前颅窝开放粉碎性骨折膜性颅底重建
林其昌
林少华
黄汉添
廖巍
1.中山大学附属中山医院神经外科,广东中山,5284002.中山大学附属中山医院神经外科,广东中山,5284003.中山大学附属中山医院神经外科,广东中山,5284004.中山大学附属中山医院神经外科,广东中山,528400
摘要：Background Clinical outcome in patients with severe traumatic brain injury ( TBI) depends on both primary and seconda-ry brain injuries.Neuroinflammation is an important secondary mechanism, which occurs by releasing interleukins ( ILs ) .Increased levels of ILs may affect clinical outcome following TBI.OBJECTIVE This study aimed to determine the relationship between the serum levels of interleukins 6, 8 and 10 and clinical outcome in patients with severe TBI 6 months after injury.PATIENTS And METHODS In a descriptive-analytical study, 44 patients with GCS≤8 ( Glasgow coma scale) and age≥14 years were included.Their blood samples were collected at first 6 hours after injury.Clinical outcome was determined based on GOS ( Glasgow Outcome Scale) at 6 months after head injury.Serum levels of interleukins 6, 8 and 10 were measured using the ELISA method.Spearmanˊs rho, independent T-Test, and Mann-Whitney Test were used for data analysis.RESULTS Comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ±51.6 and 52.2 ±31.9, respectively lower than those of group with unfavorable outcome with 162.3 ±141.1 and 173.6 ±257.3 (P<0.03) and (P<0.01).CONCLUSIONS Increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfa-vorable clinical outcome in patients with severe TBI.
关键词：颅前窝膜性颅底重建脑脊液漏
分类号：R651(外科学各论)
资助基金：中山市科技局第二批科技计划基金资助项目(20132A125)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 264-265 )
英文信息