肠道菌群在骨关节炎中的免疫作用机制
李朝霞1
高鲁2
张晓峰1
杜佳哲1
刘江燕1
徐西林3
1.150040 哈尔滨,黑龙江中医药大学2.150001 哈尔滨,黑龙江中医药大学附属第二医院3.150030 哈尔滨,黑龙江中医药大学附属第三医院
摘要：Osteoarthritis(OA)is one of the most common degenerative and progressive joint diseases,which is characterized by articular cartilage degeneration,subchondral bone remodeling,and synovial inflammation.Gut microbiota has been proposed as an additional organ regulating bone metabolism.In recent years,the pathogenic role of gut microbiota in OA has been widely recognized.The imbalance of gut microbiota can disrupt the host-gut microbial balance,trigger the host immune response and activate the"gut-joint axis",thereby aggravating OA.This review systematically summarizes the research on intestinal flora and affected immune cells in OA,as well as the regulation of intestinal barrier and intestinal flora,in order to provide new ways for clinical treatment.
关键词：骨关节炎胃肠道微生物组免疫系统肠屏障综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
资助基金：黑龙江省中医药科研课题项目(ZHY2023-011)黑龙江省重点研发计划(GZ20210)全国基层名老中医药专家传承工作室建设项目(No.2021-2024)
论文发表日期：2024-09-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 763-768 )
英文信息