via anti-inflammatory,antioxidant and anti-apoptotic properties.Additionally,QUE may have the effects of anti-depressant and anti-cancer,potentially preventing anxiety/depression and endometrial cancer in PCOS patients.While preclinical evidence supports QUE's multifaceted benefits in PCOS,further clinical studies are needed to validate its therapeutic applications.

Abstract:Endometrial receptivity refers to the dynamic remodeling of the endometrium during the short time window of the menstrual cycle(i.e.,the "implantation window period"),in which the endometrium acquires the possibility of location,adherence and initiate invasion of the blastocyst.Abnormal endometrial receptivity can lead to clinical problems such as repeated implantation failure,unexplained infertility and pregnancy loss.Recent studies have shown that microRNAs(miRNAs)play an important role in the dynamic regulation of endometrial receptivity by targeting and inhibiting the mRNA translation or promoting its degradation.This manuscript summarizes the role of miRNAs in regulating the levels of estrogen and progesterone,maintaining the stability of the immune microenvironment,mediating angiogenesis and extracellular matrix remodeling,regulating the formation of phagocytic protrusions and embryonic adhesion processes,influencing the decidualization process,and further regulating endometrial receptivity.The purpose is not only to provide a new perspective for in-depth understanding of the molecular regulatory network of endometrial receptivity,but also to offer more theoretical basis for the diagnosis and treatment of reproductive disorders such as recurrent implantation failure and infertility.

Abstract:Fructose-1,6-bisphosphatase deficiency(FBP1D),a rare inherited metabolic disorder,may lead to severe neurological sequelae if not treated promptly and effectively.We report a case of FBP1D diagnosed through trio-whole exome sequencing(trio-WES).The NM_000507.4(FBP1)c.977T＞C variant in this patient has not been reported in China.We summarized and analyzed the genotypic and phenotypic characteristics of 31 Chinese FBP1D patients from literature.The typical clinical manifestations included hypoglycemia,metabolic acidosis,gastrointestinal symptoms,and impaired consciousness,with the infection being the most common triggering factor.Genetic analysis revealed that the c.960dup variant in the FBP1 gene is the most prevalent variant among Chinese patients.Enhancing clinicians' awareness of FBP1D can facilitate early diagnosis and active intervention,thereby significantly improve patient prognosis.

Abstract:Objective:To explore the application of mindfulness-based interventions(MBIs)in the patients undergoing in vitro fertilization-embryo transfer(IVF-ET),with a scoping review.Methods:Following the Joanna Briggs Institute methodology for scoping reviews,we systematically searched PubMed,Web of Science,Embase,Cochrane Library,CINAHL,CNKI,WanFang Data,VIP and CBM databases.Two researchers independently performed literature screening and data extraction,followed by synthesis and analysis of included studies.Results:Twenty-two studies were included.The intervention modalities included mindfulness-based stress reduction(MBSR),mindfulness-based cognitive therapy(MBCT),mindfulness-based yoga,mindfulness-based childbirth and parenting(MBCP),and acceptance and commitment therapy(ACT).The delivery formats included in-person training,online training and hybrid approaches.Most interventions were administered weekly(1-2 h/session).Most studies have shown that mindfulness intervention can alleviate anxiety and depression,significantly reduce the symptoms such as hostility and interpersonal sensitivity,and effectively lower the sense of stigma and enhance the happiness index and marital satisfaction,while mindfulness intervention can improve the sleep quality and physical comfort,as well as the quality of life and marriage.Meanwhile,most of IVF-ET patients expressed their satisfaction and recognition of the mindfulness intervention course.Conclusions:Preliminary evidence supports the diversity,integrative potential,efficacy and feasibility of MBIs in IVF-ET patients.Future research should optimize the personalized intervention protocols,explore the web-based remote delivery strategies,and further validate the long-term effect across multidimensional outcomes including psychological well-bing,sleep quality,mindfulness levels,and quality of life in IVF-ET patients.

Abstract:The uterine tumor resembling ovarian sex cord tumor(UTROSCT),as a special pathological type of primary uterine tumor,is difficult to be diagnosed early due to its extreme rarity and unspecial manifestations in clinical.We report a case of UTROSCT combined with adenomyosis.The patient was admitted to the hospital due to the discovery of uterine fibroids for more than 3 months and intermittent vaginal bleeding for 12 days.The patient was admitted the hospital with a outpatient diagnosis of uterine fibroids.After admission,the relevant auxiliary examinations were completed.Pelvic ultrasound suggested the possibility of uterine fibroids,and there was no obvious abnormalities in tumor markers.Single-port laparoscopic myomectomy and opportunistic salpingectomy were performed.During the operation,the tumor capsule was gray-white,the tumor was extremely soft,and the boundary between the tumor and the uterus was unclear.The intraoperative rapid pathological examination suggested the possibility of small-cell malignant tumor,so total hysterectomy and bilateral adnexectomy were immediately performed.Finally,the postoperative pathology report showed UTROSCT.After 4-year follow-up,the patient's condition was stable and there was no recurrence.We concluded that surgical treatment is the main treatment for UTROSCT,the prognosis is usually good,and that the possibility of recurrence and metastasis should be noted.

Abstract:Ovarian steroid cell tumor-not otherwise specified(SCT-NOS)is an exceedingly rare subtype of pure ovarian stromal tumor with malignant potential.Due to its low incidence and nonspecific clinical manifestations,it is frequently misdiagnosed or overlooked,with only sporadic cases reported in the literature.We report a case of ovarian SCT-NOS in a reproductive-aged woman presenting with massive ascites.The patient was admitted with a six-month history of intermenstrual vaginal bleeding.Color Doppler ultrasound revealed a right adnexal mass accompanied by significant pelvic and abdominal effusion.Pelvic magnetic resonance imaging was performed.After that,the multi-disciplinary team recommended exploratory laparotomy.The patient underwent a right salpingo-oophorectomy with left ovarian biopsy.Histopathological examination confirmed the diagnosis of right ovarian SCT-NOS.The postoperative follow-up at one year showed no evidence of ascites recurrence or tumor progression.Based on this case and a comprehensive literature review,we discuss the epidemiology,clinical characteristics,diagnostic challenges(including differential diagnoses),management strategies,and prognostic factors of SCT-NOS,with the aims to enhance clinical awareness and provide references for the diagnosis and treatment of this rare entity.

Abstract:Objective:To identify the oxidative stress-related key genes that differentially expressed(OS-DEG)in teratozoospermia through bioinformatics analysis,and to predict the candidate targeted Chinese herbal medicines.Methods:The GSE6969 gene expression profile from the GEO(Gene Expression Omnibus)database was retrieved,and the differentially expressed genes were screened.These genes were then intersected with the oxidative stress-related genes that retrieved from the GeneCards database.The key pathways and genes were identified through Gene Ontology(GO)enrichment analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis,and protein-protein interaction(PPI)network analysis.Finally,the potential candidate herbal medicines targeting those key genes were searched from the Encyclopedia of Traditional Chinese Medicine(ETCM)database.Results:A total of 261 OS-DEGs Key genes were identified by differential analysis,including PTEN,JUN,glycogen synthase kinase 3β(GSK3β),and superoxide dismutase 2(SOD2)were screened using Cytoscape.The candidate Chinese herbal medicines were identified,such as Portulaca oleracea,Glehnia littoralis,Pinellia ternata,Verbena officinalis,Salvia miltiorrhiza,Typhonium giganteum.Conclusions:In this study,bioinformatics analysis was used to screen the genes related to oxidative stress in teratozoospermia,which provided a new insight into the treatment of teratozoospermia with traditional Chinese medicine.

Abstract:High intensity focused ultrasound(HIFU),as a kind of non-invasive treatment,can project the ultrasound wave to the target tissues of the body,causing coagulative necrosis of the target tissues.HIFU has good clinical efficacy for patients with uterine fibroids who have fertility requirements.HIFU can improve the physiological function,relieve pain,and shorten the hospitalisation time and reduce medical costs.It can also reduce the likelihood of bleeding and infection.HIFU treatment for fibroids has less impact on ovarian function,improves endometrial tolerance,and reduces the incidence of pelvic adhesions,suggesting therapeutic advantages for protecting women's fertility.HIFU treatment for fibroids can shorten the interval between pregnancies after the treatment.The quality and reliability of studies on the effect of HIFU on pregnancy need to be further improved.In this paper,we review the effects of HIFU treatment of fibroids on ovarian function,the female reproductive tract,pregnancy,and fertility reservation.

Abstract:Objective:Based on the latent profile analysis,to understand the categorical characteristics of stigma in infertile women and the influencing factors of stigma in those infertile women.Methods:A cross-sectional survey was conducted,using convenience sampling to select 345 infertile women who visited the Reproductive Medicine Center of The First Affiliated Hospital of Anhui Medical University from April 2020 to June 2020.The General Information Survey,Female Infertility Stigma Scale(ISS),and Herth Hope Index(HHI)were used for the evaluation of stigma.Results:Latent profile analysis showed that the characteristics of stigma in infertile women were divided into three potential categories:"low stigma and low family stigma group"150 cases(43.48％),"middle stigma group"140 cases(40.58％),and"high stigma and high social stigma group"55 cases(15.94％).There were significant differences in the stigma among different categories of infertile women in terms of educational level,occupation,marital history,place of residence,and relationship with their husbands(all P＜0.05).Using the"low stigma and low family stigma group"as a reference,high school/vocational education level(OR=2.484,P=0.048)is a risk factor for the"middle stigma group",while being in a first marriage(OR=0.268,P=0.006)is a protective factor for the"middle stigma group".Living in rural towns(OR=2.764,P=0.046)is a risk factor for the"high stigma and high social stigma group",whereas having a good relationship with the husband(OR=0.382,P=0.034)and having a high total HHI score(OR=0.582,P=0.010)are two protective factors for the"high stigma and high social stigma group".Using the"middle stigma group"as a reference,having a high total HHI score(OR=0.531,P=0.002)is a protective factor for the"high stigma and high social stigma group".Conclusions:Clarifying the potential categories of stigma among infertile women can help medical staff take intervention measures targeting the influencing factors to reduce their feeling of stigma,and improve their psychological health.

Abstract:Objective:To explore the clinical significance of detecting Xp22.31 microdeletion/microduplication in prenatal diagnosis.Methods:A retrospective analysis was conducted on the data of 6 015 pregnant women who underwent the chromosome karyotype analysis and single nucleotide polymorphism array(SNP-array)testing of amniotic fluid/umbilical cord blood at the Prenatal Diagnosis Center of Quanzhou Women's and Children's Hospital from January 2017 to October 2023.The cases were grouped based on the confirmed Xp22.31 microdeletion/microduplication fetuses.The prenatal manifestations,genetic testing results,and follow-up outcomes were analyzed and compared between the two groups.Results:Among the 6 015 pregnant women,68 cases of Xp22.31 microdeletion/microduplication were found by SNP-array.There were 18 cases of Xp22.31 microdeletion(13 males and 5 females).Five cases were verified by parents,of which 4 cases were inherited from their mothers with normal phenotype and 1 case was de novo mutation.Among 14 cases of Xp22.31 microdeletion with high risk of prenatal Down's syndrome screening(DSS),11 cases had unconjugated estriol multiple of the median(uE3MOM)values＜0.1,which was significantly lower than the normal range.Among the 13 male microdeletion carriers,1 terminated pregnancy,1 lost follow-up,11 continued pregnancy,9 cases were diagnosed with ichthyosis after birth,and 2 had no obvious abnormalities.Five female deletion carriers were all born without obvious abnormalities.There were 50 cases of Xp22.31 microduplication(19 males and 31 females),27 cases were verified by parents,and all of them were inherited from their parents.Of the 50 fetuses,5 fetuses terminated pregnancy,2 fetuses were lost to follow-up,and 43 fetuses continued pregnancy.Two fetuses had abnormal symptoms after birth,and the remaining 41 fetuses had no abnormalities.There were no significant differences in maternal age,ultrasound abnormality rate,and parental verification results between the two groups(all P＞0.05).The high-risk rate of DSS and the proportion of male fetuses in the microdeletion group were higher than those in the microduplication group,while the detection rate and the rate of benign pregnancy outcomes in the microdeletion group were lower than those in the microduplication group(both P＜0.05).The uE3MOM value of high-risk fetuses in the DSS of the microdeletion group was lower than that of the microduplication group(P＜0.05).Conclusions:Fetuses with Xp22.31 microdeletion/microduplication lack typical prenatal clinical features.For pregnant women with high risk of prenatal serological screening,especially those whose uE3MOM value is significantly lower than the normal range,chromosomal microchange detection should be recommended.Male fetuses with Xp22.31 microdeletion mainly present with ichthyosis phenotype after birth,while female Xp22.31 microdeletion carriers have good pregnancy outcomes.Most of the Xp22.31 microduplication is parental inheritance,and the pregnancy outcome of fetus is likely to be benign.

Abstract:Coenzyme Q10(CoQ10)is an endogenous lipid antioxidant that protects cellular function by scavenging free radicals and inhibiting lipid peroxidation.The human body requires approximately 500 mg of CoQ10 per day,yet only about 5 mg from dietary sources.Therefore,the exogenous supplementation of CoQ10 is necessary to maintain the normal reproductive function.Male infertility is significantly associated with the decreased sperm quality,and its core pathological mechanism lies in oxidative stress.CoQ10 reduces reactive oxygen species(ROS)-induced damage to sperm by improving mitochondrial function.Female infertility is often related to reproductive aging,postovulatory aging and endometriosis.CoQ10 can restore oocyte energy metabolism,decrease ROS to reduce the risk of embryonic abnormalities,and facilitate endometrial receptivity for embryo implantation.This review summarizes the critical role of CoQ10 in improving the functions of both male and female reproductive systems,and the application in improving the outcomes of assisted reproduction,by targeting the oxidative stress pathway.Future research should further explore the optimization of CoQ10 dosages and synergistic strategies with other antioxidants to advance its application in reproductive medicine.

Abstract:Objective:To analyze the clinical characteristics and prognosis of cervical mucinous adenocarcinoma.Methods:The data of the patients diagnosed with cervical mucinous adenocarcinoma and cervical usual-type adenocarcinoma from the Surveillance,Epidemiology,and End Results(SEER)database,from 2000 to 2021,was retrospectively collected.The clinical characteristics and prognosis were analyzed and compared.Kaplan-Meier method was used for survival analysis,and Cox proportional hazards regression was employed to analyze the prognostic factors.Results:A total of 9 404 patients with cervical adenocarcinoma were included,among which 917 had mucinous adenocarcinoma and 8 487 had usual-type adenocarcinoma.The comparison of age at diagnosis,race,International Federation of Gynecology and Obstetrics(FIGO)2018 staging,National Comprehensive Cancer Network(NCCN)staging,tumor diameter,lymph node metastasis status,and treatment modalities(surgery,radiotherapy,and chemotherapy)between patients with cervical mucinous adenocarcinoma and those with usual-type adenocarcinoma showed statistically significant differences(all P＜0.05).Compared to the patients with usual-type adenocarcinoma,the patients with cervical mucinous adenocarcinoma had a higher proportion of Asian or Pacific Islander patients(14.2％vs.10.5％),a higher proportion of locally advanced(42.1％vs.36.7％)and metastatic(17.2％vs.9.8％)patients,and a higher rate of lymph node metastasis(22.4％vs.14.8％).For early-stage patients,surgical intervention was the main treatment method for both histological types;for locally advanced and metastatic patients,non-surgical treatments(chemotherapy and radiotherapy)were predominant,with a higher treatment rate for mucinous adenocarcinoma patients.The overall survival(OS)of patients with cervical mucinous adenocarcinoma was significantly shorter,particularly in early and locally advanced patients(both P＜0.01).Multivariate Cox regression analysis revealed that older age,higher FIGO stage,and larger tumor diameter were independent risk factors for OS in the patients with cervical mucinous adenocarcinoma,while surgery and chemotherapy were independent protective factors.Surgery improved OS in the patients with cervical mucinous adenocarcinoma across different stages(all P＜0.05).Conclusions:Compared to usual-type adenocarcinoma,cervical mucinous adenocarcinoma has worse prognosis,higher tendency for lymph node and distant metastasis.Surgical intervention can improve the OS of patients with mucinous adenocarcinoma,and has a certain protective effect on the locally advanced patients.

Abstract:Ovarian vein thrombosis(OVT),a rare puerperal complication,is often caused by puerperal infective endometritis.If left untreated,OVT may lead to serious complications such as infection spread or pulmonary embolism.However,OVT is prone to misdiagnosis and missed diagnosis in clinical practice.By reviewing the data of two patients admitted postpartum with low back pain,with or without fever,who were eventually diagnosed with OVT,we found that both patients had hydronephrosis on imaging during the course of their visits.After treatment,the hydronephrosis and ovarian vein thrombosis disappeared.Many relevant literatures showed that there are certain limitations in the original triple syndrome of puerperal OVT(fever,abdominal pain and abdominal mass).Hydronephrosis could be companied with puerperal OVT,suggesting that the ultrasound examination of urinary system should be performed routinely.If hydronephrosis be found,also suggesting the possibility of OVT in puerperal patients,a clear diagnosis should be make as soon as possible.

Abstract:Women of childbearing age are a group with the second highest incidence of essential thrombocythemia,and the reproductive challenges of this group have attracted clinical attention.We report a case of an infertile patient with essential thrombocythaemia who gave birth successfully through in vitro fertilization-embryo transfer(IVF-ET).The patient received IVF-ET due to primary infertility and ineffective ovulation induction.During the treatment,the medication regimen was adjusted multiple times due to abnormal platelet level.Aspirin alone before and after the first transplantation and aspirin combined with low molecular weight heparin calcium before and after the subsequent transplantation did not get successfully pregnancy.The treatment strategy was then adjusted to use firstly aspirin combined with interferon-α to reduce the platelet level.After platelet level was well controlled,aspirin combined with low molecular weight heparin calcium treatment was used before and after embryo transfer.After successful pregnancy,this regimen was continued until delivery.Ultimately,a successful live birth was achieved.By exploring the clinical characteristics,treatment methods and successful experience of this case,the key role of individualized treatment plan in improving the success rate of assisted pregnancy is emphasized.

Abstract:Objective:To compare the short-term outcomes of intrauterine cavity reconstruction and menstrual function recovery after hysteroscopic adhesiolysis between patients with intrauterine adhesions(IUAs)caused by endometrial tuberculosis(ETB)and those with trauma-induced IUAs.Methods:A retrospective matched cohort study was conducted on patients with IUAs who underwent hysteroscopic adhesiolysis at Fuxing Hospital Affiliated Capital Medical University between July 2012 and January 2023.The study group included 54 patients with pathologically confirmed ETB who had completed anti-tuberculosis treatment,while the control group consisted of 108 patients with non-infectious,trauma-induced IUAs.The 1∶2 matching was performed based on age and preoperative American Fertility Society(AFS)scores.Changes in AFS scores before and one month after surgery,as well as improvements in menstrual patterns,were compared between the two groups.Subgroup analysis was conducted based on the severity of adhesions(moderate and severe).Results:No significant differences were observed between the two groups in terms of age,preoperative AFS scores,postoperative AFS scores,or the magnitude of score reduction(all P＞0.05).The overall menstrual improvement rates were 68.5％(37/54)in the study group and 76.8％(83/108)in the control group,with no significant difference(P＞0.05).Among patients with preoperative moderate IUAs,no statistically significant difference was observed in postoperative AFS scores between the two groups(P＞0.05).In contrast,among those with severe IUAs,the study group had significantly higher postoperative AFS scores(P=0.031).Nevertheless,postoperative menstrual improvement rates did not differ significantly between the two groups in either the moderate or severe IUA subgroups(both P＞0.05).Conclusions:Patients with ETB-related IUAs can achieve comparable short-term recovery in menstrual function to those with trauma-induced IUAs after standardized anti-tuberculosis treatment and hysteroscopic adhesiolysis.Moderate adhesions demonstrate promising potential for anatomical restoration,while severe adhesions present more limited recovery.Early identification and timely intervention are essential,and future strategies may benefit from severity-based stratified management and the integration of regenerative treatment for severe cases.

Abstract:Postpartum uterine necrosis is a rare condition,with only a few cases reported in the literature.It is closely associated with uterine ischemia and bacterial infections,with a poor prognosis,often necessitating hysterectomy.Uterine artery embolization,uterine compression suturing,and pelvic vessel ligation are important methods for managing refractory postpartum hemorrhage,primarily by interrupting uterine blood flow to achieve hemostasis.However,the combined use of multiple hemostatic techniques can often lead to uterine ischemia.If the patient also has concurrent genital tract inflammation,the infection may be exacerbated,leading to uterine necrosis and posing a potential risk of mortality.Currently,there is no standardized treatment protocol for postpartum uterine necrosis.Multidisciplinary team management can facilitate early identification and timely control of the condition,thereby preventing severe complications.Improving uterine blood flow and actively controlling infections are critical for preventing uterine necrosis.This article discusses the risk factors,preventive strategies,and clinical management approaches for postpartum uterine necrosis.The aim is to enhance obstetricians' abilitity of identifying risks and manage complications,thereby protecting maternal reproductive function and ensuring life safety.

Abstract:Pelvic tuberculosis is difficult to be discovered in clinic,and easy to be misdiagnosed,because of its concealed condition,no obvious clinical features and signs.We report a case of 29-year-old female who underwent laparoscopic exploration for a mass in the left adnexal area with the elevated carbohydrate antigen 125(CA125)during in vitro fertilization-embryo transfer(IVF-ET).A large number of miliary nodules were found on the serosa surface of the uterus and fallopian tube under the laparoscopy.Pathological examination of the biopsy tissue showed granulomatous inflammation,with negative acid fast staining indicating a high possibility of tuberculosis.After empirical anti-tuberculosis treatment and CA125 levels were reduced to normal,the frozen-thawed embryo transfer was performed.The patient achieved a successful pregnancy and a healthy live birth.This case report combined with the literature review provides us a reference for the early diagnosis and treatment of infertile patients with pelvic tuberculosis.

Abstract:In recent years,the number of patients seeking medical treatment due to hyperemesis gravidarum has been increasing year by year,becoming the second leading indication of hospitalization for pregnant women in early pregnancy in China.It can also increase the risk of postpartum depression,anxiety,and post-traumatic stress disorder for pregnant women.It is an important therapeutic principle of traditional Chinese medicine to treat the pregnancy-related diseases by simultaneously treating the disease and pacifying the fetus.As an important part of the classic of traditional Chinese medicine,acupuncture and moxibustion therapy,based on the meridian pathogenesis of hyperemesis gravidarum,combined with the pathogenic factors of hyperemesis gravidarum,individual endowment and special physiological conditions during pregnancy,has therapeutic advantages such as good therapeutic effect,high safety,convenient and flexible operation,etc.The treatment methods mainly include filiform needle acupuncture,moxibustion,point injection,press needle acupuncture,traditional Chinese medicine point application and combined therapy,which can effectively relieve nausea,vomiting,fatigue and other symptoms of patients with hyperemesis gravidarum.Therefore,it provides an option for the treatment of hyperemesis gravidarum.