腺苷受体在骨关节炎中的作用研究进展
郭虎1
吕中阳2
史冬泉1
1.210008 江苏省,南京大学医学院附属鼓楼医院运动医学与成人重建外科2.210002 江苏省,南京大学医学院附属金陵医院骨科
摘要：Osteoarthritis(OA)is the most common degenerative joint disease,with synovial inflammation and articular cartilage degeneration as primary manifestations.Adenosine is an endogenous purine nucleoside that typically binds to its transmembrane G protein coupled receptors(ADORA1,ADORA2A,ADORA2B,ADORA3)to exert physiological effects.Adenosine receptor-mediated signals are widely involved in physiological processes such as inflammatory responses,and their expression levels or activation states change with the progression of OA,which suggests that adenosine receptors hold promise as targets for OA therapy.Therefore,we summarize the role of the four adenosine receptors in OA and the main methods of regulation of them in this review,with a view to provide references for subsequent research efforts on novel targets for intervention in the course of OA.
关键词：骨关节炎腺苷腺苷受体综述
分类号：R684.3(骨科学（运动系疾病、矫形外科学）)
资助基金：国家自然科学基金(82325035)国家自然科学基金(82172481)江苏省六大人才高峰项目(WSW-079)
论文发表日期：2024-09-19
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 758-763 )
英文信息